BR112014024964A8 - formulação compósita compreendendo comprimido esferoidal de multi-unidade (must) encapsulado em cápsula dura e método para sua preparação - Google Patents
formulação compósita compreendendo comprimido esferoidal de multi-unidade (must) encapsulado em cápsula dura e método para sua preparaçãoInfo
- Publication number
- BR112014024964A8 BR112014024964A8 BR112014024964A BR112014024964A BR112014024964A8 BR 112014024964 A8 BR112014024964 A8 BR 112014024964A8 BR 112014024964 A BR112014024964 A BR 112014024964A BR 112014024964 A BR112014024964 A BR 112014024964A BR 112014024964 A8 BR112014024964 A8 BR 112014024964A8
- Authority
- BR
- Brazil
- Prior art keywords
- capsule
- unit
- hard capsule
- composite formulation
- formulation
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4808—Preparations in capsules, e.g. of gelatin, of chocolate characterised by the form of the capsule or the structure of the filling; Capsules containing small tablets; Capsules with outer layer for immediate drug release
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4422—1,4-Dihydropyridines, e.g. nifedipine, nicardipine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
- A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4833—Encapsulating processes; Filling of capsules
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4891—Coated capsules; Multilayered drug free capsule shells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Abstract
formulação compósita compreendendo comprimido esferoidal de multi-unidade (must) encapsulado em cápsula dura e método para preparação. a presente invenção refere-se a uma formulação compósita compreendendo comprimidos esferoidais de multi-unidades (musts) encapsulados em uma cápsula dura e a um método para preparação da mesma. a formulação compósita de cápsula dura da invenção pode efetivamente carregar os must's no espaço limitado da cápsula,o que permite o carregamento de uma dose elevada de ingredientes farmaceuticamente ativos diferentes, em uma cápsula com um tamanho relativamente pequeno, para desse modo, aumentar a produtividade e torná-la facilmente administrada a pacientes. além disso, a cápsula tem uma boa taxa de dissolução porque os ingredientes farmaceuticamente ativos contidos na cápsula são separados uns dos outros; por conseguinte, as taxas de dissolução dos ingredientes são menos afetadas por outras. também pode ser possível maximizar os efeitos terapêuticos dos ingredientes farmaceuticamente ativos, uma vez que a formulação compósita tem boa estabilidade.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR10-2012-0038594 | 2012-04-13 | ||
KR1020120038594A KR101378973B1 (ko) | 2012-04-13 | 2012-04-13 | 구형에 가까운 형태의 다중 투여 단위 정제를 포함하는 경질 캡슐 복합 제형 및 이의 제조방법 |
PCT/KR2013/003099 WO2013154390A1 (en) | 2012-04-13 | 2013-04-12 | Composite formulation comprising multi-unit spheroidal tablet (must) encapsulated in hard capsule and method for preparing same |
Publications (3)
Publication Number | Publication Date |
---|---|
BR112014024964A2 BR112014024964A2 (pt) | 2017-06-20 |
BR112014024964A8 true BR112014024964A8 (pt) | 2021-06-15 |
BR112014024964B1 BR112014024964B1 (pt) | 2022-03-15 |
Family
ID=49327885
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112014024964-4A BR112014024964B1 (pt) | 2012-04-13 | 2013-04-12 | Formulação compósita compreendendo comprimido esferoidal de multi-unidade (must) encapsulado em cápsula dura e método para sua preparação |
Country Status (22)
Country | Link |
---|---|
US (1) | US20150098992A1 (pt) |
