BR112013012627A2 - proteína de ligação de antígeno, polinucleotídeo, composição farmacêutica, e uso da referida composição - Google Patents
proteína de ligação de antígeno, polinucleotídeo, composição farmacêutica, e uso da referida composiçãoInfo
- Publication number
- BR112013012627A2 BR112013012627A2 BR112013012627A BR112013012627A BR112013012627A2 BR 112013012627 A2 BR112013012627 A2 BR 112013012627A2 BR 112013012627 A BR112013012627 A BR 112013012627A BR 112013012627 A BR112013012627 A BR 112013012627A BR 112013012627 A2 BR112013012627 A2 BR 112013012627A2
- Authority
- BR
- Brazil
- Prior art keywords
- composition
- polynucleotide
- flow meter
- fuel flow
- antigen binding
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- C07K16/248—IL-6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/515—Complete light chain, i.e. VL + CL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/522—CH1 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/54—F(ab')2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Pain & Pain Management (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Volume Flow (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
proteína de ligação de antígeno, polinucleotídeo, composição farmacêutica, método de tratar um paciente humano afetado com um distúrbio ou doença imflamatória, e uso da composição. métodos e sistemas para detectar fraude causada por adulteração de um medidor de fluxo de combustível. em uma forma de realização, o método compreende prover um medidor de fluxo de combustível para medir o fluxo de combustível líquido. o medidor de fluxo tem pelo menos um eixo suportando um rotor. o método compreende adicionalmente prover o medidor de fluxo com um sensor de deslocamento rotativo. também, o método compreende medir uma primeira posição angular do eixo no término de uma primeira transação de abastecimento, e medir uma segunda posição angular do eixo no início de uma segunda transação de abastecimento. finalmente, o método compreende comparar dados indicativos das primeiras e segunda posições angulares do eixo para determinar se ocorreu fraude.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US41649510P | 2010-11-23 | 2010-11-23 | |
PCT/EP2011/070604 WO2012069433A2 (en) | 2010-11-23 | 2011-11-21 | Antigen binding proteins |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112013012627A2 true BR112013012627A2 (pt) | 2016-10-04 |
Family
ID=45001764
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112013012627A BR112013012627A2 (pt) | 2010-11-23 | 2011-11-21 | proteína de ligação de antígeno, polinucleotídeo, composição farmacêutica, e uso da referida composição |
Country Status (38)
Country | Link |
---|---|
US (4) | US8916695B2 (pt) |
EP (3) | EP3369744A1 (pt) |
JP (2) | JP6351973B2 (pt) |
KR (2) | KR20130119948A (pt) |
CN (1) | CN103328508B (pt) |
AR (1) | AR083937A1 (pt) |
AU (1) | AU2011333878B2 (pt) |
BR (1) | BR112013012627A2 (pt) |
CA (1) | CA2818534A1 (pt) |
CL (1) | CL2013001466A1 (pt) |
CO (1) | CO6801627A2 (pt) |
CY (1) | CY1120448T1 (pt) |
DK (1) | DK2643352T3 (pt) |
DO (1) | DOP2013000113A (pt) |
EA (1) | EA027256B1 (pt) |
ES (1) | ES2681949T3 (pt) |
HR (1) | HRP20181092T1 (pt) |
HU (1) | HUE039412T2 (pt) |
IL (1) | IL226157B (pt) |
JO (1) | JO3455B1 (pt) |
LT (1) | LT2643352T (pt) |
MA (1) | MA34742B1 (pt) |
ME (1) | ME03069B (pt) |
MX (1) | MX351887B (pt) |
MY (1) | MY170404A (pt) |
NZ (1) | NZ610464A (pt) |
PE (1) | PE20140519A1 (pt) |
