BR112014019212A8 - Processo para a preparação de derivados quirais azetidina isoxazolina como agentes antiparasitários - Google Patents
Processo para a preparação de derivados quirais azetidina isoxazolina como agentes antiparasitáriosInfo
- Publication number
- BR112014019212A8 BR112014019212A8 BR112014019212A BR112014019212A BR112014019212A8 BR 112014019212 A8 BR112014019212 A8 BR 112014019212A8 BR 112014019212 A BR112014019212 A BR 112014019212A BR 112014019212 A BR112014019212 A BR 112014019212A BR 112014019212 A8 BR112014019212 A8 BR 112014019212A8
- Authority
- BR
- Brazil
- Prior art keywords
- isoxazoline
- azetidine
- preparation
- chiral
- derivatives
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- LZNQKPCMSCHBFF-UHFFFAOYSA-N azetidine;4,5-dihydro-1,2-oxazole Chemical compound C1CNC1.C1CC=NO1 LZNQKPCMSCHBFF-UHFFFAOYSA-N 0.000 title abstract 3
- 238000002360 preparation method Methods 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 230000000590 parasiticidal effect Effects 0.000 abstract 1
- 239000002297 parasiticide Substances 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261594614P | 2012-02-03 | 2012-02-03 | |
| PCT/US2013/023673 WO2013116236A1 (en) | 2012-02-03 | 2013-01-29 | Process for the preparation of chiral isoxazoline azetidine derivatives as antiparasitic agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112014019212A2 BR112014019212A2 (https=) | 2017-06-20 |
| BR112014019212A8 true BR112014019212A8 (pt) | 2017-07-11 |
Family
ID=47679107
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112014019212A BR112014019212A8 (pt) | 2012-02-03 | 2013-01-29 | Processo para a preparação de derivados quirais azetidina isoxazolina como agentes antiparasitários |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US20140371464A1 (https=) |
| EP (1) | EP2809667A1 (https=) |
| JP (1) | JP2015505560A (https=) |
| CN (1) | CN104169276A (https=) |
| AR (1) | AR092793A1 (https=) |
| AU (1) | AU2013215374A1 (https=) |
| BR (1) | BR112014019212A8 (https=) |
| CA (1) | CA2863629A1 (https=) |
| CL (1) | CL2014002034A1 (https=) |
| MX (1) | MX2014009388A (https=) |
| RU (1) | RU2014131950A (https=) |
| UY (1) | UY34612A (https=) |
| WO (1) | WO2013116236A1 (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2013169622A1 (en) * | 2012-05-09 | 2013-11-14 | Zoetis Llc | Azetidine derivatives as antiparasitic agents |
| UY37137A (es) | 2016-02-24 | 2017-09-29 | Merial Inc | Compuestos antiparasitarios de isoxazolina, formulaciones inyectables de acción prolongada que los comprenden, métodos y usos de los mismos |
| ES2903286T3 (es) | 2016-04-06 | 2022-03-31 | Boehringer Ingelheim Animal Health Usa Inc | Proceso de preparación de compuestos de isoxazolina enriquecidos enantioméricamente y de solvato de tolueno cristalino de (S)-afoxolaner |
| WO2018071535A1 (en) | 2016-10-14 | 2018-04-19 | Merial, Inc. | Pesticidal and parasiticidal vinyl isoxazoline compounds |
| BR112020003217A2 (pt) | 2017-08-14 | 2020-10-06 | Boehringer Ingelheim Animal Health USA Inc. | compostos pesticidas e parasiticidas de pirazolisoxazolina |
