BR112015011944A8 - linhagem bacteriana atenuada estável, seus usos e método para sua geração, composição de vacina - Google Patents

linhagem bacteriana atenuada estável, seus usos e método para sua geração, composição de vacina Download PDF

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Publication number
BR112015011944A8
BR112015011944A8 BR112015011944A BR112015011944A BR112015011944A8 BR 112015011944 A8 BR112015011944 A8 BR 112015011944A8 BR 112015011944 A BR112015011944 A BR 112015011944A BR 112015011944 A BR112015011944 A BR 112015011944A BR 112015011944 A8 BR112015011944 A8 BR 112015011944A8
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BR
Brazil
Prior art keywords
generation
bacterial strain
vaccine composition
attenuated bacterial
stable attenuated
Prior art date
Application number
BR112015011944A
Other languages
English (en)
Other versions
BR112015011944A2 (pt
Inventor
Grosse- Herrenthey Anke
Linde Klaus
Original Assignee
Lohmann Animal Health Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lohmann Animal Health Gmbh filed Critical Lohmann Animal Health Gmbh
Priority claimed from PCT/EP2013/068373 external-priority patent/WO2014037445A1/en
Publication of BR112015011944A2 publication Critical patent/BR112015011944A2/pt
Publication of BR112015011944A8 publication Critical patent/BR112015011944A8/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/105—Delta proteobacteriales, e.g. Lawsonia; Epsilon proteobacteriales, e.g. campylobacter, helicobacter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/025—Enterobacteriales, e.g. Enterobacter
    • A61K39/0275—Salmonella
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C12N1/205—Bacterial isolates
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/36—Adaptation or attenuation of cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K2039/106—Vibrio; Campylobacter; Not used, see subgroups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/542—Mucosal route oral/gastrointestinal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
    • A61K2039/552—Veterinary vaccine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
    • C12R2001/00—Microorganisms ; Processes using microorganisms
    • C12R2001/01—Bacteria or Actinomycetales ; using bacteria or Actinomycetales
    • C12R2001/42—Salmonella
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • General Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

resumo patente de invenção: "preparação de vacinas vivas". a presente invenção refere-se a um método para a geração de uma vacina viva contendo bactérias estáveis possuindo pelo menos três mutações atenuantes e a uma vacina contendo as bactérias obtidas por tal método.
BR112015011944A 2012-12-07 2013-09-05 linhagem bacteriana atenuada estável, seus usos e método para sua geração, composição de vacina BR112015011944A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12008206 2012-12-07
PCT/EP2013/068373 WO2014037445A1 (en) 2012-09-05 2013-09-05 Preparation of live vaccines

Publications (2)

Publication Number Publication Date
BR112015011944A2 BR112015011944A2 (pt) 2017-07-11
BR112015011944A8 true BR112015011944A8 (pt) 2019-10-08

Family

ID=47355770

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015011944A BR112015011944A8 (pt) 2012-12-07 2013-09-05 linhagem bacteriana atenuada estável, seus usos e método para sua geração, composição de vacina

Country Status (15)

Country Link
US (2) US10828362B2 (pt)
EP (3) EP3415643B1 (pt)
JP (1) JP6336461B2 (pt)
KR (1) KR101835946B1 (pt)
CN (2) CN104995292A (pt)
AU (2) AU2013311675A1 (pt)
BR (1) BR112015011944A8 (pt)
CA (1) CA2901322C (pt)
EA (1) EA030355B1 (pt)
ES (2) ES2686325T3 (pt)
HK (1) HK1213949A1 (pt)
MX (1) MX368393B (pt)
NZ (1) NZ709154A (pt)
PL (2) PL2929058T3 (pt)
PT (1) PT2929058T (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2929058T3 (pl) * 2012-12-07 2018-11-30 Lohmann Animal Health Gmbh Wytwarzanie żywych szczepionek
CN114107162A (zh) * 2021-12-08 2022-03-01 塔里木大学 诱导细菌形成小菌落变异体的制备方法

