BR112015010501A2 - composto, composição farmacêutica, nanopartículas, método para tratar câncer em um paciente e composição liofilizada - Google Patents

composto, composição farmacêutica, nanopartículas, método para tratar câncer em um paciente e composição liofilizada

Info

Publication number
BR112015010501A2
BR112015010501A2 BR112015010501A BR112015010501A BR112015010501A2 BR 112015010501 A2 BR112015010501 A2 BR 112015010501A2 BR 112015010501 A BR112015010501 A BR 112015010501A BR 112015010501 A BR112015010501 A BR 112015010501A BR 112015010501 A2 BR112015010501 A2 BR 112015010501A2
Authority
BR
Brazil
Prior art keywords
nanoparticles
freeze
patient
compound
treating cancer
Prior art date
Application number
BR112015010501A
Other languages
English (en)
Portuguese (pt)
Inventor
S Drager Anthony
Chen Jian
d brown Peter
R Patel Piyush
Y Labell Rachel
C Roemmele Renee
Mckean Robert
P Bakale Roger
Original Assignee
Ignyta Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ignyta Inc filed Critical Ignyta Inc
Publication of BR112015010501A2 publication Critical patent/BR112015010501A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/16—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
BR112015010501A 2012-11-12 2013-11-12 composto, composição farmacêutica, nanopartículas, método para tratar câncer em um paciente e composição liofilizada BR112015010501A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261725213P 2012-11-12 2012-11-12
US201361776951P 2013-03-12 2013-03-12
PCT/US2013/069550 WO2014075035A1 (en) 2012-11-12 2013-11-12 Bendamustine derivatives and methods of using same

Publications (1)

Publication Number Publication Date
BR112015010501A2 true BR112015010501A2 (pt) 2017-07-11

Family

ID=49667594

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015010501A BR112015010501A2 (pt) 2012-11-12 2013-11-12 composto, composição farmacêutica, nanopartículas, método para tratar câncer em um paciente e composição liofilizada

Country Status (17)

Country Link
US (7) US9452988B2 (https=)
EP (1) EP2917183A1 (https=)
JP (1) JP6262246B2 (https=)
KR (1) KR20150086308A (https=)
AR (1) AR093457A1 (https=)
AU (1) AU2013342015B2 (https=)
BR (1) BR112015010501A2 (https=)
CA (1) CA2890462A1 (https=)
CL (1) CL2015001246A1 (https=)
EA (1) EA029706B1 (https=)
HK (2) HK1212977A1 (https=)
IL (1) IL238662A (https=)
MX (1) MX2015005805A (https=)
PH (1) PH12015501024A1 (https=)
SG (1) SG11201503560TA (https=)
TW (1) TWI598341B (https=)
WO (1) WO2014075035A1 (https=)

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TWI752098B (zh) 2016-10-10 2022-01-11 美商亞雷生物製藥股份有限公司 作為ret激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物
WO2018136661A1 (en) 2017-01-18 2018-07-26 Andrews Steven W SUBSTITUTED PYRAZOLO[1,5-a]PYRAZINE COMPOUNDS AS RET KINASE INHIBITORS
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TWI791053B (zh) 2017-10-10 2023-02-01 美商亞雷生物製藥股份有限公司 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之結晶形式及其醫藥組合物
TWI876442B (zh) 2017-10-10 2025-03-11 美商絡速藥業公司 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之調配物
US11472802B2 (en) 2018-01-18 2022-10-18 Array Biopharma Inc. Substituted pyrazolyl[4,3-c]pyridine compounds as RET kinase inhibitors
JP7060694B2 (ja) 2018-01-18 2022-04-26 アレイ バイオファーマ インコーポレイテッド Ｒｅｔキナーゼ阻害剤としての置換ピロロ［２，３－ｄ］ピリミジン化合物
EP3740490A1 (en) 2018-01-18 2020-11-25 Array Biopharma, Inc. Substituted pyrazolo[3,4-d]pyrimidine compounds as ret kinase inhibitors
CN117285467A (zh) 2018-07-31 2023-12-26 罗索肿瘤学公司 喷雾干燥的分散体和制剂
CN112996794A (zh) 2018-09-10 2021-06-18 阿雷生物药品公司 作为ret激酶抑制剂的稠合杂环化合物

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Also Published As

Publication number Publication date
KR20150086308A (ko) 2015-07-27
EA201590925A1 (ru) 2015-09-30
AR093457A1 (es) 2015-06-10
MX2015005805A (es) 2016-04-15
SG11201503560TA (en) 2015-06-29
US20180147186A1 (en) 2018-05-31
IL238662A (en) 2017-08-31
EP2917183A1 (en) 2015-09-16
AU2013342015A1 (en) 2015-05-28
IL238662A0 (en) 2015-06-30
CN105051016A (zh) 2015-11-11
WO2014075035A1 (en) 2014-05-15
CA2890462A1 (en) 2014-05-15
US9452988B2 (en) 2016-09-27
EA029706B1 (ru) 2018-05-31
US20160016912A1 (en) 2016-01-21
JP2015536996A (ja) 2015-12-24
US20150246023A1 (en) 2015-09-03
US9913827B2 (en) 2018-03-13
US9150517B2 (en) 2015-10-06
AU2013342015B2 (en) 2016-11-24
PH12015501024A1 (en) 2015-07-27
CL2015001246A1 (es) 2016-01-15
US20150232427A1 (en) 2015-08-20
US20160289198A1 (en) 2016-10-06
HK1212977A1 (zh) 2016-06-24
TWI598341B (zh) 2017-09-11
US20150274675A1 (en) 2015-10-01
JP6262246B2 (ja) 2018-01-17
TW201439069A (zh) 2014-10-16
HK1215701A1 (zh) 2016-09-09
US9149464B2 (en) 2015-10-06
US9630926B2 (en) 2017-04-25
US20170182008A1 (en) 2017-06-29

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06I Publication of requirement cancelled [chapter 6.9 patent gazette]

Free format text: ANULADA A PUBLICACAO CODIGO 6.6.1 NA RPI NO 2462 DE 13/03/2018 POR TER SIDO INDEVIDA.

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2540 DE 10-09-2019 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.