BR112013025128A2 - derivados de pirrol como moduladores de receptor de acetilcolina nicotínico para uso no tratamento de distúrbios neurodegenenerativos tal como doença de alzheimer e doença de parkinson - Google Patents
derivados de pirrol como moduladores de receptor de acetilcolina nicotínico para uso no tratamento de distúrbios neurodegenenerativos tal como doença de alzheimer e doença de parkinsonInfo
- Publication number
- BR112013025128A2 BR112013025128A2 BR112013025128A BR112013025128A BR112013025128A2 BR 112013025128 A2 BR112013025128 A2 BR 112013025128A2 BR 112013025128 A BR112013025128 A BR 112013025128A BR 112013025128 A BR112013025128 A BR 112013025128A BR 112013025128 A2 BR112013025128 A2 BR 112013025128A2
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- Prior art keywords
- disease
- alzheimer
- acetylcholine receptor
- nicotinic acetylcholine
- parkinson
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- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/402—1-aryl substituted, e.g. piretanide
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- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
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- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
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- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
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- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pyrrole Compounds (AREA)
Abstract
derivados de pirrol como moduladores de receptor de acetilcolina nicotínico para uso no tratamento de distúrbios neurodegenenerativos tal como doença de alzheimer e doença de parkinson é revelado um composto da fórmula i: em que "a" e r^ 1^ a r^ 5^ são conforme descrito no presente documento, como um modulador de receptores nicotínicos de acetilcolina, particulamente o subtipo <244>7, em um sujeito que precisa do mesmo, assim como análogos, pró-fármacos, análogos isitopicamente substituídos, metabólitos, sais farmaceuticamente aceitáveis, polimorfos, solvatos, isômeros, claratos e cocristais dos mesmos, para uso seja sozinho ou em combinações com outros medicamentos adequados e composições farmacêuticas que contém tais compostos e análogos. um processo de preparação dos compostos e os usos pretendidos dos mesmos em terapia, particularmente na profilaxia e na terapia de distúrbios tais como doença de alzheimer, deficiência cognitiva leve, demência senil e semelhantes também são revelados.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN458KO2011 | 2011-03-31 | ||
PCT/IB2012/051451 WO2012131576A1 (en) | 2011-03-31 | 2012-03-27 | Pyrrole derivatives as nicotinic acetylcholine receptor modulators for use in the treatment of neurodegenerative disorders such as alzheimer's and parkinson's disease |
Publications (1)
Publication Number | Publication Date |
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BR112013025128A2 true BR112013025128A2 (pt) | 2017-02-14 |
Family
ID=54192842
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112013025128A BR112013025128A2 (pt) | 2011-03-31 | 2012-03-27 | derivados de pirrol como moduladores de receptor de acetilcolina nicotínico para uso no tratamento de distúrbios neurodegenenerativos tal como doença de alzheimer e doença de parkinson |
Country Status (12)
Country | Link |
---|---|
US (1) | US9187420B2 (pt) |
EP (1) | EP2691368A1 (pt) |
JP (2) | JP2014509641A (pt) |
KR (1) | KR20140025395A (pt) |
CN (1) | CN103443075A (pt) |
AU (1) | AU2012235779B2 (pt) |
BR (1) | BR112013025128A2 (pt) |
CA (1) | CA2829860A1 (pt) |
MX (1) | MX344696B (pt) |
SG (1) | SG193387A1 (pt) |
WO (1) | WO2012131576A1 (pt) |
ZA (1) | ZA201306833B (pt) |
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AP3649A (en) | 2011-02-23 | 2016-03-18 | Lupin Ltd | Heteroaryl derivatives as alpha7 nachr modulators |
KR20140025395A (ko) * | 2011-03-31 | 2014-03-04 | 루핀 리미티드 | 알츠하이머병 및 파킨슨병을 포함하는 신경병성 장애 치료용 니코틴성 아세틸콜린 수용체 조절인자로서의 피롤 유도체 |
AU2013229177B2 (en) | 2012-03-06 | 2017-03-23 | Lupin Limited | Thiazole derivatives as alpha 7 nAChR modulators |
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WO2014203150A1 (en) | 2013-06-17 | 2014-12-24 | Lupin Limited | Pyrrole derivatives as alpha 7 nachr modulators |
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EP3307269A4 (en) | 2015-06-10 | 2019-02-20 | Axovant Sciences GmbH | AMINOBENZIS OXAZOL COMPOUNDS AS AGONISTS OF A7 NICOTINE ACETYLCHOLIN RECEPTORS |
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JO3078B1 (ar) | 2009-11-27 | 2017-03-15 | Janssen Pharmaceutica Nv | مورفولينوثيازولات بصفتها منظمات الوستيرية نوع الفا 7 موجبة |
EP2670744B1 (en) * | 2011-02-03 | 2015-05-27 | Lupin Limited | Pyrrole derivatives used as modulators of alpha7 nachr |
KR20140025395A (ko) * | 2011-03-31 | 2014-03-04 | 루핀 리미티드 | 알츠하이머병 및 파킨슨병을 포함하는 신경병성 장애 치료용 니코틴성 아세틸콜린 수용체 조절인자로서의 피롤 유도체 |
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2012
- 2012-03-27 KR KR1020137027448A patent/KR20140025395A/ko not_active Application Discontinuation
- 2012-03-27 CN CN2012800153608A patent/CN103443075A/zh active Pending
- 2012-03-27 MX MX2013011290A patent/MX344696B/es active IP Right Grant
- 2012-03-27 EP EP12715188.4A patent/EP2691368A1/en not_active Withdrawn
- 2012-03-27 BR BR112013025128A patent/BR112013025128A2/pt not_active IP Right Cessation
- 2012-03-27 AU AU2012235779A patent/AU2012235779B2/en not_active Ceased
- 2012-03-27 CA CA2829860A patent/CA2829860A1/en not_active Abandoned
- 2012-03-27 WO PCT/IB2012/051451 patent/WO2012131576A1/en active Application Filing
- 2012-03-27 SG SG2013068077A patent/SG193387A1/en unknown
- 2012-03-27 JP JP2014501763A patent/JP2014509641A/ja active Pending
- 2012-03-27 US US14/007,458 patent/US9187420B2/en not_active Expired - Fee Related
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2013
- 2013-09-11 ZA ZA2013/06833A patent/ZA201306833B/en unknown
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2017
- 2017-01-12 JP JP2017003574A patent/JP2017081986A/ja active Pending
Also Published As
Publication number | Publication date |
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MX344696B (es) | 2017-01-03 |
WO2012131576A1 (en) | 2012-10-04 |
EP2691368A1 (en) | 2014-02-05 |
US20140018327A1 (en) | 2014-01-16 |
SG193387A1 (en) | 2013-10-30 |
AU2012235779B2 (en) | 2017-03-02 |
KR20140025395A (ko) | 2014-03-04 |
JP2014509641A (ja) | 2014-04-21 |
JP2017081986A (ja) | 2017-05-18 |
NZ615583A (en) | 2015-09-25 |
US9187420B2 (en) | 2015-11-17 |
AU2012235779A1 (en) | 2013-10-03 |
CN103443075A (zh) | 2013-12-11 |
CA2829860A1 (en) | 2012-10-04 |
ZA201306833B (en) | 2015-04-29 |
MX2013011290A (es) | 2013-12-06 |
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