AR093327A1 - Analogos quimericos de somatostatina-dopamina - Google Patents
Analogos quimericos de somatostatina-dopaminaInfo
- Publication number
- AR093327A1 AR093327A1 ARP130104001A ARP130104001A AR093327A1 AR 093327 A1 AR093327 A1 AR 093327A1 AR P130104001 A ARP130104001 A AR P130104001A AR P130104001 A ARP130104001 A AR P130104001A AR 093327 A1 AR093327 A1 AR 093327A1
- Authority
- AR
- Argentina
- Prior art keywords
- somatostatina
- dopamina
- chemical analogs
- cushing
- neoplasia
- Prior art date
Links
- 208000014311 Cushing syndrome Diseases 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 208000010067 Pituitary ACTH Hypersecretion Diseases 0.000 abstract 1
- 208000020627 Pituitary-dependent Cushing syndrome Diseases 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- 230000009826 neoplastic cell growth Effects 0.000 abstract 1
- 201000011519 neuroendocrine tumor Diseases 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 201000009395 primary hyperaldosteronism Diseases 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
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- A—HUMAN NECESSITIES
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- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/31—Somatostatins
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- A—HUMAN NECESSITIES
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/55—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound the modifying agent being also a pharmacologically or therapeutically active agent, i.e. the entire conjugate being a codrug, i.e. a dimer, oligomer or polymer of pharmacologically or therapeutically active compounds
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
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- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
- C07C215/46—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
- C07C215/48—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups
- C07C215/52—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups bound to carbon atoms of at least one six-membered aromatic ring and amino groups bound to acyclic carbon atoms or to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton with amino groups linked to the six-membered aromatic ring, or to the condensed ring system containing that ring, by carbon chains not further substituted by hydroxy groups linked by carbon chains having two carbon atoms between the amino groups and the six-membered aromatic ring or the condensed ring system containing that ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/655—Somatostatins
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Diabetes (AREA)
- Epidemiology (AREA)
- Endocrinology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Hematology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Obesity (AREA)
- Urology & Nephrology (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Toxicology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurosurgery (AREA)
- Rheumatology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Addiction (AREA)
- Vascular Medicine (AREA)
Abstract
Análogos quiméricos de somatostatina-dopamina y sus usos terapéuticos para la inhibición, la prevención y/o el tratamiento de la neoplasia, los tumores neuroendocrinos, la enfermedad/síndrome de Cushing, y otras afecciones. Composición farmacéutica.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261721372P | 2012-11-01 | 2012-11-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR093327A1 true AR093327A1 (es) | 2015-06-03 |
Family
ID=50547875
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP130104001A AR093327A1 (es) | 2012-11-01 | 2013-11-01 | Analogos quimericos de somatostatina-dopamina |
Country Status (18)
Country | Link |
---|---|
US (3) | US8952128B2 (es) |
EP (1) | EP2914280B1 (es) |
JP (2) | JP5908184B2 (es) |
KR (1) | KR101770231B1 (es) |
CN (1) | CN104768570B (es) |
AR (1) | AR093327A1 (es) |
AU (1) | AU2013337851A1 (es) |
BR (1) | BR112015009602A2 (es) |
CA (1) | CA2888765A1 (es) |
EA (1) | EA038157B1 (es) |
ES (1) | ES2663956T3 (es) |
HK (1) | HK1213485A1 (es) |
IL (1) | IL238080A0 (es) |
