BR112015023298A2 - inibidores tripeptídicos da epóxi cetona protease - Google Patents

inibidores tripeptídicos da epóxi cetona protease

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Publication number
BR112015023298A2
BR112015023298A2 BR112015023298A BR112015023298A BR112015023298A2 BR 112015023298 A2 BR112015023298 A2 BR 112015023298A2 BR 112015023298 A BR112015023298 A BR 112015023298A BR 112015023298 A BR112015023298 A BR 112015023298A BR 112015023298 A2 BR112015023298 A2 BR 112015023298A2
Authority
BR
Brazil
Prior art keywords
protease inhibitors
epoxy ketone
ketone protease
tripeptide epoxy
tripeptide
Prior art date
Application number
BR112015023298A
Other languages
English (en)
Other versions
BR112015023298B1 (pt
Inventor
C Moebius David
Mcminn Dustin
Johnson Henry
Bowers Simeon
Original Assignee
Onyx Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=51581125&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=BR112015023298(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Onyx Therapeutics Inc filed Critical Onyx Therapeutics Inc
Publication of BR112015023298A2 publication Critical patent/BR112015023298A2/pt
Publication of BR112015023298B1 publication Critical patent/BR112015023298B1/pt

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    • C07KPEPTIDES
    • C07K5/00Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08Tripeptides
    • C07K5/0821Tripeptides with the first amino acid being heterocyclic, e.g. His, Pro, Trp
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/06Tripeptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
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    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
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    • C07D303/12Compounds containing oxirane rings with hydrocarbon radicals, substituted by singly or doubly bound oxygen atoms
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    • C07K5/0202Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-X-X-C(=0)-, X being an optionally substituted carbon atom or a heteroatom, e.g. beta-amino acids
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    • C07K5/0205Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
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BR112015023298-1A 2013-03-14 2014-03-14 Inibidores tripeptídicos da epóxi cetona protease BR112015023298B1 (pt)

Applications Claiming Priority (14)

Application Number Priority Date Filing Date Title
US201361785608P 2013-03-14 2013-03-14
US201361786086P 2013-03-14 2013-03-14
US61/785,608 2013-03-14
US61/786,086 2013-03-14
US201361847780P 2013-07-18 2013-07-18
US61/847,780 2013-07-18
US201361856847P 2013-07-22 2013-07-22
US201361883843P 2013-09-27 2013-09-27
US201361883798P 2013-09-27 2013-09-27
US201461941798P 2014-02-19 2014-02-19
US61/941,798 2014-02-19
ARP140100970A AR095426A1 (es) 2013-03-14 2014-03-13 Inhibidores tripeptídicos de la epoxicetona proteasa
ARP20140100970 2014-03-13
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