JP6196224B2 - シアル酸類似体 - Google Patents
シアル酸類似体 Download PDFInfo
- Publication number
- JP6196224B2 JP6196224B2 JP2014537380A JP2014537380A JP6196224B2 JP 6196224 B2 JP6196224 B2 JP 6196224B2 JP 2014537380 A JP2014537380 A JP 2014537380A JP 2014537380 A JP2014537380 A JP 2014537380A JP 6196224 B2 JP6196224 B2 JP 6196224B2
- Authority
- JP
- Japan
- Prior art keywords
- compound
- group
- structural formula
- hydrogen
- item
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
- C07H7/02—Acyclic radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/04—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals attached to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
- C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
- C07H13/10—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to heterocyclic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
- C07H7/02—Acyclic radicals
- C07H7/027—Keto-aldonic acids
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Physical Education & Sports Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Neurology (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161550610P | 2011-10-24 | 2011-10-24 | |
| US61/550,610 | 2011-10-24 | ||
| PCT/US2012/061737 WO2013063149A1 (en) | 2011-10-24 | 2012-10-24 | Sialic acid analogs |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014530882A JP2014530882A (ja) | 2014-11-20 |
| JP2014530882A5 JP2014530882A5 (https=) | 2015-09-10 |
| JP6196224B2 true JP6196224B2 (ja) | 2017-09-13 |
Family
ID=48168447
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014537380A Active JP6196224B2 (ja) | 2011-10-24 | 2012-10-24 | シアル酸類似体 |
Country Status (13)
| Country | Link |
|---|---|
| US (5) | US8840926B2 (https=) |
| EP (1) | EP2771348B1 (https=) |
| JP (1) | JP6196224B2 (https=) |
| KR (1) | KR102049214B1 (https=) |
| CN (1) | CN103974965B (https=) |
| AU (1) | AU2012328874B2 (https=) |
| BR (1) | BR112014009760B1 (https=) |
| CA (1) | CA2849114C (https=) |
| ES (1) | ES2807890T3 (https=) |
| HK (1) | HK1201067A1 (https=) |
| IL (1) | IL231714B (https=) |
| MX (1) | MX347541B (https=) |
| WO (1) | WO2013063149A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9241896B2 (en) | 2008-12-19 | 2016-01-26 | Ultragenyx Pharmaceutical Inc. | Methods and formulations for treating sialic acid deficiencies |
| CA2805222A1 (en) | 2010-07-13 | 2012-01-19 | Ultragenyx Pharmaceutical Inc. | Methods and formulations for treating sialic acid deficiencies |
| HK1201067A1 (en) | 2011-10-24 | 2015-08-21 | 罕见病药物研发公司 | Sialic acid analogs |
| CA2862836A1 (en) * | 2012-01-18 | 2013-07-25 | Ultragenyx Pharmaceutical Inc. | Methods and formulations for treating sialic acid deficiencies |
| US10385085B2 (en) | 2015-09-14 | 2019-08-20 | Ultragenyx Pharmaceutical Inc. | Crystal forms of sialic acid or salt or solvate thereof |
| WO2024173797A1 (en) * | 2023-02-17 | 2024-08-22 | Ultragenyx Pharmaceutical Inc. | Crystalline forms of sialic acid derivatives and methods for their use |
Family Cites Families (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6168418A (ja) | 1984-09-11 | 1986-04-08 | Kanto Ishi Pharma Co Ltd | 去痰薬 |
| JPS63139193A (ja) * | 1986-11-28 | 1988-06-10 | Mect Corp | シアル酸誘導体１，７−ラクトン |
| US6156544A (en) | 1993-06-09 | 2000-12-05 | Glaxo Group Limited | Process for the preparation of N-acetylneuraminic acid |
| EP0820305A2 (en) | 1995-04-04 | 1998-01-28 | Wound Healing of Oklahoma | Cancer treatment by photodynamic therapy, in combination with an immunoadjuvant |
| US5624677A (en) | 1995-06-13 | 1997-04-29 | Pentech Pharmaceuticals, Inc. | Controlled release of drugs delivered by sublingual or buccal administration |
| WO1999052931A1 (fr) | 1998-04-10 | 1999-10-21 | Mitsubishi Chemical Corporation | Dispersion solide contenant un derive d'acide sialique |
| KR20030006721A (ko) | 2001-07-14 | 2003-01-23 | 삼성전자 주식회사 | 리소그라피 시스템 및 이를 이용한 레티클 표면의 파티클제거방법 |
| RU2362807C2 (ru) | 2002-06-21 | 2009-07-27 | Ново Нордиск Хелт Кэр Аг | Конъюгат полипептида фактора vii, способ его получения, его применение и содержащая его фармацевтическая композиция |
| US7238677B2 (en) | 2003-03-28 | 2007-07-03 | Kimberly-Clark Worldwide, Inc. | Prevention of urogenital infections |
| US20050201974A1 (en) * | 2003-12-09 | 2005-09-15 | Spherics, Inc. | Bioadhesive polymers with catechol functionality |
| WO2006096161A1 (en) | 2005-03-03 | 2006-09-14 | Mannatech, Inc. | Methods and compositions for modified release of nutritional supplements |
| WO2007103286A2 (en) * | 2006-03-02 | 2007-09-13 | Spherics, Inc. | Rate-controlled bioadhesive oral dosage formulations |
| WO2008027557A2 (en) * | 2006-08-31 | 2008-03-06 | Spherics, Inc. | Topiramate compositions and methods of enhancing its bioavailability |
| EP2155207A2 (en) | 2007-05-31 | 2010-02-24 | Government Of The United States Of America As Represented by Secretary of the Dep. of Health and Human Services National Institute of Health | N-acetyl mannosamine as a therapeutic agent |
| WO2009032605A2 (en) | 2007-08-27 | 2009-03-12 | Massachusetts Institute Of Technology | Bi-functional polymer-attached inhibitors of influenza virus |
| CN102316730A (zh) | 2008-05-09 | 2012-01-11 | 天雅瑞药业有限公司 | 用于减轻全身性炎症和/或血管炎症的n-乙酰半胱氨酸(nac)的控释 |
| KR101116864B1 (ko) | 2008-08-01 | 2012-02-29 | 주식회사 베네비오 | 고지혈증, 지방간 또는 비만의 예방 또는 치료용 조성물 |
| US9241896B2 (en) | 2008-12-19 | 2016-01-26 | Ultragenyx Pharmaceutical Inc. | Methods and formulations for treating sialic acid deficiencies |
| US20100159001A1 (en) | 2008-12-19 | 2010-06-24 | Cardinal John R | Extended-Release Pharmaceutical Formulations |
| US20100160363A1 (en) | 2008-12-19 | 2010-06-24 | Aaipharma Services Corp. | Extended-release pharmaceutical formulations |
| CN102427817B (zh) | 2009-05-15 | 2015-02-11 | 财团法人日本健康科学振兴财团 | 起因于gne蛋白质功能降低的疾病的治疗用药物、食品组合物、食品添加剂 |
| CA2805222A1 (en) | 2010-07-13 | 2012-01-19 | Ultragenyx Pharmaceutical Inc. | Methods and formulations for treating sialic acid deficiencies |
| HK1201067A1 (en) | 2011-10-24 | 2015-08-21 | 罕见病药物研发公司 | Sialic acid analogs |
| CA2862836A1 (en) | 2012-01-18 | 2013-07-25 | Ultragenyx Pharmaceutical Inc. | Methods and formulations for treating sialic acid deficiencies |
| JP6671305B2 (ja) | 2015-01-28 | 2020-03-25 | 協和発酵バイオ株式会社 | Ｎ−アセチルノイラミン酸アンモニウム塩・無水和物の結晶及びその製造方法 |
| US10385085B2 (en) | 2015-09-14 | 2019-08-20 | Ultragenyx Pharmaceutical Inc. | Crystal forms of sialic acid or salt or solvate thereof |
-
2012
- 2012-10-24 HK HK15101526.4A patent/HK1201067A1/xx unknown
- 2012-10-24 US US13/659,550 patent/US8840926B2/en active Active
- 2012-10-24 AU AU2012328874A patent/AU2012328874B2/en active Active
- 2012-10-24 MX MX2014004928A patent/MX347541B/es active IP Right Grant
- 2012-10-24 CA CA2849114A patent/CA2849114C/en active Active
- 2012-10-24 JP JP2014537380A patent/JP6196224B2/ja active Active
- 2012-10-24 BR BR112014009760-7A patent/BR112014009760B1/pt active IP Right Grant
- 2012-10-24 EP EP12843460.2A patent/EP2771348B1/en active Active
- 2012-10-24 CN CN201280052218.0A patent/CN103974965B/zh active Active
- 2012-10-24 ES ES12843460T patent/ES2807890T3/es active Active
- 2012-10-24 WO PCT/US2012/061737 patent/WO2013063149A1/en not_active Ceased
- 2012-10-24 KR KR1020147013997A patent/KR102049214B1/ko active Active
-
2014
- 2014-03-26 IL IL231714A patent/IL231714B/en active IP Right Grant
