BR112013007566A2 - novos compostos bicíclicos - Google Patents

novos compostos bicíclicos

Info

Publication number
BR112013007566A2
BR112013007566A2 BR112013007566A BR112013007566A BR112013007566A2 BR 112013007566 A2 BR112013007566 A2 BR 112013007566A2 BR 112013007566 A BR112013007566 A BR 112013007566A BR 112013007566 A BR112013007566 A BR 112013007566A BR 112013007566 A2 BR112013007566 A2 BR 112013007566A2
Authority
BR
Brazil
Prior art keywords
formula
compounds
gpcr
polymorphs
prodrugs
Prior art date
Application number
BR112013007566A
Other languages
English (en)
Portuguese (pt)
Inventor
Jagattaran Das
Nishan Singh
Rajesh Jain
Sanjay Trehan
Sudhir Kumar Sharma
Original Assignee
Panacea Biotec Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Panacea Biotec Ltd filed Critical Panacea Biotec Ltd
Publication of BR112013007566A2 publication Critical patent/BR112013007566A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
BR112013007566A 2010-09-28 2011-09-27 novos compostos bicíclicos BR112013007566A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN2322DE2010 2010-09-28
IN1515DE2011 2011-05-26
PCT/IN2011/000669 WO2012042539A2 (en) 2010-09-28 2011-09-27 Novel bicyclic compounds

Publications (1)

Publication Number Publication Date
BR112013007566A2 true BR112013007566A2 (pt) 2016-08-02

Family

ID=45048157

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112013007566A BR112013007566A2 (pt) 2010-09-28 2011-09-27 novos compostos bicíclicos

Country Status (6)

Country Link
US (1) US9133116B2 (https=)
EP (1) EP2621902B1 (https=)
JP (1) JP2013542929A (https=)
AR (1) AR083202A1 (https=)
BR (1) BR112013007566A2 (https=)
WO (1) WO2012042539A2 (https=)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2685828A4 (en) * 2011-03-17 2014-08-13 Merck Sharp & Dohme SUBSTITUTED 3-AZABICYCLO [3,1,0-] HEXAN DERIVATIVES AS CCR2 ANTAGONISTS
JP5936849B2 (ja) * 2011-11-24 2016-06-22 東洋ゴム工業株式会社 空気入りタイヤの製造方法
WO2015123505A1 (en) * 2014-02-14 2015-08-20 Takeda Pharmaceutical Company Limited Pyridopyrazines modulators of gpr6
US9575560B2 (en) 2014-06-03 2017-02-21 Google Inc. Radar-based gesture-recognition through a wearable device
US9811164B2 (en) 2014-08-07 2017-11-07 Google Inc. Radar-based gesture sensing and data transmission
US10268321B2 (en) 2014-08-15 2019-04-23 Google Llc Interactive textiles within hard objects
US11169988B2 (en) 2014-08-22 2021-11-09 Google Llc Radar recognition-aided search
US9778749B2 (en) 2014-08-22 2017-10-03 Google Inc. Occluded gesture recognition
US9600080B2 (en) 2014-10-02 2017-03-21 Google Inc. Non-line-of-sight radar-based gesture recognition
EP3289432B1 (en) 2015-04-30 2019-06-12 Google LLC Rf-based micro-motion tracking for gesture tracking and recognition
CN107466389B (zh) 2015-04-30 2021-02-12 谷歌有限责任公司 用于确定类型不可知的rf信号表示的方法和装置
EP3289434A1 (en) 2015-04-30 2018-03-07 Google LLC Wide-field radar-based gesture recognition
US10088908B1 (en) 2015-05-27 2018-10-02 Google Llc Gesture detection and interactions
US9693592B2 (en) 2015-05-27 2017-07-04 Google Inc. Attaching electronic components to interactive textiles
US10817065B1 (en) 2015-10-06 2020-10-27 Google Llc Gesture recognition using multiple antenna
CN115531553A (zh) * 2015-12-22 2022-12-30 武田药品工业株式会社 内体g蛋白-偶联的受体的三部分调节剂
US10492302B2 (en) 2016-05-03 2019-11-26 Google Llc Connecting an electronic component to an interactive textile
WO2017200949A1 (en) 2016-05-16 2017-11-23 Google Llc Interactive fabric
WO2017200570A1 (en) 2016-05-16 2017-11-23 Google Llc Interactive object with multiple electronics modules
WO2018053587A1 (en) * 2016-09-21 2018-03-29 Vectus Biosystems Limited Compositions for the treatment of hypertension and/or fibrosis
US10579150B2 (en) 2016-12-05 2020-03-03 Google Llc Concurrent detection of absolute distance and relative movement for sensing action gestures
TWI860849B (zh) 2021-09-14 2024-11-01 美商美國禮來大藥廠 Sstr4促效劑鹽

