BR112015022856A2 - inibidores da protease do tripeptídeo e dipeptídeo da cetona epóxi - Google Patents

inibidores da protease do tripeptídeo e dipeptídeo da cetona epóxi

Info

Publication number
BR112015022856A2
BR112015022856A2 BR112015022856A BR112015022856A BR112015022856A2 BR 112015022856 A2 BR112015022856 A2 BR 112015022856A2 BR 112015022856 A BR112015022856 A BR 112015022856A BR 112015022856 A BR112015022856 A BR 112015022856A BR 112015022856 A2 BR112015022856 A2 BR 112015022856A2
Authority
BR
Brazil
Prior art keywords
dipeptide
protease inhibitors
epoxy ketone
tripeptide
tripeptide protease
Prior art date
Application number
BR112015022856A
Other languages
English (en)
Other versions
BR112015022856A8 (pt
Inventor
C Moebius David
Mcminn Dustin
Johnson Henry
Original Assignee
Onyx Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Onyx Therapeutics Inc filed Critical Onyx Therapeutics Inc
Publication of BR112015022856A2 publication Critical patent/BR112015022856A2/pt
Publication of BR112015022856A8 publication Critical patent/BR112015022856A8/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
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    • C07D303/32—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by aldehydo- or ketonic radicals
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    • C—CHEMISTRY; METALLURGY
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    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
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    • C—CHEMISTRY; METALLURGY
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    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
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    • C—CHEMISTRY; METALLURGY
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    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
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    • C07K5/06113—Asp- or Asn-amino acid
    • C07K5/06121—Asp- or Asn-amino acid the second amino acid being aromatic or cycloaliphatic
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    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
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  • Diabetes (AREA)
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  • Crystallography & Structural Chemistry (AREA)
  • Physical Education & Sports Medicine (AREA)
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BR112015022856A 2013-03-14 2014-03-14 inibidores de protease de cetona de epóxi de tripeptídeo e dipeptídeo BR112015022856A8 (pt)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US201361786086P 2013-03-14 2013-03-14
US201361785608P 2013-03-14 2013-03-14
US201361847780P 2013-07-18 2013-07-18
US201361856847P 2013-07-22 2013-07-22
US201361883798P 2013-09-27 2013-09-27
US201361883843P 2013-09-27 2013-09-27
US201461941798P 2014-02-19 2014-02-19
PCT/US2014/026980 WO2014152127A1 (en) 2013-03-14 2014-03-14 Dipeptide and tripeptide epoxy ketone protease inhibitors

Publications (2)

Publication Number Publication Date
BR112015022856A2 true BR112015022856A2 (pt) 2017-07-18
BR112015022856A8 BR112015022856A8 (pt) 2019-11-26

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ES2687368T3 (es) 2018-10-24
BR112015022856A8 (pt) 2019-11-26
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CA2904085A1 (en) 2014-09-25
AU2019203282B2 (en) 2021-02-18
IL241180A0 (en) 2015-11-30
NZ711794A (en) 2020-12-18
MX2015011770A (es) 2016-06-02
JP2016515127A (ja) 2016-05-26
TW201446807A (zh) 2014-12-16
AU2014240122B2 (en) 2019-02-14
EA201591752A1 (ru) 2016-02-29
AU2014240122A1 (en) 2015-09-24
WO2014152127A1 (en) 2014-09-25
DK2970225T3 (en) 2018-09-24
AU2019203282A1 (en) 2019-05-30
IL258297B (en) 2020-06-30
US20160031934A1 (en) 2016-02-04
JO3326B1 (ar) 2019-03-13
CA2904085C (en) 2021-07-06
EA030957B1 (ru) 2018-10-31
JP2019206531A (ja) 2019-12-05
EP2970225B1 (en) 2018-08-15
MX362489B (es) 2019-01-21
CN105164117A (zh) 2015-12-16
TWI662047B (zh) 2019-06-11
SG11201507106PA (en) 2015-10-29
JP6871310B2 (ja) 2021-05-12
IL258297A (en) 2018-05-31
US9657057B2 (en) 2017-05-23
CN105164117B (zh) 2019-02-01
UY35455A (es) 2014-09-30

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