EP1343494A4 - Tetrapartate prodrugs - Google Patents

Tetrapartate prodrugs

Info

Publication number
EP1343494A4
EP1343494A4 EP01987164A EP01987164A EP1343494A4 EP 1343494 A4 EP1343494 A4 EP 1343494A4 EP 01987164 A EP01987164 A EP 01987164A EP 01987164 A EP01987164 A EP 01987164A EP 1343494 A4 EP1343494 A4 EP 1343494A4
Authority
EP
European Patent Office
Prior art keywords
tetrapartate
prodrugs
tetrapartate prodrugs
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP01987164A
Other languages
German (de)
French (fr)
Other versions
EP1343494A2 (en
Inventor
Richard B Greenwald
Hong Zhao
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Enzon Pharmaceuticals Inc
Original Assignee
Enzon Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/758,993 external-priority patent/US6720306B2/en
Application filed by Enzon Inc filed Critical Enzon Inc
Publication of EP1343494A2 publication Critical patent/EP1343494A2/en
Publication of EP1343494A4 publication Critical patent/EP1343494A4/en
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Polyethers (AREA)
EP01987164A 2000-12-01 2001-11-30 Tetrapartate prodrugs Ceased EP1343494A4 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US758993 1991-09-10
US72851200A 2000-12-01 2000-12-01
US09/758,993 US6720306B2 (en) 1997-12-17 2001-01-12 Tetrapartate prodrugs
PCT/US2001/045127 WO2002043663A2 (en) 2000-12-01 2001-11-30 Tetrapartate prodrugs
US728512 2003-12-04

Publications (2)

Publication Number Publication Date
EP1343494A2 EP1343494A2 (en) 2003-09-17
EP1343494A4 true EP1343494A4 (en) 2005-08-03

Family

ID=27111706

Family Applications (1)

Application Number Title Priority Date Filing Date
EP01987164A Ceased EP1343494A4 (en) 2000-12-01 2001-11-30 Tetrapartate prodrugs

Country Status (5)

Country Link
EP (1) EP1343494A4 (en)
JP (1) JP2004518776A (en)
AU (1) AU2002239405A1 (en)
CA (1) CA2428018A1 (en)
WO (1) WO2002043663A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6624142B2 (en) * 1997-12-30 2003-09-23 Enzon, Inc. Trimethyl lock based tetrapartate prodrugs
CA2485125A1 (en) * 2002-05-08 2003-11-20 Medical Enzymes Ag Active carbohydrate containing protecting reagents for chemical modifications, their production and use
WO2005030835A1 (en) * 2003-09-25 2005-04-07 Terumo Kabushiki Kaisha Polyethylene glycol derivatives and drug carriers containing the same as the membrane constituent
CN100415801C (en) * 2003-10-28 2008-09-03 北京键凯科技有限公司 Polyethylene glycol amino acid N-internal ring carbonyl anhydride active derivatives, and medicinal bonding compound and gel thereof
CN100543063C (en) * 2006-04-03 2009-09-23 中国科学院过程工程研究所 Polyethyleneglycol of end group of amino acid and preparation method thereof
KR20090083334A (en) * 2006-09-15 2009-08-03 엔존 파마슈티컬즈, 인코포레이티드 Polyalkylene oxides having hindered ester-based biodegradable linkers
MX2009002859A (en) * 2006-09-15 2009-03-30 Enzon Pharmaceuticals Inc Hindered ester-based biodegradable linkers for oligonucleotide delivery.
DE102011118029A1 (en) 2011-06-20 2012-12-20 Universität Leipzig Modified antibiotic peptides with variable systemic release
JP6262246B2 (en) * 2012-11-12 2018-01-17 イグニタ、インク． Bendamustine derivative and method of using the same
WO2015052155A1 (en) * 2013-10-08 2015-04-16 Ascendis Pharma A/S Protecting group comprising a purification tag

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010031873A1 (en) * 1997-12-17 2001-10-18 Greenwald Richard B. Tetrapartate prodrugs

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9501052D0 (en) * 1995-01-19 1995-03-08 Cancer Res Campaign Tech Improvements relating to prodrugs
ATE278700T1 (en) * 1995-06-27 2004-10-15 Pharmachemie Bv ANTHRACYCLINE PRODRUGS, METHOD FOR THE PRODUCTION THEREOF AND THEIR USE IN SELECTIVE CHEMOTHERAPY

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20010031873A1 (en) * 1997-12-17 2001-10-18 Greenwald Richard B. Tetrapartate prodrugs

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
BALIMANE ET AL: "Diret evidence for peptide transporter (PepT1)-Mediated Uptake of a nonpeptide prodrug, valacyclovir.", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, vol. 250, 1998, pages 246 - 251 *
BAURAIN ET AL: "Amino acid and dipeptide derivatives of daunorubicin. 2. Cellular pharmacology and antitumor activity on L1210 leukemic cells in vitro and in vivo.", J. MED. CHEM., vol. 23, 1980, pages 1171 - 1174 *
CONOVER ET AL: "Camptothecin delivery systems: the utility of amino acid spacers for the conjugation of camptothecin with polyethylene glycol to create prodrugs.", ANTI-CANCER DRUG DESIGN, vol. 14, 1999, pages 499 - 506 *
GREENWALD ET AL: "Poly(ethylene glycol) conjugates drugs and prodrugs: a comprehensive review", CRITICAL REVIEWS IN THERAPEUTIC DRUG CARRIER SYSTEMS, vol. 17, 2000, pages 101 - 161 *
HAN ET AL: "Cellular uptake mechanism of amino acid ester prodrugs in caco-2/hPEPT1 cells overexpressing a humna peptide transporter.", PHARMACEUTICAL RESEARCH, vol. 15, 1998, pages 1382 - 1386 *
No further relevant documents disclosed *
PECHAR ET AL: "Poly(ethylene glycol) multiblock copolymer as a carrier of anti-cancer drug doxorubicin.", BIOCONJUGATE CHEMISTRY, vol. 11, 15 February 2000 (2000-02-15), pages 131 - 139, XP002961562 *
SENTER P.D. ET AL: "POLY(ETHYLENE GLYCOL)-DOXURUBICIN CONJUGATES CONTAINING-LACTAMASE-SENSITIVE LINKERS", BIOCONJUGATE CHEMISTRY, vol. 6, no. 4, 1 July 1995 (1995-07-01), ACS, WASHINGTON, DC, US, pages 389 - 394, XP000517227 *

Also Published As

Publication number Publication date
WO2002043663A3 (en) 2002-07-25
AU2002239405A1 (en) 2002-06-11
WO2002043663A2 (en) 2002-06-06
EP1343494A2 (en) 2003-09-17
CA2428018A1 (en) 2002-06-06
JP2004518776A (en) 2004-06-24

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Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

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17P Request for examination filed

Effective date: 20030612

AK Designated contracting states

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Designated state(s): AT BE CH CY DE DK ES FI FR GB GR IE IT LI LU MC NL PT SE TR

AX Request for extension of the european patent

Extension state: AL LT LV MK RO SI

RIN1 Information on inventor provided before grant (corrected)

Inventor name: ZHAO, HONG

Inventor name: GREENWALD, RICHARD, B.

A4 Supplementary search report drawn up and despatched

Effective date: 20050622

17Q First examination report despatched

Effective date: 20051216

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION HAS BEEN REFUSED

18R Application refused

Effective date: 20090922