Family Cites Families (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4435419A (en) 1981-07-01 1984-03-06 American Cyanamid Company Method of treating depression using azabicyclohexanes
US4438130A (en) 1981-11-12 1984-03-20 The Upjohn Company Analgesic 1-oxa-, aza- and thia-spirocyclic compounds
US4560767A (en) 1983-06-17 1985-12-24 The Upjohn Company N-(2-amino-cycloalkenyl)benzeneacetamide and -benzamide analgesics and tritiated kappa agonists therefrom
WO1991002526A1 (en) 1989-08-16 1991-03-07 Pfizer Inc. Azabicyclo quinolone carboxylic acids
US5164402A (en) 1989-08-16 1992-11-17 Pfizer Inc Azabicyclo quinolone and naphthyridinone carboxylic acids
DE4341403A1 (de) * 1993-12-04 1995-06-08 Basf Ag N-substituierte 3-Azabicycloalkan-Derivate, ihre Herstellung und Verwendung
AU685225B2 (en) 1994-02-10 1998-01-15 Yamanouchi Pharmaceutical Co., Ltd. Novel carbamate derivative and medicinal composition containing the same
US5475116A (en) * 1994-04-29 1995-12-12 Pfizer Inc. Aza bicyclo[3,1,0]hexane intermediates useful in the synthesis of quinolones
GB9524157D0 (en) 1995-11-25 1996-01-24 Pfizer Ltd Therapeutic agents
HUP9902455A3 (en) 1996-03-29 2000-06-28 Pfizer 6-phenylpyridyl-2-amine derivatives, pharmaceutical compositions containing them
US5914338A (en) 1996-04-02 1999-06-22 Novo Nordisk Heterocyclic compounds and their preparation and use
US5968929A (en) 1996-10-30 1999-10-19 Schering Corporation Piperazino derivatives as neurokinin antagonists
TWI244481B (en) 1998-12-23 2005-12-01 Pfizer 3-azabicyclo[3.1.0]hexane derivatives useful in therapy
GB0015562D0 (en) 2000-06-23 2000-08-16 Pfizer Ltd Heterocycles
US20030207876A1 (en) 2000-06-23 2003-11-06 Banks Bernard Joseph 3-Azabicyclo[3.1.0]hexane derivatives useful in therapy
CA2425288A1 (en) 2000-10-11 2002-05-02 Sander G. Mills Pyrrolidine modulators of ccr5 chemokine receptor activity
US6372919B1 (en) 2001-01-11 2002-04-16 Dov Pharmaceutical, Inc. (+)-1-(3,4-dichlorophenyl)-3-azabicyclo[3.1.0]hexane, compositions thereof, and uses as an anti-depressant agent
ATE304536T1 (de) 2001-04-17 2005-09-15 Merck & Co Inc Bicyclo(3,1,0)hexan als strukturelement enthaltende oxazolidinon-antibiotika und deren derivate
US20030232739A1 (en) 2001-08-15 2003-12-18 Pfizer Inc. Pharmaceutical combinations comprising a NOS inhibitor and an NMDA receptor antagonist
EA006708B1 (ru) 2001-10-22 2006-02-24 Пфайзер Продактс Инк. Производные 3-азабицикло (3.1.0) гексана в качестве антагонистов опиоидного рецептора
US7141588B2 (en) 2002-02-25 2006-11-28 Pfizer, Inc. N-aryl-2-oxazolidinone-5-carboxamides and their derivatives
GB0208897D0 (en) 2002-04-18 2002-05-29 Merck Sharp & Dohme New method of treatment
AU2002345266B2 (en) 2002-07-08 2009-07-02 Ranbaxy Laboratories Limited 3,6-disubstituted azabicyclo [3.1.0]hexane derivatives useful as muscarinic receptor antagonists
WO2004014363A1 (en) 2002-08-09 2004-02-19 Ranbaxy Laboratories Limited 3,6-disubstituted azabicyclo [3.1.0] hexane derivatives useful as muscarinic receptor antagonist
EP1534675B1 (en) 2002-08-23 2009-02-25 Ranbaxy Laboratories, Ltd. Fluoro and sulphonylamino containing 3,6-disubstituted azabicyclo¬3.1.0 hexane derivatives as muscarinic receptor antagonists
US6875784B2 (en) 2002-10-09 2005-04-05 Pharmacia & Upjohn Company Antimibicrobial [3.1.0.] bicyclic oxazolidinone derivatives