| MX2021013507A (es) * | 2019-06-19 | 2021-12-10 | Nmd Pharma As | Proceso para la preparacion de inhibidores del canal de cloruro ciec-1. |
| KR20230043904A (ko) | 2020-07-24 | 2023-03-31 | 엘랑코 유에스 인코포레이티드 | 이속사졸린 화합물 및 이의 중간체의 제조 공정 |
| EP4384514A1 (en) | 2021-08-11 | 2024-06-19 | Elanco Us Inc. | Process for making diaryl isoxazoline derivative |
| WO2026043852A1 (en) | 2024-08-20 | 2026-02-26 | Zoetis Services Llc | Process for preparing optically enriched isoxazolines |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA200804080B (en) * | 2005-12-16 | 2009-10-28 | Du Pont | 5-Aryl isoxazolines for controlling invertebrate pests |
| TW200803740A (en) | 2005-12-16 | 2008-01-16 | Du Pont | 5-aryl isoxazolines for controlling invertebrate pests |
| WO2007105814A1 (ja) | 2006-03-10 | 2007-09-20 | Nissan Chemical Industries, Ltd. | 置換イソキサゾリン化合物及び有害生物防除剤 |
| JP2008044880A (ja) * | 2006-08-15 | 2008-02-28 | Bayer Cropscience Ag | 殺虫性イソオキサゾリン類 |
| US8303622B2 (en) | 2007-03-14 | 2012-11-06 | St. Jude Medical, Inc. | Heart valve chordae replacement methods and apparatus |
| JP2008260691A (ja) * | 2007-04-10 | 2008-10-30 | Bayer Cropscience Ag | 殺虫性アリールイソオキサゾリン誘導体 |
| JP5365806B2 (ja) | 2007-09-10 | 2013-12-11 | 日産化学工業株式会社 | 置換イソキサゾリン化合物及び有害生物防除剤 |
| JP5365807B2 (ja) | 2007-11-12 | 2013-12-11 | 日産化学工業株式会社 | 光学活性イソキサゾリン化合物の触媒的不斉合成方法 |
| HUE015568T4 (en) * | 2008-12-19 | 2017-10-30 | Elanco Tiergesundheit Ag | Isoxazoline derivatives and their use as pesticides |
| CA2790963A1 (en) | 2010-02-25 | 2011-09-01 | Syngenta Participations Ag | Process for the preparation of isoxazoline derivatives |
| CN103270036B (zh) * | 2010-08-05 | 2015-11-25 | 佐蒂斯有限责任公司 | 作为抗寄生物剂的异噁唑啉衍生物 |
-
2013
- 2013-01-29 RU RU2014131950A patent/RU2014131950A/ru unknown
- 2013-01-29 EP EP13703287.6A patent/EP2809667A1/en not_active Withdrawn
- 2013-01-29 US US14/375,056 patent/US20140371464A1/en not_active Abandoned
- 2013-01-29 CN CN201380014566.3A patent/CN104169276A/zh active Pending
- 2013-01-29 BR BR112014019212A patent/BR112014019212A8/pt not_active IP Right Cessation
- 2013-01-29 CA CA2863629A patent/CA2863629A1/en not_active Abandoned
- 2013-01-29 AU AU2013215374A patent/AU2013215374A1/en not_active Abandoned
- 2013-01-29 WO PCT/US2013/023673 patent/WO2013116236A1/en not_active Ceased
- 2013-01-29 MX MX2014009388A patent/MX2014009388A/es unknown
- 2013-01-29 JP JP2014555626A patent/JP2015505560A/ja active Pending
- 2013-02-01 AR ARP130100321A patent/AR092793A1/es unknown
- 2013-02-04 UY UY0001034612A patent/UY34612A/es not_active Application Discontinuation
-
2014
- 2014-07-30 CL CL2014002034A patent/CL2014002034A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AR092793A1 (es) | 2015-05-06 |
| US20140371464A1 (en) | 2014-12-18 |
| RU2014131950A (ru) | 2016-03-27 |
| BR112014019212A2 (https=) | 2017-06-20 |
| JP2015505560A (ja) | 2015-02-23 |
| EP2809667A1 (en) | 2014-12-10 |
| AU2013215374A1 (en) | 2014-08-21 |
| CN104169276A (zh) | 2014-11-26 |
| CL2014002034A1 (es) | 2014-11-14 |
| UY34612A (es) | 2013-09-30 |
| CA2863629A1 (en) | 2013-08-08 |
| WO2013116236A1 (en) | 2013-08-08 |
| MX2014009388A (es) | 2014-08-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |