BR112014001634A2 - compostos bicíclicos de pirimidona - Google Patents

compostos bicíclicos de pirimidona

Info

Publication number
BR112014001634A2
BR112014001634A2 BR112014001634A BR112014001634A BR112014001634A2 BR 112014001634 A2 BR112014001634 A2 BR 112014001634A2 BR 112014001634 A BR112014001634 A BR 112014001634A BR 112014001634 A BR112014001634 A BR 112014001634A BR 112014001634 A2 BR112014001634 A2 BR 112014001634A2
Authority
BR
Brazil
Prior art keywords
pyrimidone compounds
bicyclic pyrimidone
bicyclic
compounds
pla2
Prior art date
Application number
BR112014001634A
Other languages
English (en)
Portuguese (pt)
Inventor
Yu Haihua
Long Kai
Zhang Xiaomin
Wan Zehong
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of BR112014001634A2 publication Critical patent/BR112014001634A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Obesity (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Hospice & Palliative Care (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
BR112014001634A 2011-07-27 2012-07-25 compostos bicíclicos de pirimidona BR112014001634A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CN2011077702 2011-07-27
PCT/EP2012/064598 WO2013014185A1 (en) 2011-07-27 2012-07-25 Bicyclic pyrimidone compounds

Publications (1)

Publication Number Publication Date
BR112014001634A2 true BR112014001634A2 (pt) 2017-02-14

Family

ID=46579034

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014001634A BR112014001634A2 (pt) 2011-07-27 2012-07-25 compostos bicíclicos de pirimidona

Country Status (12)

Country Link
US (2) US9273054B2 (https=)
EP (1) EP2736908A1 (https=)
JP (1) JP2014521625A (https=)
KR (1) KR20140059204A (https=)
AR (1) AR087309A1 (https=)
AU (1) AU2012288865B2 (https=)
BR (1) BR112014001634A2 (https=)
CA (1) CA2843102A1 (https=)
RU (1) RU2014107486A (https=)
TW (1) TW201321382A (https=)
UY (1) UY34216A (https=)
WO (1) WO2013014185A1 (https=)

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EP2736908A1 (en) * 2011-07-27 2014-06-04 Glaxo Group Limited Bicyclic pyrimidone compounds
WO2014082880A1 (en) 2012-11-27 2014-06-05 Basf Se Substituted [1,2,4] triazole compounds
US20150307459A1 (en) 2012-11-27 2015-10-29 Basf Se Substituted 2-[phenoxy-phenyl]-1-[1,2,4]triazol-1-yl-ethanol Compounds and Their Use as Fungicides
US20160029630A1 (en) 2012-11-27 2016-02-04 Basf Se Substituted 2-[phenoxy-phenyl]-1-[1,2,4]triazol-1-yl-ethanol compounds and their use as fungicides
CA2899124A1 (en) * 2013-01-25 2014-07-31 Glaxosmithkline Intellectual Property Development Limited Compounds
BR112015017397A2 (pt) * 2013-01-25 2017-07-11 Glaxosmithkline Ip Dev Ltd compostos pirimidona bicíclica como inibidores de lp-pla2
CN104968665A (zh) * 2013-01-25 2015-10-07 葛兰素史密斯克莱知识产权发展有限公司 作为lp-pla2抑制剂的双环嘧啶酮化合物
US9630896B2 (en) 2013-11-22 2017-04-25 Tansna Therapeutics, Inc. 2,5-dialkyl-4-H/halo/ether-phenol compounds
CN106536525B (zh) 2014-07-22 2019-05-03 葛兰素史密斯克莱知识产权发展有限公司 化合物
WO2016012916A1 (en) 2014-07-22 2016-01-28 Glaxosmithkline Intellectual Property Development Limited 1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidine derivatives useful in the treatment of diseases and disorders mediated by lp-pla2
WO2016012917A1 (en) 2014-07-22 2016-01-28 Glaxosmithkline Intellectual Property Development Limited 1,2,3,5-tetrahydroimidazo[1,2-c]pyrimidine derivatives useful in the treatment of diseases and disorders mediated by lp-pla2
CN105777653A (zh) * 2014-12-26 2016-07-20 中国科学院上海药物研究所 用作Lp-PLA2抑制剂的嘧啶酮类化合物及其药物组合物
CN106188063A (zh) * 2015-05-08 2016-12-07 中国科学院上海药物研究所 用作Lp-PLA2抑制剂的双环类化合物、其制备方法及医药用途
EP3344632A4 (en) * 2015-09-04 2019-03-20 Lysosomal Therapeutics Inc. Heterocyclic pyrimidine compounds and their use in the treatment of medical disorders
GB201522179D0 (en) * 2015-12-16 2016-01-27 Autifony Therapeutics Ltd Novel compounds
US11370771B2 (en) 2018-02-16 2022-06-28 Boehringer Ingelheim International Gmbh Inhibitors of TRPC6
CN112574221B (zh) * 2019-09-30 2022-03-04 上海纽思克生物科技有限公司 四环嘧啶酮类化合物、其制备方法、其组合物和用途
CN114805389B (zh) 2019-11-09 2023-08-29 上海赛默罗生物科技有限公司 三环二氢咪唑并嘧啶酮衍生物、其制备方法、药物组合物和用途
AU2021269603A1 (en) * 2020-05-13 2022-12-15 Neusco Biotech Limited Bridged cyclic pyrimidinone compound, preparation method therefor, composition containing same and use thereof
CN113912622B (zh) * 2020-07-10 2023-12-01 上海纽思克生物科技有限公司 三环嘧啶酮类化合物、其制备方法、其组合物和用途
CN115304620A (zh) 2021-05-07 2022-11-08 上海赛默罗生物科技有限公司 嘧啶酮衍生物、其制备方法、药物组合物和用途
TWI896037B (zh) 2023-07-17 2025-09-01 大陸商上海樞境生物科技有限公司 雙環[5,6]咪唑嘧啶酮類衍生物、其製備方法和應用

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US20080090852A1 (en) 2006-10-13 2008-04-17 Colin Andrew Leach Bicyclic Heteroaromatic Compounds
US8962633B2 (en) 2007-05-11 2015-02-24 Thomas Jefferson University Methods of treatment and prevention of metabolic bone diseases and disorders
US20080279846A1 (en) 2007-05-11 2008-11-13 Thomas Jefferson University Methods of treatment and prevention of neurodegenerative diseases and disorders
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JP2011088847A (ja) * 2009-10-21 2011-05-06 Takeda Chem Ind Ltd 三環性化合物およびその用途
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Also Published As

Publication number Publication date
US20130030012A1 (en) 2013-01-31
RU2014107486A (ru) 2015-09-10
AU2012288865B2 (en) 2015-10-01
WO2013014185A1 (en) 2013-01-31
EP2736908A1 (en) 2014-06-04
AU2012288865A1 (en) 2014-02-13
US9273054B2 (en) 2016-03-01
TW201321382A (zh) 2013-06-01
JP2014521625A (ja) 2014-08-28
CA2843102A1 (en) 2013-01-31
KR20140059204A (ko) 2014-05-15
UY34216A (es) 2013-02-28
US20140179716A1 (en) 2014-06-26
AR087309A1 (es) 2014-03-12

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Legal Events

Date Code Title Description
B08F Application fees: dismissal - article 86 of industrial property law
B08K Lapse as no evidence of payment of the annual fee has been furnished to inpi (acc. art. 87)