|
US5164410A
(en)
|
1988-01-09 |
1992-11-17 |
Takeda Chemical Industries, Ltd. |
Fumagillol derivatives and pharmaceutical compositions thereof
|
|
PH26256A
(en)
|
1988-08-12 |
1992-04-01 |
Fujisawa Pharmaceutical Co |
Oxaspiro [2,5] octane derivative
|
|
KR0138530B1
(ko)
|
1988-09-01 |
1998-05-15 |
우메모또 요시마사 |
푸마길롤 유도체
|
|
US5180738A
(en)
|
1988-09-01 |
1993-01-19 |
Takeda Chemical Industries |
Fumagillol derivatives and pharmaceutical compositions thereof
|
|
US5166172A
(en)
|
1988-09-01 |
1992-11-24 |
Takeda Chemical Industries, Ltd. |
Fumagillol derivatives and pharmaceutical compositions thereof
|
|
ATE87623T1
(de)
|
1989-03-06 |
1993-04-15 |
Takeda Chemical Industries Ltd |
6-epifumagillole, ihre herstellung und ihre verwendung.
|
|
US5288722A
(en)
|
1989-03-06 |
1994-02-22 |
Takeda Chemical Industries, Ltd. |
6-amino-6-desoxyfumagillols, production and use thereof
|
|
US6017954A
(en)
|
1989-08-10 |
2000-01-25 |
Children's Medical Center Corp. |
Method of treating tumors using O-substituted fumagillol derivatives
|
|
US5290807A
(en)
|
1989-08-10 |
1994-03-01 |
Children's Medical Center Corporation |
Method for regressing angiogenesis using o-substituted fumagillol derivatives
|
|
EP0415294A3
(en)
|
1989-08-31 |
1991-06-12 |
Takeda Chemical Industries, Ltd. |
Cyclohexanol derivatives, production and use thereof
|
|
TW282399B
(GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
|
1990-05-25 |
1996-08-01 |
Takeda Pharm Industry Co Ltd |
|
|
US5238950A
(en)
|
1991-12-17 |
1993-08-24 |
Schering Corporation |
Inhibitors of platelet-derived growth factor
|
|
EP0555693B1
(en)
|
1992-01-30 |
2001-09-05 |
Takeda Chemical Industries, Ltd. |
Method of producing highly watersoluble cyclodextrin complex
|
|
EP0602586B1
(en)
|
1992-12-16 |
1997-06-04 |
Takeda Chemical Industries, Ltd. |
Stable pharmaceutical composition of fumagillol derivatives
|
|
ES2128846T3
(es)
|
1995-03-27 |
1999-05-16 |
Sanofi Sa |
Utilizacion del fumagilol y sus derivados para preparar los medicamentos destinados a combatir las infecciones intestinales.
|
|
WO1997013509A1
(fr)
|
1995-10-11 |
1997-04-17 |
Fujisawa Pharmaceutical Co., Ltd. |
Inhibiteur de permeation vasculaire
|
|
EP0799616A1
(en)
|
1996-04-01 |
1997-10-08 |
Takeda Chemical Industries, Ltd. |
Oral composition comprising a fumagillol derivative
|
|
AU3968597A
(en)
|
1996-08-02 |
1998-02-25 |
Children's Medical Center Corporation |
Method of regulating the female reproductive system through angiogenesis inhibitors
|
|
US6281245B1
(en)
|
1996-10-28 |
2001-08-28 |
Versicor, Inc. |
Methods for solid-phase synthesis of hydroxylamine compounds and derivatives, and combinatorial libraries thereof
|
|
US7115632B1
(en)
|
1999-05-12 |
2006-10-03 |
G. D. Searle & Co. |
Sulfonyl aryl or heteroaryl hydroxamic acid compounds
|
|
CA2283272A1
(en)
|
1997-03-04 |
1998-09-11 |
Monsanto Company |
Aromatic sulfonyl alpha-cycloamino hydroxamic acid compounds
|
|
WO1998056372A1
(en)
|
1997-06-09 |
1998-12-17 |
Massachusetts Institute Of Technology |
TYPE 2 METHIONINE AMINOPEPTIDASE (MetAP2) INHIBITORS AND USES THEROF
|
|
DE69824750T2
(de)
|
1997-10-31 |
2005-07-07 |
