BR112014010980B1 - Método para produção de camadas de cerâmica em magnésio e suas ligas e implante revestido para reparo ósseo - Google Patents
Método para produção de camadas de cerâmica em magnésio e suas ligas e implante revestido para reparo ósseo Download PDFInfo
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- BR112014010980B1 BR112014010980B1 BR112014010980-0A BR112014010980A BR112014010980B1 BR 112014010980 B1 BR112014010980 B1 BR 112014010980B1 BR 112014010980 A BR112014010980 A BR 112014010980A BR 112014010980 B1 BR112014010980 B1 BR 112014010980B1
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- implant
- mol
- magnesium
- coated
- coating
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- 239000007943 implant Substances 0.000 title claims abstract description 155
- 239000011777 magnesium Substances 0.000 title claims abstract description 117
- 229910052749 magnesium Inorganic materials 0.000 title claims abstract description 107
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 title claims abstract description 106
- 239000000919 ceramic Substances 0.000 title claims abstract description 82
- 229910045601 alloy Inorganic materials 0.000 title claims abstract description 21
- 239000000956 alloy Substances 0.000 title claims abstract description 21
- 210000000988 bone and bone Anatomy 0.000 title claims description 48
- 238000004519 manufacturing process Methods 0.000 title claims description 5
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 claims abstract description 66
- 239000003792 electrolyte Substances 0.000 claims abstract description 66
- 238000000576 coating method Methods 0.000 claims abstract description 42
- 238000000034 method Methods 0.000 claims abstract description 40
- 229910021529 ammonia Inorganic materials 0.000 claims abstract description 32
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims abstract description 30
- 239000004202 carbamide Substances 0.000 claims abstract description 30
- 229910052751 metal Inorganic materials 0.000 claims abstract description 26
- 239000002184 metal Substances 0.000 claims abstract description 26
- 230000003647 oxidation Effects 0.000 claims abstract description 7
- 238000007254 oxidation reaction Methods 0.000 claims abstract description 7
- 239000011248 coating agent Substances 0.000 claims description 32
- NBIIXXVUZAFLBC-UHFFFAOYSA-L Phosphate ion(2-) Chemical compound OP([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-L 0.000 claims description 30
- 229910000861 Mg alloy Inorganic materials 0.000 claims description 28
- 238000007654 immersion Methods 0.000 claims description 23
- 238000006731 degradation reaction Methods 0.000 claims description 16
- 230000015556 catabolic process Effects 0.000 claims description 15
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 12
- 239000001257 hydrogen Substances 0.000 claims description 11
- 229910052739 hydrogen Inorganic materials 0.000 claims description 11
- 238000005524 ceramic coating Methods 0.000 claims description 8
- 239000012890 simulated body fluid Substances 0.000 claims description 8
- 150000001412 amines Chemical class 0.000 claims description 5
- 238000000354 decomposition reaction Methods 0.000 claims description 5
- 239000011888 foil Substances 0.000 claims description 4
- 239000004922 lacquer Substances 0.000 claims description 4
- 239000000463 material Substances 0.000 abstract description 14
- 239000000560 biocompatible material Substances 0.000 abstract 1
- MNNHAPBLZZVQHP-UHFFFAOYSA-N diammonium hydrogen phosphate Chemical compound [NH4+].[NH4+].OP([O-])([O-])=O MNNHAPBLZZVQHP-UHFFFAOYSA-N 0.000 abstract 1
- 239000010410 layer Substances 0.000 description 79
- 239000007789 gas Substances 0.000 description 43
- 235000013877 carbamide Nutrition 0.000 description 28
- 238000012360 testing method Methods 0.000 description 21