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE294420C (pt)
DE3751641D1 (de) * 1986-10-10 1996-02-01 Tad Pharm Werk Salmonella-Lebendimpfstoffe mit Wirtsspezies-angepassten Attenuierungshöhen und antiepidemischer Potenz
US5112749A (en) * 1987-10-02 1992-05-12 Praxis Biologics, Inc. Vaccines for the malaria circumsporozoite protein
DD294420A5 (de) * 1990-05-18 1991-10-02 Karl-Marx-Universitaet Leipzig,De Verfahren zur herstellung von lebendimpfstoffen gegen listeriose
CA2097931C (en) * 1990-12-18 2003-07-29 Samuel I. Miller, Iii Salmonella vaccines
US6136325A (en) 1993-04-09 2000-10-24 Lohmann Animal Health Gmbh & Co. Kg Live vaccine constituting minor risk for humans
PT642796E (pt) * 1993-09-04 2002-05-31 Lohmann Animal Health Gmbh Vacina viva de salmonella
DE4333742A1 (de) * 1993-10-04 1995-04-06 Klaus Prof Dr Linde Lebendimpfstoff mit erhöhter Stabilität
US6479056B1 (en) 1994-09-02 2002-11-12 Lohman Animal Health Gmbh & Co. Kg Live vaccine constituting minor risk for humans
GB9806449D0 (en) * 1998-03-25 1998-05-27 Peptide Therapeutics Ltd Attenuated bacteria useful in vaccines
GB0024203D0 (en) * 2000-10-03 2000-11-15 Peptide Therapeutics Ltd Stabilisation of plasmid inheritance in bacteria
US20050180985A9 (en) * 2001-10-04 2005-08-18 Vladoianu Ion R. Live attenuated salmonella strains for producing monovalent or multivalent vaccines
GB0308691D0 (en) * 2003-04-07 2003-05-21 Xenova Res Ltd Vaccine preparations
NZ549084A (en) * 2004-02-12 2009-10-30 Univ Queensland Live attenuated salmonella for use as vaccine
UA100370C2 (uk) * 2006-12-11 2012-12-25 Мериал Лимитед Спосіб вакцинації птахів проти salmonella
DE102007012824A1 (de) * 2007-03-17 2008-09-18 Universität Leipzig Impfstämme mit abgestuften Koloniegrößen/Attenuierungen und Verfahren zu deren Isolierung
DE102008062941A1 (de) * 2008-12-23 2010-07-01 Universität Leipzig Impfstämme gegen bakterielle und fungale Infektionen
PL2929058T3 (pl) * 2012-12-07 2018-11-30 Lohmann Animal Health Gmbh Wytwarzanie żywych szczepionek

Also Published As

Publication number Publication date
KR101835946B1 (ko) 2018-03-07
EP2929058B1 (en) 2018-07-11
AU2017219152A1 (en) 2017-09-21
US10828362B2 (en) 2020-11-10
AU2017219152B2 (en) 2019-05-16
EA201590856A1 (ru) 2015-09-30
ES2686325T3 (es) 2018-10-17
US20220088168A1 (en) 2022-03-24
JP6336461B2 (ja) 2018-06-06
US20150297705A1 (en) 2015-10-22
MX368393B (es) 2019-10-01
BR112015011944A2 (pt) 2017-07-11
HK1213949A1 (zh) 2016-07-15
PL3415643T3 (pl) 2020-06-01
MX2015007195A (es) 2016-03-07
NZ709154A (en) 2019-10-25
US11904008B2 (en) 2024-02-20
EA030355B1 (ru) 2018-07-31
PL2929058T3 (pl) 2018-11-30
CA2901322C (en) 2019-07-02
EP3714899A1 (en) 2020-09-30
CA2901322A1 (en) 2014-03-13
EP3415643B1 (en) 2020-02-19
KR20150082480A (ko) 2015-07-15
EP2929058A1 (en) 2015-10-14
JP2015536142A (ja) 2015-12-21
CN104995292A (zh) 2015-10-21
CN112760252A (zh) 2021-05-07
AU2013311675A1 (en) 2015-05-21
PT2929058T (pt) 2018-07-27
EP3415643A1 (en) 2018-12-19
ES2776429T3 (es) 2020-07-30

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B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06I Publication of requirement cancelled [chapter 6.9 patent gazette]

Free format text: ANULADA A PUBLICACAO CODIGO 6.6.1 NA RPI NO 2462 DE 13/03/2018 POR TER SIDO INDEVIDA.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8A ANUIDADE.

B08G Application fees: restoration [chapter 8.7 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B12B Appeal against refusal [chapter 12.2 patent gazette]