SG11201507106PA - Dipeptide and tripeptide epoxy ketone protease inhibitors - Google Patents

Dipeptide and tripeptide epoxy ketone protease inhibitors

Info

Publication number
SG11201507106PA
SG11201507106PA SG11201507106PA SG11201507106PA SG11201507106PA SG 11201507106P A SG11201507106P A SG 11201507106PA SG 11201507106P A SG11201507106P A SG 11201507106PA SG 11201507106P A SG11201507106P A SG 11201507106PA SG 11201507106P A SG11201507106P A SG 11201507106PA
Authority
SG
Singapore
Prior art keywords
dipeptide
protease inhibitors
epoxy ketone
ketone protease
tripeptide epoxy
Prior art date
Application number
SG11201507106PA
Inventor
Dustin Mcminn
Henry Johnson
David C Moebius
Original Assignee
Onyx Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Onyx Therapeutics Inc filed Critical Onyx Therapeutics Inc
Publication of SG11201507106PA publication Critical patent/SG11201507106PA/en

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C07K5/0802—Tripeptides with the first amino acid being neutral
    • C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
    • C07K5/0806—Tripeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
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    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06—Tripeptides
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    • C07D303/32—Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms by aldehydo- or ketonic radicals
    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
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    • C07K5/06113—Asp- or Asn-amino acid
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    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
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SG11201507106PA 2013-03-14 2014-03-14 Dipeptide and tripeptide epoxy ketone protease inhibitors SG11201507106PA (en)

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US201361785608P 2013-03-14 2013-03-14
US201361786086P 2013-03-14 2013-03-14
US201361847780P 2013-07-18 2013-07-18
US201361856847P 2013-07-22 2013-07-22
US201361883843P 2013-09-27 2013-09-27
US201361883798P 2013-09-27 2013-09-27
US201461941798P 2014-02-19 2014-02-19
PCT/US2014/026980 WO2014152127A1 (en) 2013-03-14 2014-03-14 Dipeptide and tripeptide epoxy ketone protease inhibitors

Publications (1)

Publication Number Publication Date
SG11201507106PA true SG11201507106PA (en) 2015-10-29

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SG11201507106PA SG11201507106PA (en) 2013-03-14 2014-03-14 Dipeptide and tripeptide epoxy ketone protease inhibitors

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Country Link
US (1) US9657057B2 (en)
EP (1) EP2970225B1 (en)
JP (2) JP2016515127A (en)
KR (1) KR20150131276A (en)
CN (1) CN105164117B (en)
AU (2) AU2014240122B2 (en)
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