BR112014023460B1 - Composto, formulação farmacêutica, uso de um composto - Google Patents

Composto, formulação farmacêutica, uso de um composto Download PDF

Info

Publication number
BR112014023460B1
BR112014023460B1 BR112014023460-4A BR112014023460A BR112014023460B1 BR 112014023460 B1 BR112014023460 B1 BR 112014023460B1 BR 112014023460 A BR112014023460 A BR 112014023460A BR 112014023460 B1 BR112014023460 B1 BR 112014023460B1
Authority
BR
Brazil
Prior art keywords
administration
compound
amino
disease
pyrido
Prior art date
Application number
BR112014023460-4A
Other languages
English (en)
Portuguese (pt)
Inventor
Hong Woo Kim
Hee Kyu Lee
Ho-Juhn Song
Jaekyoo Lee
Jong Sung Koh
Jung-Ho Kim
Se Won Kim
In Yong Lee
Original Assignee
Oscotec, Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oscotec, Inc filed Critical Oscotec, Inc
Publication of BR112014023460B1 publication Critical patent/BR112014023460B1/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/28Compounds containing heavy metals
    • A61K31/305Mercury compounds
    • A61K31/31Mercury compounds containing nitrogen
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D239/00Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
BR112014023460-4A 2012-03-22 2013-03-15 Composto, formulação farmacêutica, uso de um composto BR112014023460B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261614274P 2012-03-22 2012-03-22
US61/614,274 2012-03-22
PCT/US2013/032575 WO2013142382A1 (en) 2012-03-22 2013-03-15 Substituted pyridopyrimidine compounds and their use as flt3 inhibitors

Publications (1)

Publication Number Publication Date
BR112014023460B1 true BR112014023460B1 (pt) 2020-09-01

Family

ID=49223277

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014023460-4A BR112014023460B1 (pt) 2012-03-22 2013-03-15 Composto, formulação farmacêutica, uso de um composto

Country Status (21)

Country Link
US (1) US8877763B2 (enExample)
EP (1) EP2828259B1 (enExample)
JP (1) JP6101341B2 (enExample)
KR (1) KR102011770B1 (enExample)
CN (1) CN104428298B (enExample)
AU (1) AU2013235344B2 (enExample)
BR (1) BR112014023460B1 (enExample)
CA (1) CA2868156C (enExample)
CL (1) CL2014002505A1 (enExample)
EA (1) EA031267B1 (enExample)
ES (1) ES2694223T3 (enExample)
IL (1) IL234802B (enExample)
IN (1) IN2014MN02082A (enExample)
MX (1) MX360912B (enExample)
MY (1) MY184858A (enExample)
NZ (1) NZ700283A (enExample)
PL (1) PL2828259T3 (enExample)
SG (1) SG11201405942RA (enExample)
TR (1) TR201816480T4 (enExample)
WO (1) WO2013142382A1 (enExample)
ZA (1) ZA201407588B (enExample)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102228034B1 (ko) * 2013-10-21 2021-03-16 제노스코 치환된 피리미딘 화합물 및 syk 억제제로서의 이의 용도
ES2747249T3 (es) * 2014-07-17 2020-03-10 Sunshine Lake Pharma Co Ltd Derivados de 1-(5-(terc-butil)isoxazol-3-il)-3-(4-((fenil)etinil)fenil)urea y compuestos relacionados como inhibidores de FLT3 para el tratamiento de cáncer
KR20160035411A (ko) * 2014-09-23 2016-03-31 주식회사 오스코텍 LRRK2 (Leucine Rich Repeat Kinase 2) 키나제 억제제로서의 피리도피리미딘 유도체 화합물
KR20170087913A (ko) * 2014-11-17 2017-07-31 로드아일랜드하스피틀 나노물질, 조성물, 합성, 및 어셈블리
BR112020026641A2 (pt) * 2018-06-27 2021-03-30 Oscotec Inc. Derivados de piridopirimidinona para o uso como inibidores de axl
KR20200022712A (ko) * 2018-08-23 2020-03-04 주식회사 오스코텍 8-브로모-2-(1-메틸피페리딘-4-일아미노)-4-(4-페녹시페닐아미노)피리도[4,3-d]피리미딘-5(6H)-온 염산염의 결정다형체 및 그 제조방법
KR102230721B1 (ko) * 2019-02-01 2021-03-22 주식회사 오스코텍 피리도피리미딘계 염산염을 포함하는 경구용 고형제제 및 이의 제조방법
BR112021018168B1 (pt) 2019-03-21 2023-11-28 Onxeo Composição farmacêutica, combinação e kit compreendendo uma molécula dbait e um inibidor de quinase para o tratamento de câncer
CN110327347B (zh) * 2019-08-16 2021-06-01 陕西科技大学 G-749在制备抗真菌药物中的应用
TWI759829B (zh) * 2019-08-23 2022-04-01 財團法人生物技術開發中心 作為第iii型受體酪胺酸激酶抑制劑之雜環吡唑衍生物
CA3159348A1 (en) 2019-11-08 2021-05-14 Inserm (Institut National De La Sante Et De La Recherche Medicale) Methods for the treatment of cancers that have acquired resistance to kinase inhibitors
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
WO2023027966A1 (en) 2021-08-24 2023-03-02 Biomea Fusion, Inc. Pyrazine compounds as irreversible inhibitors of flt3
JP2025502748A (ja) 2021-12-30 2025-01-28 バイオメア フュージョン,インコーポレイテッド Flt3の阻害剤としてのピラジン化合物
EP4525873A1 (en) 2022-05-17 2025-03-26 Biomea Fusion, Inc. Flt3 combination therapy for cancer and compositions therefor
KR102440707B1 (ko) 2022-07-10 2022-09-05 이우미 공장 추천 시스템

