KR20150086308A - 벤다무스틴 유도체 및 그의 사용 방법 - Google Patents

벤다무스틴 유도체 및 그의 사용 방법 Download PDF

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Publication number
KR20150086308A
KR20150086308A KR1020157015682A KR20157015682A KR20150086308A KR 20150086308 A KR20150086308 A KR 20150086308A KR 1020157015682 A KR1020157015682 A KR 1020157015682A KR 20157015682 A KR20157015682 A KR 20157015682A KR 20150086308 A KR20150086308 A KR 20150086308A
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KR
South Korea
Prior art keywords
alkyl
cancer
formula
rti
mmol
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KR1020157015682A
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English (en)
Korean (ko)
Inventor
로져 피. 바케일
피터 디. 브라운
지안 첸
앤쏘니 에스. 드레이져
레이첼 와이. 라벨
로버트 이. 맥킨
피유쉬 알. 파텔
리니 씨. 로엠멜르
Original Assignee
이그니타, 인코포레이티드
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Publication of KR20150086308A publication Critical patent/KR20150086308A/ko
Withdrawn legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/16—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
KR1020157015682A 2012-11-12 2013-11-12 벤다무스틴 유도체 및 그의 사용 방법 Withdrawn KR20150086308A (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201261725213P 2012-11-12 2012-11-12
US61/725,213 2012-11-12
US201361776951P 2013-03-12 2013-03-12
US61/776,951 2013-03-12

Publications (1)

Publication Number Publication Date
KR20150086308A true KR20150086308A (ko) 2015-07-27

Family

ID=49667594

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020157015682A Withdrawn KR20150086308A (ko) 2012-11-12 2013-11-12 벤다무스틴 유도체 및 그의 사용 방법

Country Status (17)

Country Link
US (7) US9452988B2 (https=)
EP (1) EP2917183A1 (https=)
JP (1) JP6262246B2 (https=)
KR (1) KR20150086308A (https=)
AR (1) AR093457A1 (https=)
AU (1) AU2013342015B2 (https=)
BR (1) BR112015010501A2 (https=)
CA (1) CA2890462A1 (https=)
CL (1) CL2015001246A1 (https=)
EA (1) EA029706B1 (https=)
HK (2) HK1212977A1 (https=)
IL (1) IL238662A (https=)
MX (1) MX2015005805A (https=)
PH (1) PH12015501024A1 (https=)
SG (1) SG11201503560TA (https=)
TW (1) TWI598341B (https=)
WO (1) WO2014075035A1 (https=)

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BR112015010501A2 (pt) 2012-11-12 2017-07-11 Ignyta Inc composto, composição farmacêutica, nanopartículas, método para tratar câncer em um paciente e composição liofilizada
US9598377B2 (en) 2013-03-12 2017-03-21 Cephalon, Inc. Nanoparticulate and macroparticulate formulations
BR112018000808A2 (pt) 2015-07-16 2018-09-04 Array Biopharma Inc compostos de pirazolo[1,5-a]piridina substituída como inibidores de ret cinase
US11071789B2 (en) * 2016-07-13 2021-07-27 Cephalon, Inc. Pharmaceutical prodrugs and methods of their preparation and use
TWI704148B (zh) 2016-10-10 2020-09-11 美商亞雷生物製藥股份有限公司 作為ｒｅｔ激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物
TWI752098B (zh) 2016-10-10 2022-01-11 美商亞雷生物製藥股份有限公司 作為ret激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物
US11168090B2 (en) 2017-01-18 2021-11-09 Array Biopharma Inc. Substituted pyrazolo[1,5-a]pyrazines as RET kinase inhibitors
WO2018136663A1 (en) 2017-01-18 2018-07-26 Array Biopharma, Inc. Ret inhibitors
JOP20190213A1 (ar) 2017-03-16 2019-09-16 Array Biopharma Inc مركبات حلقية ضخمة كمثبطات لكيناز ros1
TWI812649B (zh) 2017-10-10 2023-08-21 美商絡速藥業公司 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之調配物
TWI791053B (zh) 2017-10-10 2023-02-01 美商亞雷生物製藥股份有限公司 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之結晶形式及其醫藥組合物
CN111615514B (zh) 2018-01-18 2022-10-11 奥瑞生物药品公司 作为ret激酶抑制剂的取代的吡唑并[4,3-c]吡啶化合物
EP3740491A1 (en) 2018-01-18 2020-11-25 Array Biopharma, Inc. Substituted pyrrolo[2,3-d]pyrimidines compounds as ret kinase inhibitors
WO2019143991A1 (en) 2018-01-18 2019-07-25 Array Biopharma Inc. SUBSTITUTED PYRAZOLO[3,4-d]PYRIMIDINE COMPOUNDS AS RET KINASE INHIBITORS
US12109193B2 (en) 2018-07-31 2024-10-08 Loxo Oncology Inc. Spray-dried dispersions, formulations, and polymorphs of (s)-5-amino-3-(4-((5-fluoro-2-methoxybenzamido)methyl)phenyl)-1-(1,1,1-trifluoropropan-2-yl)-1H-pyrazole-4-carboxamide
EP3849986B1 (en) 2018-09-10 2022-06-08 Array Biopharma, Inc. Fused heterocyclic compounds as ret kinase inhibitors

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BR112015010501A2 (pt) * 2012-11-12 2017-07-11 Ignyta Inc composto, composição farmacêutica, nanopartículas, método para tratar câncer em um paciente e composição liofilizada

Also Published As

Publication number Publication date
US9149464B2 (en) 2015-10-06
US9150517B2 (en) 2015-10-06
IL238662A (en) 2017-08-31
AU2013342015B2 (en) 2016-11-24
TWI598341B (zh) 2017-09-11
TW201439069A (zh) 2014-10-16
US20150246023A1 (en) 2015-09-03
CN105051016A (zh) 2015-11-11
EA029706B1 (ru) 2018-05-31
JP2015536996A (ja) 2015-12-24
EP2917183A1 (en) 2015-09-16
CA2890462A1 (en) 2014-05-15
US9913827B2 (en) 2018-03-13
US20180147186A1 (en) 2018-05-31
US9630926B2 (en) 2017-04-25
US20160016912A1 (en) 2016-01-21
IL238662A0 (en) 2015-06-30
SG11201503560TA (en) 2015-06-29
US20170182008A1 (en) 2017-06-29
CL2015001246A1 (es) 2016-01-15
US20150274675A1 (en) 2015-10-01
AU2013342015A1 (en) 2015-05-28
EA201590925A1 (ru) 2015-09-30
HK1215701A1 (zh) 2016-09-09
PH12015501024A1 (en) 2015-07-27
HK1212977A1 (zh) 2016-06-24
AR093457A1 (es) 2015-06-10
WO2014075035A1 (en) 2014-05-15
US9452988B2 (en) 2016-09-27
JP6262246B2 (ja) 2018-01-17
US20150232427A1 (en) 2015-08-20
US20160289198A1 (en) 2016-10-06
BR112015010501A2 (pt) 2017-07-11
MX2015005805A (es) 2016-04-15

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PA0105 International application

Patent event date: 20150612

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
PC1203 Withdrawal of no request for examination
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid