BR112014004190A2 - método para construir uma cepa fúngida filamentosa, cepa fúngida filamentosa, método para produzir múltiplos polipeptídeos recombinantes, e, construto em tandem - Google Patents
método para construir uma cepa fúngida filamentosa, cepa fúngida filamentosa, método para produzir múltiplos polipeptídeos recombinantes, e, construto em tandemInfo
- Publication number
- BR112014004190A2 BR112014004190A2 BR112014004190A BR112014004190A BR112014004190A2 BR 112014004190 A2 BR112014004190 A2 BR 112014004190A2 BR 112014004190 A BR112014004190 A BR 112014004190A BR 112014004190 A BR112014004190 A BR 112014004190A BR 112014004190 A2 BR112014004190 A2 BR 112014004190A2
- Authority
- BR
- Brazil
- Prior art keywords
- filamentous fungal
- fungal strain
- constructing
- recombinant polypeptides
- producing multiple
- Prior art date
Links
- 230000002538 fungal effect Effects 0.000 title 2
- 238000004519 manufacturing process Methods 0.000 title 1
- 238000000034 method Methods 0.000 title 1
- 229920001184 polypeptide Polymers 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2405—Glucanases
- C12N9/2434—Glucanases acting on beta-1,4-glucosidic bonds
- C12N9/2437—Cellulases (3.2.1.4; 3.2.1.74; 3.2.1.91; 3.2.1.150)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01091—Cellulose 1,4-beta-cellobiosidase (3.2.1.91)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/0115—Oligoxyloglucan reducing-end-specific cellobiohydrolase (3.2.1.150)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Mycology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161526809P | 2011-08-24 | 2011-08-24 | |
| PCT/US2012/052143 WO2013028912A2 (en) | 2011-08-24 | 2012-08-23 | Methods for producing multiple recombinant polypeptides in a filamentous fungal host cell |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112014004190A2 true BR112014004190A2 (pt) | 2017-03-01 |
Family
ID=47358264
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112014004190A BR112014004190A2 (pt) | 2011-08-24 | 2012-08-23 | método para construir uma cepa fúngida filamentosa, cepa fúngida filamentosa, método para produzir múltiplos polipeptídeos recombinantes, e, construto em tandem |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US9493790B2 (https=) |
| EP (1) | EP2748322A2 (https=) |
| CN (2) | CN109136114A (https=) |
| AU (1) | AU2012298799B2 (https=) |
| BR (1) | BR112014004190A2 (https=) |
| IN (1) | IN2014CN02136A (https=) |
| WO (1) | WO2013028912A2 (https=) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IN2014CN02136A (https=) * | 2011-08-24 | 2015-05-29 | Novozymes Inc | |
| US9404101B2 (en) * | 2011-08-24 | 2016-08-02 | Novozymes, Inc. | Methods for obtaining positive transformants of a filamentous fungal host cell |
| RU2645252C2 (ru) | 2012-01-05 | 2018-02-19 | Глюкос Финланд Ой | Клетка нитчатых грибов с дефицитом протеаз и способы ее применения |
| EP2852610B1 (en) | 2012-05-23 | 2018-07-11 | Glykos Finland Oy | Production of fucosylated glycoproteins |
| SG11201600115SA (en) | 2013-07-10 | 2016-02-26 | Novartis Ag | Multiple proteases deficient filamentous fungal cells and methods of use thereof |
| US20150147774A1 (en) * | 2013-11-22 | 2015-05-28 | National University Of Singapore | Expression construct for yeast and a method of using the construct |
| AU2015269381B2 (en) * | 2014-06-06 | 2019-04-18 | Novozymes A/S | Enzyme compositions and uses thereof |