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1433417A (zh) * 2000-01-27 2003-07-30 沃尼尔·朗伯公司 用于治疗神经变性疾病的吡啶并嘧啶酮衍生物
CA2420286A1 (en) * 2000-08-31 2002-03-07 F. Hoffmann-La Roche Ag 7-oxo pyridopyrimidines as inhibitors of a cellular proliferation
CN100358892C (zh) * 2000-08-31 2008-01-02 霍夫曼-拉罗奇有限公司 7-氧代吡啶并嘧啶
EP2025678A1 (en) * 2007-08-17 2009-02-18 Oncalis AG Pyrazolo[3,4-d]pyrimidine compounds and their use as modulators of protein kinase
TW200938542A (en) * 2008-02-01 2009-09-16 Irm Llc Compounds and compositions as kinase inhibitors
ES2432414T3 (es) * 2008-08-12 2013-12-03 Glaxosmithkline Llc Compuestos químicos
US8338481B2 (en) * 2009-01-28 2012-12-25 Ramot At Tel-Aviv University Ltd. Alkoxyalkyl S-prenylthiosalicylates for treatment of cancer
BR112012003661A2 (pt) * 2009-08-19 2017-04-25 Ambit Biosciences Corp "compostos de biarila e métodos de uso dos mesmos."
ES2658290T3 (es) * 2009-10-29 2018-03-09 Genosco Inhibidores de cinasa

Also Published As

Publication number Publication date
KR20140144709A (ko) 2014-12-19
SG11201405942RA (en) 2014-10-30
ZA201407588B (en) 2015-11-25
EA201491747A1 (ru) 2015-10-30
WO2013142382A1 (en) 2013-09-26
US20130274274A1 (en) 2013-10-17
EA031267B1 (ru) 2018-12-28
AU2013235344B2 (en) 2017-03-16
TR201816480T4 (tr) 2018-11-21
ES2694223T3 (es) 2018-12-19
HK1208453A1 (en) 2016-03-04
JP2015510942A (ja) 2015-04-13
NZ700283A (en) 2016-08-26
MX2014011354A (es) 2014-12-05
MX360912B (es) 2018-11-22
CA2868156C (en) 2020-07-28
CA2868156A1 (en) 2013-09-26
EP2828259A4 (en) 2015-08-19
IN2014MN02082A (enExample) 2015-08-21
EP2828259A1 (en) 2015-01-28
CL2014002505A1 (es) 2015-10-02
PL2828259T3 (pl) 2019-02-28
AU2013235344A1 (en) 2014-10-09
US8877763B2 (en) 2014-11-04
CN104428298A (zh) 2015-03-18
EP2828259B1 (en) 2018-08-08
MY184858A (en) 2021-04-27
JP6101341B2 (ja) 2017-03-22
IL234802B (en) 2018-10-31
KR102011770B1 (ko) 2019-08-19
CN104428298B (zh) 2017-03-01

Similar Documents

Publication Publication Date Title
AU2013235344B2 (en) Substituted pyridopyrimidine compounds and their use as FLT3 inhibitors
US8404677B2 (en) Kinase inhibitors
EP2498607B1 (en) Kinase inhibitors
CN105566321B (zh) 杂芳化合物及其在药物中的应用
JP2022526854A (ja) ホスファチジルイノシトール3-キナーゼ阻害剤
JPWO2015022926A1 (ja) 新規な縮合ピリミジン化合物又はその塩
TW200835495A (en) Substituted 8-piperidinyl-2-pyridinyl-pyrimido[1,2-a] pyrimidin-6-one and 8-piperidinyl-2-pyrimidinyl-pyrimido[1,2-a] pyrimidin-6-one derivatives
JPWO2008001885A1 (ja) Ablキナーゼ阻害剤
JP7200453B2 (ja) Axl阻害剤として使用するためのピリドピリミジノン誘導体
CN118369323A (zh) 作为shp2抑制剂的杂环化合物、包括该杂环化合物的组合物、及其使用方法
CA3173569C (en) Allosteric chromenone inhibitors of phosphoinositide 3-kinase (pi3k) for the treatment of disease
AU2010313240B2 (en) Kinase inhibitors
HK1208453B (en) Substituted pyridopyrimidine compounds and their use as flt3 inhibitors
HK40043096B (zh) 吡啶并嘧啶酮衍生物用作axl抑制剂
EA043296B1 (ru) Производные пиридопиримидинона для применения в качестве ингибиторов axl

Legal Events

Date Code Title Description
B25A Requested transfer of rights approved

Owner name: OSCOTEC, INC (KR)

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06T Formal requirements before examination [chapter 6.20 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 15/03/2013, OBSERVADAS AS CONDICOES LEGAIS.