MA34742B1 - Proteines de liaison à l'antigène - Google Patents
Proteines de liaison à l'antigèneInfo
- Publication number
- MA34742B1 MA34742B1 MA36018A MA36018A MA34742B1 MA 34742 B1 MA34742 B1 MA 34742B1 MA 36018 A MA36018 A MA 36018A MA 36018 A MA36018 A MA 36018A MA 34742 B1 MA34742 B1 MA 34742B1
- Authority
- MA
- Morocco
- Prior art keywords
- binding proteins
- antigen binding
- osm
- methods
- relates
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
- C07K16/248—IL-6
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/515—Complete light chain, i.e. VL + CL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/522—CH1 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/54—F(ab')2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/567—Framework region [FR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Volume Flow (AREA)
Abstract
L'invention se réfère à des protéines de liaison à l'antigène et à des fragments de celles-ci qui se lient spécifiquement à l'oncostatine M (OSM), en particulier l'OSM humaine (hOSM), et qui inhibent la liaison de l'OSM au récepteur gp130 mais n'interagissent pas directement avec des résidus du site II. L'invention concerne aussi un procédé d'humanisation d'anticorps. Elle concerne en outre des compositions pharmaceutiques, des procédés de criblage et des méthodes de traitement médical.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US41649510P | 2010-11-23 | 2010-11-23 | |
PCT/EP2011/070604 WO2012069433A2 (fr) | 2010-11-23 | 2011-11-21 | Protéines de liaison à l'antigène |
Publications (1)
Publication Number | Publication Date |
---|---|
MA34742B1 true MA34742B1 (fr) | 2013-12-03 |
Family
ID=45001764
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA36018A MA34742B1 (fr) | 2010-11-23 | 2013-06-19 | Proteines de liaison à l'antigène |
Country Status (38)
Country | Link |
---|---|
US (4) | US8916695B2 (fr) |
EP (3) | EP2643352B1 (fr) |
JP (2) | JP6351973B2 (fr) |
KR (2) | KR20130119948A (fr) |
CN (1) | CN103328508B (fr) |
AR (1) | AR083937A1 (fr) |
AU (1) | AU2011333878B2 (fr) |
BR (1) | BR112013012627A2 (fr) |
CA (1) | CA2818534A1 (fr) |
CL (1) | CL2013001466A1 (fr) |
CO (1) | CO6801627A2 (fr) |
CY (1) | CY1120448T1 (fr) |
DK (1) | DK2643352T3 (fr) |
DO (1) | DOP2013000113A (fr) |
EA (1) | EA027256B1 (fr) |
ES (1) | ES2681949T3 (fr) |
HR (1) | HRP20181092T1 (fr) |
HU (1) | HUE039412T2 (fr) |
IL (1) | IL226157B (fr) |
JO (1) | JO3455B1 (fr) |
LT (1) | LT2643352T (fr) |
MA (1) | MA34742B1 (fr) |
ME (1) | ME03069B (fr) |
MX (1) | MX351887B (fr) |
MY (1) | MY170404A (fr) |
NZ (1) | NZ610464A (fr) |
PE (1) | PE20140519A1 (fr) |
PL (1) | PL2643352T3 (fr) |
PT (1) | PT2643352T (fr) |
RS (1) | RS57502B1 (fr) |
SG (2) | SG190232A1 (fr) |
SI (1) | SI2643352T1 (fr) |
TR (1) | TR201810773T4 (fr) |
TW (1) | TWI504609B (fr) |
UA (1) | UA111954C2 (fr) |
UY (1) | UY33743A (fr) |
WO (1) | WO2012069433A2 (fr) |
ZA (1) | ZA201303541B (fr) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2627356B1 (fr) | 2010-10-13 | 2019-05-22 | Janssen Biotech, Inc. | Anticorps contre l'oncostatine m humaine et procédés d'utilisation |
BR112013012627A2 (pt) | 2010-11-23 | 2016-10-04 | Glaxo Group Ltd | proteína de ligação de antígeno, polinucleotídeo, composição farmacêutica, e uso da referida composição |
US9550828B2 (en) | 2013-09-05 | 2017-01-24 | Boise State University | Oncostatin M (OSM) antagonists for preventing cancer metastasis and IL-6 related disorders |
EP3197480A1 (fr) | 2014-09-24 | 2017-08-02 | Universita' Degli Studi Di Padova | Composition pour induire la mobilisation des cellules souches de la moelle osseuse |
EP3250599B1 (fr) | 2015-01-29 | 2021-04-14 | Oxford University Innovation Limited | Biomarqueur |
GB201614627D0 (en) * | 2016-08-30 | 2016-10-12 | Glaxosmithkline Ip Dev Ltd | Antigen binding proteins |
FR3090637A1 (fr) * | 2018-12-21 | 2020-06-26 | Universite De Poitiers | Protéine de liaison spécifique capable de se lier spécifiquement à l’oncostatine M humaine (hOSM) et ses utilisations. |
US11633457B2 (en) | 2019-04-11 | 2023-04-25 | Boise State University | Pharmaceutical compositions comprising oncostatin m (OSM) antagonist derivatives and methods of use |