| SG11201700446XA (en) | 2014-07-21 | 2017-02-27 | Glykos Finland Oy | Production of glycoproteins with mammalian-like n-glycans in filamentous fungi |
| WO2016045569A1 (en) | 2014-09-23 | 2016-03-31 | Novozymes A/S | Processes for producing ethanol and fermenting organisms |
| CN107429255B (zh) * | 2015-03-09 | 2022-01-25 | 诺维信公司 | 将多种表达构建体引入真核细胞的方法 |
| BR112018067371A2 (pt) | 2016-03-02 | 2019-01-15 | Novozymes As | variante de celobio-hidrolase, composição de enzimas, formulação de caldo inteiro ou composição de cultura de células, polinucleotídeo, célula hospedeira recombinante, planta, parte de planta ou célula de planta transgênica, métodos para produção e para obtenção de uma variante de celobio-hidrolase, planta trangênica, e, processos para degradação de um material celulósico, para produção de um produto de fermentação e para fermentação de um material celulósico |
| WO2018093752A1 (en) * | 2016-11-15 | 2018-05-24 | Danisco Us Inc. | Filamentous fungi with improved protein production |
| EP3551759A1 (en) | 2016-12-06 | 2019-10-16 | Novozymes A/S | Improved processes for production of ethanol from xylose-containing cellulosic substrates using engineered yeast strains |
| US11091753B2 (en) | 2017-05-31 | 2021-08-17 | Novozymes A/S | Xylose fermenting yeast strains and processes thereof for ethanol production |
| CN110730824A (zh) | 2017-06-02 | 2020-01-24 | 诺维信公司 | 用于乙醇生产的改善的酵母 |
| CN109988714B (zh) * | 2017-12-29 | 2021-12-28 | 青岛蔚蓝生物集团有限公司 | 一种里氏木霉及其应用 |
| EP3746545A1 (en) | 2018-01-29 | 2020-12-09 | Novozymes A/S | Microorganisms with improved nitrogen utilization for ethanol production |
| MX2021000893A (es) | 2018-07-25 | 2021-03-31 | Novozymes As | Levadura que expresa enzimas para la producción de etanol. |
| CN113286889A (zh) | 2018-10-08 | 2021-08-20 | 诺维信公司 | 用于生产乙醇的表达酶的酵母 |
| US20220064228A1 (en) * | 2018-12-12 | 2022-03-03 | Novozymes A/S | Methods For Increasing The Productivity Of A Filamentous Fungal Cell In The Production Of A Polypeptide |
| WO2021021458A1 (en) | 2019-07-26 | 2021-02-04 | Novozymes A/S | Microorganisms with improved nitrogen transport for ethanol production |
| MX2021015818A (es) | 2019-08-06 | 2022-02-03 | Novozymes As | Proteinas de fusion para mejorar la expresion de enzimas. |
| CN110724643B (zh) * | 2019-11-18 | 2022-07-15 | 河南省农业科学院植物保护研究所 | 一株具有防病促生功能的橘灰青霉及其菌剂和应用 |
| CA3158982A1 (en) | 2019-12-10 | 2021-06-17 | Monica TASSONE | Microorganism for improved pentose fermentation |
| MX2023002490A (es) | 2020-09-04 | 2023-03-09 | Novozymes As | Organismo fermentador mejorado para la produccion de etanol. |
| AU2022288057A1 (en) | 2021-06-07 | 2023-12-21 | Novozymes A/S | Engineered microorganism for improved ethanol fermentation |
| CN114561303B (zh) * | 2022-02-14 | 2023-11-17 | 大连理工大学 | 一株分泌高性能纤维素酶的里氏木霉工程菌株及其应用 |
| CN115651933A (zh) * | 2022-06-06 | 2023-01-31 | 福州市皮肤病防治院 | 高效精准替换红色毛癣菌基因的方法 |
| WO2024064901A2 (en) | 2022-09-23 | 2024-03-28 | Novozymes A/S | Improved fermenting organism for ethanol production |
| WO2025088155A1 (en) | 2023-10-25 | 2025-05-01 | Novozymes A/S | Improved fermenting organism for ethanol production |
| CN117757643B (zh) * | 2024-01-12 | 2025-06-13 | 华东理工大学 | 一种分泌表达人溶菌酶的里氏木霉工程菌及其构建方法和应用 |
Family Cites Families (118)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FI864473L (fi) * | 1985-11-20 | 1987-05-21 | Panlabs Inc | Sammansatta yttryckskassetter foer fungaltransformering. |