- 238000000338 in vitro Methods 0.000 description 19
- 230000007797 corrosion Effects 0.000 description 18
- 238000005260 corrosion Methods 0.000 description 18
- 238000001727 in vivo Methods 0.000 description 17
- 238000005452 bending Methods 0.000 description 16
- 239000000203 mixture Substances 0.000 description 13
- 230000014759 maintenance of location Effects 0.000 description 10
- 239000011148 porous material Substances 0.000 description 9
- 239000000126 substance Substances 0.000 description 9
- KRHYYFGTRYWZRS-UHFFFAOYSA-N Fluorane Chemical compound F KRHYYFGTRYWZRS-UHFFFAOYSA-N 0.000 description 8
- 238000002474 experimental method Methods 0.000 description 8
- 239000011521 glass Substances 0.000 description 8
- 244000309715 mini pig Species 0.000 description 8
- 239000004033 plastic Substances 0.000 description 8
- 229920003023 plastic Polymers 0.000 description 8
- 241001465754 Metazoa Species 0.000 description 7
- 239000000047 product Substances 0.000 description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- 229910019142 PO4 Inorganic materials 0.000 description 6
- 230000001680 brushing effect Effects 0.000 description 6
- 239000007857 degradation product Substances 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 description 6
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 6
- 239000010452 phosphate Substances 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 230000015572 biosynthetic process Effects 0.000 description 5
- 238000005259 measurement Methods 0.000 description 5
- 238000013001 point bending Methods 0.000 description 5
- 230000004580 weight loss Effects 0.000 description 5
- 206010015548 Euthanasia Diseases 0.000 description 4
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 4
- 238000007743 anodising Methods 0.000 description 4
- 239000002585 base Substances 0.000 description 4
- 238000006243 chemical reaction Methods 0.000 description 4
- 239000010408 film Substances 0.000 description 4
- 238000001878 scanning electron micrograph Methods 0.000 description 4
- 239000000243 solution Substances 0.000 description 4
- 229910052719 titanium Inorganic materials 0.000 description 4
- 239000010936 titanium Substances 0.000 description 4
- 238000002048 anodisation reaction Methods 0.000 description 3
- 230000008901 benefit Effects 0.000 description 3
- 229910052791 calcium Inorganic materials 0.000 description 3
- 239000011575 calcium Substances 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 238000002591 computed tomography Methods 0.000 description 3
- 238000002513 implantation Methods 0.000 description 3
- VTHJTEIRLNZDEV-UHFFFAOYSA-L magnesium dihydroxide Chemical compound [OH-].[OH-].[Mg+2] VTHJTEIRLNZDEV-UHFFFAOYSA-L 0.000 description 3
- 239000000347 magnesium hydroxide Substances 0.000 description 3
- 229910001862 magnesium hydroxide Inorganic materials 0.000 description 3
- 229910052760 oxygen Inorganic materials 0.000 description 3
- 210000004872 soft tissue Anatomy 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 2
- 238000010521 absorption reaction Methods 0.000 description 2
- 239000002253 acid Substances 0.000 description 2
- 238000007605 air drying Methods 0.000 description 2
- 229910001854 alkali hydroxide Inorganic materials 0.000 description 2
- 150000008044 alkali metal hydroxides Chemical class 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 2
- 229910052729 chemical element Inorganic materials 0.000 description 2
- 239000000460 chlorine Substances 0.000 description 2
- 238000005336 cracking Methods 0.000 description 2
- 230000032798 delamination Effects 0.000 description 2
- 239000006185 dispersion Substances 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 238000001035 drying Methods 0.000 description 2
- 238000010292 electrical insulation Methods 0.000 description 2
