BR112013011815A2 - ''método para produzir uma cepa de saccharomyces cerevisiae com genes introduzidos que codificam xilose redutase,xilitol desidrogenase e xiluloquinase e com produção de etanol aprimorada,conversão de xilose aprimorada e produção de axitol reduzida ,cepa de saccharomyces cerevisiae com genes introduzidos que codificam xilose redutase,xilitol desidrogenase e xiluloquinase e com produção de etanol aprimorada,conversão de xilose aprimorada e produção de xilitol reduzida,cepa de saccharomyces cerevisiae com produção de etanol aprimorada,conversão de xilose aprimorada e produção de xilitol reduzida,cepa de saccharomyces cerevisiae com produção de etanol aprimorada,conversão de xilose aprimorada,produção de xilitol reduzida, cepa de saccaromyces cerevisiae com produção de etanol aprimorada,conversão de xilose aprimorada ,produção de etanol aprimorada,produção de xilitol reduzida e tolerância a inibidor aumentada e uso de uma cepa'' - Google Patents
''método para produzir uma cepa de saccharomyces cerevisiae com genes introduzidos que codificam xilose redutase,xilitol desidrogenase e xiluloquinase e com produção de etanol aprimorada,conversão de xilose aprimorada e produção de axitol reduzida ,cepa de saccharomyces cerevisiae com genes introduzidos que codificam xilose redutase,xilitol desidrogenase e xiluloquinase e com produção de etanol aprimorada,conversão de xilose aprimorada e produção de xilitol reduzida,cepa de saccharomyces cerevisiae com produção de etanol aprimorada,conversão de xilose aprimorada e produção de xilitol reduzida,cepa de saccharomyces cerevisiae com produção de etanol aprimorada,conversão de xilose aprimorada,produção de xilitol reduzida, cepa de saccaromyces cerevisiae com produção de etanol aprimorada,conversão de xilose aprimorada ,produção de etanol aprimorada,produção de xilitol reduzida e tolerância a inibidor aumentada e uso de uma cepa''Info
- Publication number
- BR112013011815A2 BR112013011815A2 BR112013011815A BR112013011815A BR112013011815A2 BR 112013011815 A2 BR112013011815 A2 BR 112013011815A2 BR 112013011815 A BR112013011815 A BR 112013011815A BR 112013011815 A BR112013011815 A BR 112013011815A BR 112013011815 A2 BR112013011815 A2 BR 112013011815A2
- Authority
- BR
- Brazil
- Prior art keywords
- enhanced
- production
- cerevisiae strain
- reduced
- ethanol
- Prior art date
Links
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 title 12
- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 title 10
- 238000004519 manufacturing process Methods 0.000 title 9
- 240000004808 Saccharomyces cerevisiae Species 0.000 title 5
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 title 5
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 title 5
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 title 5
- 238000006243 chemical reaction Methods 0.000 title 5
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 title 4
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 title 4
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 title 4
- 229960002675 xylitol Drugs 0.000 title 4
- 235000010447 xylitol Nutrition 0.000 title 4
- 239000000811 xylitol Substances 0.000 title 4
- 102000016912 Aldehyde Reductase Human genes 0.000 title 2
- 108010053754 Aldehyde reductase Proteins 0.000 title 2
- 108010058076 D-xylulose reductase Proteins 0.000 title 2
- 102100026974 Sorbitol dehydrogenase Human genes 0.000 title 2
- 102100029089 Xylulose kinase Human genes 0.000 title 2
- 108091022915 xylulokinase Proteins 0.000 title 2
- 239000003112 inhibitor Substances 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/06—Ethanol, i.e. non-beverage
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
- C12N1/14—Fungi; Culture media therefor
- C12N1/16—Yeasts; Culture media therefor
- C12N1/18—Baker's yeast; Brewer's yeast
- C12N1/185—Saccharomyces isolates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/01—Preparation of mutants without inserting foreign genetic material therein; Screening processes therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
- C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0006—Oxidoreductases (1.) acting on CH-OH groups as donors (1.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
- C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P7/00—Preparation of oxygen-containing organic compounds
- C12P7/02—Preparation of oxygen-containing organic compounds containing a hydroxy group
- C12P7/04—Preparation of oxygen-containing organic compounds containing a hydroxy group acyclic
- C12P7/06—Ethanol, i.e. non-beverage
- C12P7/08—Ethanol, i.e. non-beverage produced as by-product or from waste or cellulosic material substrate
- C12P7/10—Ethanol, i.e. non-beverage produced as by-product or from waste or cellulosic material substrate substrate containing cellulosic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
- C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01009—D-Xylulose reductase (1.1.1.9), i.e. xylitol dehydrogenase
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/0101—L-Xylulose reductase (1.1.1.10)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y101/00—Oxidoreductases acting on the CH-OH group of donors (1.1)
- C12Y101/01—Oxidoreductases acting on the CH-OH group of donors (1.1) with NAD+ or NADP+ as acceptor (1.1.1)
- C12Y101/01307—D-Xylose reductase (1.1.1.307)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y207/00—Transferases transferring phosphorus-containing groups (2.7)
- C12Y207/01—Phosphotransferases with an alcohol group as acceptor (2.7.1)
- C12Y207/01017—Xylulokinase (2.7.1.17)
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12R—INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- C12R2001/00—Microorganisms ; Processes using microorganisms
- C12R2001/645—Fungi ; Processes using fungi
- C12R2001/85—Saccharomyces
- C12R2001/865—Saccharomyces cerevisiae
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
- Y02E50/00—Technologies for the production of fuel of non-fossil origin
- Y02E50/10—Biofuels, e.g. bio-diesel
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Botany (AREA)
- Tropical Medicine & Parasitology (AREA)
- Virology (AREA)
- Immunology (AREA)
- Analytical Chemistry (AREA)
- Toxicology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE1051194 | 2010-11-15 | ||
SE1051194-7 | 2010-11-15 | ||
PCT/SE2011/051368 WO2012067571A1 (en) | 2010-11-15 | 2011-11-15 | New strains of saccharomyces cerevisiae |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112013011815A2 true BR112013011815A2 (pt) | 2017-10-31 |
BR112013011815B1 BR112013011815B1 (pt) | 2021-07-20 |
Family
ID=46084287
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112013011815-6A BR112013011815B1 (pt) | 2010-11-15 | 2011-11-15 | Cepa de saccharomyces cerevisiae, e método de produção de etanol |
BR112013011817-2A BR112013011817B1 (pt) | 2010-11-15 | 2011-11-15 | Cepa de saccharomyces cerevisiae e uso de uma cepa |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112013011817-2A BR112013011817B1 (pt) | 2010-11-15 | 2011-11-15 | Cepa de saccharomyces cerevisiae e uso de uma cepa |
Country Status (7)
Country | Link |
---|---|
US (2) | US8962289B2 (pt) |
EP (2) | EP2640836B1 (pt) |
CN (2) | CN103354836B (pt) |
BR (2) | BR112013011815B1 (pt) |
CA (2) | CA2817707C (pt) |
WO (2) | WO2012067571A1 (pt) |
ZA (2) | ZA201304233B (pt) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8962289B2 (en) | 2010-11-15 | 2015-02-24 | Scandinavian Technology Group Ab | Strains of Saccharomyces cerevisiae |
CN105637083A (zh) * | 2013-05-28 | 2016-06-01 | 波特研究公司 | 用于管理酵母以促进乙醇生产的系统 |
US9803254B2 (en) * | 2013-10-16 | 2017-10-31 | Scandinavian Technology Group Ab | Saccharomyces cerevisae strains |
CN103627644B (zh) * | 2013-10-26 | 2015-09-30 | 三峡大学 | 一种酿酒酵母变异菌株及其应用 |
WO2015163814A1 (en) | 2014-04-23 | 2015-10-29 | Scandinavian Technology Group Ab | Saccharomyces cerevisiae strains |
TWI551688B (zh) * | 2015-02-04 | 2016-10-01 | 遠東新世紀股份有限公司 | 發酵纖維素水解液來生成乙醇的方法 |
