BR112014000814A2 - partículas esféricas de bisulfato de clopidogrel, composição farmacêutica compreendendo as mesmas e seu método de preparação - Google Patents

partículas esféricas de bisulfato de clopidogrel, composição farmacêutica compreendendo as mesmas e seu método de preparação

Info

Publication number
BR112014000814A2
BR112014000814A2 BR112014000814A BR112014000814A BR112014000814A2 BR 112014000814 A2 BR112014000814 A2 BR 112014000814A2 BR 112014000814 A BR112014000814 A BR 112014000814A BR 112014000814 A BR112014000814 A BR 112014000814A BR 112014000814 A2 BR112014000814 A2 BR 112014000814A2
Authority
BR
Brazil
Prior art keywords
spherical
preparation
pharmaceutical composition
clopidogrel bisulfate
particles
Prior art date
Application number
BR112014000814A
Other languages
English (en)
Inventor
Eui Hwan Cho
Sun Hwan Lee
Jong Sun Park
Hee Jong Shin
Woo Heon Song
Jong Bae Yoon
Original Assignee
Astech Co Ltd
Samjin Pharm Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astech Co Ltd, Samjin Pharm Co Ltd filed Critical Astech Co Ltd
Publication of BR112014000814A2 publication Critical patent/BR112014000814A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T428/00—Stock material or miscellaneous articles
    • Y10T428/29—Coated or structually defined flake, particle, cell, strand, strand portion, rod, filament, macroscopic fiber or mass thereof
    • Y10T428/2982—Particulate matter [e.g., sphere, flake, etc.]
BR112014000814A 2011-07-12 2011-10-27 partículas esféricas de bisulfato de clopidogrel, composição farmacêutica compreendendo as mesmas e seu método de preparação BR112014000814A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR1020110069039A KR101324862B1 (ko) 2011-07-12 2011-07-12 클로피도그렐 황산수소염의 구형 입자, 이를 포함하는 약학적 조성물 및 이의 제조방법
PCT/KR2011/008071 WO2013008981A1 (ko) 2011-07-12 2011-10-27 클로피도그렐 황산수소염의 구형 입자, 이를 포함하는 약학적 조성물 및 이의 제조방법

Publications (1)

Publication Number Publication Date
BR112014000814A2 true BR112014000814A2 (pt) 2017-02-21

Family

ID=47506246

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112014000814A BR112014000814A2 (pt) 2011-07-12 2011-10-27 partículas esféricas de bisulfato de clopidogrel, composição farmacêutica compreendendo as mesmas e seu método de preparação

Country Status (8)

Country Link
US (1) US20140154330A1 (pt)
EP (1) EP2732810A1 (pt)
JP (1) JP2014506919A (pt)
KR (1) KR101324862B1 (pt)
CN (1) CN103717207A (pt)
BR (1) BR112014000814A2 (pt)
MA (1) MA35264B1 (pt)
WO (1) WO2013008981A1 (pt)

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CN104817571B (zh) * 2014-12-31 2016-04-20 天津大学 一种制备球形硫酸氢氯吡格雷i晶型的方法
KR101710922B1 (ko) 2015-06-03 2017-02-28 경동제약 주식회사 클로피도그렐 황산염 결정형 i형의 제조방법
CN105012298B (zh) * 2015-07-17 2016-06-01 深圳信立泰药业股份有限公司 一种含有球形硫酸氢氯吡格雷i晶型的药物组合物及其制备方法
CN105748419B (zh) * 2015-07-17 2018-09-14 深圳信立泰药业股份有限公司 一种含有球形硫酸氢氯吡格雷i晶型的药物组合物及其制备方法
CN105061459B (zh) * 2015-07-21 2016-08-24 深圳信立泰药业股份有限公司 一种硫酸氢氯吡格雷i晶型球形结晶的制备方法
KR102532121B1 (ko) * 2017-10-18 2023-05-12 고려제약주식회사 돌미나리 추출물 및 항혈전제를 포함하는 항혈전용 조성물
JP7218949B2 (ja) * 2018-04-16 2023-02-07 チャンスー ヴィーケア ファーマテック カンパニー リミテッド 抗凝固薬の即時放出医薬製剤及びその調製方法
CN109096302A (zh) * 2018-07-27 2018-12-28 天津大学 球形硫酸氢氯吡格雷ii晶型及制备方法
WO2021261837A1 (ko) * 2020-06-24 2021-12-30 뉴지랩파마 주식회사 나파모스타트 메실레이트를 유효성분으로 포함하는 경구용 약제학적 조성물
CN114369100B (zh) * 2021-12-15 2023-06-20 浙江车头制药股份有限公司 一种硫酸氢氯吡格雷球形晶型i的制备方法

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JP2766073B2 (ja) * 1990-04-04 1998-06-18 クノル アクチェンゲゼルシャフト β―フェニルプロピオフェノンの単結晶
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KR20070044323A (ko) * 2005-10-24 2007-04-27 에스케이케미칼주식회사 보관안정성이 개선된 클로피도그렐 황산수소염 함유 경구용제제
KR100809903B1 (ko) * 2006-09-05 2008-03-06 주식회사유한양행 안정화된 클로피도그렐-함유 입자, 그의 제조방법, 및 이를포함하는 약학 조성물
CA2683611A1 (en) * 2007-04-09 2008-10-16 Usv Limited Novel stable pharmaceutical compositions of clopidogrel bisulfate and process of preparation thereof
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KR20090092106A (ko) * 2008-02-26 2009-08-31 주식회사 대희화학 클로피도그렐 황산수소염을 포함하는 정제
CN101721410B (zh) * 2008-10-30 2012-01-25 南京正大天晴制药有限公司 硫酸氢氯吡格雷的固体药物组合物
KR101130445B1 (ko) * 2009-10-29 2012-03-27 동아제약주식회사 클로피도그랠 황산수소염 ⅰ형 제조방법
CN101851247B (zh) * 2010-06-04 2013-05-29 浙江华海药业股份有限公司 含有硫酸氢氯吡格雷晶体颗粒的组合物

Also Published As

Publication number Publication date
US20140154330A1 (en) 2014-06-05
KR101324862B1 (ko) 2013-11-01
EP2732810A1 (en) 2014-05-21
KR20130010098A (ko) 2013-01-25
MA35264B1 (fr) 2014-07-03
JP2014506919A (ja) 2014-03-20
WO2013008981A1 (ko) 2013-01-17
CN103717207A (zh) 2014-04-09

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]