BR112014009760B1 - Análogos de ácido siálico, seu uso e composição farmacêutica - Google Patents

Análogos de ácido siálico, seu uso e composição farmacêutica Download PDF

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Publication number
BR112014009760B1
BR112014009760B1 BR112014009760-7A BR112014009760A BR112014009760B1 BR 112014009760 B1 BR112014009760 B1 BR 112014009760B1 BR 112014009760 A BR112014009760 A BR 112014009760A BR 112014009760 B1 BR112014009760 B1 BR 112014009760B1
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BR
Brazil
Prior art keywords
compound
group
sialic acid
acid
structural formula
Prior art date
Application number
BR112014009760-7A
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English (en)
Portuguese (pt)
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BR112014009760A2 (pt
BR112014009760A8 (pt
Inventor
Emil Kakkis
Steven Jungles
He Zhao
Original Assignee
Ultragenyx Pharmaceutical Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Ultragenyx Pharmaceutical Inc filed Critical Ultragenyx Pharmaceutical Inc
Publication of BR112014009760A2 publication Critical patent/BR112014009760A2/pt
Publication of BR112014009760A8 publication Critical patent/BR112014009760A8/pt
Publication of BR112014009760B1 publication Critical patent/BR112014009760B1/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/02—Acyclic radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/10—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/02—Acyclic radicals
    • C07H7/027—Keto-aldonic acids

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Medicinal Preparation (AREA)
BR112014009760-7A 2011-10-24 2012-10-24 Análogos de ácido siálico, seu uso e composição farmacêutica BR112014009760B1 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161550610P 2011-10-24 2011-10-24
US61/550.610 2011-10-24
PCT/US2012/061737 WO2013063149A1 (en) 2011-10-24 2012-10-24 Sialic acid analogs

Publications (3)

Publication Number Publication Date
BR112014009760A2 BR112014009760A2 (pt) 2017-04-18
BR112014009760A8 BR112014009760A8 (pt) 2018-01-16
BR112014009760B1 true BR112014009760B1 (pt) 2022-11-29

Family

ID=48168447

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014009760-7A BR112014009760B1 (pt) 2011-10-24 2012-10-24 Análogos de ácido siálico, seu uso e composição farmacêutica

Country Status (13)

Country Link
US (5) US8840926B2 (https=)
EP (1) EP2771348B1 (https=)
JP (1) JP6196224B2 (https=)
KR (1) KR102049214B1 (https=)
CN (1) CN103974965B (https=)
AU (1) AU2012328874B2 (https=)
BR (1) BR112014009760B1 (https=)
CA (1) CA2849114C (https=)
ES (1) ES2807890T3 (https=)
HK (1) HK1201067A1 (https=)
IL (1) IL231714B (https=)
MX (1) MX347541B (https=)
WO (1) WO2013063149A1 (https=)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9241896B2 (en) 2008-12-19 2016-01-26 Ultragenyx Pharmaceutical Inc. Methods and formulations for treating sialic acid deficiencies
CA2805222A1 (en) 2010-07-13 2012-01-19 Ultragenyx Pharmaceutical Inc. Methods and formulations for treating sialic acid deficiencies
HK1201067A1 (en) 2011-10-24 2015-08-21 罕见病药物研发公司 Sialic acid analogs
CA2862836A1 (en) * 2012-01-18 2013-07-25 Ultragenyx Pharmaceutical Inc. Methods and formulations for treating sialic acid deficiencies
US10385085B2 (en) 2015-09-14 2019-08-20 Ultragenyx Pharmaceutical Inc. Crystal forms of sialic acid or salt or solvate thereof
WO2024173797A1 (en) * 2023-02-17 2024-08-22 Ultragenyx Pharmaceutical Inc. Crystalline forms of sialic acid derivatives and methods for their use