| DK122686D0 (da) | 1986-03-17 | 1986-03-17 | Novo Industri As | Fremstilling af proteiner |
| US5989870A (en) | 1986-04-30 | 1999-11-23 | Rohm Enzyme Finland Oy | Method for cloning active promoters |
| US5648263A (en) | 1988-03-24 | 1997-07-15 | Novo Nordisk A/S | Methods for reducing the harshness of a cotton-containing fabric |
| DK115890D0 (da) | 1990-05-09 | 1990-05-09 | Novo Nordisk As | Enzym |
| ES2170748T3 (es) * | 1990-10-05 | 2002-08-16 | Genencor Int | Procedimientos para el tratamiento de tejidos que contienen algodon con celulasa. |
| DE69333747T2 (de) * | 1992-07-31 | 2005-12-29 | Ab Enzymes Gmbh | Rekombinante zelle, dna-konstruktionen, vektoren und methoden zur expression von phytatabbauenden enzymen in gewünschten verhältnissen |
| ATE258224T1 (de) | 1993-03-10 | 2004-02-15 | Novozymes As | Enzyme mit xylanaseaktivität aus aspergillus aculeatus |
| FI964808A0 (fi) | 1994-06-03 | 1996-12-02 | Novo Nordisk Biotech Inc | Puhdistetut Myceliophthora lakkaasit ja niitä koodaavat nukleiinihapot |
| US6060305A (en) * | 1994-06-30 | 2000-05-09 | Novo Nordisk Biotech, Inc. | Non-toxic, non-toxigenic, non-pathogenic Fusarium expression system |
| CN101659926A (zh) | 1994-06-30 | 2010-03-03 | 诺沃奇梅兹有限公司 | 非毒性、非产毒性、非致病性镰孢属表达系统及所用启动子和终止子 |
| US20030044956A1 (en) | 1995-08-23 | 2003-03-06 | Short Jay M. | Enzymes having carboxymethyl cellulase activity and methods of use thereof |
| CN1231588C (zh) | 1996-01-19 | 2005-12-14 | 诺沃奇梅兹生物技术有限公司 | 丝状真菌的形态突变体 |
| JP4436934B2 (ja) * | 1996-09-13 | 2010-03-24 | ノボザイムス，インコーポレイティド | 変更された量のポリペプチドを生成するｄｎａ挿入突然変異を有する細胞 |
| US6451063B1 (en) | 1996-09-25 | 2002-09-17 | Genencor International, Inc. | Cellulase for use in industrial processes |
| US6017870A (en) | 1996-10-09 | 2000-01-25 | Genencor International, Inc. | Purified cellulase and method of producing |
| US5811381A (en) | 1996-10-10 | 1998-09-22 | Mark A. Emalfarb | Cellulase compositions and methods of use |
| US7883872B2 (en) | 1996-10-10 | 2011-02-08 | Dyadic International (Usa), Inc. | Construction of highly efficient cellulase compositions for enzymatic hydrolysis of cellulose |
| US6265204B1 (en) * | 1997-01-17 | 2001-07-24 | Genencor International, Inc. | DNA sequences, vectors, and fusion polypeptides for secretion of polypeptides in filamentous fungi |
| NZ502444A (en) | 1997-07-31 | 2001-11-30 | Dsm N | Polypeptides with cellobiohydrolase activity (CBH A and CBH B) from Aspergillus |
| US5871550A (en) | 1997-08-26 | 1999-02-16 | Genencor International, Inc. | Mutant Thermonospora spp. cellulase |
| JP2001523464A (ja) | 1997-11-19 | 2001-11-27 | ジェネンコア インターナショナル インコーポレーテッド | 放線菌類により産生されるセルラーゼとその産生方法 |
| NZ505295A (en) | 1997-12-16 | 2002-12-20 | Genencor Int | A method of identifying cellulase gene sequences using conserved amino acid sequence fragments from known cellulase enzymes to provide primer nucleotide sequences |
| ES2143408B1 (es) * | 1998-04-02 | 2000-12-01 | Urquima Sa | Promotor y construcciones para expresion de proteinas recombinantes en hongos filamentosos. |
| AU4188099A (en) * | 1998-05-15 | 1999-12-06 | Novo Nordisk A/S | Methods for producing polypeptides in filamentous fungal mutant cells |
| CN100510096C (zh) | 1999-03-22 | 2009-07-08 | 诺沃奇梅兹有限公司 | 用于在真菌细胞中表达基因的启动子 |
| EP1395653A2 (en) | 2001-05-18 | 2004-03-10 | Novozymes A/S | Polypeptides having cellobiase activity and polynucleotides encoding same |
| US6982159B2 (en) | 2001-09-21 | 2006-01-03 | Genencor International, Inc. | Trichoderma β-glucosidase |
| US7045332B2 (en) | 2001-12-18 | 2006-05-16 | Genencor International, Inc. | BGL4 β-glucosidase and nucleic acids encoding the same |
| US7056721B2 (en) | 2001-12-18 | 2006-06-06 | Genencor International, Inc. | EGVI endoglucanase and nucleic acids encoding the same |
| US7045331B2 (en) | 2001-12-18 | 2006-05-16 | Genencor International, Inc. | EGVII endoglucanase and nucleic acids encoding the same |
| US7049125B2 (en) | 2001-12-18 | 2006-05-23 | Genencor International, Inc. | EGVIII endoglucanase and nucleic acids encoding the same |
| US7005289B2 (en) | 2001-12-18 | 2006-02-28 | Genencor International, Inc. | BGL5 β-glucosidase and nucleic acids encoding the same |
| DK2305801T3 (en) | 2002-08-16 | 2017-10-09 | Danisco Us Inc | Hitherto UNKNOWN HYPOCREA JECORINA-CBH1 CELLULASES |
| AU2003291395A1 (en) | 2002-11-07 | 2004-06-03 | Genencor International, Inc. | Bgl6 beta-glucosidase and nucleic acids encoding the same |
| US7407788B2 (en) | 2002-11-21 | 2008-08-05 | Danisco A/S, Genencor Division | BGL7 beta-glucosidase and nucleic acids encoding the same |
| CN1898381B (zh) | 2003-03-21 | 2013-07-17 | 金克克国际有限公司 | Cbh1同源物和cbh1纤维素酶变体 |
| EP2385104A1 (en) | 2003-04-01 | 2011-11-09 | Danisco US Inc. | Variant Scytalidium thermophilium CBH1 |
| ES2393058T3 (es) | 2003-05-02 | 2012-12-18 | Novozymes Inc. | Variantes de beta-glucosidasa |
| EP1627049B1 (en) | 2003-05-29 | 2010-02-17 | Genencor International, Inc. | Novel trichoderma genes |
| DK1682656T3 (da) | 2003-10-28 | 2013-11-18 | Novozymes Inc | Polypeptider med beta-glucosidaseaktivitet og polynukleotider, der koder for dem |
| ES2469840T3 (es) | 2004-01-30 | 2014-06-20 | Novozymes Inc. | Polip�ptidos con actividad de mejora celulol�tica y polinucle�tidos que los codifican |
| CN103667215A (zh) | 2004-02-06 | 2014-03-26 | 诺维信股份有限公司 | 具有增强分解纤维素活性的多肽和编码所述多肽的多核苷酸 |
| WO2006078256A2 (en) | 2004-02-12 | 2006-07-27 | Novozymes, Inc. | Polypeptides having xylanase activity and polynucleotides encoding same |
| CN1930294A (zh) | 2004-03-25 | 2007-03-14 | 金克克国际有限公司 | 纤维素酶融合蛋白和编码该纤维素酶融合蛋白的异源纤维素酶融合构建物 |
| US8097445B2 (en) | 2004-03-25 | 2012-01-17 | Danisco Us Inc. | Exo-endo cellulase fusion protein |
| DK2292747T3 (en) | 2004-12-30 | 2017-04-24 | Danisco Us Inc | CBH2 CELLULASE VARIETIES OF HYPOCREA JECORINA |
| US7220565B2 (en) | 2005-01-06 | 2007-05-22 | Novozymes, Inc. | Polypeptides having cellobiohydrolase activity and polynucleotides encoding same |
| AR053066A1 (es) | 2005-04-26 | 2007-04-18 | Novozymes As | Arabinofuranosidasas |
| WO2006117432A1 (en) | 2005-04-29 | 2006-11-09 | Ab Enzymes Oy | Improved cellulases |
| US8097772B2 (en) | 2005-08-04 | 2012-01-17 | Novozymes, Inc. | Polypeptides having beta-glucosidase activity and polynucleotides encoding same |
| KR20080069980A (ko) | 2005-09-30 | 2008-07-29 | 노보자임스 인코포레이티드 | 셀룰로오스성 물질의 분해 또는 전환을 증진하는 방법 |
| FI120045B (fi) | 2005-12-22 | 2009-06-15 | Roal Oy | Selluloosamateriaalin käsittely ja siinä käyttökelpoiset entsyymit |
| DK1969123T3 (en) | 2005-12-22 | 2017-08-28 | Ab Enzymes Oy | Hitherto UNKNOWN ENZYMS |
| CA2651456A1 (en) | 2006-05-19 | 2007-11-29 | Glycofi, Inc. | Recombinant vectors |
| US8304212B2 (en) | 2006-07-10 | 2012-11-06 | Dyadic International, Inc. | Methods and compositions for degradation of lignocellulosic material |
| GB0614442D0 (en) * | 2006-07-20 | 2006-08-30 | Fluxome Sciences As | Metabolically engineered cells for the production of pinosylvin |
| CN101516906B (zh) | 2006-07-21 | 2013-11-06 | 诺维信股份有限公司 | 提高具有生物学活性之多肽的分泌的方法 |
| EP2505651A3 (en) * | 2006-12-10 | 2013-01-09 | Dyadic International, Inc. | Isolated fungus with reduced protease activity |
| WO2008148131A1 (en) | 2007-05-31 | 2008-12-04 | Novozymes, Inc. | Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same |
| EP2489732A1 (en) | 2007-05-31 | 2012-08-22 | Novozymes Inc. | Compositions for degrading cellulosic material |
| US9969993B2 (en) * | 2007-05-31 | 2018-05-15 | Novozymes, Inc. | Filamentous fungal host cells and methods of recombinantly producing proteins |
| BRPI0817474B1 (pt) | 2007-09-28 | 2018-04-24 | Novozymes A/S | Célula hospedeira microbiana transgênica, construção de ácido nucleico, vetor de expressão, composição detergente, e, métodos para produzir uma proteína, para degradar ou converter um material celulósico, e para produzir um produto de fermentação |
| WO2009042846A1 (en) | 2007-09-28 | 2009-04-02 | Novozymes A/S | Polypeptides having acetylxylan esterase activity and polynucleotides encoding same |
| DK2215224T3 (da) | 2007-11-27 | 2014-01-27 | Novozymes As | Polypeptider med alfa-glucuronidaseaktivitet og polynukleotider, der koder for dem |
| CA2707017A1 (en) | 2007-11-30 | 2009-06-11 | Novozymes A/S | Polypeptides having arabinofuranosidase activity and polynucleotides encoding same |
| EP2220219A2 (en) | 2007-12-05 | 2010-08-25 | Novozymes A/S | Polypeptides having xylanase activity and polynucleotides encoding same |
| WO2009073709A1 (en) | 2007-12-06 | 2009-06-11 | Novozymes A/S | Polypeptides having acetylxylan esterase activity and polynucleotides encoding same |
| US8034995B2 (en) | 2007-12-07 | 2011-10-11 | Novozymes A/S | Polypeptides having feruloyl esterase activity and polynucleotides encoding same |
| CA2709485A1 (en) | 2007-12-19 | 2009-07-09 | Novozymes A/S | Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same |
| US20100306881A1 (en) | 2007-12-19 | 2010-12-02 | Novozymes A/S | Polypeptides having Cellulolytic Enhancing Activity and Polynucleotides Encoding Same |
| BRPI0822090A2 (pt) | 2007-12-19 | 2017-05-23 | Novozymes As | polipeptídeo isolado, polinucleotídeo isolado, construção de ácido nucléico, célula hospedeira recombinante, métodos para produzir o polipeptídeo, para produzir um mutante de uma célula precursora, de inibir a expressão de um polipeptídeo, para produzir uma proteína, para degradar ou converter um material celulósico, para a produção de um produto de fermentação, para fermentar um material celulósico, planta transgênica, parte vegetal ou célula vegetal, molécula de rna inibidora de duplo filamento |
| NZ598403A (en) | 2007-12-19 | 2012-07-27 | Novozymes As | Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same |
| CN101952303A (zh) * | 2008-02-25 | 2011-01-19 | 诺维信公司 | 提高目标蛋白质的表达产率的方法 |
| WO2009127729A1 (en) | 2008-04-17 | 2009-10-22 | Novozymes A/S | Polypeptides having ferulic acid esterase activity and polynucleotides encoding same |
| DK2310497T3 (da) | 2008-07-29 | 2016-07-25 | Novozymes As | Polypeptider med alfa-glucuronidaseaktivitet og polynukleotider, der koder for dem |
| CA2732099A1 (en) | 2008-07-31 | 2010-02-04 | Novozymes A/S | Polypeptides having acetylxylan esterase activity and polynucleotides encoding same |
| CN105671027A (zh) * | 2008-09-30 | 2016-06-15 | 诺维信股份有限公司 | 在丝状真菌细胞中使用阳性和阴性选择性基因的方法 |