Children's Medical Center Corp., Boston |
Methoden zur regulierung der grösse und des wachstums von durchblutetem normalem gewebe
|
|
NZ502963A
(en)
|
1997-12-23 |
2002-06-28 |
Warner Lambert Co |
Thiourea and benzamide compounds and methods of treating or preventing inflammatory diseases and atherosclerosis
|
|
US6242494B1
(en)
|
1998-05-01 |
2001-06-05 |
Abbott Laboratories |
Substituted β-amino acid inhibitors of methionine aminopeptidase-2
|
|
KR100357541B1
(ko)
|
1998-05-15 |
2002-10-18 |
주식회사종근당 |
5-데메톡시 푸마질롤 유도체 및 그 제조방법
|
|
KR100357542B1
(ko)
|
1998-05-15 |
2002-10-18 |
주식회사종근당 |
푸마질롤 유도체 및 그 제조방법
|
|
JP2000116337A
(ja)
|
1998-10-09 |
2000-04-25 |
Nippon Shokuhin Kako Co Ltd |
ペットフード
|
|
US6383471B1
(en)
|
1999-04-06 |
2002-05-07 |
Lipocine, Inc. |
Compositions and methods for improved delivery of ionizable hydrophobic therapeutic agents
|
|
RU2278860C2
(ru)
|
1999-04-28 |
2006-06-27 |
Санофи-Авентис Дойчланд Гмбх |
Производные триарил-содержащих кислот в качестве лигандов рецепторов ппар
|
|
US6593480B2
(en)
*
|
1999-09-01 |
2003-07-15 |
Abbott Laboratories |
Glucocorticoid receptor antagonists for treatment of diabetes
|
|
JP2003510359A
(ja)
|
1999-10-01 |
2003-03-18 |
スミスクライン・ビーチャム・コーポレイション |
化合物および方法
|
|
US20020002152A1
(en)
|
2000-04-14 |
2002-01-03 |
Craig Richard A. |
Hydrazide and alkoxyamide angiogenesis inhibitors
|
|
US6323228B1
(en)
|
2000-09-15 |
2001-11-27 |
Abbott Laboratories |
3-substituted indole angiogenesis inhibitors
|
|
PE20020376A1
(es)
|
2000-09-29 |
2002-05-13 |
Abbott Lab |
Polipeptidos antiangiogenicos y metodos para inhibir la angiogenesis
|
|
US6548477B1
(en)
|
2000-11-01 |
2003-04-15 |
Praecis Pharmaceuticals Inc. |
Therapeutic agents and methods of use thereof for the modulation of angiogenesis
|
|
CN1505617A
(zh)
|
2000-11-01 |
2004-06-16 |
������˹ҩƷ��˾ |
作为Met-AP2抑制剂的肽
|
|
CA2432181C
(en)
|
2000-12-20 |
2009-11-17 |
Bristol-Myers Squibb Company |
Substituted pyrroloquinolines and pyridoquinolines as serotonin agonists and antagonists
|
|
US20040116495A1
(en)
|
2001-03-29 |
2004-06-17 |
Marino Jr. Joseph P. |
Compounds and methods
|
|
US20020183242A1
(en)
|
2001-04-11 |
2002-12-05 |
Jack Henkin |
Peptide antiangiogenic drugs
|
|
WO2003027104A1
(en)
|
2001-09-27 |
2003-04-03 |
Idrtech Inc. |
Fumagillol derivatives and preparing method thereof
|
|
US6803382B2
(en)
|
2001-11-09 |
2004-10-12 |
Galderma Research & Development, S.N.C. |
Angiogenesis inhibitors and pharmaceutical and cosmetic use thereof
|
|
US7119120B2
(en)
|
2001-12-26 |
2006-10-10 |
Genzyme Corporation |
Phosphate transport inhibitors
|
|
KR100451485B1
(ko)
|
2002-03-28 |
2004-10-06 |
주식회사종근당 |
푸마질롤 유도체 또는 그 염의 포접 화합물, 및 이를포함하는 약제학적 조성물
|
|
US6989392B2
(en)
|
2002-06-18 |
2006-01-24 |
Abbott Laboratories |
2-Aminoquinolines as melanin concentrating hormone receptor antagonists
|
|
US7030262B2
(en)
|
2002-08-06 |
2006-04-18 |
Abbott Laboratories |
3-Amino-2-hydroxyalkanoic acids and their prodrugs
|
|
US20040067266A1
(en)
|
2002-10-07 |
2004-04-08 |
Toppo Frank R. |
Weight loss compound
|
|
US20040157836A1
(en)
|
2002-10-08 |
2004-08-12 |
Comess Kenneth M. |
