BR112015002737A2 - mistura de compostos, composto, e, métodos para produção de um composto e para separação de um composto - Google Patents
mistura de compostos, composto, e, métodos para produção de um composto e para separação de um compostoInfo
- Publication number
- BR112015002737A2 BR112015002737A2 BR112015002737A BR112015002737A BR112015002737A2 BR 112015002737 A2 BR112015002737 A2 BR 112015002737A2 BR 112015002737 A BR112015002737 A BR 112015002737A BR 112015002737 A BR112015002737 A BR 112015002737A BR 112015002737 A2 BR112015002737 A2 BR 112015002737A2
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- separating
- producing
- methods
- mixing compounds
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D319/00—Heterocyclic compounds containing six-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D319/04—1,3-Dioxanes; Hydrogenated 1,3-dioxanes
- C07D319/06—1,3-Dioxanes; Hydrogenated 1,3-dioxanes not condensed with other rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
- C07C201/06—Preparation of nitro compounds
- C07C201/12—Preparation of nitro compounds by reactions not involving the formation of nitro groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
- C07C201/06—Preparation of nitro compounds
- C07C201/16—Separation; Purification; Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
- C07C205/50—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C211/00—Compounds containing amino groups bound to a carbon skeleton
- C07C211/01—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms
- C07C211/26—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring
- C07C211/27—Compounds containing amino groups bound to a carbon skeleton having amino groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing at least one six-membered aromatic ring having amino groups linked to the six-membered aromatic ring by saturated carbon chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/04—Formation of amino groups in compounds containing carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/38—Separation; Purification; Stabilisation; Use of additives
- C07C227/40—Separation; Purification
- C07C227/42—Crystallisation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/32—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing rings other than six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/08—Preparation of carboxylic acid nitriles by addition of hydrogen cyanide or salts thereof to unsaturated compounds
- C07C253/10—Preparation of carboxylic acid nitriles by addition of hydrogen cyanide or salts thereof to unsaturated compounds to compounds containing carbon-to-carbon double bonds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C253/00—Preparation of carboxylic acid nitriles
- C07C253/32—Separation; Purification; Stabilisation; Use of additives
- C07C253/34—Separation; Purification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C255/00—Carboxylic acid nitriles
- C07C255/45—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C255/47—Carboxylic acid nitriles having cyano groups bound to carbon atoms of rings other than six-membered aromatic rings to carbon atoms of rings being part of condensed ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
- C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/608—Esters of carboxylic acids having a carboxyl group bound to an acyclic carbon atom and having a ring other than a six-membered aromatic ring in the acid moiety
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/20—All rings being cycloaliphatic the ring system containing seven carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Toxicology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2013143052 | 2013-07-08 | ||
| JP2013-143052 | 2013-07-08 | ||
| PCT/JP2014/068101 WO2015005298A1 (ja) | 2013-07-08 | 2014-07-08 | 光学活性な二環性γ－アミノ酸誘導体の製造方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112015002737A2 true BR112015002737A2 (pt) | 2017-07-04 |
| BR112015002737B1 BR112015002737B1 (pt) | 2020-12-01 |
Family
ID=52279978
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112015002737-7A BR112015002737B1 (pt) | 2013-07-08 | 2014-07-08 | mistura de compostos, composto, e, métodos para produção de um composto e para separação de um composto |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US9469623B2 (pt) |
| EP (1) | EP2871176B1 (pt) |
| JP (2) | JP5683761B1 (pt) |
| KR (1) | KR102213954B1 (pt) |
| CN (1) | CN104755456B (pt) |
| BR (1) | BR112015002737B1 (pt) |
| CA (1) | CA2881471C (pt) |
| ES (1) | ES2611947T3 (pt) |
| HK (1) | HK1209101A1 (pt) |
| HU (1) | HUE030165T2 (pt) |
| IL (1) | IL237109A (pt) |
| TW (1) | TWI635071B (pt) |
| WO (1) | WO2015005298A1 (pt) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9663479B2 (en) * | 2013-12-18 | 2017-05-30 | Novassay S.A. | γ-aminobutyric acid (GABA) analogues for the treatment of pain and other disorders |
| WO2017107907A1 (zh) * | 2015-12-25 | 2017-06-29 | 四川海思科制药有限公司 | 稠合环γ-氨基酸衍生物及其制备方法和在医药上的应用 |
| TW201806928A (zh) * | 2016-07-01 | 2018-03-01 | 第一三共股份有限公司 | 胺基羧酸之酸加成鹽的結晶及其製造方法 |
| CN110818582B (zh) * | 2019-11-20 | 2023-06-09 | 合肥拓锐生物科技有限公司 | 一种gaba类似物及其盐，及其合成方法、应用、药物 |
| CN111116345A (zh) * | 2019-12-30 | 2020-05-08 | 上海华理生物医药股份有限公司 | 一种制备Mirogabalin的新方法 |
| CN114195661B (zh) * | 2021-12-21 | 2023-12-22 | 苏州楚凯药业有限公司 | 一种苯磺酸米洛巴林的制备方法 |
| CN114264751B (zh) * | 2021-12-28 | 2024-02-27 | 江苏威凯尔医药科技有限公司 | 一种高效液相色谱法分离米洛巴林中间体及其对映异构体的方法 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GEP20094817B (en) | 1997-10-27 | 2009-11-10 | Warner Lambert Co | Cyclic amino acids and derivatives thereof useful as pharmaceutical agents |
| HN2000000224A (es) | 1999-10-20 | 2001-04-11 | Warner Lambert Co | Aminoacidos biciclicos como agentes farmaceuticos |
| CA2444053C (en) | 2001-04-19 | 2008-06-17 | Warner-Lambert Company Llc | Fused bicyclic or tricyclic amino acids |
| WO2004006836A2 (en) | 2002-07-11 | 2004-01-22 | Merck & Co., Inc. | Treatment of neuropathic pain with 6h-pyrrolo[3,4-d]pyridazine compounds |
| EP2657219B1 (en) * | 2007-09-28 | 2014-12-10 | Daiichi Sankyo Company, Limited | Intermediate for producing bicyclic y-amino acid derivative |
| JP2010241796A (ja) * | 2009-03-17 | 2010-10-28 | Daiichi Sankyo Co Ltd | 二環性γ−アミノ酸誘導体含有医薬組成物 |
| WO2010110361A1 (ja) | 2009-03-26 | 2010-09-30 | 第一三共株式会社 | 二環性γ－アミノ酸誘導体の製造方法 |
| US20110130454A1 (en) * | 2009-11-24 | 2011-06-02 | Xenoport, Inc. | Prodrugs of gamma-amino acid, alpha-2-delta ligands, pharmaceutical compositions and uses thereof |
| HUE037046T2 (hu) * | 2011-06-08 | 2018-08-28 | Daiichi Sankyo Co Ltd | Eljárás biciklusos vegyület elõállítására iminium són keresztül |
| ES2649968T3 (es) * | 2011-06-08 | 2018-01-16 | Daiichi Sankyo Company, Limited | Procedimiento de producción de un compuesto bicíclico vía transposición de Claisen |
| CN103987687B (zh) | 2011-12-15 | 2015-12-02 | 第一三共株式会社 | 使用不对称催化剂的双环化合物的光学拆分方法 |
| BR112014025158B1 (pt) | 2012-04-10 | 2021-09-21 | Daiichi Sankyo Company, Limited | Método para produzir um composto |
| JP2013245215A (ja) * | 2012-05-29 | 2013-12-09 | Daiichi Sankyo Co Ltd | 不斉環化反応による光学活性二環性化合物の製造方法 |
-
2014
- 2014-07-07 TW TW103123253A patent/TWI635071B/zh active
- 2014-07-08 JP JP2014548802A patent/JP5683761B1/ja active Active
- 2014-07-08 BR BR112015002737-7A patent/BR112015002737B1/pt active IP Right Grant
- 2014-07-08 EP EP14823864.5A patent/EP2871176B1/en active Active
- 2014-07-08 CN CN201480002091.0A patent/CN104755456B/zh active Active
- 2014-07-08 HU HUE14823864A patent/HUE030165T2/en unknown
- 2014-07-08 CA CA2881471A patent/CA2881471C/en active Active
- 2014-07-08 WO PCT/JP2014/068101 patent/WO2015005298A1/ja active Application Filing
- 2014-07-08 ES ES14823864.5T patent/ES2611947T3/es active Active
- 2014-07-08 KR KR1020157002876A patent/KR102213954B1/ko active IP Right Grant
- 2014-12-05 JP JP2014246712A patent/JP2015063547A/ja active Pending
-
2015
- 2015-02-05 IL IL237109A patent/IL237109A/en active IP Right Grant
- 2015-02-06 US US14/615,972 patent/US9469623B2/en active Active
- 2015-10-09 HK HK15109880.7A patent/HK1209101A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US9469623B2 (en) | 2016-10-18 |
| KR102213954B1 (ko) | 2021-02-08 |
| HK1209101A1 (zh) | 2016-03-24 |
| BR112015002737B1 (pt) | 2020-12-01 |
| CN104755456A (zh) | 2015-07-01 |
| TWI635071B (zh) | 2018-09-11 |
| ES2611947T3 (es) | 2017-05-11 |
| KR20160030064A (ko) | 2016-03-16 |
| CN104755456B (zh) | 2016-10-12 |
| JPWO2015005298A1 (ja) | 2017-03-02 |
| IL237109A (en) | 2017-07-31 |
| JP5683761B1 (ja) | 2015-03-11 |
| TW201536724A (zh) | 2015-10-01 |
| EP2871176A4 (en) | 2015-06-24 |
| EP2871176A1 (en) | 2015-05-13 |
| HUE030165T2 (en) | 2017-04-28 |
| CA2881471C (en) | 2017-03-21 |
| JP2015063547A (ja) | 2015-04-09 |
| CA2881471A1 (en) | 2015-01-15 |
| EP2871176B1 (en) | 2016-08-31 |
| WO2015005298A1 (ja) | 2015-01-15 |
| US20150218123A1 (en) | 2015-08-06 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 08/07/2014, OBSERVADAS AS CONDICOES LEGAIS. |