PL (1) | PL2643352T3 (pt) |
PT (1) | PT2643352T (pt) |
RS (1) | RS57502B1 (pt) |
SG (2) | SG190232A1 (pt) |
SI (1) | SI2643352T1 (pt) |
TR (1) | TR201810773T4 (pt) |
TW (1) | TWI504609B (pt) |
UA (1) | UA111954C2 (pt) |
UY (1) | UY33743A (pt) |
WO (1) | WO2012069433A2 (pt) |
ZA (1) | ZA201303541B (pt) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN103261223B (zh) | 2010-10-13 | 2017-03-29 | 詹森生物科技公司 | 人制瘤素m抗体及使用方法 |
TR201810773T4 (tr) | 2010-11-23 | 2018-08-27 | Glaxo Group Ltd | Onkostatin m?ye (osm) antijen bağlayıcı proteinler. |
US9550828B2 (en) | 2013-09-05 | 2017-01-24 | Boise State University | Oncostatin M (OSM) antagonists for preventing cancer metastasis and IL-6 related disorders |
US20170327573A1 (en) | 2014-09-24 | 2017-11-16 | Universitá Degli Studi Di Padova | Composition to induce bone marrow stem cell mobilization |
EP3974450A3 (en) | 2015-01-29 | 2022-06-22 | Oxford University Innovation Limited | Biomarker |
GB201614627D0 (en) * | 2016-08-30 | 2016-10-12 | Glaxosmithkline Ip Dev Ltd | Antigen binding proteins |
FR3090637A1 (fr) * | 2018-12-21 | 2020-06-26 | Universite De Poitiers | Protéine de liaison spécifique capable de se lier spécifiquement à l’oncostatine M humaine (hOSM) et ses utilisations. |
US11633457B2 (en) | 2019-04-11 | 2023-04-25 | Boise State University | Pharmaceutical compositions comprising oncostatin m (OSM) antagonist derivatives and methods of use |
Family Cites Families (48)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS57106673A (en) | 1980-12-24 | 1982-07-02 | Chugai Pharmaceut Co Ltd | Dibenzo(b,f)(1,4)oxazepin derivative |
US4666884A (en) | 1984-04-10 | 1987-05-19 | New England Deaconess Hospital | Method of inhibiting binding of von Willebrand factor to human platelets and inducing interaction of platelets with vessel walls |
GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
JP3101690B2 (ja) | 1987-03-18 | 2000-10-23 | エス・ビィ・2・インコーポレイテッド | 変性抗体の、または変性抗体に関する改良 |
US4873316A (en) | 1987-06-23 | 1989-10-10 | Biogen, Inc. | Isolation of exogenous recombinant proteins from the milk of transgenic mammals |
ATE158615T1 (de) | 1990-03-20 | 1997-10-15 | Univ Columbia | Chimäre antikörper mit rezeptor-bindenden liganden anstelle ihrer konstanten region |
CA2118508A1 (en) | 1992-04-24 | 1993-11-11 | Elizabeth S. Ward | Recombinant production of immunoglobulin-like domains in prokaryotic cells |
US5783672A (en) * | 1994-05-26 | 1998-07-21 | Immunex Corporation | Receptor for oncostatin M |
GB9424449D0 (en) | 1994-12-02 | 1995-01-18 | Wellcome Found | Antibodies |
US5747035A (en) | 1995-04-14 | 1998-05-05 | Genentech, Inc. | Polypeptides with increased half-life for use in treating disorders involving the LFA-1 receptor |
US6096871A (en) | 1995-04-14 | 2000-08-01 | Genentech, Inc. | Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life |
US5869046A (en) | 1995-04-14 | 1999-02-09 | Genentech, Inc. | Altered polypeptides with increased half-life |
WO1997043316A1 (en) | 1996-05-10 | 1997-11-20 | Beth Israel Deaconess Medical Center, Inc. | Physiologically active molecules with extended half-lives and methods of using same |
DE19742706B4 (de) | 1997-09-26 | 2013-07-25 | Pieris Proteolab Ag | Lipocalinmuteine |
US5958442A (en) * | 1997-10-24 | 1999-09-28 | Bristol-Myers Squibb Company | Oncostatin M for treating inflammation |
PL199659B1 (pl) | 1998-02-25 | 2008-10-31 | Merck Patent Gmbh | Białko fuzyjne przeciwciała hu-KS IL2, cząsteczka DNA kodująca białko fuzyjne przeciwciała hu-KS IL2 i sposób wytwarzania białka fuzyjnego przeciwciała hu-KS IL2 |
GB9806530D0 (en) * | 1998-03-26 | 1998-05-27 | Glaxo Group Ltd | Inflammatory mediator |
GB9809839D0 (en) | 1998-05-09 | 1998-07-08 | Glaxo Group Ltd | Antibody |
EP1105427A2 (en) | 1998-08-17 | 2001-06-13 | Abgenix, Inc. | Generation of modified molecules with increased serum half-lives |
IL127127A0 (en) | 1998-11-18 | 1999-09-22 | Peptor Ltd | Small functional units of antibody heavy chain variable regions |
US6818418B1 (en) | 1998-12-10 | 2004-11-16 | Compound Therapeutics, Inc. | Protein scaffolds for antibody mimics and other binding proteins |
US7115396B2 (en) | 1998-12-10 | 2006-10-03 | Compound Therapeutics, Inc. | Protein scaffolds for antibody mimics and other binding proteins |
PL209786B1 (pl) | 1999-01-15 | 2011-10-31 | Genentech Inc | Przeciwciało zawierające wariant regionu Fc ludzkiej IgG1, przeciwciało wiążące czynnik wzrostu śródbłonka naczyń oraz immunoadhezyna |
ES2569919T3 (es) | 1999-04-09 | 2016-05-13 | Kyowa Hakko Kirin Co., Ltd. | Procedimiento para controlar la actividad de una molécula inmunofuncional |
WO2001029246A1 (fr) | 1999-10-19 | 2001-04-26 | Kyowa Hakko Kogyo Co., Ltd. | Procede de production d'un polypeptide |
DE60037648T2 (de) * | 2000-04-21 | 2010-06-17 | Conaris Research Institute Ag | Fusionsproteine, die zwei lösliche gp130 Moleküle enthalten |
JP5291279B2 (ja) | 2000-09-08 | 2013-09-18 | ウニヴェルジテート・チューリッヒ | 反復モジュールを含む反復タンパク質の集合体 |
US6374470B1 (en) | 2000-10-06 | 2002-04-23 | Milliken & Company | Face plate for spun-like textured yarn |
US6946292B2 (en) | 2000-10-06 | 2005-09-20 | Kyowa Hakko Kogyo Co., Ltd. | Cells producing antibody compositions with increased antibody dependent cytotoxic activity |
EP2357187A1 (en) | 2000-12-12 | 2011-08-17 | MedImmune, LLC | Molecules with extended half-lives, compositions and uses thereof |
IL166244A0 (en) * | 2001-07-12 | 2006-01-15 | Jefferson Foote | Super humanized antibodies |
NZ603111A (en) | 2001-08-03 | 2014-05-30 | Roche Glycart Ag | Antibody glycosylation variants having increased antibody-dependent cellular cytotoxicity |
CA2457636C (en) | 2001-08-10 | 2012-01-03 | Aberdeen University | Antigen binding domains |
WO2005003156A1 (en) | 2003-07-04 | 2005-01-13 | Affibody Ab | Polypeptides having binding affinity for her2 |
AU2003275958A1 (en) | 2003-08-25 | 2005-03-10 | Pieris Proteolab Ag | Muteins of tear lipocalin |
PE20050925A1 (es) * | 2003-11-10 | 2005-11-29 | Schering Corp | Anticuerpo recombinante humanizado anti-interleuquina 10 |
BRPI0417302A (pt) | 2003-12-05 | 2007-03-06 | Compound Therapeutics Inc | inibidores de receptores de fator de crescimento endotelial vascular do tipo 2 |
GB0407197D0 (en) * | 2004-03-30 | 2004-05-05 | Glaxo Group Ltd | Immunoglobulins |
SI1730191T1 (sl) * | 2004-03-30 | 2011-11-30 | Glaxo Group Ltd | Imunoglobulin-vezavni hOSM |
CA2573745A1 (en) | 2004-07-21 | 2007-01-12 | Glycofi, Inc. | Immunoglobulins comprising predominantly a glcnac2man3glcnac2 glycoform |
US7923538B2 (en) | 2005-07-22 | 2011-04-12 | Kyowa Hakko Kirin Co., Ltd | Recombinant antibody composition |
KR101318611B1 (ko) | 2005-07-22 | 2013-11-13 | 교와 핫꼬 기린 가부시키가이샤 | 유전자 재조합 항체 조성물 |
ES2514495T3 (es) * | 2006-05-25 | 2014-10-28 | Glaxo Group Limited | Anticuerpos humanizados modificados anti-interleucina-18 |
EP1958957A1 (en) | 2007-02-16 | 2008-08-20 | NascaCell Technologies AG | Polypeptide comprising a knottin protein moiety |