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS6168418A (ja) 1984-09-11 1986-04-08 Kanto Ishi Pharma Co Ltd 去痰薬
JPS63139193A (ja) * 1986-11-28 1988-06-10 Mect Corp シアル酸誘導体１，７−ラクトン
US6156544A (en) 1993-06-09 2000-12-05 Glaxo Group Limited Process for the preparation of N-acetylneuraminic acid
EP0820305A2 (en) 1995-04-04 1998-01-28 Wound Healing of Oklahoma Cancer treatment by photodynamic therapy, in combination with an immunoadjuvant
US5624677A (en) 1995-06-13 1997-04-29 Pentech Pharmaceuticals, Inc. Controlled release of drugs delivered by sublingual or buccal administration
WO1999052931A1 (fr) 1998-04-10 1999-10-21 Mitsubishi Chemical Corporation Dispersion solide contenant un derive d'acide sialique
KR20030006721A (ko) 2001-07-14 2003-01-23 삼성전자 주식회사 리소그라피 시스템 및 이를 이용한 레티클 표면의 파티클제거방법
RU2362807C2 (ru) 2002-06-21 2009-07-27 Ново Нордиск Хелт Кэр Аг Конъюгат полипептида фактора vii, способ его получения, его применение и содержащая его фармацевтическая композиция
US7238677B2 (en) 2003-03-28 2007-07-03 Kimberly-Clark Worldwide, Inc. Prevention of urogenital infections
US20050201974A1 (en) * 2003-12-09 2005-09-15 Spherics, Inc. Bioadhesive polymers with catechol functionality
WO2006096161A1 (en) 2005-03-03 2006-09-14 Mannatech, Inc. Methods and compositions for modified release of nutritional supplements
WO2007103286A2 (en) * 2006-03-02 2007-09-13 Spherics, Inc. Rate-controlled bioadhesive oral dosage formulations
WO2008027557A2 (en) * 2006-08-31 2008-03-06 Spherics, Inc. Topiramate compositions and methods of enhancing its bioavailability
EP2155207A2 (en) 2007-05-31 2010-02-24 Government Of The United States Of America As Represented by Secretary of the Dep. of Health and Human Services National Institute of Health N-acetyl mannosamine as a therapeutic agent
WO2009032605A2 (en) 2007-08-27 2009-03-12 Massachusetts Institute Of Technology Bi-functional polymer-attached inhibitors of influenza virus
CN102316730A (zh) 2008-05-09 2012-01-11 天雅瑞药业有限公司 用于减轻全身性炎症和/或血管炎症的n-乙酰半胱氨酸(nac)的控释
KR101116864B1 (ko) 2008-08-01 2012-02-29 주식회사 베네비오 고지혈증, 지방간 또는 비만의 예방 또는 치료용 조성물
US9241896B2 (en) 2008-12-19 2016-01-26 Ultragenyx Pharmaceutical Inc. Methods and formulations for treating sialic acid deficiencies
US20100159001A1 (en) 2008-12-19 2010-06-24 Cardinal John R Extended-Release Pharmaceutical Formulations
US20100160363A1 (en) 2008-12-19 2010-06-24 Aaipharma Services Corp. Extended-release pharmaceutical formulations
CN102427817B (zh) 2009-05-15 2015-02-11 财团法人日本健康科学振兴财团 起因于gne蛋白质功能降低的疾病的治疗用药物、食品组合物、食品添加剂
CA2805222A1 (en) 2010-07-13 2012-01-19 Ultragenyx Pharmaceutical Inc. Methods and formulations for treating sialic acid deficiencies
HK1201067A1 (en) 2011-10-24 2015-08-21 罕见病药物研发公司 Sialic acid analogs
CA2862836A1 (en) 2012-01-18 2013-07-25 Ultragenyx Pharmaceutical Inc. Methods and formulations for treating sialic acid deficiencies
JP6671305B2 (ja) 2015-01-28 2020-03-25 協和発酵バイオ株式会社 Ｎ−アセチルノイラミン酸アンモニウム塩・無水和物の結晶及びその製造方法
US10385085B2 (en) 2015-09-14 2019-08-20 Ultragenyx Pharmaceutical Inc. Crystal forms of sialic acid or salt or solvate thereof

Also Published As

Publication number Publication date
IL231714A0 (en) 2014-05-28
US20150038693A1 (en) 2015-02-05
MX347541B (es) 2017-04-28
ES2807890T3 (es) 2021-02-24
CA2849114C (en) 2020-12-15
US9221858B2 (en) 2015-12-29
US10457701B2 (en) 2019-10-29
JP2014530882A (ja) 2014-11-20
MX2014004928A (es) 2014-11-10
WO2013063149A1 (en) 2013-05-02
US10889607B2 (en) 2021-01-12
KR102049214B1 (ko) 2019-11-28
KR20140084277A (ko) 2014-07-04
US10065981B2 (en) 2018-09-04
US20200131215A1 (en) 2020-04-30
JP6196224B2 (ja) 2017-09-13
HK1201067A1 (en) 2015-08-21
US8840926B2 (en) 2014-09-23
US20130122094A1 (en) 2013-05-16
AU2012328874A1 (en) 2014-04-10
EP2771348B1 (en) 2020-05-20
EP2771348A1 (en) 2014-09-03
AU2012328874B2 (en) 2017-08-31
US20160297846A1 (en) 2016-10-13
EP2771348A4 (en) 2015-09-09
BR112014009760A2 (pt) 2017-04-18
CA2849114A1 (en) 2013-05-02
IL231714B (en) 2018-10-31
CN103974965A (zh) 2014-08-06
US20190127409A1 (en) 2019-05-02
CN103974965B (zh) 2019-09-24
BR112014009760A8 (pt) 2018-01-16

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Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE DEVOLUCAO DO PEDIDO POR NAO SE ENQUADRAR NO ART. 229-C DA LPI.

B06T Formal requirements before examination [chapter 6.20 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B09X Republication of the decision to grant [chapter 9.1.3 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 24/10/2012, OBSERVADAS AS CONDICOES LEGAIS. PATENTE CONCEDIDA CONFORME ADI 5.529/DF, QUE DETERMINA A ALTERACAO DO PRAZO DE CONCESSAO.