Family Cites Families (49)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS57106673A (en) | 1980-12-24 | 1982-07-02 | Chugai Pharmaceut Co Ltd | Dibenzo(b,f)(1,4)oxazepin derivative |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US4666884A (en) | 1984-04-10 | 1987-05-19 | New England Deaconess Hospital | Method of inhibiting binding of von Willebrand factor to human platelets and inducing interaction of platelets with vessel walls |
GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
EP0307434B2 (fr) | 1987-03-18 | 1998-07-29 | Scotgen Biopharmaceuticals, Inc. | Anticorps alteres |
US4873316A (en) | 1987-06-23 | 1989-10-10 | Biogen, Inc. | Isolation of exogenous recombinant proteins from the milk of transgenic mammals |
EP0521985B1 (fr) | 1990-03-20 | 1997-09-24 | The Trustees Of Columbia University In The City Of New York | Anticorps chimeriques utilisant des ligands de liaison de recepteurs a la place de leur region constante |
AU4116793A (en) | 1992-04-24 | 1993-11-29 | Board Of Regents, The University Of Texas System | Recombinant production of immunoglobulin-like domains in prokaryotic cells |
US5783672A (en) | 1994-05-26 | 1998-07-21 | Immunex Corporation | Receptor for oncostatin M |
GB9424449D0 (en) | 1994-12-02 | 1995-01-18 | Wellcome Found | Antibodies |
US5869046A (en) | 1995-04-14 | 1999-02-09 | Genentech, Inc. | Altered polypeptides with increased half-life |
US5747035A (en) | 1995-04-14 | 1998-05-05 | Genentech, Inc. | Polypeptides with increased half-life for use in treating disorders involving the LFA-1 receptor |
US6096871A (en) | 1995-04-14 | 2000-08-01 | Genentech, Inc. | Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life |
WO1997043316A1 (fr) | 1996-05-10 | 1997-11-20 | Beth Israel Deaconess Medical Center, Inc. | Molecules physiologiquement actives a demi-vies prolongees et methode d'utilisation de ces dernieres |
DE19742706B4 (de) | 1997-09-26 | 2013-07-25 | Pieris Proteolab Ag | Lipocalinmuteine |
US5958442A (en) * | 1997-10-24 | 1999-09-28 | Bristol-Myers Squibb Company | Oncostatin M for treating inflammation |
EP1060194A1 (fr) | 1998-02-25 | 2000-12-20 | Lexigen Pharmaceuticals Corp. | Amelioration de la demi-vie circulante de proteines hybrides a base d'anticorps |
GB9806530D0 (en) * | 1998-03-26 | 1998-05-27 | Glaxo Group Ltd | Inflammatory mediator |
GB9809839D0 (en) | 1998-05-09 | 1998-07-08 | Glaxo Group Ltd | Antibody |
AU770555B2 (en) | 1998-08-17 | 2004-02-26 | Abgenix, Inc. | Generation of modified molecules with increased serum half-lives |
IL127127A0 (en) | 1998-11-18 | 1999-09-22 | Peptor Ltd | Small functional units of antibody heavy chain variable regions |
US7115396B2 (en) | 1998-12-10 | 2006-10-03 | Compound Therapeutics, Inc. | Protein scaffolds for antibody mimics and other binding proteins |
US6818418B1 (en) | 1998-12-10 | 2004-11-16 | Compound Therapeutics, Inc. | Protein scaffolds for antibody mimics and other binding proteins |
KR100887482B1 (ko) | 1999-01-15 | 2009-03-10 | 제넨테크, 인크. | 효과기 기능이 변화된 폴리펩티드 변이체 |
EP3031917A1 (fr) | 1999-04-09 | 2016-06-15 | Kyowa Hakko Kirin Co., Ltd. | Procédé de contrôle de l'activité d'une molécule immunologiquement fonctionnelle |
US7504256B1 (en) | 1999-10-19 | 2009-03-17 | Kyowa Hakko Kogyo Co., Ltd. | Process for producing polypeptide |
EP1148065B1 (fr) * | 2000-04-21 | 2008-01-02 | CONARIS research institute AG | Protéines de fusion comprenant deux molécules gp130 solubles |
AU2002218166A1 (en) | 2000-09-08 | 2002-03-22 | Universitat Zurich | Collections of repeat proteins comprising repeat modules |
US6374470B1 (en) | 2000-10-06 | 2002-04-23 | Milliken & Company | Face plate for spun-like textured yarn |
US6946292B2 (en) | 2000-10-06 | 2005-09-20 | Kyowa Hakko Kogyo Co., Ltd. | Cells producing antibody compositions with increased antibody dependent cytotoxic activity |
WO2002060919A2 (fr) | 2000-12-12 | 2002-08-08 | Medimmune, Inc. | Molecules a demi-vies longues, compositions et utilisations de celles-ci |
MXPA05000511A (es) * | 2001-07-12 | 2005-09-30 | Jefferson Foote | Anticuepros super humanizados. |