WO2010056893A1 (en) * | 2008-11-13 | 2010-05-20 | Imclone Llc | Humanization and affinity-optimization of antibodies |
CN103261223B (zh) * | 2010-10-13 | 2017-03-29 | 詹森生物科技公司 | 人制瘤素m抗体及使用方法 |
TR201810773T4 (tr) | 2010-11-23 | 2018-08-27 | Glaxo Group Ltd | Onkostatin m?ye (osm) antijen bağlayıcı proteinler. |
-
2011
- 2011-11-21 TR TR2018/10773T patent/TR201810773T4/tr unknown
- 2011-11-21 DK DK11785424.0T patent/DK2643352T3/en active
- 2011-11-21 NZ NZ610464A patent/NZ610464A/en not_active IP Right Cessation
- 2011-11-21 MY MYPI2013700832A patent/MY170404A/en unknown
- 2011-11-21 CN CN201180065512.0A patent/CN103328508B/zh active Active
- 2011-11-21 HU HUE11785424A patent/HUE039412T2/hu unknown
- 2011-11-21 UY UY0001033743A patent/UY33743A/es not_active Application Discontinuation
- 2011-11-21 LT LTEP11785424.0T patent/LT2643352T/lt unknown
- 2011-11-21 KR KR1020137016213A patent/KR20130119948A/ko active Application Filing
- 2011-11-21 JO JOP/2011/0353A patent/JO3455B1/ar active
- 2011-11-21 PE PE2013001238A patent/PE20140519A1/es active IP Right Grant
- 2011-11-21 PT PT117854240T patent/PT2643352T/pt unknown
- 2011-11-21 EA EA201390537A patent/EA027256B1/ru not_active IP Right Cessation
- 2011-11-21 MX MX2013005843A patent/MX351887B/es active IP Right Grant
- 2011-11-21 KR KR1020187027871A patent/KR101947356B1/ko active IP Right Grant
- 2011-11-21 EP EP18163940.2A patent/EP3369744A1/en not_active Withdrawn
- 2011-11-21 JP JP2013539295A patent/JP6351973B2/ja active Active
- 2011-11-21 UA UAA201305873A patent/UA111954C2/uk unknown
- 2011-11-21 EP EP17166131.7A patent/EP3211009A1/en not_active Withdrawn
- 2011-11-21 ES ES11785424.0T patent/ES2681949T3/es active Active
- 2011-11-21 AR ARP110104328A patent/AR083937A1/es unknown
- 2011-11-21 ME MEP-2018-182A patent/ME03069B/me unknown
- 2011-11-21 EP EP11785424.0A patent/EP2643352B1/en active Active
- 2011-11-21 WO PCT/EP2011/070604 patent/WO2012069433A2/en active Application Filing
- 2011-11-21 CA CA2818534A patent/CA2818534A1/en not_active Abandoned
- 2011-11-21 SI SI201131537T patent/SI2643352T1/sl unknown
- 2011-11-21 PL PL11785424T patent/PL2643352T3/pl unknown
- 2011-11-21 US US13/989,191 patent/US8916695B2/en active Active
- 2011-11-21 SG SG2013035951A patent/SG190232A1/en unknown
- 2011-11-21 TW TW100142577A patent/TWI504609B/zh not_active IP Right Cessation
- 2011-11-21 SG SG10201500388PA patent/SG10201500388PA/en unknown
- 2011-11-21 BR BR112013012627A patent/BR112013012627A2/pt not_active Application Discontinuation
- 2011-11-21 AU AU2011333878A patent/AU2011333878B2/en active Active
- 2011-11-21 RS RS20180819A patent/RS57502B1/sr unknown
-
2013
- 2013-05-05 IL IL226157A patent/IL226157B/en active IP Right Grant
- 2013-05-15 ZA ZA2013/03541A patent/ZA201303541B/en unknown
- 2013-05-17 CO CO13122422A patent/CO6801627A2/es unknown
- 2013-05-21 DO DO2013000113A patent/DOP2013000113A/es unknown
- 2013-05-23 CL CL2013001466A patent/CL2013001466A1/es unknown
- 2013-06-19 MA MA36018A patent/MA34742B1/fr unknown
-
2014
- 2014-11-13 US US14/540,247 patent/US9605063B2/en active Active
-
2016
- 2016-11-11 JP JP2016220093A patent/JP2017078072A/ja active Pending
-
2017
- 2017-02-09 US US15/428,528 patent/US10808029B2/en active Active
-
2018
- 2018-07-11 HR HRP20181092TT patent/HRP20181092T1/hr unknown
- 2018-07-24 CY CY20181100770T patent/CY1120448T1/el unknown
-
2020
- 2020-07-09 US US16/924,628 patent/US20210017270A1/en not_active Abandoned
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
BR112013012627A2 (pt) | proteína de ligação de antígeno, polinucleotídeo, composição farmacêutica, e uso da referida composição | |
WO2012076666A3 (en) | Fuel dispenser flow meter sensor fraud prevention | |
BR112013026975A2 (pt) | unidade de medidor de fluxo de combustível | |
BRPI0822593B8 (pt) | Método para detectar, de modo audível, uma mudança de estado de fluxo de fluido e corrigir uma medição de um medidor de fluxo em uma tubulação de medidor de fluxo, e, sistema para melhorar a precisão de um medidor de fluxo | |
Breyer et al. | Better nephrology for mice—and man | |
BR112012020270A2 (pt) | sistema e método para administrar medicamentos com base em valores de urina. | |
EP2549237A3 (en) | High-resolution non-contacting multi-turn sensing systems and methods | |
BR112015005052B8 (pt) | Sistema de medição de fluxo ultrassônico, e, método para compensação de temperatura em medição ultrassônica | |
WO2010092544A3 (en) | Flow meter | |
BR112014006855B8 (pt) | Sistema de medição de fluxo ultrassônico, método para medir fluxo de fluido, e, mídia legível por computador | |
BRPI0909791A2 (pt) | Cartucho, dispositivo sensor e método para detecção de componentes alvo em uma amostra líquida, e, uso do cartucho ou do dispositivo sensor. | |
NZ710981A (en) | Fluid flow meter | |
GB201302242D0 (en) | Apparatus adapted to provide an indication of an angular position of an input member over multiple turns | |
BR112015029794A2 (pt) | disposição para a detecção de um volume de distribuição, dispositivo, sistema de extração, métodos para a detecção de um volume de distribuição e para a medição de uma usina de proteção | |
BR112014008952A2 (pt) | sensor para gás solúvel em fluido | |
BR112015001102A2 (pt) | método de detecção de câncer, droga ou kit e método de seleção de droga terapêutica | |
EP3144670A3 (en) | Anticancer agent sensitivity-determining marker | |
EA201591780A1 (ru) | Обнаружение и предотвращение мошенничества при использовании расходомера топливораздаточной колонки | |
BR112012024619A2 (pt) | sistema e método para avaliação de candidato a medicamento anticancer | |
WO2010080341A3 (en) | A method for field-measuring fluid flow meters | |
HK1136873A1 (en) | Use of nnmt as a marker for lung cancer | |
Li et al. | The benefit of a glucose-sparing PD therapy on glycemic control measured by serum fructosamine in diabetic patients in a randomized, controlled trial (IMPENDIA) | |
BR112014024911B8 (pt) | Sistema de medição de fluxo ultrassônico, e, método para a substituição do medidor de fluxo | |
UA38918U (ru) | Топливная система двигателя с участком для измерения расхода топлива | |
Han | The human capital loss of air pollution in cities, China |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07D | Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette] |
Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NAO 10196/2001, QUE MODIFICOU A LEI NAO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUAANCIA PRA VIA DA ANVISA. CONSIDERANDO A APROVAA AO DOS TERMOS DO PARECER NAO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NAO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDAANCIAS CABA-VEIS. |
|
B07E | Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette] | ||
B06U | Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette] | ||
B11B | Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements | ||
B350 | Update of information on the portal [chapter 15.35 patent gazette] |