BR112015009602A2 - análogos quiméricos de somatostatina-dopamina - Google Patents
análogos quiméricos de somatostatina-dopaminaInfo
- Publication number
- BR112015009602A2 BR112015009602A2 BR112015009602A BR112015009602A BR112015009602A2 BR 112015009602 A2 BR112015009602 A2 BR 112015009602A2 BR 112015009602 A BR112015009602 A BR 112015009602A BR 112015009602 A BR112015009602 A BR 112015009602A BR 112015009602 A2 BR112015009602 A2 BR 112015009602A2
- Authority
- BR
- Brazil
- Prior art keywords
- somatostatin
- dopamine chimeric
- chimeric analogs
- dopamine
- analogs
- Prior art date
Links
- 229960003638 dopamine Drugs 0.000 title abstract 3
- 208000014311 Cushing syndrome Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000010067 Pituitary ACTH Hypersecretion Diseases 0.000 abstract 1
- 208000020627 Pituitary-dependent Cushing syndrome Diseases 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 230000009826 neoplastic cell growth Effects 0.000 abstract 1
- 201000011519 neuroendocrine tumor Diseases 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 201000009395 primary hyperaldosteronism Diseases 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
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- A61K38/00—Medicinal preparations containing peptides
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- A—HUMAN NECESSITIES
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- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/31—Somatostatins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
- C07C215/52—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups linked by carbon chains having two carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Toxicology (AREA)
- Rheumatology (AREA)
- Addiction (AREA)
- Cardiology (AREA)
- Neurosurgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Oncology (AREA)
Abstract
resumo análogos quiméricos de somatostatina-dopamina a presente invenção refere-se a novos análogos quiméricos de somatostatinadopamina e suas utilizações terapêuticas para a inibição, prevenção e / ou tratamento de neoplasia, tumores neuroendócrinos, doença / síndrome de cushing, e outras condições.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261721372P | 2012-11-01 | 2012-11-01 | |
PCT/US2013/067661 WO2014070971A2 (en) | 2012-11-01 | 2013-10-31 | Somatostatin-dopamine chimeric analogs |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112015009602A2 true BR112015009602A2 (pt) | 2017-11-14 |
Family
ID=50547875
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112015009602A BR112015009602A2 (pt) | 2012-11-01 | 2013-10-31 | análogos quiméricos de somatostatina-dopamina |
Country Status (18)
Country | Link |
---|---|
US (3) | US9731027B2 (pt) |
EP (1) | EP2914280B1 (pt) |
JP (2) | JP5908184B2 (pt) |
KR (1) | KR101770231B1 (pt) |
CN (1) | CN104768570B (pt) |
AR (1) | AR093327A1 (pt) |
AU (1) | AU2013337851A1 (pt) |
BR (1) | BR112015009602A2 (pt) |
CA (1) | CA2888765A1 (pt) |
EA (1) | EA038157B1 (pt) |
ES (1) | ES2663956T3 (pt) |
HK (1) | HK1213485A1 (pt) |
IL (1) | IL238080A0 (pt) |
MX (1) | MX2015005531A (pt) |
SA (1) | SA515360377B1 (pt) |
SG (1) | SG11201502486RA (pt) |
TW (1) | TWI523863B (pt) |
WO (1) | WO2014070971A2 (pt) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2015120570A (ru) * | 2012-11-01 | 2016-12-20 | Ипсен Фарма С.А.С. | Аналоги соматостатина и их димеры |
TWI523863B (zh) | 2012-11-01 | 2016-03-01 | 艾普森藥品公司 | 體抑素-多巴胺嵌合體類似物 |
CN105820215A (zh) * | 2016-05-09 | 2016-08-03 | 中国人民解放军第二军医大学 | 一种高效合成Stylissatin A天然环七肽的制备方法 |
EP3850954A4 (en) * | 2018-09-14 | 2022-06-08 | Megumi Tanaka | ANTI-AGING AGENT AND ANTI-AGING PROCESS |
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US2619488A (en) | 1952-11-25 | Method of preparing d | ||
US2589978A (en) | 1952-03-18 | Lysergyl and isolysergyl glycines | ||
AT258479B (de) | 1961-05-29 | 1967-11-27 | Farmaceutici Italia | Verfahren zur Herstellung von neuen Verbindungen aus der Klasse des D-6-Methyl- (und -1,6-Dimethyl)-8-amino-methyl-ergolins I |
FR98F (pt) | 1961-05-29 | |||
US3966941A (en) | 1970-09-23 | 1976-06-29 | Spofa United Pharmaceutical Works | Composition for preventing lactation or pregnancy in mammals and the method for using the same |
US3901894A (en) | 1974-06-06 | 1975-08-26 | Lilly Co Eli | 8-thiomethylergolines |
HU172479B (hu) | 1976-03-09 | 1978-09-28 | Gyogyszerkutato Intezet | Sposob poluchenija novykh soedinenij s ehrgolenovymi i |
US4166182A (en) | 1978-02-08 | 1979-08-28 | Eli Lilly And Company | 6-n-propyl-8-methoxymethyl or methylmercaptomethylergolines and related compounds |
DD140044A1 (de) | 1978-11-08 | 1980-02-06 | Guenter Losse | Verfahren zur herstellung von lysergyl-enkephalin-derivaten |
US4526892A (en) | 1981-03-03 | 1985-07-02 | Farmitalia Carlo Erba, S.P.A. | Dimethylaminoalkyl-3-(ergoline-8'βcarbonyl)-ureas |
GB2103603B (en) | 1981-08-11 | 1985-04-11 | Erba Farmitalia | Ergoline derivatives |
GB2112382B (en) | 1981-11-06 | 1985-03-06 | Erba Farmitalia | Ergoline derivatives |
CH652720A5 (en) | 1983-02-16 | 1985-11-29 | Sandoz Ag | Ergoline derivatives, their preparation and use |
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- 2013-10-31 CN CN201380057080.8A patent/CN104768570B/zh not_active Expired - Fee Related
- 2013-10-31 US US14/439,162 patent/US9731027B2/en active Active
- 2013-10-31 AU AU2013337851A patent/AU2013337851A1/en not_active Abandoned
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- 2013-10-31 SG SG11201502486RA patent/SG11201502486RA/en unknown
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- 2013-10-31 ES ES13851845.1T patent/ES2663956T3/es active Active
- 2013-10-31 KR KR1020157012881A patent/KR101770231B1/ko active IP Right Grant
- 2013-10-31 WO PCT/US2013/067661 patent/WO2014070971A2/en active Application Filing
- 2013-10-31 EA EA201590841A patent/EA038157B1/ru unknown
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SA515360377B1 (ar) | 2016-10-10 |
US20150290330A1 (en) | 2015-10-15 |
SG11201502486RA (en) | 2015-04-29 |
HK1213485A1 (zh) | 2016-07-08 |
EP2914280B1 (en) | 2018-01-03 |
AU2013337851A1 (en) | 2015-04-23 |
EP2914280A2 (en) | 2015-09-09 |
CN104768570B (zh) | 2017-12-15 |
WO2014070971A2 (en) | 2014-05-08 |
US20150148522A1 (en) | 2015-05-28 |
JP2015535286A (ja) | 2015-12-10 |
US9603942B2 (en) | 2017-03-28 |
US20140121354A1 (en) | 2014-05-01 |
KR101770231B1 (ko) | 2017-08-23 |
IL238080A0 (en) | 2015-05-31 |
JP2016166206A (ja) | 2016-09-15 |
KR20150076195A (ko) | 2015-07-06 |
TW201422636A (zh) | 2014-06-16 |
CN104768570A (zh) | 2015-07-08 |
MX2015005531A (es) | 2015-07-17 |
ES2663956T3 (es) | 2018-04-17 |
TWI523863B (zh) | 2016-03-01 |
WO2014070971A3 (en) | 2014-07-03 |
US9731027B2 (en) | 2017-08-15 |
JP5908184B2 (ja) | 2016-04-26 |
EP2914280A4 (en) | 2016-04-27 |
AR093327A1 (es) | 2015-06-03 |
EA038157B1 (ru) | 2021-07-15 |
US8952128B2 (en) | 2015-02-10 |
CA2888765A1 (en) | 2014-05-08 |
EA201590841A1 (ru) | 2015-12-30 |
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