- 2014-08-15 US US14/461,295 patent/US9221858B2/en active Active
-
2015
- 2015-11-18 US US14/944,779 patent/US10065981B2/en active Active
-
2018
- 2018-07-31 US US16/050,343 patent/US10457701B2/en active Active
-
2019
- 2019-09-16 US US16/571,589 patent/US10889607B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| IL231714A0 (en) | 2014-05-28 |
| US20150038693A1 (en) | 2015-02-05 |
| MX347541B (es) | 2017-04-28 |
| ES2807890T3 (es) | 2021-02-24 |
| CA2849114C (en) | 2020-12-15 |
| US9221858B2 (en) | 2015-12-29 |
| US10457701B2 (en) | 2019-10-29 |
| JP2014530882A (ja) | 2014-11-20 |
| MX2014004928A (es) | 2014-11-10 |
| WO2013063149A1 (en) | 2013-05-02 |
| US10889607B2 (en) | 2021-01-12 |
| KR102049214B1 (ko) | 2019-11-28 |
| KR20140084277A (ko) | 2014-07-04 |
| US10065981B2 (en) | 2018-09-04 |
| US20200131215A1 (en) | 2020-04-30 |
| HK1201067A1 (en) | 2015-08-21 |
| US8840926B2 (en) | 2014-09-23 |
| US20130122094A1 (en) | 2013-05-16 |
| AU2012328874A1 (en) | 2014-04-10 |
| EP2771348B1 (en) | 2020-05-20 |
| EP2771348A1 (en) | 2014-09-03 |
| AU2012328874B2 (en) | 2017-08-31 |
| BR112014009760B1 (pt) | 2022-11-29 |
| US20160297846A1 (en) | 2016-10-13 |
| EP2771348A4 (en) | 2015-09-09 |
| BR112014009760A2 (pt) | 2017-04-18 |
| CA2849114A1 (en) | 2013-05-02 |
| IL231714B (en) | 2018-10-31 |
| CN103974965A (zh) | 2014-08-06 |
| US20190127409A1 (en) | 2019-05-02 |
| CN103974965B (zh) | 2019-09-24 |
| BR112014009760A8 (pt) | 2018-01-16 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US10889607B2 (en) | Sialic acid analogs | |
| JP6857124B2 (ja) | Ｆｘｒ／ｔｇｒ５アゴニストとしての胆汁酸誘導体およびその使用方法 | |
| JP6065052B2 (ja) | テトラヒドロカルボリン誘導体 | |
| AU2019351494B2 (en) | Nitroxoline prodrug and use thereof | |
| WO2014198195A1 (zh) | 联芳基取代的4-氨基丁酸衍生物及其制备方法和用途 | |
| JP7057783B2 (ja) | スルホニル尿素胆汁酸誘導体の調製方法 | |
| WO2008016006A1 (fr) | Composé auquel un groupe cyclique est lié par une liaison spiro et son utilisation | |
| TW202233591A (zh) | 2-吡啶酮及其使用方法 | |
| EP3904357A1 (en) | Spiro compound and medical uses thereof | |
| JP2012522796A (ja) | プロスタグランジンｅレセプター拮抗薬 | |
| US11565999B2 (en) | Methods of synthesizing aztreonam derivatives | |
| EP4166547A1 (en) | Aryl glucoside derivative | |
| HK40055242A (zh) | 噻吩并嘧啶二酮acc抑制剂的固体形式及其制备方法 | |
| JP2021161092A (ja) | 新規ｃｄｐ−リビトール誘導体 | |
| TW202130619A (zh) | 硝羥喹啉前藥及其用途 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20150724 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20150724 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20160606 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20160906 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20160927 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20170222 |
|
| A601 | Written request for extension of time |
Free format text: JAPANESE INTERMEDIATE CODE: A601 Effective date: 20170519 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20170630 |
|
| TRDD | Decision of grant or rejection written | ||
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 Effective date: 20170801 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20170817 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 6196224 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| S531 | Written request for registration of change of domicile |
Free format text: JAPANESE INTERMEDIATE CODE: R313531 |
|
| S533 | Written request for registration of change of name |
Free format text: JAPANESE INTERMEDIATE CODE: R313533 |
|
| R350 | Written notification of registration of transfer |
Free format text: JAPANESE INTERMEDIATE CODE: R350 |
|
| RD03 | Notification of appointment of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: R3D03 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |