BR112013024706B1 - Método para preparar análogos de exendina peguilada e análogo de exendina peguilada - Google Patents
Método para preparar análogos de exendina peguilada e análogo de exendina peguilada Download PDFInfo
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- BR112013024706B1 BR112013024706B1 BR112013024706-1A BR112013024706A BR112013024706B1 BR 112013024706 B1 BR112013024706 B1 BR 112013024706B1 BR 112013024706 A BR112013024706 A BR 112013024706A BR 112013024706 B1 BR112013024706 B1 BR 112013024706B1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C07K14/575—Hormones
- C07K14/57563—Vasoactive intestinal peptide [VIP]; Related peptides
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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Landscapes
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| PCT/CN2012/071910 WO2012130015A1 (zh) | 2011-03-30 | 2012-03-05 | 定点单取代聚乙二醇化Exendin类似物及其制备方法 |
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| WO2015086728A1 (en) | 2013-12-13 | 2015-06-18 | Sanofi | Exendin-4 peptide analogues as dual glp-1/gip receptor agonists |
| EP3080154B1 (en) | 2013-12-13 | 2018-02-07 | Sanofi | Dual glp-1/gip receptor agonists |
| KR101768446B1 (ko) | 2014-03-21 | 2017-08-17 | 애니젠 주식회사 | 신규한 엑세나타이드 유사체 및 그의 용도 |
| TW201625670A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自ｅｘｅｎｄｉｎ－４之雙重ｇｌｐ－１／升糖素受體促效劑 |
| TW201625668A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 作為胜肽性雙重ｇｌｐ－１／昇糖素受體激動劑之艾塞那肽－４衍生物 |
| TW201625669A (zh) | 2014-04-07 | 2016-07-16 | 賽諾菲公司 | 衍生自艾塞那肽－４（Ｅｘｅｎｄｉｎ－４）之肽類雙重ＧＬＰ－１／升糖素受體促效劑 |
| US9932381B2 (en) | 2014-06-18 | 2018-04-03 | Sanofi | Exendin-4 derivatives as selective glucagon receptor agonists |
| AR105319A1 (es) | 2015-06-05 | 2017-09-27 | Sanofi Sa | Profármacos que comprenden un conjugado agonista dual de glp-1 / glucagón conector ácido hialurónico |
| TW201706291A (zh) | 2015-07-10 | 2017-02-16 | 賽諾菲公司 | 作為選擇性肽雙重ｇｌｐ－１／升糖素受體促效劑之新毒蜥外泌肽（ｅｘｅｎｄｉｎ－４）衍生物 |
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| CN1162446C (zh) * | 2001-05-10 | 2004-08-18 | 上海华谊生物技术有限公司 | 促胰岛素分泌肽衍生物 |
| CN100357313C (zh) * | 2003-01-18 | 2007-12-26 | 派格斯菲尔有限公司 | 非靶位点胺基被保护的肽,其制备方法以及使用该肽制备特异性地结合的peg肽的方法 |
| JP2006520818A (ja) * | 2003-03-19 | 2006-09-14 | イーライ リリー アンド カンパニー | ポリエチレングリコール結合ｇｌｐ−１化合物 |
| US8030273B2 (en) * | 2004-10-07 | 2011-10-04 | Novo Nordisk A/S | Protracted exendin-4 compounds |
| WO2007061148A1 (en) * | 2005-11-24 | 2007-05-31 | Pegsphere Co., Ltd. | Site-specific peg conjugates of glp-1 and methods for production thereof |
| KR100890989B1 (ko) * | 2006-06-01 | 2009-03-31 | 이강춘 | 폴리에틸렌글리콜 또는 이의 유도체로 단일 수식된 엑센딘,이의 제조방법 및 이의 용도 |
| CN101125207B (zh) * | 2006-11-14 | 2012-09-05 | 上海华谊生物技术有限公司 | 带有聚乙二醇基团的艾塞丁或其类似物及其制剂和用途 |
| WO2008130666A2 (en) * | 2007-04-20 | 2008-10-30 | Master Key, Llc | System and method for music composition |
| WO2008130066A1 (en) * | 2007-04-20 | 2008-10-30 | Kang Choon Lee | Mono modified exendin with polyethylene glycol or its derivatives and uses thereof |
| MX2011009803A (es) * | 2009-03-20 | 2011-09-30 | Hanmi Holdings Co Ltd | Metodo para preparar un polipeptido conjugado fisiologicamente activo en un sitio especifico. |
| CN101870728A (zh) * | 2009-04-23 | 2010-10-27 | 派格生物医药(苏州)有限公司 | 新型Exendin变体及其缀合物 |
| CN101559041B (zh) * | 2009-05-19 | 2014-01-15 | 中国科学院过程工程研究所 | 粒径均一的多肽药物缓释微球或微囊制剂及制备方法 |
| CN104147611A (zh) * | 2009-09-30 | 2014-11-19 | 葛兰素集团有限公司 | 具有延长的半衰期的药物融合体和缀合物 |
| CN102397558B (zh) * | 2010-09-09 | 2013-08-14 | 中国人民解放军军事医学科学院毒物药物研究所 | Exendin-4类似物的定位聚乙二醇化修饰物及其用途 |
-
2011
- 2011-03-30 CN CN201710091006.8A patent/CN106928341B/zh active Active
- 2011-03-30 CN CN201110078314XA patent/CN102718868A/zh active Pending
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2012
- 2012-03-05 EP EP12765410.1A patent/EP2692730B1/en active Active
- 2012-03-05 RU RU2013147468A patent/RU2625015C2/ru active
- 2012-03-05 BR BR112013024706-1A patent/BR112013024706B1/pt active IP Right Grant
- 2012-03-05 KR KR1020137028242A patent/KR102005385B1/ko active Active
- 2012-03-05 CA CA2829122A patent/CA2829122C/en active Active
- 2012-03-05 JP JP2014501409A patent/JP6297969B2/ja active Active
- 2012-03-05 AU AU2012237899A patent/AU2012237899B2/en active Active
- 2012-03-05 WO PCT/CN2012/071910 patent/WO2012130015A1/zh not_active Ceased
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2013
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Also Published As
| Publication number | Publication date |
|---|---|
| BR112013024706A2 (pt) | 2016-09-06 |
| CA2829122C (en) | 2022-05-03 |
| KR102005385B1 (ko) | 2019-07-30 |
| WO2012130015A1 (zh) | 2012-10-04 |
| JP6297969B2 (ja) | 2018-03-20 |
| AU2012237899A1 (en) | 2013-09-19 |
| CN106928341B (zh) | 2021-06-01 |
| CA2829122A1 (en) | 2012-10-04 |
| EP2692730B1 (en) | 2018-11-14 |
| EP2692730A4 (en) | 2015-04-01 |
| CN102718868A (zh) | 2012-10-10 |
| JP2014510735A (ja) | 2014-05-01 |
| RU2013147468A (ru) | 2015-05-10 |
| RU2625015C2 (ru) | 2017-07-11 |
| US20140142037A1 (en) | 2014-05-22 |
| AU2012237899B2 (en) | 2017-04-13 |
| CN106928341A (zh) | 2017-07-07 |
| KR20140033023A (ko) | 2014-03-17 |
| EP2692730A1 (en) | 2014-02-05 |
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