JP6262246B2 - ベンダムスチン誘導体およびこれを使用する方法 - Google Patents

ベンダムスチン誘導体およびこれを使用する方法 Download PDF

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Publication number
JP6262246B2
JP6262246B2 JP2015541995A JP2015541995A JP6262246B2 JP 6262246 B2 JP6262246 B2 JP 6262246B2 JP 2015541995 A JP2015541995 A JP 2015541995A JP 2015541995 A JP2015541995 A JP 2015541995A JP 6262246 B2 JP6262246 B2 JP 6262246B2
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bendamustine
mmol
ester
solid
alkyl
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Japanese (ja)
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JP2015536996A (ja
JP2015536996A5 (https=
Inventor
バカレ、ロジャー、ピー．
ブラウン、ピーター、ディー．
チェン、ジアン
ドレーガー、アンソニー、エス．
レーベル、レイチェル、ワイ．
マッキーン、ロバート、イー．
パテル、ピユシュ、アール．
ローメリー、レネイ、シー．
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イグニタ、インク．
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/42—Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/16—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Saccharide Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2015541995A 2012-11-12 2013-11-12 ベンダムスチン誘導体およびこれを使用する方法 Expired - Fee Related JP6262246B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261725213P 2012-11-12 2012-11-12
US61/725,213 2012-11-12
US201361776951P 2013-03-12 2013-03-12
US61/776,951 2013-03-12
PCT/US2013/069550 WO2014075035A1 (en) 2012-11-12 2013-11-12 Bendamustine derivatives and methods of using same

Publications (3)

Publication Number Publication Date
JP2015536996A JP2015536996A (ja) 2015-12-24
JP2015536996A5 JP2015536996A5 (https=) 2016-12-28
JP6262246B2 true JP6262246B2 (ja) 2018-01-17

Family

ID=49667594

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JP2015541995A Expired - Fee Related JP6262246B2 (ja) 2012-11-12 2013-11-12 ベンダムスチン誘導体およびこれを使用する方法

Country Status (17)

Country Link
US (7) US9452988B2 (https=)
EP (1) EP2917183A1 (https=)
JP (1) JP6262246B2 (https=)
KR (1) KR20150086308A (https=)
AR (1) AR093457A1 (https=)
AU (1) AU2013342015B2 (https=)
BR (1) BR112015010501A2 (https=)
CA (1) CA2890462A1 (https=)
CL (1) CL2015001246A1 (https=)
EA (1) EA029706B1 (https=)
HK (2) HK1212977A1 (https=)
IL (1) IL238662A (https=)
MX (1) MX2015005805A (https=)
PH (1) PH12015501024A1 (https=)
SG (1) SG11201503560TA (https=)
TW (1) TWI598341B (https=)
WO (1) WO2014075035A1 (https=)

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ES2670995T3 (es) 2013-03-12 2018-06-04 Cephalon, Inc. Formulaciones de nanopartículas y macropartículas
BR112018000808A2 (pt) 2015-07-16 2018-09-04 Array Biopharma Inc compostos de pirazolo[1,5-a]piridina substituída como inibidores de ret cinase
EP3484519A1 (en) * 2016-07-13 2019-05-22 Cephalon, Inc. Pharmaceutical prodrugs and methods of their preparation and use
TWI704148B (zh) 2016-10-10 2020-09-11 美商亞雷生物製藥股份有限公司 作為ｒｅｔ激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物
TWI752098B (zh) 2016-10-10 2022-01-11 美商亞雷生物製藥股份有限公司 作為ret激酶抑制劑之經取代吡唑并[1,5-a]吡啶化合物
WO2018136661A1 (en) 2017-01-18 2018-07-26 Andrews Steven W SUBSTITUTED PYRAZOLO[1,5-a]PYRAZINE COMPOUNDS AS RET KINASE INHIBITORS
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TWI791053B (zh) 2017-10-10 2023-02-01 美商亞雷生物製藥股份有限公司 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之結晶形式及其醫藥組合物
TWI876442B (zh) 2017-10-10 2025-03-11 美商絡速藥業公司 6-(2-羥基-2-甲基丙氧基)-4-(6-(6-((6-甲氧基吡啶-3-基)甲基)-3,6-二氮雜雙環[3.1.1]庚-3-基)吡啶-3-基)吡唑并[1,5-a]吡啶-3-甲腈之調配物
US11472802B2 (en) 2018-01-18 2022-10-18 Array Biopharma Inc. Substituted pyrazolyl[4,3-c]pyridine compounds as RET kinase inhibitors
JP7060694B2 (ja) 2018-01-18 2022-04-26 アレイ バイオファーマ インコーポレイテッド Ｒｅｔキナーゼ阻害剤としての置換ピロロ［２，３－ｄ］ピリミジン化合物
EP3740490A1 (en) 2018-01-18 2020-11-25 Array Biopharma, Inc. Substituted pyrazolo[3,4-d]pyrimidine compounds as ret kinase inhibitors
CN117285467A (zh) 2018-07-31 2023-12-26 罗索肿瘤学公司 喷雾干燥的分散体和制剂
CN112996794A (zh) 2018-09-10 2021-06-18 阿雷生物药品公司 作为ret激酶抑制剂的稠合杂环化合物

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Also Published As

Publication number Publication date
KR20150086308A (ko) 2015-07-27
EA201590925A1 (ru) 2015-09-30
AR093457A1 (es) 2015-06-10
MX2015005805A (es) 2016-04-15
SG11201503560TA (en) 2015-06-29
US20180147186A1 (en) 2018-05-31
IL238662A (en) 2017-08-31
EP2917183A1 (en) 2015-09-16
AU2013342015A1 (en) 2015-05-28
IL238662A0 (en) 2015-06-30
CN105051016A (zh) 2015-11-11
WO2014075035A1 (en) 2014-05-15
CA2890462A1 (en) 2014-05-15
US9452988B2 (en) 2016-09-27
EA029706B1 (ru) 2018-05-31
US20160016912A1 (en) 2016-01-21
JP2015536996A (ja) 2015-12-24
US20150246023A1 (en) 2015-09-03
US9913827B2 (en) 2018-03-13
US9150517B2 (en) 2015-10-06
AU2013342015B2 (en) 2016-11-24
PH12015501024A1 (en) 2015-07-27
CL2015001246A1 (es) 2016-01-15
US20150232427A1 (en) 2015-08-20
US20160289198A1 (en) 2016-10-06
HK1212977A1 (zh) 2016-06-24
BR112015010501A2 (pt) 2017-07-11
TWI598341B (zh) 2017-09-11
US20150274675A1 (en) 2015-10-01
TW201439069A (zh) 2014-10-16
HK1215701A1 (zh) 2016-09-09
US9149464B2 (en) 2015-10-06
US9630926B2 (en) 2017-04-25
US20170182008A1 (en) 2017-06-29

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