NZ581474A (en) | 2001-08-03 | 2011-04-29 | Glycart Biotechnology Ag | Antibody glycosylation variants having increased antibody-dependent cellular cytotoxicity |
JP5133494B2 (ja) | 2001-08-10 | 2013-01-30 | アバディーン ユニバーシティ | 抗原結合ドメイン |
EP1641818B1 (fr) | 2003-07-04 | 2008-12-03 | Affibody AB | Polypeptides presentant une affinite de liaison pour le recepteur 2 du facteur de croissance epidermique humain (her2) |
AU2003275958A1 (en) | 2003-08-25 | 2005-03-10 | Pieris Proteolab Ag | Muteins of tear lipocalin |
WO2005047324A2 (fr) * | 2003-11-10 | 2005-05-26 | Schering Corp | Anticorps anti-interleukine-10 |
MXPA06006406A (es) | 2003-12-05 | 2007-03-21 | Adnexus Therapeutics Inc | Inhibidores de receptores de factor de crecimiento endotelial vascular tipo 2. |
GB0407197D0 (en) * | 2004-03-30 | 2004-05-05 | Glaxo Group Ltd | Immunoglobulins |
PE20060287A1 (es) * | 2004-03-30 | 2006-05-16 | Glaxo Group Ltd | INMUNOGLOBULINAS DE UNION SELECTIVA A hOSM |
AU2005269759A1 (en) | 2004-07-21 | 2006-02-09 | Glycofi, Inc. | Immunoglobulins comprising predominantly a GlcNAc2Man3GlcNAc2 glycoform |
JP4997108B2 (ja) | 2005-07-22 | 2012-08-08 | 協和発酵キリン株式会社 | 遺伝子組換え抗体組成物 |
US7923538B2 (en) | 2005-07-22 | 2011-04-12 | Kyowa Hakko Kirin Co., Ltd | Recombinant antibody composition |
EP2027157B1 (fr) * | 2006-05-25 | 2014-08-06 | Glaxo Group Limited | Anticorps anti-interleukine-18, modifies et humanises |
EP1958957A1 (fr) | 2007-02-16 | 2008-08-20 | NascaCell Technologies AG | Polypeptide comprenant un partie caractéristique des protéines appellées "Knottins" |
WO2010056893A1 (fr) * | 2008-11-13 | 2010-05-20 | Imclone Llc | Humanisation et optimisation d’affinité d’anticorps |
EP2627356B1 (fr) * | 2010-10-13 | 2019-05-22 | Janssen Biotech, Inc. | Anticorps contre l'oncostatine m humaine et procédés d'utilisation |
BR112013012627A2 (pt) | 2010-11-23 | 2016-10-04 | Glaxo Group Ltd | proteína de ligação de antígeno, polinucleotídeo, composição farmacêutica, e uso da referida composição |
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2011
- 2011-11-21 BR BR112013012627A patent/BR112013012627A2/pt not_active Application Discontinuation
- 2011-11-21 TR TR2018/10773T patent/TR201810773T4/tr unknown
- 2011-11-21 KR KR1020137016213A patent/KR20130119948A/ko active Application Filing
- 2011-11-21 ES ES11785424.0T patent/ES2681949T3/es active Active
- 2011-11-21 EA EA201390537A patent/EA027256B1/ru not_active IP Right Cessation
- 2011-11-21 MY MYPI2013700832A patent/MY170404A/en unknown
- 2011-11-21 PE PE2013001238A patent/PE20140519A1/es active IP Right Grant
- 2011-11-21 TW TW100142577A patent/TWI504609B/zh not_active IP Right Cessation
- 2011-11-21 SG SG2013035951A patent/SG190232A1/en unknown
- 2011-11-21 CN CN201180065512.0A patent/CN103328508B/zh active Active
- 2011-11-21 UA UAA201305873A patent/UA111954C2/uk unknown
- 2011-11-21 EP EP11785424.0A patent/EP2643352B1/fr active Active
- 2011-11-21 ME MEP-2018-182A patent/ME03069B/fr unknown
- 2011-11-21 MX MX2013005843A patent/MX351887B/es active IP Right Grant
- 2011-11-21 RS RS20180819A patent/RS57502B1/sr unknown
- 2011-11-21 CA CA2818534A patent/CA2818534A1/fr not_active Abandoned
- 2011-11-21 KR KR1020187027871A patent/KR101947356B1/ko active IP Right Grant
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- 2011-11-21 DK DK11785424.0T patent/DK2643352T3/en active
- 2011-11-21 WO PCT/EP2011/070604 patent/WO2012069433A2/fr active Application Filing
- 2011-11-21 EP EP18163940.2A patent/EP3369744A1/fr not_active Withdrawn
- 2011-11-21 SI SI201131537T patent/SI2643352T1/sl unknown
- 2011-11-21 EP EP17166131.7A patent/EP3211009A1/fr not_active Withdrawn
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- 2011-11-21 JO JOP/2011/0353A patent/JO3455B1/ar active
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2013
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- 2013-05-23 CL CL2013001466A patent/CL2013001466A1/es unknown
- 2013-06-19 MA MA36018A patent/MA34742B1/fr unknown
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2014
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2016
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2017
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