DK2346833T3 - Diazonium-fri fremgangsmåde til fremstilling af et indazolmellemprodukt i syntesen af bicyclisk 5-(trifluormethoxy)-1h-3-indazolcarboxylsyreamider - Google Patents

Diazonium-fri fremgangsmåde til fremstilling af et indazolmellemprodukt i syntesen af bicyclisk 5-(trifluormethoxy)-1h-3-indazolcarboxylsyreamider

Info

Publication number
DK2346833T3
DK2346833T3 DK09783778.5T DK09783778T DK2346833T3 DK 2346833 T3 DK2346833 T3 DK 2346833T3 DK 09783778 T DK09783778 T DK 09783778T DK 2346833 T3 DK2346833 T3 DK 2346833T3
Authority
DK
Denmark
Prior art keywords
indazolcarboxyl
acidamides
trifluormethoxy
indazol
diazonium
Prior art date
Application number
DK09783778.5T
Other languages
English (en)
Inventor
Thomas P Cleary
Yaohui Ji
Thimma Rawalpally
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Application granted granted Critical
Publication of DK2346833T3 publication Critical patent/DK2346833T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
DK09783778.5T 2008-10-13 2009-10-06 Diazonium-fri fremgangsmåde til fremstilling af et indazolmellemprodukt i syntesen af bicyclisk 5-(trifluormethoxy)-1h-3-indazolcarboxylsyreamider DK2346833T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10477708P 2008-10-13 2008-10-13
PCT/EP2009/062952 WO2010043515A1 (en) 2008-10-13 2009-10-06 Diazonium-free method to make an indazole intermediate in the synthesis of bicyclic 5-(trifluormethoxy)-1h-3-indazolecarboxylic acid amides

Publications (1)

Publication Number Publication Date
DK2346833T3 true DK2346833T3 (da) 2013-04-29

Family

ID=41508367

Family Applications (1)

Application Number Title Priority Date Filing Date
DK09783778.5T DK2346833T3 (da) 2008-10-13 2009-10-06 Diazonium-fri fremgangsmåde til fremstilling af et indazolmellemprodukt i syntesen af bicyclisk 5-(trifluormethoxy)-1h-3-indazolcarboxylsyreamider

Country Status (14)

Country Link
US (2) US8232412B2 (da)
EP (1) EP2346833B1 (da)
JP (1) JP5425915B2 (da)
KR (1) KR101338726B1 (da)
CN (1) CN102186826B (da)
BR (1) BRPI0920187A2 (da)
CA (1) CA2740311C (da)
DK (1) DK2346833T3 (da)
ES (1) ES2407647T3 (da)
IL (1) IL211931A (da)
MX (1) MX2011003429A (da)
PL (1) PL2346833T3 (da)
SI (1) SI2346833T1 (da)
WO (1) WO2010043515A1 (da)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2933398B1 (fr) 2008-07-04 2011-02-18 Saint Gobain Ct Recherches Grains fondus d'oxydes comprenant al, ti et mg et produits ceramiques comportant de tels grains
JO3250B1 (ar) 2009-09-22 2018-09-16 Novartis Ag إستعمال منشطات مستقبل نيكوتينيك أسيتيل كولين ألفا 7
JP2014503568A (ja) 2011-01-27 2014-02-13 ノバルティス アーゲー ニコチン酸アセチルコリン受容体α７活性化因子の使用
KR20140018286A (ko) 2011-03-18 2014-02-12 노파르티스 아게 파킨슨병에서의 도파민 유발 이상운동증에서 사용하기 위한 알파 7 니코틴성 아세틸콜린 수용체 활성화제 및 mGluR5 길항제의 조합물
EP2768507B1 (en) 2011-10-20 2019-12-11 Novartis AG Biomarkers predictive of responsiveness to alpha 7 nicotinic acetylcholine receptor activator treatment
CN102837985A (zh) * 2012-09-21 2012-12-26 广州广电运通金融电子股份有限公司 金融自助设备及其薄片介质传输系统和传输方法
JP6114951B2 (ja) 2012-12-11 2017-04-19 ノバルティス アーゲー アルファ７ニコチン性アセチルコリン受容体アクチベーターによる処置に対する応答性を予測するバイオマーカー
MX362819B (es) 2013-01-15 2019-02-18 Novartis Ag Uso de agonistas del receptor nicotinico de acetilcolina alfa 7 para el tratamiento de la narcolepsia.
CN105263495B (zh) 2013-01-15 2019-05-14 诺华有限公司 α7烟碱型乙酰胆碱受体激动剂的应用
CN105246485B (zh) 2013-01-15 2019-03-15 诺华有限公司 α7烟碱型乙酰胆碱受体激动剂的应用

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT1697378E (pt) 2003-12-22 2008-02-28 Memory Pharm Corp Indoles, 1h-indazoles, 1,2-benzisoxazoles e 1,2-benzisotiazoles, sua preparação e utilizações
NZ550534A (en) 2004-03-25 2009-07-31 Memory Pharm Corp Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, and preparation and uses thereof
CA2567977A1 (en) 2004-04-22 2006-01-05 Memory Pharmaceutical Corporation Indoles, 1h-indazoles, 1,2-benzisoxazoles, 1,2-benzoisothiazoles, and preparation and uses thereof
EP1745046B1 (en) 2004-05-07 2011-04-13 Memory Pharmaceuticals Corporation 1 h-indazoles, benzothiazoles, 1,2-benziosoxazoles, 1,2-benzoisothiazoles, and chromones and preparation and uses thereof
DE102004054666A1 (de) 2004-11-12 2006-05-18 Bayer Cropscience Gmbh Substituierte Pyrazol-3-carboxamide, Verfahren zur Herstellung und Verwendung als Herbizide und Pflanzenwachstumsregulatoren
US20060142247A1 (en) 2004-12-17 2006-06-29 Guy Georges Tricyclic heterocycles
AU2005319248A1 (en) 2004-12-22 2006-06-29 Memory Pharmaceuticals Corporation Nicotinic alpha-7 receptor ligands and preparation and uses thereof
JP2009509964A (ja) * 2005-09-23 2009-03-12 メモリー・ファーマシューティカルズ・コーポレイション インダゾール類、ベンゾチアゾール類、ベンゾイソオキサゾール類、ピラゾロピリジン類、イソチアゾロピリジン類、およびそれらの製造と用途

Also Published As

Publication number Publication date
BRPI0920187A2 (pt) 2019-08-27
US8232412B2 (en) 2012-07-31
CN102186826A (zh) 2011-09-14
EP2346833A1 (en) 2011-07-27
EP2346833B1 (en) 2013-03-27
IL211931A0 (en) 2011-06-30
MX2011003429A (es) 2011-05-02
WO2010043515A1 (en) 2010-04-22
CA2740311C (en) 2013-09-17
IL211931A (en) 2016-07-31
US20100094011A1 (en) 2010-04-15
KR101338726B1 (ko) 2013-12-06
CA2740311A1 (en) 2010-04-22
CN102186826B (zh) 2015-06-17
KR20110067063A (ko) 2011-06-20
US20120259120A1 (en) 2012-10-11
ES2407647T3 (es) 2013-06-13
AU2009304171A1 (en) 2010-04-22
JP5425915B2 (ja) 2014-02-26
US8354536B2 (en) 2013-01-15
SI2346833T1 (sl) 2013-06-28
PL2346833T3 (pl) 2013-08-30
JP2012505175A (ja) 2012-03-01

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