BR112021025588A2 - Processo para a preparação dos inibidores de canal de cloreto clc-1 - Google Patents

Processo para a preparação dos inibidores de canal de cloreto clc-1

Info

Publication number
BR112021025588A2
BR112021025588A2 BR112021025588A BR112021025588A BR112021025588A2 BR 112021025588 A2 BR112021025588 A2 BR 112021025588A2 BR 112021025588 A BR112021025588 A BR 112021025588A BR 112021025588 A BR112021025588 A BR 112021025588A BR 112021025588 A2 BR112021025588 A2 BR 112021025588A2
Authority
BR
Brazil
Prior art keywords
clc
preparation
chloride channel
channel inhibitors
inhibitors
Prior art date
Application number
BR112021025588A
Other languages
English (en)
Inventor
Michael Mckenzie
Nicholas Kelly
Original Assignee
Nmd Pharma As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nmd Pharma As filed Critical Nmd Pharma As
Publication of BR112021025588A2 publication Critical patent/BR112021025588A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/08—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

processo para a preparação dos inibidores de canal de cloreto clc-1. essa divulgação se refere a um processo químico melhorado para produzir compostos que são inibidores de canais de cloreto clc-1.
BR112021025588A 2019-06-19 2020-06-19 Processo para a preparação dos inibidores de canal de cloreto clc-1 BR112021025588A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP19181262 2019-06-19
PCT/EP2020/067065 WO2020254554A1 (en) 2019-06-19 2020-06-19 Process for the preparation of clc-1 chloride channel inhibitors

Publications (1)

Publication Number Publication Date
BR112021025588A2 true BR112021025588A2 (pt) 2022-02-01

Family

ID=66999603

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112021025588A BR112021025588A2 (pt) 2019-06-19 2020-06-19 Processo para a preparação dos inibidores de canal de cloreto clc-1

Country Status (15)

Country Link
US (1) US20220298124A1 (pt)
EP (1) EP3986878B1 (pt)
JP (1) JP2022537493A (pt)
KR (1) KR20220022895A (pt)
CN (1) CN113993852A (pt)
AR (1) AR119198A1 (pt)
AU (1) AU2020298092A1 (pt)
BR (1) BR112021025588A2 (pt)
CA (1) CA3137672A1 (pt)
IL (1) IL287901B1 (pt)
MX (1) MX2021013507A (pt)
SG (1) SG11202111122RA (pt)
TW (1) TWI849152B (pt)
WO (1) WO2020254554A1 (pt)
ZA (1) ZA202107653B (pt)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024068862A1 (en) 2022-09-30 2024-04-04 Nmd Pharma A/S Compositions and methods for treating myasthenia gravis
WO2024180201A1 (en) 2023-03-02 2024-09-06 Nmd Pharma A/S Compositions and methods for treating spinal muscular atrophy
WO2024180199A1 (en) 2023-03-02 2024-09-06 Nmd Pharma A/S Compositions and methods for treating charcot–marie–tooth disease

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE0301010D0 (sv) * 2003-04-07 2003-04-07 Astrazeneca Ab Novel compounds
GB0422057D0 (en) * 2004-10-05 2004-11-03 Astrazeneca Ab Novel compounds
GB0524428D0 (en) * 2005-11-30 2006-01-11 7Tm Pharma As Medicinal use of receptor ligands
BRPI0907486A2 (pt) * 2008-02-05 2015-07-14 Sanofi Aventis Triazolpiridazinas como inibidores de par1, sua produção e uso como medicamentos
MX2014009388A (es) * 2012-02-03 2014-08-27 Zoetis Llc Procedimiento para la preparacion de derivados de isoxazolina azetidina quirales como agentes antiparasitarios.
US10934244B2 (en) 2015-06-15 2021-03-02 Nmd Pharma A/S Compounds for use in treating neuromuscular disorders
US10385028B2 (en) * 2017-12-14 2019-08-20 Nmd Pharma A/S Compounds for the treatment of neuromuscular disorders
TWI780281B (zh) * 2017-12-14 2022-10-11 丹麥商Ｎｍｄ藥品公司 用於治療神經肌肉病症的化合物

Also Published As

Publication number Publication date
JP2022537493A (ja) 2022-08-26
EP3986878A1 (en) 2022-04-27
KR20220022895A (ko) 2022-02-28
IL287901A (en) 2022-01-01
TW202115003A (zh) 2021-04-16
ZA202107653B (en) 2023-05-31
AU2020298092A1 (en) 2021-11-18
CN113993852A (zh) 2022-01-28
MX2021013507A (es) 2021-12-10
SG11202111122RA (en) 2021-11-29
CA3137672A1 (en) 2020-12-24
AR119198A1 (es) 2021-12-01
IL287901B1 (en) 2024-10-01
EP3986878B1 (en) 2024-09-25
TWI849152B (zh) 2024-07-21
US20220298124A1 (en) 2022-09-22
WO2020254554A1 (en) 2020-12-24

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