- 238000002149 energy-dispersive X-ray emission spectroscopy Methods 0.000 description 2
- 150000004673 fluoride salts Chemical class 0.000 description 2
- 210000002454 frontal bone Anatomy 0.000 description 2
- 229910001385 heavy metal Inorganic materials 0.000 description 2
- 150000002431 hydrogen Chemical class 0.000 description 2
- 238000012417 linear regression Methods 0.000 description 2
- 239000000314 lubricant Substances 0.000 description 2
- 210000000537 nasal bone Anatomy 0.000 description 2
- 239000001301 oxygen Substances 0.000 description 2
- 229910052698 phosphorus Inorganic materials 0.000 description 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
- 230000002028 premature Effects 0.000 description 2
- 239000011241 protective layer Substances 0.000 description 2
- 229910052761 rare earth metal Inorganic materials 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- 229910001220 stainless steel Inorganic materials 0.000 description 2
- 239000010935 stainless steel Substances 0.000 description 2
- 238000001356 surgical procedure Methods 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 229910052727 yttrium Inorganic materials 0.000 description 2
- 229910052726 zirconium Inorganic materials 0.000 description 2
- 241000894006 Bacteria Species 0.000 description 1
- 235000005809 Carpobrotus aequilaterus Nutrition 0.000 description 1
- 101001108245 Cavia porcellus Neuronal pentraxin-2 Proteins 0.000 description 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
- 235000004550 Disphyma australe Nutrition 0.000 description 1
- 229910052692 Dysprosium Inorganic materials 0.000 description 1
- 229910052691 Erbium Inorganic materials 0.000 description 1
- 229910052688 Gadolinium Inorganic materials 0.000 description 1
- 238000012404 In vitro experiment Methods 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 229910052779 Neodymium Inorganic materials 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 229910000831 Steel Inorganic materials 0.000 description 1
- 241000282898 Sus scrofa Species 0.000 description 1
- 239000007983 Tris buffer Substances 0.000 description 1
- 239000004699 Ultra-high molecular weight polyethylene Substances 0.000 description 1
- 238000000441 X-ray spectroscopy Methods 0.000 description 1
- 229910052769 Ytterbium Inorganic materials 0.000 description 1
- QCWXUUIWCKQGHC-UHFFFAOYSA-N Zirconium Chemical compound [Zr] QCWXUUIWCKQGHC-UHFFFAOYSA-N 0.000 description 1
- 230000001464 adherent effect Effects 0.000 description 1
- 230000004075 alteration Effects 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 239000012620 biological material Substances 0.000 description 1
- 230000003592 biomimetic effect Effects 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- KGBXLFKZBHKPEV-UHFFFAOYSA-N boric acid Chemical compound OB(O)O KGBXLFKZBHKPEV-UHFFFAOYSA-N 0.000 description 1
- 239000004327 boric acid Substances 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- OKTJSMMVPCPJKN-BJUDXGSMSA-N carbon-11 Chemical compound [11C] OKTJSMMVPCPJKN-BJUDXGSMSA-N 0.000 description 1
- 239000010406 cathode material Substances 0.000 description 1
- 229910010293 ceramic material Inorganic materials 0.000 description 1
- 238000002468 ceramisation Methods 0.000 description 1
- 239000003153 chemical reaction reagent Substances 0.000 description 1
- 229910052801 chlorine Inorganic materials 0.000 description 1
- 239000008199 coating composition Substances 0.000 description 1
- 230000006835 compression Effects 0.000 description 1
- 238000007906 compression Methods 0.000 description 1
- 239000004020 conductor Substances 0.000 description 1
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- 230000003247 decreasing effect Effects 0.000 description 1
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- 210000003298 dental enamel Anatomy 0.000 description 1
