BR112013029588B1 - Processo para preparação de uma forma cristalina de cloreto de (2r,s)-, (2s)- ou (2r)- dotap, e composição farmacêutica - Google Patents
Processo para preparação de uma forma cristalina de cloreto de (2r,s)-, (2s)- ou (2r)- dotap, e composição farmacêutica Download PDFInfo
- Publication number
- BR112013029588B1 BR112013029588B1 BR112013029588-0A BR112013029588A BR112013029588B1 BR 112013029588 B1 BR112013029588 B1 BR 112013029588B1 BR 112013029588 A BR112013029588 A BR 112013029588A BR 112013029588 B1 BR112013029588 B1 BR 112013029588B1
- Authority
- BR
- Brazil
- Prior art keywords
- dotap
- chloride
- crystalline
- dotap chloride
- values
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B43/00—Formation or introduction of functional groups containing nitrogen
- C07B43/06—Formation or introduction of functional groups containing nitrogen of amide groups
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C219/04—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C219/08—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having at least one of the hydroxy groups esterified by a carboxylic acid having the esterifying carboxyl group bound to an acyclic carbon atom of an acyclic unsaturated carbon skeleton
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/23—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms
- A61K31/231—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin of acids having a carboxyl group bound to a chain of seven or more carbon atoms having one or two double bonds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Emergency Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Dispersion Chemistry (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Liquid Crystal Substances (AREA)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BR122021007641A BR122021007641B8 (pt) | 2011-05-20 | 2012-05-02 | Cloreto de (2r,s)-, (2s)- ou (2r)-dotap cristalino, e composição farmacêutica |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161488428P | 2011-05-20 | 2011-05-20 | |
| US61/488,428 | 2011-05-20 | ||
| PCT/EP2012/001882 WO2012159704A1 (en) | 2011-05-20 | 2012-05-02 | Stable crystal modifications of dotap chloride |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112013029588A2 BR112013029588A2 (pt) | 2020-11-17 |
| BR112013029588B1 true BR112013029588B1 (pt) | 2021-10-26 |
Family
ID=46044632
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR122021007641A BR122021007641B8 (pt) | 2011-05-20 | 2012-05-02 | Cloreto de (2r,s)-, (2s)- ou (2r)-dotap cristalino, e composição farmacêutica |
| BR112013029588-0A BR112013029588B1 (pt) | 2011-05-20 | 2012-05-02 | Processo para preparação de uma forma cristalina de cloreto de (2r,s)-, (2s)- ou (2r)- dotap, e composição farmacêutica |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR122021007641A BR122021007641B8 (pt) | 2011-05-20 | 2012-05-02 | Cloreto de (2r,s)-, (2s)- ou (2r)-dotap cristalino, e composição farmacêutica |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US10000445B2 (enExample) |
| EP (1) | EP2709981B1 (enExample) |
| JP (3) | JP6290076B2 (enExample) |
| KR (1) | KR101974231B1 (enExample) |
| CN (2) | CN108285422A (enExample) |
| AU (1) | AU2012261276B2 (enExample) |
| BR (2) | BR122021007641B8 (enExample) |
| CA (1) | CA2836499C (enExample) |
| ES (1) | ES2726526T3 (enExample) |
| HK (1) | HK1251217A1 (enExample) |
| HU (1) | HUE042949T2 (enExample) |
| IL (1) | IL229146B (enExample) |
| MX (1) | MX361369B (enExample) |
| NO (1) | NO344225B1 (enExample) |
| PL (1) | PL2709981T3 (enExample) |
| PT (1) | PT2709981T (enExample) |
| RU (1) | RU2627354C2 (enExample) |
| SG (2) | SG10201706859QA (enExample) |
| TR (1) | TR201906107T4 (enExample) |
| WO (1) | WO2012159704A1 (enExample) |
| ZA (1) | ZA201309638B (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT2709981T (pt) * | 2011-05-20 | 2019-05-30 | Merck Patent Gmbh | Preparação de modificações cristalinas estáveis de cloreto de dotap |
