BR112015016995A8 - uso de agonistas do receptor alfa 7 nicotínico de acetilcolina - Google Patents

uso de agonistas do receptor alfa 7 nicotínico de acetilcolina

Info

Publication number
BR112015016995A8
BR112015016995A8 BR112015016995A BR112015016995A BR112015016995A8 BR 112015016995 A8 BR112015016995 A8 BR 112015016995A8 BR 112015016995 A BR112015016995 A BR 112015016995A BR 112015016995 A BR112015016995 A BR 112015016995A BR 112015016995 A8 BR112015016995 A8 BR 112015016995A8
Authority
BR
Brazil
Prior art keywords
receptor agonists
nicotinic acetylcholine
acetylcholine alpha
alpha
onset
Prior art date
Application number
BR112015016995A
Other languages
English (en)
Other versions
BR112015016995A2 (pt
BR112015016995B8 (pt
BR112015016995B1 (pt
Inventor
Halldin Christer
Lopez-Lopez Cristina
Feuerbach Dominik
Johns Donald
Sovago Judit
Hall Mcallister Kevin
Weiss Markus
Fendt Markus
Johannes Sjoerd
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of BR112015016995A2 publication Critical patent/BR112015016995A2/pt
Publication of BR112015016995A8 publication Critical patent/BR112015016995A8/pt
Publication of BR112015016995B1 publication Critical patent/BR112015016995B1/pt
Publication of BR112015016995B8 publication Critical patent/BR112015016995B8/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Psychiatry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Emergency Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)

Abstract

resumo a invenção consiste no uso de certos agonistas do receptor alfa 7 nicotínico de acetilcolina para a facilitação do surgimento da anestesia geral.
BR112015016995A 2013-01-15 2014-01-13 Uso de agonistas do receptor alfa 7 nicotínico de acetilcolina BR112015016995B8 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361752772P 2013-01-15 2013-01-15
US61/752,772 2013-01-15
PCT/IB2014/058225 WO2014111838A1 (en) 2013-01-15 2014-01-13 Use of alpha 7 nicotinic acetylcholine receptor agonists

Publications (4)

Publication Number Publication Date
BR112015016995A2 BR112015016995A2 (pt) 2017-07-11
BR112015016995A8 true BR112015016995A8 (pt) 2018-01-23
BR112015016995B1 BR112015016995B1 (pt) 2022-02-01
BR112015016995B8 BR112015016995B8 (pt) 2022-07-26

Family

ID=50070639

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015016995A BR112015016995B8 (pt) 2013-01-15 2014-01-13 Uso de agonistas do receptor alfa 7 nicotínico de acetilcolina

Country Status (10)

Country Link
EP (1) EP2945633B1 (pt)
JP (1) JP6338223B2 (pt)
KR (1) KR101879920B1 (pt)
CN (1) CN105263495B (pt)
BR (1) BR112015016995B8 (pt)
CA (1) CA2898080C (pt)
ES (1) ES2883232T3 (pt)
MX (1) MX2015009155A (pt)
TW (1) TWI633886B (pt)
WO (1) WO2014111838A1 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR122020005073A2 (pt) 2017-08-04 2020-10-13 Skyhawk Therapeutics, Inc. Composto, composição farmacêutica e uso do composto
CN111629726A (zh) * 2017-11-22 2020-09-04 阿尔伯塔大学理事会 通过激活神经元异侧烟碱型乙酰胆碱受体抵抗呼吸抑制的方法
EP3920915A4 (en) 2019-02-05 2022-10-05 Skyhawk Therapeutics, Inc. METHODS AND COMPOSITIONS FOR MODULATING SPLICE
CN113677344A (zh) 2019-02-06 2021-11-19 斯基霍克疗法公司 用于调节剪接的方法和组合物