| EP2352831B1 (en) | 2008-09-30 | 2015-03-25 | Novozymes Inc. | Methods for producing polypeptides in enzyme-deficient mutants of fusarium venenatum |
| US8058513B2 (en) | 2008-11-10 | 2011-11-15 | Novozymes, Inc. | Polypeptides having feruloyl esterase activity and polynucleotides encoding same |
| US8805427B2 (en) | 2008-11-14 | 2014-08-12 | Microsoft Corporation | Channel reuse with cognitive low interference signals |
| US7771983B2 (en) | 2008-12-04 | 2010-08-10 | Novozymos, Inc. | Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same |
| CA2745608A1 (en) | 2008-12-04 | 2010-06-10 | Novozymes, Inc. | Polypeptides having feruloyl esterase activity and polynucleotides encoding same |
| EP2391715A1 (en) | 2009-01-28 | 2011-12-07 | Novozymes Inc. | Polypeptides having beta-glucosidase activity and polynucleotides encoding same |
| WO2010108918A1 (en) | 2009-03-24 | 2010-09-30 | Novozymes A/S | Polypeptides having acetyl xylan esterase activity and polynucleotides encoding same |
| CN102482680B (zh) | 2009-04-30 | 2014-09-10 | 诺维信股份有限公司 | 具有木聚糖酶活性的多肽和编码该多肽的多核苷酸 |
| CA2763031A1 (en) | 2009-05-29 | 2010-12-02 | Novozymes, Inc. | Methods for enhancing the degradation or conversion of cellulosic material |
| EP2438163B1 (en) | 2009-06-02 | 2015-01-21 | Novozymes Inc. | Polypeptides having cellobiohydrolase activity and polynucleotides encoding same |
| US8143021B2 (en) | 2009-07-07 | 2012-03-27 | Novozymes, Inc. | Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same |
| WO2011035027A2 (en) | 2009-09-17 | 2011-03-24 | Novozymes, Inc. | Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same |
| WO2011035029A1 (en) | 2009-09-18 | 2011-03-24 | Novozymes, Inc. | Polypeptides having beta-glucosidase activity and polynucleotides encoding same |
| CA2775347A1 (en) | 2009-09-29 | 2011-04-07 | Novozymes A/S | Polypeptides having xylanase activity and polynucleotides encoding same |
| DK2483295T3 (en) | 2009-09-29 | 2016-02-22 | Novozymes Inc | Polypeptides having cellulolytic enhancing activity and polynucleotides encoding them |
| CN102695720B (zh) | 2009-09-30 | 2018-02-16 | 诺维信股份有限公司 | 具有纤维素分解增强活性的多肽和编码该多肽的多核苷酸 |
| US8586829B2 (en) | 2009-09-30 | 2013-11-19 | Novozymes A/S | Polypeptides having cellulolytic enhancing activity and polynucleotides encoding same |
| BR112012006873A2 (pt) * | 2009-10-23 | 2015-09-08 | Novozymes Inc | variante isolada, polinucleotideo isolado, metodo para produzir uma variante, planta transgenica, parte de planta ou celula d eplanta, e, metodos para degradar ou converter um materialcelulósico, para produzir um produto de fermentação, e, para fermentar um material celulósico. |
| US20120260371A1 (en) | 2009-10-29 | 2012-10-11 | Novozymes A/S | Polypeptides Having Cellobiohydrolase Activity and Polynucleotides Encoding Same |
| WO2011057083A1 (en) | 2009-11-06 | 2011-05-12 | Novozymes, Inc. | Polypeptides having xylanase activity and polynucleotides encoding same |
| EP2496694B1 (en) | 2009-11-06 | 2017-04-19 | Novozymes, Inc. | Compositions for saccharification of cellulosic material |
| DK2513290T3 (en) | 2009-12-18 | 2016-01-25 | Novozymes Inc | Methods for Preparation of Polypeptides in Trichoderma Mutants with Protease Deficiency |
| EP2371963A1 (en) * | 2010-03-29 | 2011-10-05 | Heinrich-Heine-Universität Düsseldorf | Protein production in filamentous fungi |
| EP2558566A4 (en) * | 2010-04-14 | 2013-10-02 | Penn State Res Found | TRANSGENIC HANDLING STRATEGIES OF FILAMENTOUS FUNGI |