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- 238000009792 diffusion process Methods 0.000 description 1
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- 210000003128 head Anatomy 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 150000002680 magnesium Chemical class 0.000 description 1
- ORUIBWPALBXDOA-UHFFFAOYSA-L magnesium fluoride Chemical compound [F-].[F-].[Mg+2] ORUIBWPALBXDOA-UHFFFAOYSA-L 0.000 description 1
- 229910001635 magnesium fluoride Inorganic materials 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 229910000069 nitrogen hydride Inorganic materials 0.000 description 1
- 210000001331 nose Anatomy 0.000 description 1
- SIWVEOZUMHYXCS-UHFFFAOYSA-N oxo(oxoyttriooxy)yttrium Chemical compound O=[Y]O[Y]=O SIWVEOZUMHYXCS-UHFFFAOYSA-N 0.000 description 1
- 239000011574 phosphorus Substances 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 230000002980 postoperative effect Effects 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000001681 protective effect Effects 0.000 description 1
- 150000002910 rare earth metals Chemical class 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 238000004626 scanning electron microscopy Methods 0.000 description 1
- 150000004760 silicates Chemical class 0.000 description 1
- 210000003625 skull Anatomy 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 241000894007 species Species 0.000 description 1
- 230000006641 stabilisation Effects 0.000 description 1
- 238000011105 stabilization Methods 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 239000010959 steel Substances 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 210000002303 tibia Anatomy 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 229920000785 ultra high molecular weight polyethylene Polymers 0.000 description 1
- 238000002604 ultrasonography Methods 0.000 description 1
- 238000011179 visual inspection Methods 0.000 description 1
- 230000003442 weekly effect Effects 0.000 description 1
- VWQVUPCCIRVNHF-UHFFFAOYSA-N yttrium atom Chemical compound [Y] VWQVUPCCIRVNHF-UHFFFAOYSA-N 0.000 description 1
Classifications
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
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- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws or setting implements
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
- A61B17/80—Cortical plates, i.e. bone plates; Instruments for holding or positioning cortical plates, or for compressing bones attached to cortical plates
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- A61B17/56—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor
- A61B17/58—Surgical instruments or methods for treatment of bones or joints; Devices specially adapted therefor for osteosynthesis, e.g. bone plates, screws or setting implements
- A61B17/68—Internal fixation devices, including fasteners and spinal fixators, even if a part thereof projects from the skin
- A61B17/80—Cortical plates, i.e. bone plates; Instruments for holding or positioning cortical plates, or for compressing bones attached to cortical plates
- A61B17/8085—Cortical plates, i.e. bone plates; Instruments for holding or positioning cortical plates, or for compressing bones attached to cortical plates with pliable or malleable elements or having a mesh-like structure, e.g. small strips
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- A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
- A61F2/02—Prostheses implantable into the body
- A61F2/28—Bones
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- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
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- A61L31/022—Metals or alloys
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- A—HUMAN NECESSITIES
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- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/08—Materials for coatings
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- A61L31/086—Phosphorus-containing materials, e.g. apatite
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- A—HUMAN NECESSITIES
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- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/14—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L31/148—Materials at least partially resorbable by the body
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- C—CHEMISTRY; METALLURGY
- C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
- C25D—PROCESSES FOR THE ELECTROLYTIC OR ELECTROPHORETIC PRODUCTION OF COATINGS; ELECTROFORMING; APPARATUS THEREFOR
- C25D11/00—Electrolytic coating by surface reaction, i.e. forming conversion layers
- C25D11/02—Anodisation
- C25D11/022—Anodisation on selected surface areas
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- C—CHEMISTRY; METALLURGY
- C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
- C25D—PROCESSES FOR THE ELECTROLYTIC OR ELECTROPHORETIC PRODUCTION OF COATINGS; ELECTROFORMING; APPARATUS THEREFOR
- C25D11/00—Electrolytic coating by surface reaction, i.e. forming conversion layers
- C25D11/02—Anodisation
- C25D11/026—Anodisation with spark discharge
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- C—CHEMISTRY; METALLURGY
- C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
- C25D—PROCESSES FOR THE ELECTROLYTIC OR ELECTROPHORETIC PRODUCTION OF COATINGS; ELECTROFORMING; APPARATUS THEREFOR
- C25D11/00—Electrolytic coating by surface reaction, i.e. forming conversion layers
- C25D11/02—Anodisation
- C25D11/30—Anodisation of magnesium or alloys based thereon
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- C—CHEMISTRY; METALLURGY
- C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
- C25D—PROCESSES FOR THE ELECTROLYTIC OR ELECTROPHORETIC PRODUCTION OF COATINGS; ELECTROFORMING; APPARATUS THEREFOR
- C25D11/00—Electrolytic coating by surface reaction, i.e. forming conversion layers
- C25D11/36—Phosphatising
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- C—CHEMISTRY; METALLURGY
- C25—ELECTROLYTIC OR ELECTROPHORETIC PROCESSES; APPARATUS THEREFOR
- C25D—PROCESSES FOR THE ELECTROLYTIC OR ELECTROPHORETIC PRODUCTION OF COATINGS; ELECTROFORMING; APPARATUS THEREFOR
- C25D3/00—Electroplating: Baths therefor
- C25D3/02—Electroplating: Baths therefor from solutions
- C25D3/54—Electroplating: Baths therefor from solutions of metals not provided for in groups C25D3/04 - C25D3/50
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- A—HUMAN NECESSITIES
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- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F2210/00—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
- A61F2210/0076—Particular material properties of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof multilayered, e.g. laminated structures
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- A61L2400/00—Materials characterised by their function or physical properties
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Surgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Vascular Medicine (AREA)
- Electrochemistry (AREA)
- Materials Engineering (AREA)
- Metallurgy (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Inorganic Chemistry (AREA)
- Biomedical Technology (AREA)
- Medical Informatics (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Transplantation (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Cardiology (AREA)
- Materials For Medical Uses (AREA)
- Prostheses (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161556563P | 2011-11-07 | 2011-11-07 | |
| US61/556,563 | 2011-11-07 | ||
| PCT/US2012/063815 WO2013070669A1 (en) | 2011-11-07 | 2012-11-07 | Lean electrolyte for biocompatible plasmaelectrolytic coatings on magnesium implant material |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112014010980A2 BR112014010980A2 (pt) | 2017-06-06 |
| BR112014010980B1 true BR112014010980B1 (pt) | 2019-09-24 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112014010980-0A BR112014010980B1 (pt) | 2011-11-07 | 2012-11-07 | Método para produção de camadas de cerâmica em magnésio e suas ligas e implante revestido para reparo ósseo |
Country Status (11)
| Country | Link |
|---|---|
| US (2) | US9066999B2 (enExample) |
| EP (1) | EP2776083B1 (enExample) |
| JP (1) | JP6177789B2 (enExample) |
| KR (1) | KR102122707B1 (enExample) |
| CN (1) | CN104023759B (enExample) |
| AU (1) | AU2012335990B2 (enExample) |
| BR (1) | BR112014010980B1 (enExample) |
| CA (1) | CA2854667C (enExample) |
| IN (1) | IN2014DN03158A (enExample) |
| TW (1) | TWI569819B (enExample) |
| WO (1) | WO2013070669A1 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3011979A4 (en) * | 2013-06-18 | 2017-02-15 | Olympus Corporation | Implant for living organisms |
| JP2015085098A (ja) * | 2013-11-01 | 2015-05-07 | オリンパス株式会社 | 生体用インプラント |
| JP2015228906A (ja) * | 2014-06-03 | 2015-12-21 | オリンパス株式会社 | 骨接合用インプラント |
| JP2015229792A (ja) * | 2014-06-05 | 2015-12-21 | オリンパス株式会社 | インプラントとその製造方法 |
| JP6253528B2 (ja) * | 2014-06-26 | 2017-12-27 | オリンパス株式会社 | インプラント |
| KR101695858B1 (ko) * | 2015-07-14 | 2017-01-13 | 전북대학교산학협력단 | 생체 분해성 임플란트 및 이의 제조방법 |
| WO2018134930A1 (ja) * | 2017-01-19 | 2018-07-26 | オリンパス株式会社 | 整形外科用インプラントおよびその製造方法 |
| EP3981444A1 (en) * | 2017-03-30 | 2022-04-13 | Biomet Manufacturing, LLC | Methods of modifying the porous surface of implants |
| KR102056844B1 (ko) | 2018-04-19 | 2019-12-17 | 조선대학교산학협력단 | 전해질 조성물과 그 조성물을 이용하는 플라즈마 전해 산화 공정이 포함된 임플란트 제조방법 |
| CN110585481B (zh) * | 2019-08-28 | 2021-12-17 | 华南师范大学 | 一种针对脊柱损伤修复的纳米氢氧化镁区域性涂布聚乳酸-己内酯支架的制备及应用 |
| CN113373491B (zh) * | 2020-12-15 | 2024-07-09 | 北京航空航天大学 | 一种类牙釉质结构复合材料的制备方法 |
| CN116940390A (zh) * | 2021-02-03 | 2023-10-24 | 博恩解决方案有限公司 | 用于骨科植入物的镁基多孔涂层 |
| DE102021103786B4 (de) | 2021-02-17 | 2023-07-20 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung eingetragener Verein | Implantat zum Implantieren in einen Organismus und Verfahren |
| CN116098691B (zh) * | 2022-12-30 | 2025-10-10 | 沪创医疗科技（上海）有限公司 | 可降解镁金属颅骨固定系统 |
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| US1105105A (en) * | 1912-02-10 | 1914-07-28 | William O'n Sherman | Surgical appliance. |
| DE8706912U1 (de) * | 1987-05-14 | 1987-08-27 | Howmedica GmbH, 2314 Schönkirchen | Kleinknochenplatte und Schrauben, insbesondere für die Versorgung von Frakturen des Schädel- und Gesichtsskeletts o. dgl. |
| US4905679A (en) * | 1988-02-22 | 1990-03-06 | M P Operation, Inc. | Bone fracture reduction device and method of internal fixation of bone fractures |
| DE3808609A1 (de) * | 1988-03-15 | 1989-09-28 | Electro Chem Eng Gmbh | Verfahren zur erzeugung von korrosions- und verschleissbestaendigen schutzschichten auf magnesium und magnesiumlegierungen |
| US5264113A (en) | 1991-07-15 | 1993-11-23 | Technology Applications Group, Inc. | Two-step electrochemical process for coating magnesium alloys |
| DE4139006C3 (de) * | 1991-11-27 | 2003-07-10 | Electro Chem Eng Gmbh | Verfahren zur Erzeugung von Oxidkeramikschichten auf sperrschichtbildenden Metallen und auf diese Weise erzeugte Gegenstände aus Aluminium, Magnesium, Titan oder deren Legierungen mit einer Oxidkeramikschicht |
| US5792335A (en) * | 1995-03-13 | 1998-08-11 | Magnesium Technology Limited | Anodization of magnesium and magnesium based alloys |
| CN1081298C (zh) | 1999-03-17 | 2002-03-20 | 任久东 | 可伸缩杆 |
| JP2003515426A (ja) | 1999-12-06 | 2003-05-07 | ジンテーズ アクチエンゲゼルシャフト クール | 再吸収可能な骨板 |
| CN100342063C (zh) * | 2002-04-27 | 2007-10-10 | 中国科学院上海微系统与信息技术研究所 | 镁合金表面复合陶瓷质膜和生成方法 |
| US20050149032A1 (en) | 2003-12-30 | 2005-07-07 | Douglas Vaughen | Resorbable surgical fixation device |
| US7717946B2 (en) * | 2004-06-07 | 2010-05-18 | Degima Gmbh | Polymeric plate bendable without thermal energy and methods of manufacture |
| ZA200700096B (en) * | 2004-06-07 | 2008-05-28 | Synthes Gmbh | Orthopaedic implant with sensors |
| US20060016690A1 (en) * | 2004-07-23 | 2006-01-26 | Ilya Ostrovsky | Method for producing a hard coating with high corrosion resistance on articles made anodizable metals or alloys |
| CN101484599A (zh) * | 2006-04-28 | 2009-07-15 | 生物镁系统有限公司 | 生物可降解的镁合金及其用途 |
| KR100929133B1 (ko) * | 2006-09-22 | 2009-12-01 | 유앤아이 주식회사 | 생체분해성 금속을 포함하는 임플란트 및 이의 제조방법 |
| DE102008040253A1 (de) * | 2008-07-08 | 2010-01-14 | Biotronik Vi Patent Ag | Implantatsystem mit einem Funktionsimplantat aus abbaubarem Metallmaterial |
| DE102008037204B4 (de) * | 2008-08-11 | 2016-01-07 | Alfred Buck | Platte zur Fixierung von Knochenfragmenten sowie Verfahren zu deren Herstellung |
| DE102008037200B4 (de) * | 2008-08-11 | 2015-07-09 | Aap Implantate Ag | Verwendung eines Druckgussverfahrens zur Herstellung eines Implantats aus Magnesium sowie Magnesiumlegierung |
| US9107712B2 (en) * | 2008-09-15 | 2015-08-18 | Biomet C.V. | Bone plate system for hand fractures and other small bones |
| DE102008043970A1 (de) * | 2008-11-21 | 2010-05-27 | Biotronik Vi Patent Ag | Verfahren zur Herstellung einer korrosionshemmenden Beschichtung auf einem Implantat aus einer biokorrodierbaren Magnesiumlegierung sowie nach dem Verfahren hergestelltes Implantat |
| DE102008054400A1 (de) * | 2008-12-09 | 2010-06-10 | Biotronik Vi Patent Ag | Implantat und Verfahren zur Herstellung desselben |
| US9131973B2 (en) * | 2010-07-09 | 2015-09-15 | Medartis Ag | Osteosynthesis system |
| CN101871119B (zh) * | 2010-07-28 | 2012-01-18 | 哈尔滨工业大学 | 一种镁合金表面微弧氧化/喷涂复合膜的制备方法 |
| BR112013000997B1 (pt) * | 2010-08-31 | 2021-05-04 | Synthes Gmbh | controle da degradação de implantes de metal bioreabsorvíveis |
| US20120277748A1 (en) * | 2011-04-28 | 2012-11-01 | Warsaw Orthopedic, Inc. | Bone plate |
-
2012
- 2012-11-07 KR KR1020147015428A patent/KR102122707B1/ko active Active
- 2012-11-07 WO PCT/US2012/063815 patent/WO2013070669A1/en not_active Ceased
- 2012-11-07 EP EP12787322.2A patent/EP2776083B1/en active Active
- 2012-11-07 CA CA2854667A patent/CA2854667C/en active Active
- 2012-11-07 CN CN201280054582.0A patent/CN104023759B/zh not_active Expired - Fee Related
- 2012-11-07 AU AU2012335990A patent/AU2012335990B2/en not_active Ceased
- 2012-11-07 BR BR112014010980-0A patent/BR112014010980B1/pt not_active IP Right Cessation
- 2012-11-07 US US13/670,803 patent/US9066999B2/en active Active
- 2012-11-07 IN IN3158DEN2014 patent/IN2014DN03158A/en unknown
- 2012-11-07 JP JP2014540206A patent/JP6177789B2/ja not_active Expired - Fee Related
- 2012-11-07 TW TW101141367A patent/TWI569819B/zh not_active IP Right Cessation
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2015
- 2015-05-27 US US14/722,568 patent/US9682176B2/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| CN104023759B (zh) | 2016-06-22 |
| US20150258252A1 (en) | 2015-09-17 |
| JP2015502193A (ja) | 2015-01-22 |
| JP6177789B2 (ja) | 2017-08-09 |
| WO2013070669A1 (en) | 2013-05-16 |
| KR20140091579A (ko) | 2014-07-21 |
| KR102122707B1 (ko) | 2020-06-29 |
| EP2776083B1 (en) | 2017-07-26 |
| EP2776083A1 (en) | 2014-09-17 |
| IN2014DN03158A (enExample) | 2015-05-22 |
| AU2012335990B2 (en) | 2016-03-24 |
| TW201334816A (zh) | 2013-09-01 |
| AU2012335990A1 (en) | 2014-05-29 |
| CA2854667A1 (en) | 2013-05-16 |
| CA2854667C (en) | 2021-03-30 |
| US9682176B2 (en) | 2017-06-20 |
| CN104023759A (zh) | 2014-09-03 |
| US9066999B2 (en) | 2015-06-30 |
| BR112014010980A2 (pt) | 2017-06-06 |
| TWI569819B (zh) | 2017-02-11 |
| US20130116696A1 (en) | 2013-05-09 |
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