Sulfonamides having antiangiogenic and anticancer activity
|
|
US20040068012A1
(en)
|
2002-10-08 |
2004-04-08 |
Comess Kenneth M. |
Sulfonamides having antiangiogenic and anticancer activity
|
|
US7491718B2
(en)
|
2002-10-08 |
2009-02-17 |
Abbott Laboratories |
Sulfonamides having antiangiogenic and anticancer activity
|
|
US20040204472A1
(en)
|
2003-03-04 |
2004-10-14 |
Pharmacia Corporation |
Treatment and prevention of obesity with COX-2 inhibitors alone or in combination with weight-loss agents
|
|
US7304051B2
(en)
|
2003-08-08 |
2007-12-04 |
Janssen Pharmaceutica N.V. |
Quinoxaline compounds
|
|
AR046330A1
(es)
|
2003-09-09 |
2005-12-07 |
Japan Tobacco Inc |
Inhibidor de dipeptidilpeptidasa iv
|
|
BRPI0417323A
(pt)
|
2003-12-22 |
2007-03-27 |
Memory Pharm Corp |
indóis, 1h-indazóis, 1,2-benzisoxazóis, e 1,2-benzisotiazóis, composto, composição farmacêutica e usos dos mesmos
|
|
JP2007537147A
(ja)
|
2003-12-29 |
2007-12-20 |
プレーシス ファーマスーティカルズ インコーポレイテッド |
メチオニンアミノペプチダーゼ−２のインヒビターおよびその使用
|
|
KR100552043B1
(ko)
|
2004-02-28 |
2006-02-20 |
주식회사종근당 |
푸마질롤 유도체를 포함하는 비만치료용 조성물
|
|
AU2005245401A1
(en)
|
2004-05-12 |
2005-12-01 |
Chemocentryx |
Aryl sulfonamides
|
|
EP1781303A4
(en)
|
2004-06-30 |
2008-07-02 |
Combinatorx Inc |
METHOD AND REAGENTS FOR THE TREATMENT OF METABOLISM DISEASES
|
|
US20060045865A1
(en)
|
2004-08-27 |
2006-03-02 |
Spherics, Inc. |
Controlled regional oral delivery
|
|
WO2006036670A1
(en)
|
2004-09-24 |
2006-04-06 |
Janssen Pharmaceutica, N.V. |
Sulfonamide compounds
|
|
CA2594951A1
(en)
|
2005-01-26 |
2006-08-03 |
Chong Kun Dang Pharmaceutical Corp. |
Fumagillol derivatives or method for preparation of fumagillol derivatives, and pharmaceutical compositions comprising the same
|
|
FR2886855B1
(fr)
|
2005-06-08 |
2009-07-17 |
Agronomique Inst Nat Rech |
Utilisation de la fumagilline et de ses derives pour augmenter la biodisponibilite des lactones macrocyliques
|
|
US20070078172A1
(en)
|
2005-06-16 |
2007-04-05 |
Jenrin Discovery |
Mao-b inhibitors useful for treating obesity
|
|
EP1962830B1
(en)
|
2005-12-23 |
2013-03-27 |
GlaxoSmithKline LLC |
Azaindole inhibitors of aurora kinases
|
|
US20100234364A1
(en)
|
2006-07-14 |
2010-09-16 |
Arindrajit Basak |
Ccr2 inhibitors and methods of use thereof
|
|
DE102007020492A1
(de)
|
2007-04-30 |
2008-11-06 |
Grünenthal GmbH |
Substituierte Sulfonamid-Derivate
|
|
JP2010531896A
(ja)
|
2007-06-26 |
2010-09-30 |
チルドレンズ メディカル センター コーポレーション |
治療的投与のためのＭｅｔＡＰ−２阻害剤ポリマーソーム
|
|
US20090011994A1
(en)
|
2007-07-06 |
2009-01-08 |
Bristol-Myers Squibb Company |
Non-basic melanin concentrating hormone receptor-1 antagonists and methods
|
|
EP2217283A2
(en)
|
2007-11-28 |
2010-08-18 |
Mersana Therapeutics, Inc. |
Biocompatible biodegradable fumagillin analog conjugates
|
|
DE502008003324D1
(de)
|
2007-11-30 |
2011-06-01 |
Bayer Schering Pharma Ag |
Heteroaryl-substituierte piperidine
|
|
NZ590732A
(en)
|
2008-07-18 |
2012-09-28 |
Zafgen Inc |
Methods of treating an overweight or obese subject using fumagillin
|
|
ES2641471T3
(es)
|
2008-10-06 |
2017-11-10 |
The Johns Hopkins University |
Compuestos de quinolina como inhibidores de la angiogénesis, metionina aminopeptidasa humana, y SirT1, y procedimientos de tratamiento de trastornos
