PE20140519A1 - Proteinas de union a antigenos oncostatina m (osm) - Google Patents

Proteinas de union a antigenos oncostatina m (osm)

Info

Publication number
PE20140519A1
PE20140519A1 PE2013001238A PE2013001238A PE20140519A1 PE 20140519 A1 PE20140519 A1 PE 20140519A1 PE 2013001238 A PE2013001238 A PE 2013001238A PE 2013001238 A PE2013001238 A PE 2013001238A PE 20140519 A1 PE20140519 A1 PE 20140519A1
Authority
PE
Peru
Prior art keywords
seq
variant
osm
tyr
oncostatin
Prior art date
Application number
PE2013001238A
Other languages
English (en)
Inventor
Gary Peter Bembridge
Chun-Wa Chung
Maria Feeney
Susannah Karen Ford
Ian Kirby
Ruth Mcadam
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45001764&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PE20140519(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of PE20140519A1 publication Critical patent/PE20140519A1/es

Links

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • C07K16/248—IL-6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/522—CH1 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/54—F(ab')2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Measuring Volume Flow (AREA)

Abstract

SE REFIERE A UNA PROTEINA DE UNION A ANTIGENO QUE SE UNE ESPECIFICAMENTE A ONCOSTATINA (OSM) QUE INHIBE LA UNION DE OSM CON EL RECEPTOR gp130, DONDE DICHA PROTEINA COMPRENDE i) UN CDRH3 DE SEC ID N�: 3 O UNA VARIANTE, DONDE Val 102 SUSTITUYE A Tyr, His, Ile, ENTRE OTROS; ii) UN CDRH2 DE SEC ID N�: 2 O UNA VARIANTE, DONDE Thr50 SUSTITUYE A Gly, Tyr, Phe, ENTRE OTROS; iii) UN CDRL1 DE SEC ID N�: 4 O UNA VARIANTE, DONDE Ser27A SUSTITUYE A Asn, Asp, Thr, ENTRE OTROS; iv) UN CDRL3 DE SEC ID N�: 6 O UNA VARIANTE, DONDE Leu89 SUSTITUYE A Gln, Ser, Gly, ENTRE OTROS; v) UN CDRH1 DE SEC ID N�: 1 O UNA VARIANTE, DONDE Tyr 32 SUSTITUYE A Ile, His, Phe, ENTRE OTROS; vi) UN CDRL2 DE SEC ID N�: 5; vii) UNA REGION VARIABLE DE CADENA PESADA CODIFICADA POR LA SEC ID N�: 73; Y viii) UNA REGION VARIABLE DE CADENA LIGERA CODIFICADA POR LA SEC ID N�: 71. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA UTIL EN EL TRATAMIENTO DE ARTRITIS REUMATOIDE, OSTEOARTRITIS, ESPONDILITIS ANQUILOSANTE
PE2013001238A 2010-11-23 2011-11-21 Proteinas de union a antigenos oncostatina m (osm) PE20140519A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US41649510P 2010-11-23 2010-11-23

Publications (1)

Publication Number Publication Date
PE20140519A1 true PE20140519A1 (es) 2014-04-30

Family

ID=45001764

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2013001238A PE20140519A1 (es) 2010-11-23 2011-11-21 Proteinas de union a antigenos oncostatina m (osm)

Country Status (38)

Country Link
US (4) US8916695B2 (es)
EP (3) EP2643352B1 (es)
JP (2) JP6351973B2 (es)
KR (2) KR20130119948A (es)
CN (1) CN103328508B (es)
AR (1) AR083937A1 (es)
AU (1) AU2011333878B2 (es)
BR (1) BR112013012627A2 (es)
CA (1) CA2818534A1 (es)
CL (1) CL2013001466A1 (es)
CO (1) CO6801627A2 (es)
CY (1) CY1120448T1 (es)
DK (1) DK2643352T3 (es)
DO (1) DOP2013000113A (es)
EA (1) EA027256B1 (es)
ES (1) ES2681949T3 (es)
HR (1) HRP20181092T1 (es)
HU (1) HUE039412T2 (es)
IL (1) IL226157B (es)
JO (1) JO3455B1 (es)
LT (1) LT2643352T (es)
MA (1) MA34742B1 (es)
ME (1) ME03069B (es)
MX (1) MX351887B (es)
MY (1) MY170404A (es)
NZ (1) NZ610464A (es)
PE (1) PE20140519A1 (es)
PL (1) PL2643352T3 (es)
PT (1) PT2643352T (es)
RS (1) RS57502B1 (es)
SG (2) SG190232A1 (es)
SI (1) SI2643352T1 (es)
TR (1) TR201810773T4 (es)
TW (1) TWI504609B (es)
UA (1) UA111954C2 (es)
UY (1) UY33743A (es)
WO (1) WO2012069433A2 (es)
ZA (1) ZA201303541B (es)

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RS57502B1 (sr) 2018-10-31
SG10201500388PA (en) 2015-03-30
CO6801627A2 (es) 2013-11-29
CY1120448T1 (el) 2019-07-10
US20210017270A1 (en) 2021-01-21
BR112013012627A2 (pt) 2016-10-04
CL2013001466A1 (es) 2014-06-27
NZ610464A (en) 2015-02-27
EP2643352B1 (en) 2018-05-02
JP6351973B2 (ja) 2018-07-04
CN103328508A (zh) 2013-09-25
US20130251724A1 (en) 2013-09-26
SG190232A1 (en) 2013-06-28
MX2013005843A (es) 2013-07-05
IL226157B (en) 2020-10-29
US8916695B2 (en) 2014-12-23
CA2818534A1 (en) 2012-05-31
EA201390537A1 (ru) 2014-01-30
CN103328508B (zh) 2015-12-16
WO2012069433A2 (en) 2012-05-31
US20170152312A1 (en) 2017-06-01
EP3369744A1 (en) 2018-09-05
DOP2013000113A (es) 2013-12-15
AU2011333878A1 (en) 2013-05-09
US10808029B2 (en) 2020-10-20
US9605063B2 (en) 2017-03-28
KR101947356B1 (ko) 2019-02-12
MY170404A (en) 2019-07-27
UA111954C2 (uk) 2016-07-11
MX351887B (es) 2017-11-01
UY33743A (es) 2012-06-29
JP2017078072A (ja) 2017-04-27
KR20180110199A (ko) 2018-10-08
TWI504609B (zh) 2015-10-21
US20150064201A1 (en) 2015-03-05
AR083937A1 (es) 2013-04-10
JO3455B1 (ar) 2020-07-05
MA34742B1 (fr) 2013-12-03
PT2643352T (pt) 2018-08-01
KR20130119948A (ko) 2013-11-01
ES2681949T3 (es) 2018-09-17
TR201810773T4 (tr) 2018-08-27
ME03069B (me) 2019-01-20
PL2643352T3 (pl) 2018-10-31
ZA201303541B (en) 2014-11-26
EP2643352A2 (en) 2013-10-02
EA027256B1 (ru) 2017-07-31
JP2014507373A (ja) 2014-03-27
HUE039412T2 (hu) 2018-12-28
LT2643352T (lt) 2018-08-10
WO2012069433A3 (en) 2012-08-09
AU2011333878B2 (en) 2016-01-14
SI2643352T1 (sl) 2018-12-31
IL226157A0 (en) 2013-06-27
HRP20181092T1 (hr) 2018-09-21
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DK2643352T3 (en) 2018-07-30
TW201235358A (en) 2012-09-01

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