EP (1) | EP2836207B1 (pt) |
JP (1) | JP6129295B2 (pt) |
KR (1) | KR101378973B1 (pt) |
CN (2) | CN110051642B (pt) |
BR (1) | BR112014024964B1 (pt) |
CL (1) | CL2014002717A1 (pt) |
CO (1) | CO7131367A2 (pt) |
ES (1) | ES2778864T3 (pt) |
HK (1) | HK1204959A1 (pt) |
MX (1) | MX354328B (pt) |
MY (1) | MY171703A (pt) |
PE (1) | PE20142035A1 (pt) |
PH (1) | PH12014502271B1 (pt) |
PL (1) | PL2836207T3 (pt) |
PT (1) | PT2836207T (pt) |
RU (1) | RU2014145557A (pt) |
SG (1) | SG11201406298RA (pt) |
TW (1) | TWI544936B (pt) |
UA (1) | UA116102C2 (pt) |
WO (1) | WO2013154390A1 (pt) |
ZA (1) | ZA201408285B (pt) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101910901B1 (ko) * | 2013-11-29 | 2018-10-24 | 한미약품 주식회사 | 암로디핀, 로자탄 및 로수바스타틴을 포함하는 약제학적 복합 제제 |
CA2965237C (en) * | 2014-10-21 | 2023-11-21 | Reckitt Benckiser Llc | Pharmaceutical capsule containing at least two tablets |
KR20170003459A (ko) * | 2015-06-30 | 2017-01-09 | 한미약품 주식회사 | 암로디핀, 로자탄 및 로수바스타틴을 포함하는 약제학적 복합 제제 |
BE1023011B1 (nl) * | 2015-08-05 | 2016-11-04 | Nordic Specialty Pharma Bvba | Acetylsalicylzuur tablet met onmiddellijke afgifte |
WO2017062997A1 (en) | 2015-10-09 | 2017-04-13 | Reckitt Benckiser Llc | Pharmaceutical formulation |
KR101625344B1 (ko) * | 2015-12-21 | 2016-06-08 | 주식회사 유영제약 | 세레콕시브 및 둘록세틴을 함유하는 약제학적 조성물 |
EP3222279B1 (en) | 2016-03-21 | 2021-11-17 | Invest Bielany Spolka z ograniczona odpowiedzialnoscia | Oral pharmaceutical formulation of montelukast and levocetirizine and method for its production |
KR101920996B1 (ko) * | 2017-04-26 | 2018-11-22 | 알보젠코리아 주식회사 | HMG-CoA 환원효소 저해제 및 칼슘채널 차단제를 포함하는 복합제제 |
US20200368219A1 (en) * | 2017-09-28 | 2020-11-26 | Hanmi Pharm. Co., Ltd. | Pharmaceutical composition including multi-unit spheroidal tablet containing esomeprazole and spheroidal pharmaceutically acceptable salt thereof, and method of preparing the pharmaceutical composition |
KR102026982B1 (ko) * | 2018-02-02 | 2019-09-30 | 주식회사 씨티씨바이오 | 캡슐 충진 장치 |
MX2021011795A (es) * | 2019-04-02 | 2022-01-18 | Hanmi Pharm Ind Co Ltd | Composición farmaceutica que comprende esomeprazol 0 sal farmaceuticamente aceptable del mismo y que tiene un perfil de liberación doble. |
KR20210052281A (ko) * | 2019-10-29 | 2021-05-10 | 신에쓰 가가꾸 고교 가부시끼가이샤 | 캡슐 충전용 조성물 및 이것을 사용한 캡슐 제제의 제조 방법 그리고 캡슐 제제 |
US20210275531A1 (en) * | 2020-03-04 | 2021-09-09 | VK Research Associates Inc | Phosphodiesterase-5 inhibitor combinations, methods of making, and methods of use thereof |
KR20230005229A (ko) | 2020-04-17 | 2023-01-09 | 허니브레인즈, 엘엘씨 | 신경정신계 장애를 치료하기 위한 조성물 및 방법 |
EP4085903A1 (de) * | 2021-05-07 | 2022-11-09 | Midas Pharma GmbH | Minitablette enthaltend losartan für pädiatrische anwendungen |
CA3229117A1 (en) * | 2021-08-19 | 2023-02-23 | Dorit MIMROD | Method of treating parkinson's disease |
KR20240045586A (ko) | 2022-09-30 | 2024-04-08 | 주식회사 제뉴원사이언스 | 레보세티리진 또는 이의 약학적으로 허용가능한 염 및 몬테루카스트 또는 이의 약학적으로 허용가능한 염을 포함하는 안정성이 향상된 이층정 정제 및 그의 제조방법 |
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IL147826A0 (en) * | 1999-07-30 | 2002-08-14 | Smithkline Beecham Plc | Multi-component pharmaceutical dosage form |
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WO2005048979A2 (en) * | 2003-10-06 | 2005-06-02 | Torrent Pharmaceuticals Limited | Pharmaceutical composition having casing with multiple micro tablets |
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KR100795419B1 (ko) * | 2006-01-03 | 2008-01-17 | (주)네오메딕스 | 암로디핀 및 아스피린을 함유하는 약학 제제 |