US11639506B2 (en) * | 2015-05-15 | 2023-05-02 | Wisconsin Alumni Research Foundation | Recombinant yeast having increased tolerance to ionic liquids and methods of use |
CN106906152B (zh) * | 2017-05-04 | 2020-06-19 | 天津大学 | 一种酿酒酵母及其用途 |
CN111100801B (zh) * | 2019-09-09 | 2024-02-23 | 四川农业大学 | 一种糠醛等抑制物耐受酵母工程菌株及其构建方法与应用 |
CN112877273B (zh) * | 2020-12-09 | 2021-08-17 | 山东太阳纸业股份有限公司 | 一种分解半乳糖、甘露糖等杂糖的酵母菌 |
CN116223733B (zh) * | 2023-01-04 | 2023-09-15 | 齐鲁工业大学(山东省科学院) | 一种c5/c6共利用酿酒酵母木糖代谢与鲁棒性之间拮抗程度的定量表征方法 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DK1282686T3 (da) * | 2000-05-15 | 2008-01-07 | Forskarpatent I Syd | Rekombinant gær til lignocelluloseråmaterialer |
SE0200857D0 (sv) * | 2002-03-19 | 2002-03-19 | Forskarpatent I Syd Ab | Metabolic engineering for improved xylose utilisation of saccharomyces cerevisiae |
SE0200855D0 (sv) | 2002-03-19 | 2002-03-19 | Forskarpatent I Syd Ab | SACCHAROMYCES cerevisiae MUTANT |
WO2004085627A1 (en) * | 2003-03-26 | 2004-10-07 | Forskarpatent I Syd Ab | New saccharomyces cerevisiae strains utilizing xylose |
SE0400815D0 (sv) | 2004-03-26 | 2004-03-26 | Forskarpatent I Syd Ab | Traits in recombinant xylose-growing saccharomyces cerevisiae strains using genome-wide transcription analysis |
WO2005113759A2 (en) * | 2004-05-19 | 2005-12-01 | Biotechnology Research And Development Corporation | Microbial production of xylitol via a hexose phosphate and a pentose phosphate intermediate |
SE0401303D0 (sv) | 2004-05-19 | 2004-05-19 | Forskarpatent I Syd Ab | Ethanol productivities of microbial strains in fermentation of dilute-acid hydrolyzates depend on their furan reduction capacities |
CN101463328B (zh) * | 2007-12-19 | 2011-06-29 | 中国科学院微生物研究所 | 一株利用木糖发酵产乙醇的代谢工程酵母菌 |
WO2009132201A2 (en) | 2008-04-23 | 2009-10-29 | Georgia Tech Research Corporation | Improved strains of zymomonas mobilis for fermentation of biomass |
US8962289B2 (en) | 2010-11-15 | 2015-02-24 | Scandinavian Technology Group Ab | Strains of Saccharomyces cerevisiae |
-
2011
- 2011-11-15 US US13/885,037 patent/US8962289B2/en not_active Expired - Fee Related
- 2011-11-15 US US13/885,031 patent/US9115376B2/en not_active Expired - Fee Related
- 2011-11-15 EP EP11840813.7A patent/EP2640836B1/en not_active Not-in-force
- 2011-11-15 CA CA2817707A patent/CA2817707C/en active Active
- 2011-11-15 WO PCT/SE2011/051368 patent/WO2012067571A1/en active Application Filing
- 2011-11-15 CN CN201180054540.2A patent/CN103354836B/zh not_active Expired - Fee Related
- 2011-11-15 BR BR112013011815-6A patent/BR112013011815B1/pt not_active IP Right Cessation
- 2011-11-15 EP EP11841824.3A patent/EP2640837B1/en not_active Not-in-force
- 2011-11-15 WO PCT/SE2011/051369 patent/WO2012067572A1/en active Application Filing
- 2011-11-15 CA CA2817714A patent/CA2817714C/en active Active
- 2011-11-15 CN CN201180054537.0A patent/CN103403155B/zh not_active Expired - Fee Related
- 2011-11-15 BR BR112013011817-2A patent/BR112013011817B1/pt not_active IP Right Cessation
-
2013
- 2013-06-10 ZA ZA2013/04233A patent/ZA201304233B/en unknown
- 2013-06-10 ZA ZA2013/04232A patent/ZA201304232B/en unknown
Also Published As
Publication number | Publication date |
---|---|
CA2817707A1 (en) | 2012-05-24 |
US20130295620A1 (en) | 2013-11-07 |
CN103403155B (zh) | 2015-02-18 |
EP2640837A4 (en) | 2014-05-21 |
EP2640837A1 (en) | 2013-09-25 |
CN103354836B (zh) | 2015-11-25 |
US8962289B2 (en) | 2015-02-24 |
WO2012067572A1 (en) | 2012-05-24 |
CN103354836A (zh) | 2013-10-16 |
BR112013011817B1 (pt) | 2021-08-03 |
ZA201304233B (en) | 2014-08-27 |
BR112013011817A2 (pt) | 2017-10-31 |
BR112013011815B1 (pt) | 2021-07-20 |
CA2817714C (en) | 2019-02-05 |
CN103403155A (zh) | 2013-11-20 |
EP2640836A4 (en) | 2014-05-21 |
EP2640837B1 (en) | 2017-03-08 |
EP2640836B1 (en) | 2019-02-20 |
US9115376B2 (en) | 2015-08-25 |
CA2817707C (en) | 2020-05-05 |
US20130244247A1 (en) | 2013-09-19 |
ZA201304232B (en) | 2014-08-27 |
WO2012067571A1 (en) | 2012-05-24 |
EP2640836A1 (en) | 2013-09-25 |
CA2817714A1 (en) | 2012-05-24 |
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