| KR102583917B1 (ko) * | 2014-12-08 | 2023-10-04 | 니치유 가부시키가이샤 | 양이온성 지질을 제조하는 방법 |
| CN107827762B (zh) * | 2017-11-14 | 2020-10-02 | 苏州东南药业股份有限公司 | 一种(2,3-二油酰基-丙基)三甲基氯化铵及其制备方法和用途 |
| CN119371322A (zh) * | 2023-07-27 | 2025-01-28 | 上海医药工业研究院有限公司 | 一种1,2-二油酰氧基-3-(二甲氨基)丙烷的制备和纯化方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5264618A (en) | 1990-04-19 | 1993-11-23 | Vical, Inc. | Cationic lipids for intracellular delivery of biologically active molecules |
| DE4013632A1 (de) | 1990-04-27 | 1991-10-31 | Max Planck Gesellschaft | Liposomen mit positiver ueberschussladung |
| DE19521412A1 (de) * | 1995-06-14 | 1996-12-19 | Boehringer Mannheim Gmbh | Neue kationische und polykationische Amphiphile, diese enthaltende Reagenzien und deren Verwendung |
| US5869715A (en) | 1995-09-27 | 1999-02-09 | The Reagents Of The University Of California | Polyfunctional cationic cytofectins |
| US20030129223A1 (en) | 2000-10-11 | 2003-07-10 | Targesome, Inc. | Targeted multivalent macromolecules |
| AU2002953285A0 (en) * | 2002-12-12 | 2003-01-02 | Protech Research Pty Ltd | Yeast treatment |
| ITMI20032185A1 (it) * | 2003-11-12 | 2005-05-13 | Chemi Spa | Processo per la sintesi di lipidi cationici. |
| DE102004057303A1 (de) * | 2004-11-26 | 2006-06-01 | Merck Patent Gmbh | Stabile Kristallmodifikationen von DOTAP Chlorid |
| PT2709981T (pt) * | 2011-05-20 | 2019-05-30 | Merck Patent Gmbh | Preparação de modificações cristalinas estáveis de cloreto de dotap |
-
2012
- 2012-05-02 PT PT12719274T patent/PT2709981T/pt unknown
- 2012-05-02 CN CN201810169562.7A patent/CN108285422A/zh active Pending
- 2012-05-02 SG SG10201706859QA patent/SG10201706859QA/en unknown
- 2012-05-02 TR TR2019/06107T patent/TR201906107T4/tr unknown
- 2012-05-02 BR BR122021007641A patent/BR122021007641B8/pt active Search and Examination
- 2012-05-02 RU RU2013156477A patent/RU2627354C2/ru active
- 2012-05-02 CA CA2836499A patent/CA2836499C/en active Active
- 2012-05-02 WO PCT/EP2012/001882 patent/WO2012159704A1/en not_active Ceased
- 2012-05-02 MX MX2013013403A patent/MX361369B/es active IP Right Grant
- 2012-05-02 JP JP2014511756A patent/JP6290076B2/ja active Active
- 2012-05-02 KR KR1020137034017A patent/KR101974231B1/ko active Active
- 2012-05-02 US US14/118,571 patent/US10000445B2/en active Active
- 2012-05-02 HU HUE12719274A patent/HUE042949T2/hu unknown
- 2012-05-02 PL PL12719274T patent/PL2709981T3/pl unknown
- 2012-05-02 EP EP12719274.8A patent/EP2709981B1/en active Active
- 2012-05-02 SG SG2013084363A patent/SG194957A1/en unknown
- 2012-05-02 AU AU2012261276A patent/AU2012261276B2/en active Active
- 2012-05-02 ES ES12719274T patent/ES2726526T3/es active Active
- 2012-05-02 CN CN201280024160.9A patent/CN103547560A/zh active Pending
- 2012-05-02 BR BR112013029588-0A patent/BR112013029588B1/pt active IP Right Grant
-
2013
- 2013-10-30 IL IL229146A patent/IL229146B/en active IP Right Grant
- 2013-12-18 NO NO20131703A patent/NO344225B1/no unknown
- 2013-12-19 ZA ZA2013/09638A patent/ZA201309638B/en unknown
-
2016
- 2016-12-02 JP JP2016234716A patent/JP2017075166A/ja active Pending
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2018
- 2018-08-22 HK HK18110787.6A patent/HK1251217A1/zh unknown
- 2018-09-25 JP JP2018178658A patent/JP2018203776A/ja active Pending
Also Published As
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| Publication | Publication Date | Title |
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| US9457087B2 (en) | Stable crystal modifications of DOTAP chloride | |
| JP2018203776A (ja) | Ｄｏｔａｐ塩化物の安定な結晶改質物 | |
| HK1192536A (en) | Stable crystal modifications of dotap chloride | |
| NZ619175B2 (en) | Stable crystal modifications of dotap chloride | |
| HK1178143B (en) | Stable crystalline modifications of dotap chloride |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
| B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 02/05/2012, OBSERVADAS AS CONDICOES LEGAIS. |