|
|
JP5712133B2
(ja)
|
2008-10-24 |
2015-05-07 |
ウェイク フォレスト ユニバーシティ |
白金アクリジン抗癌化合物とその製造方法
|
|
US20120010290A1
(en)
|
2008-12-04 |
2012-01-12 |
Vath James E |
Methods of Treating an Overweight or Obese Subject
|
|
WO2010065883A2
(en)
*
|
2008-12-04 |
2010-06-10 |
Zafgen Corporation |
Method of treating an overweight or obese subject
|
|
WO2010065881A2
(en)
|
2008-12-04 |
2010-06-10 |
Zafgen Corporation |
Methods of treating an overweight or obese subject
|
|
WO2010065877A2
(en)
|
2008-12-04 |
2010-06-10 |
Zafgen Corporation |
Methods of treating an overweight or obese subject
|
|
WO2011044506A2
(en)
|
2009-10-09 |
2011-04-14 |
Zafgen Corporation |
Sulphone compounds and methods of making and using same
|
|
US8815309B2
(en)
|
2010-01-08 |
2014-08-26 |
Zafgen, Inc. |
Methods of treating a subject with benign prostate hyperplasia
|
|
WO2011088055A2
(en)
|
2010-01-12 |
2011-07-21 |
Zafgen Corporation |
Methods and compositions for treating cardiovascular disorders
|
|
WO2011127304A2
(en)
|
2010-04-07 |
2011-10-13 |
Zafgen Corporation |
Methods of treating an overweight subject
|
|
US20130210821A1
(en)
|
2010-05-27 |
2013-08-15 |
James E. Vath |
Methods for Treating Obesity
|
|
JP5913310B2
(ja)
*
|
2010-07-22 |
2016-04-27 |
ザフゲン，インコーポレイテッド |
三環式化合物ならびにその作製および使用方法
|
|
WO2012051318A1
(en)
|
2010-10-12 |
2012-04-19 |
Zafgen Corporation |
Sulphonamide compounds and methods of making and using same
|
|
PH12013500934A1
(en)
|
2010-11-09 |
2022-10-24 |
Zafgen Inc |
Crystalline solids of a metap-2 inhibitor and methods of making and using same
|
|
US20140073691A1
(en)
|
2010-11-10 |
2014-03-13 |
Zafgen, Inc. |
Methods and composition for Treating Thyroid Hormone Related Disorders
|
|
WO2012074968A1
(en)
|
2010-11-29 |
2012-06-07 |
Zafgen Corporation |
Methods of reducing risk of hepatobiliary dysfunction during rapid weight loss with metap-2 inhibitors
|
|
WO2012075026A1
(en)
|
2010-11-29 |
2012-06-07 |
Zafgen Corporation |
Methods of treating obesity using an effective dose of a metap-2 inhibitor
|
|
KR20140009273A
(ko)
|
2010-11-29 |
2014-01-22 |
자프겐 인크. |
6-o-(4-디메틸아미노에톡시)신나모일 푸마길롤의 비-일일 투여를 사용하는 비만의 치료
|
|
CA2825408A1
(en)
|
2011-01-26 |
2012-08-02 |
Zafgen, Inc. |
Tetrazole compounds and methods of making and using same
|
|
BR112013028665A2
(pt)
|
2011-05-06 |
2016-09-06 |
Zafgen Inc |
compostos de sulfonamida tricíclicos e métodos para fazer e usar os mesmos
|
|
CN103764652B
(zh)
|
2011-05-06 |
2016-03-23 |
扎夫根股份有限公司 |
三环吡唑磺酰胺化合物及其制备和使用方法
|
|
MX345535B
(es)
|
2011-05-06 |
2017-02-03 |
Zafgen Inc |
Compuestos tricíclicos parcialmente saturados y métodos para su fabricación y su uso.
|
|
US9090640B2
(en)
|
2011-09-02 |
2015-07-28 |
Ulrich Bierbach |
Targeted delivery and prodrug designs for platinum-acridine anti-cancer compounds and methods thereof
|
|
BR112014017673A8
(pt)
|
2012-01-18 |
2017-07-11 |
Zafgen Inc |
Compostos de sulfonamida tricíclicos e métodos para fazer e usar os mesmos
|
|
AU2013209719A1
(en)
|
2012-01-18 |
2014-08-07 |
Zafgen, Inc. |
Tricyclic sulfone compounds and methods of making and using same
|