CA2662542A1 (en) * | 2006-09-12 | 2008-03-20 | Glaxo Group Limited | Pharmaceutical composition comprising a plurality of mini-tablets comprising a factor xa inhibitor |
KR100888131B1 (ko) * | 2006-10-10 | 2009-03-11 | 한올제약주식회사 | 시간차 투약 원리를 이용한 심혈관계 질환 치료용 복합제제 |
WO2008132712A2 (en) * | 2007-05-01 | 2008-11-06 | Sigmoid Pharma Limited | Combination pharmaceutical compositions |
KR100949273B1 (ko) * | 2008-02-22 | 2010-03-25 | 한올제약주식회사 | 복합제제 |
KR20090091084A (ko) * | 2008-02-22 | 2009-08-26 | 한올제약주식회사 | 방출성이 제어된 약제학적 제제 |
US8753680B2 (en) * | 2008-03-28 | 2014-06-17 | Ferrer Internacional S.A. | Capsule for the prevention of cardiovascular diseases |
TR201005325A2 (tr) * | 2010-06-30 | 2012-01-23 | Bi̇lgi̇ç Mahmut | Atorvastatin ve aspirin içeren farmasötik formülasyonlar |
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-
2012
- 2012-04-13 KR KR1020120038594A patent/KR101378973B1/ko active IP Right Grant
-
2013
- 2013-04-12 JP JP2015505646A patent/JP6129295B2/ja not_active Expired - Fee Related
- 2013-04-12 PE PE2014001632A patent/PE20142035A1/es not_active Application Discontinuation
- 2013-04-12 TW TW102113097A patent/TWI544936B/zh not_active IP Right Cessation
- 2013-04-12 CN CN201910062530.1A patent/CN110051642B/zh active Active
- 2013-04-12 WO PCT/KR2013/003099 patent/WO2013154390A1/en active Application Filing
- 2013-04-12 PT PT137758140T patent/PT2836207T/pt unknown
- 2013-04-12 BR BR112014024964-4A patent/BR112014024964B1/pt active IP Right Grant
- 2013-04-12 CN CN201380019865.6A patent/CN104220050A/zh active Pending
- 2013-04-12 MX MX2014012144A patent/MX354328B/es active IP Right Grant
- 2013-04-12 SG SG11201406298RA patent/SG11201406298RA/en unknown
- 2013-04-12 MY MYPI2014702956A patent/MY171703A/en unknown
- 2013-04-12 UA UAA201412220A patent/UA116102C2/uk unknown
- 2013-04-12 ES ES13775814T patent/ES2778864T3/es active Active
- 2013-04-12 EP EP13775814.0A patent/EP2836207B1/en active Active
- 2013-04-12 US US14/391,111 patent/US20150098992A1/en not_active Abandoned
- 2013-04-12 PL PL13775814T patent/PL2836207T3/pl unknown
- 2013-04-12 RU RU2014145557A patent/RU2014145557A/ru unknown
-
2014
- 2014-10-08 PH PH12014502271A patent/PH12014502271B1/en unknown
- 2014-10-09 CL CL2014002717A patent/CL2014002717A1/es unknown
- 2014-11-10 CO CO14247711A patent/CO7131367A2/es unknown
- 2014-11-12 ZA ZA2014/08285A patent/ZA201408285B/en unknown
-
2015
- 2015-06-16 HK HK15105701.2A patent/HK1204959A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
US20150098992A1 (en) | 2015-04-09 |
TW201345568A (zh) | 2013-11-16 |
JP2015517998A (ja) | 2015-06-25 |
ES2778864T3 (es) | 2020-08-12 |
RU2014145557A (ru) | 2016-06-10 |
PH12014502271A1 (en) | 2014-12-10 |
MY171703A (en) | 2019-10-23 |
HK1204959A1 (en) | 2015-12-11 |
MX2014012144A (es) | 2014-12-05 |
WO2013154390A1 (en) | 2013-10-17 |
BR112014024964A2 (pt) | 2017-06-20 |
EP2836207B1 (en) | 2020-02-19 |
UA116102C2 (uk) | 2018-02-12 |
CN104220050A (zh) | 2014-12-17 |
ZA201408285B (en) | 2016-09-28 |
PE20142035A1 (es) | 2014-12-24 |
EP2836207A4 (en) | 2015-08-19 |
TWI544936B (zh) | 2016-08-11 |
PT2836207T (pt) | 2020-03-26 |
SG11201406298RA (en) | 2014-11-27 |
EP2836207A1 (en) | 2015-02-18 |
CL2014002717A1 (es) | 2015-01-09 |
KR20130115864A (ko) | 2013-10-22 |
PL2836207T3 (pl) | 2020-07-27 |
MX354328B (es) | 2018-02-27 |
JP6129295B2 (ja) | 2017-05-17 |
CN110051642A (zh) | 2019-07-26 |
BR112014024964B1 (pt) | 2022-03-15 |
CN110051642B (zh) | 2021-12-31 |
CO7131367A2 (es) | 2014-12-01 |
KR101378973B1 (ko) | 2014-03-28 |
PH12014502271B1 (en) | 2014-12-10 |
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