| US9090918B2 (en) * | 2010-11-22 | 2015-07-28 | Novozymes A/A | Compositions and methods for 3-hydroxypropionic acid production |
| JP6067564B2 (ja) * | 2011-08-12 | 2017-01-25 | 国立大学法人東北大学 | 免疫応答を回避するための薬剤 |
| IN2014CN02136A (https=) * | 2011-08-24 | 2015-05-29 | Novozymes Inc | |
| US9404101B2 (en) * | 2011-08-24 | 2016-08-02 | Novozymes, Inc. | Methods for obtaining positive transformants of a filamentous fungal host cell |
| US20130109055A1 (en) * | 2011-10-31 | 2013-05-02 | Bp Corporation North America Inc. | Use of mammalian promoters in filamentous fungi |
| WO2013076280A1 (en) * | 2011-11-23 | 2013-05-30 | Dsm Ip Assets B.V. | Nucleic acid assembly system |
| CN104066841B (zh) * | 2012-01-23 | 2018-01-02 | 旭硝子株式会社 | 表达载体和蛋白质的制造方法 |
| US10023872B2 (en) * | 2012-12-21 | 2018-07-17 | Novozymes, Inc. | Methods for producing heterologous polypeptides in mutants of trichoderma |
| CN105164254B (zh) * | 2013-03-08 | 2019-06-28 | 诺维信公司 | 纤维二糖水解酶变体和编码它们的多核苷酸 |
| WO2014145768A2 (en) * | 2013-03-15 | 2014-09-18 | Bp Corporation North America Inc. | Use of non-fungal 5' utrs in filamentous fungi |
| EP2840139A1 (en) * | 2013-08-23 | 2015-02-25 | Wageningen Universiteit | Method for the single step introduction of a plurality of genes in microbial cells |
| AU2015269381B2 (en) * | 2014-06-06 | 2019-04-18 | Novozymes A/S | Enzyme compositions and uses thereof |
| DK3183343T3 (da) * | 2014-08-20 | 2020-03-23 | Novozymes As | Rekombinase-medieret integration af et polynukleotidbibliotek |
| CN107429255B (zh) * | 2015-03-09 | 2022-01-25 | 诺维信公司 | 将多种表达构建体引入真核细胞的方法 |
| US20200063166A1 (en) * | 2017-03-13 | 2020-02-27 | Dsm Ip Assets B.V. | Zinc binuclear cluster transcriptional regulator-deficient strain |
| WO2018226900A2 (en) * | 2017-06-06 | 2018-12-13 | Zymergen Inc. | A htp genomic engineering platform for improving fungal strains |
-
2012
- 2012-08-23 IN IN2136CHN2014 patent/IN2014CN02136A/en unknown
- 2012-08-23 CN CN201810953356.5A patent/CN109136114A/zh active Pending
- 2012-08-23 BR BR112014004190A patent/BR112014004190A2/pt not_active Application Discontinuation
- 2012-08-23 WO PCT/US2012/052143 patent/WO2013028912A2/en not_active Ceased
- 2012-08-23 AU AU2012298799A patent/AU2012298799B2/en active Active
- 2012-08-23 US US14/238,691 patent/US9493790B2/en active Active
- 2012-08-23 CN CN201280052277.8A patent/CN103890180A/zh active Pending
- 2012-08-23 EP EP12801652.4A patent/EP2748322A2/en not_active Ceased
-
2016
- 2016-09-29 US US15/280,706 patent/US10301610B2/en active Active
-
2019
- 2019-04-25 US US16/394,951 patent/US10822601B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US10301610B2 (en) | 2019-05-28 |
| US10822601B2 (en) | 2020-11-03 |
| US20170015986A1 (en) | 2017-01-19 |
| US20140212977A1 (en) | 2014-07-31 |
| AU2012298799B2 (en) | 2018-02-01 |
| WO2013028912A3 (en) | 2013-06-06 |
| EP2748322A2 (en) | 2014-07-02 |
| US9493790B2 (en) | 2016-11-15 |
| IN2014CN02136A (https=) | 2015-05-29 |
| CN103890180A (zh) | 2014-06-25 |
| WO2013028912A2 (en) | 2013-02-28 |
| CN109136114A (zh) | 2019-01-04 |
| AU2012298799A1 (en) | 2014-02-13 |
| US20190249161A1 (en) | 2019-08-15 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| BR112014004190A2 (pt) | método para construir uma cepa fúngida filamentosa, cepa fúngida filamentosa, método para produzir múltiplos polipeptídeos recombinantes, e, construto em tandem | |
| BR112012031844A2 (pt) | cepa bacteriana recombinante, processo para aperfeiçoar a utilização de xilose em uma cepa bacteriana recombinante e método para produção de etanol | |
| BR112014003350A2 (pt) | composto laminado termoplástico, estrutura de composto, composto laminado, e, método para formar um composto laminado | |
| BR112016013450A2 (pt) | Material compósito curável, e, métodos para fabricar um material compósito curável e para fabricar uma estrutura compósita | |
| BR112014010023A2 (pt) | método in vitro para à produção de uma proteína heterodimérica, e, sequência de nucleotídeo | |
| BR112014008603A2 (pt) | tablete, e, método para produzir um tablete | |
| BR112014003566A2 (pt) | célula hospedeira recombinante, e, método para produzir um ácido c4-dicarboxílico | |
| BR112013001848A2 (pt) | estrutura compósita, processo para produzir uma estrutura compósita, estrutura compósita sobremoldada e processo para produzir uma estrutura compósita sobremoldada | |
| BR112014002174A2 (pt) | estrutura de válvula cardíaca, estrutura de válvula cardíaca em múltiplas-lâminas e método para fabricar uma estrutura de válvula cardíaca | |
| BR112013018379A2 (pt) | levedura recombinante e método de produção de substância usando a mesma | |
| BR112013030914A2 (pt) | material combinado, compósito lignocelulósico, e, método para produzir um compósito lignocelulósico | |
| BR112013025716A2 (pt) | cepa bacteriana recombinante, processo para a produção de uma cepa de zymomonas e método para a produção de etanol | |
| BR112013001851A2 (pt) | estrutura compósita, processo para a produção de uma estrutura compósita, estrutura compósita sobremoldada e processo para a produção de uma estrutura compósita sobremoldada | |
| CL2014003318A1 (es) | Un método para el fraccionamiento de lignina: fraccion de lignina. | |
| BR112014003798A2 (pt) | método para fabricar um composto, e, composto | |
| BR112014005310A2 (pt) | compósito fibroso, método para formar um compósito fibroso, e compósito | |
| BR112014005309A2 (pt) | processo, produto, processo para formar um compósito fibroso, e compósito fibroso | |
| BR112014003444A2 (pt) | célula hospedeira recombinante, e, método para produzir um ácido c4-dicarboxílico | |
| BR112014005411A2 (pt) | invólucro de cilindro, e método para fabricar o mesmo | |
| LT2834526T (lt) | Lengvo svorio konstrukcinė plokštė, jungianti konstrukcija ir būdas jungiančiai konstrukcijai gaminti | |
| BR112012031848A2 (pt) | estrutura compósita e processo para fazer a estrutura compósita | |
| BR112014027475A2 (pt) | camada central, método para produzir uma camada central, compósito em multicamada e uso de uma camada central | |
| BR112014032483A2 (pt) | produto semiacabado em camadas e método para a sua produção. | |
| FI20105224L (fi) | Menetelmä komposiittimateriaalien valmistamiseksi | |
| BR112013033337A2 (pt) | corda, e, método para fabricar uma corda |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B06T | Formal requirements before examination [chapter 6.20 patent gazette] | ||
| B07A | Technical examination (opinion): publication of technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] | ||
| B09B | Patent application refused [chapter 9.2 patent gazette] | ||
| B09S | Decision of refusal: publication cancelled |
Free format text: ANULADA A PUBLICACAO CODIGO 9.2 NA RPI NO 2618 DE 09/03/2021 POR TER SIDO INDEVIDA. |
|
| B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL |