BR112015009602A2 - análogos quiméricos de somatostatina-dopamina - Google Patents

análogos quiméricos de somatostatina-dopamina

Info

Publication number
BR112015009602A2
BR112015009602A2 BR112015009602A BR112015009602A BR112015009602A2 BR 112015009602 A2 BR112015009602 A2 BR 112015009602A2 BR 112015009602 A BR112015009602 A BR 112015009602A BR 112015009602 A BR112015009602 A BR 112015009602A BR 112015009602 A2 BR112015009602 A2 BR 112015009602A2
Authority
BR
Brazil
Prior art keywords
somatostatin
dopamine chimeric
chimeric analogs
dopamine
analogs
Prior art date
Application number
BR112015009602A
Other languages
English (en)
Inventor
Hyuk Kim Sun
Shen Yeelana
Xin Dong Zheng
Original Assignee
Ipsen Pharma Sas
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ipsen Pharma Sas filed Critical Ipsen Pharma Sas
Publication of BR112015009602A2 publication Critical patent/BR112015009602A2/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/31—Somatostatins
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
    • A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
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    • A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
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    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
    • C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
    • C07C215/52—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups linked by carbon chains having two carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes

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  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
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  • Diabetes (AREA)
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  • Hematology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
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  • Neurology (AREA)
  • Toxicology (AREA)
  • Heart & Thoracic Surgery (AREA)
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  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Ophthalmology & Optometry (AREA)

Abstract

resumo “análogos quiméricos de somatostatina-dopamina” a presente invenção refere-se a novos análogos quiméricos de somatostatina­dopamina e suas utilizações terapêuticas para a inibição, prevenção e / ou tratamento de neoplasia, tumores neuroendócrinos, doença / síndrome de cushing, e outras condições.
BR112015009602A 2012-11-01 2013-10-31 análogos quiméricos de somatostatina-dopamina BR112015009602A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261721372P 2012-11-01 2012-11-01
PCT/US2013/067661 WO2014070971A2 (en) 2012-11-01 2013-10-31 Somatostatin-dopamine chimeric analogs

Publications (1)

Publication Number Publication Date
BR112015009602A2 true BR112015009602A2 (pt) 2017-11-14

Family

ID=50547875

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015009602A BR112015009602A2 (pt) 2012-11-01 2013-10-31 análogos quiméricos de somatostatina-dopamina

Country Status (18)

Country Link
US (3) US9731027B2 (pt)
EP (1) EP2914280B1 (pt)
JP (2) JP5908184B2 (pt)
KR (1) KR101770231B1 (pt)
CN (1) CN104768570B (pt)
AR (1) AR093327A1 (pt)
AU (1) AU2013337851A1 (pt)
BR (1) BR112015009602A2 (pt)
CA (1) CA2888765A1 (pt)
EA (1) EA038157B1 (pt)
ES (1) ES2663956T3 (pt)
HK (1) HK1213485A1 (pt)
IL (1) IL238080A0 (pt)
MX (1) MX2015005531A (pt)
SA (1) SA515360377B1 (pt)
SG (1) SG11201502486RA (pt)
TW (1) TWI523863B (pt)
WO (1) WO2014070971A2 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2914276A4 (en) * 2012-11-01 2016-07-13 Ipsen Pharma Sas SOMATOSTATIN ANALOGA AND DIMERE OUT
TWI523863B (zh) * 2012-11-01 2016-03-01 艾普森藥品公司 體抑素－多巴胺嵌合體類似物
CN105820215A (zh) * 2016-05-09 2016-08-03 中国人民解放军第二军医大学 一种高效合成Stylissatin A天然环七肽的制备方法
JPWO2020054795A1 (ja) * 2018-09-14 2021-08-30 めぐみ 田中 老化防止剤及び老化防止方法

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CN104768570B (zh) 2017-12-15
US20150290330A1 (en) 2015-10-15
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