MX (1) | MX2015005531A (es) |
SA (1) | SA515360377B1 (es) |
SG (1) | SG11201502486RA (es) |
TW (1) | TWI523863B (es) |
WO (1) | WO2014070971A2 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
TWI523863B (zh) | 2012-11-01 | 2016-03-01 | 艾普森藥品公司 | 體抑素-多巴胺嵌合體類似物 |
CN104768565B (zh) * | 2012-11-01 | 2017-04-26 | 益普生制药股份有限公司 | 促生长素抑制素类似物及其二聚体 |
CN105820215A (zh) * | 2016-05-09 | 2016-08-03 | 中国人民解放军第二军医大学 | 一种高效合成Stylissatin A天然环七肽的制备方法 |
EP3850954A4 (en) * | 2018-09-14 | 2022-06-08 | Megumi Tanaka | ANTI-AGING AGENT AND ANTI-AGING PROCESS |
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NL278401A (es) | 1961-05-29 | |||
US3966941A (en) | 1970-09-23 | 1976-06-29 | Spofa United Pharmaceutical Works | Composition for preventing lactation or pregnancy in mammals and the method for using the same |
US3901894A (en) | 1974-06-06 | 1975-08-26 | Lilly Co Eli | 8-thiomethylergolines |
HU172479B (hu) | 1976-03-09 | 1978-09-28 | Gyogyszerkutato Intezet | Sposob poluchenija novykh soedinenij s ehrgolenovymi i |
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DD140044A1 (de) | 1978-11-08 | 1980-02-06 | Guenter Losse | Verfahren zur herstellung von lysergyl-enkephalin-derivaten |
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GB2112382B (en) | 1981-11-06 | 1985-03-06 | Erba Farmitalia | Ergoline derivatives |
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2013
- 2013-10-30 TW TW102139290A patent/TWI523863B/zh not_active IP Right Cessation
- 2013-10-31 MX MX2015005531A patent/MX2015005531A/es unknown
- 2013-10-31 BR BR112015009602A patent/BR112015009602A2/pt active Search and Examination
- 2013-10-31 ES ES13851845.1T patent/ES2663956T3/es active Active
- 2013-10-31 CN CN201380057080.8A patent/CN104768570B/zh not_active Expired - Fee Related
- 2013-10-31 EP EP13851845.1A patent/EP2914280B1/en not_active Not-in-force
- 2013-10-31 EA EA201590841A patent/EA038157B1/ru unknown
- 2013-10-31 SG SG11201502486RA patent/SG11201502486RA/en unknown
- 2013-10-31 AU AU2013337851A patent/AU2013337851A1/en not_active Abandoned
- 2013-10-31 JP JP2015540761A patent/JP5908184B2/ja not_active Expired - Fee Related
- 2013-10-31 KR KR1020157012881A patent/KR101770231B1/ko active IP Right Grant
- 2013-10-31 WO PCT/US2013/067661 patent/WO2014070971A2/en active Application Filing
- 2013-10-31 US US14/068,286 patent/US8952128B2/en not_active Expired - Fee Related
- 2013-10-31 US US14/439,162 patent/US9731027B2/en active Active
- 2013-10-31 CA CA2888765A patent/CA2888765A1/en not_active Abandoned
- 2013-11-01 AR ARP130104001A patent/AR093327A1/es unknown
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2015
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- 2015-04-01 IL IL238080A patent/IL238080A0/en unknown
- 2015-04-30 SA SA515360377A patent/SA515360377B1/ar unknown
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2016
- 2016-02-11 HK HK16101501.2A patent/HK1213485A1/zh not_active IP Right Cessation
- 2016-03-16 JP JP2016051880A patent/JP2016166206A/ja active Pending
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US9603942B2 (en) | 2017-03-28 |
KR101770231B1 (ko) | 2017-08-23 |
WO2014070971A3 (en) | 2014-07-03 |
US20140121354A1 (en) | 2014-05-01 |
JP2015535286A (ja) | 2015-12-10 |
US9731027B2 (en) | 2017-08-15 |
EP2914280A4 (en) | 2016-04-27 |
MX2015005531A (es) | 2015-07-17 |
US20150290330A1 (en) | 2015-10-15 |
SA515360377B1 (ar) | 2016-10-10 |
WO2014070971A2 (en) | 2014-05-08 |
EA038157B1 (ru) | 2021-07-15 |
EP2914280A2 (en) | 2015-09-09 |
SG11201502486RA (en) | 2015-04-29 |
AU2013337851A1 (en) | 2015-04-23 |
CN104768570A (zh) | 2015-07-08 |
KR20150076195A (ko) | 2015-07-06 |
CA2888765A1 (en) | 2014-05-08 |
BR112015009602A2 (pt) | 2017-11-14 |
HK1213485A1 (zh) | 2016-07-08 |
US20150148522A1 (en) | 2015-05-28 |
JP2016166206A (ja) | 2016-09-15 |
US8952128B2 (en) | 2015-02-10 |
IL238080A0 (en) | 2015-05-31 |
EP2914280B1 (en) | 2018-01-03 |
CN104768570B (zh) | 2017-12-15 |
JP5908184B2 (ja) | 2016-04-26 |
EA201590841A1 (ru) | 2015-12-30 |
TW201422636A (zh) | 2014-06-16 |
TWI523863B (zh) | 2016-03-01 |
ES2663956T3 (es) | 2018-04-17 |
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