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6953855B2 (en) 1998-12-11 2005-10-11 Targacept, Inc. 3-substituted-2(arylalkyl)-1-azabicycloalkanes and methods of use thereof
GB0010955D0 (en) 2000-05-05 2000-06-28 Novartis Ag Organic compounds
DE10164139A1 (de) 2001-12-27 2003-07-10 Bayer Ag 2-Heteroarylcarbonsäureamide
GB0220581D0 (en) * 2002-09-04 2002-10-09 Novartis Ag Organic Compound
CA2499128C (en) 2002-09-25 2012-07-31 Memory Pharmaceuticals Corporation Indazoles, benzothiazoles, and benzoisothiazoles, and preparation and uses thereof
US20050245531A1 (en) 2003-12-22 2005-11-03 Abbott Laboratories Fused bicycloheterocycle substituted quinuclidine derivatives
CA2551486A1 (en) 2003-12-22 2006-06-22 Abbott Laboratories Fused bicycloheterocycle substituted quinuclidine derivatives
GB0412019D0 (en) 2004-05-28 2004-06-30 Novartis Ag Organic compounds
PE20060437A1 (es) 2004-06-18 2006-06-08 Novartis Ag COMPUESTOS AZA-BICICLONONANOS COMO LIGANDOS COLINERGICOS DE nAChR
GB0415746D0 (en) * 2004-07-14 2004-08-18 Novartis Ag Organic compounds
GB0521508D0 (en) 2005-10-21 2005-11-30 Novartis Ag Organic compounds
GB0525673D0 (en) 2005-12-16 2006-01-25 Novartis Ag Organic compounds
GB0525672D0 (en) 2005-12-16 2006-01-25 Novartis Ag Organic compounds
TW200813067A (en) 2006-05-17 2008-03-16 Astrazeneca Ab Nicotinic acetylcholine receptor ligands
DK2018380T3 (da) 2006-05-19 2012-01-23 Abbott Lab CNS-aktiverede kondenserede bi-heterocyklisk-substituerede azabicykliske alkanderivater
US8314119B2 (en) 2006-11-06 2012-11-20 Abbvie Inc. Azaadamantane derivatives and methods of use
CN100448468C (zh) * 2006-11-14 2009-01-07 赵玉民 一种口服用于治疗胃病的药粉
SA08290475B1 (ar) 2007-08-02 2013-06-22 Targacept Inc (2s، 3r)-n-(2-((3-بيردينيل)ميثيل)-1-آزا بيسيكلو[2، 2، 2]أوكت-3-يل)بنزو فيوران-2-كربوكساميد، وصور أملاحه الجديدة وطرق استخدامه
WO2009066107A1 (en) 2007-11-21 2009-05-28 Astrazeneca Ab Use of a nicotinic receptor agonist
DK2346833T3 (da) 2008-10-13 2013-04-29 Hoffmann La Roche Diazonium-fri fremgangsmåde til fremstilling af et indazolmellemprodukt i syntesen af bicyclisk 5-(trifluormethoxy)-1h-3-indazolcarboxylsyreamider
EP2364150A1 (en) * 2008-11-11 2011-09-14 Targacept Inc. Treatment with alpha 7-selective ligands
TW201031664A (en) 2009-01-26 2010-09-01 Targacept Inc Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide
TWI558398B (zh) * 2009-09-22 2016-11-21 諾華公司 菸鹼乙醯膽鹼受體α７活化劑之用途
CN103732260B (zh) * 2010-11-10 2018-08-10 H.隆德贝克有限公司 放射性标记的基于苯基咪唑的配体
US20140171448A1 (en) * 2011-01-27 2014-06-19 Novartis Ag Use of nicotinic acetylcholine receptor alpha 7 activators
JPWO2013002365A1 (ja) * 2011-06-30 2015-02-23 東レ株式会社 止痒剤

Also Published As

Publication number Publication date
JP2016509595A (ja) 2016-03-31
CN105263495B (zh) 2019-05-14
TW201440766A (zh) 2014-11-01
WO2014111838A1 (en) 2014-07-24
CN105263495A (zh) 2016-01-20
KR101879920B1 (ko) 2018-07-18
TWI633886B (zh) 2018-09-01
MX2015009155A (es) 2016-03-04
CA2898080A1 (en) 2014-07-24
ES2883232T3 (es) 2021-12-07
BR112015016995A2 (pt) 2017-07-11
EP2945633A1 (en) 2015-11-25
KR20150105469A (ko) 2015-09-16
JP6338223B2 (ja) 2018-06-06
BR112015016995B8 (pt) 2022-07-26
EP2945633B1 (en) 2021-06-30
BR112015016995B1 (pt) 2022-02-01
CA2898080C (en) 2018-01-09

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Legal Events

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B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 13/01/2014, OBSERVADAS AS CONDICOES LEGAIS.

B16C Correction of notification of the grant [chapter 16.3 patent gazette]

Free format text: REF. RPI 2665 DE 01/02/2022 QUANTO AO INVENTOR.