EP1590345A1 (en) 2002-12-23 2005-11-02 Ranbaxy Laboratories, Ltd. Xanthine derivatives as muscarinic receptor antagonists
JP2006522791A (ja) 2003-04-09 2006-10-05 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー 抗微生物性［３．１．０］ビシクロヘキシルフェニルオキサゾリジノン誘導体および類似体
JP2006522787A (ja) 2003-04-11 2006-10-05 ランバクシー ラボラトリーズ リミテッド ムスカリン様受容体アンタゴニストとしてのアザビシクロ誘導体
ATE471937T1 (de) 2003-07-02 2010-07-15 Merck Sharp & Dohme Cyclopropylgruppensubstituierte oxazolidinonantibiotika und derivate davon
AU2004256086B2 (en) 2003-07-02 2007-12-06 Kyorin Pharmaceutical Co., Ltd. Oxazolidinone antibiotics and derivatives thereof
CA2529292A1 (en) 2003-07-02 2005-01-20 Merck & Co., Inc. Oxazolidinone antibiotics and derivatives thereof
US20070185132A1 (en) 2003-07-02 2007-08-09 Yasumichi Fukuda Cyclopropyl group substituted oxazolidinone antibiotics and derivatives thereo
EP1670759A1 (en) 2003-09-18 2006-06-21 Ranbaxy Laboratories Limited PROCESS FOR THE PREPARATION OF (1a, 5a, 6a)-6-AMINOME THYL-3-BENZYL-3-AZABICYCLO 3.1.0 HEXANE
US7153976B2 (en) 2003-10-06 2006-12-26 Pfizer Inc. Purification process for an azabicyclo[3.1.0]hexane compound
RS20060190A (sr) 2003-10-14 2008-08-07 Pfizer Products Inc., Biciklični /3.1.0/ derivati kao inhibitori transportera glicina
JP2007508367A (ja) 2003-10-16 2007-04-05 ファイザー・プロダクツ・インク ３−アザビシクロ［３．１．０］ヘキサン誘導体の製造方法
DE602005021760D1 (de) 2004-02-27 2010-07-22 Schering Corp Schwefelverbindungen als inhibitoren der ns3-serinprotease des hepatitis-c-virus
US20050282859A1 (en) 2004-06-04 2005-12-22 Thor Karl B Dual acting SNRI-NMDA antagonists for the treatment of genitourinary disorders
MX2007000015A (es) 2004-06-22 2007-03-07 Schering Corp Ligandos de receptor de canabinoide.
MX2007002136A (es) 2004-09-01 2007-04-02 Pfizer Prod Inc Antagonistas amino azabiciclicos del receptor 3 de la histamina.
JP4887297B2 (ja) 2004-09-24 2012-02-29 アクテリオン ファーマシューティカルズ リミテッド 新規二環式抗生物質
US20100016400A1 (en) 2004-11-19 2010-01-21 Naresh Kumar Azabicyclic muscarinic receptor antagonists
EP1828126A1 (en) 2004-12-15 2007-09-05 Ranbaxy Laboratories Limited Acid addition salts of muscarinic receptor antagonists
US20060223875A1 (en) 2005-03-08 2006-10-05 Phil Skolnick Methods and compositions for production, formulation and use of 1-aryl-3-azabicyclo[3.1.0]hexanes
GEP20105053B (en) 2005-04-08 2010-07-26 Pfizer Prod Inc Bicyclic [3.1.0] heteroaryl amides as type i glycine transport inhibitors
WO2006117754A1 (en) 2005-05-03 2006-11-09 Ranbaxy Laboratories Limited 3,6-disubstituted azabicyclo [3.1.0] hexane derivatives as muscarinic receptor antagonists
GB0510204D0 (en) 2005-05-19 2005-06-22 Chroma Therapeutics Ltd Enzyme inhibitors
US20090012116A1 (en) 2005-07-11 2009-01-08 Naresh Kumar Muscarinic Receptor Antagonists
WO2007006117A1 (en) 2005-07-13 2007-01-18 Nicogen Inc. Novel cyp2a6 inhibitors
US20070082939A1 (en) 2005-07-26 2007-04-12 Lippa Arnold S Methods and compositions for the treatment of neuropathies and related disorders
EP1915146A4 (en) 2005-07-27 2010-06-02 Dov Pharmaceutical Inc NOVEL 1-ARYL-3-AZABICYCLO [3.1.0] HEXANEES. PREPARATION AND USE FOR THE TREATMENT OF NEUROPSYCHIATRIC DISEASES
WO2007127421A2 (en) 2006-04-28 2007-11-08 Merck & Co., Inc. Process for the synthesis of (+) and (-)-1-aryl-3-azabicyclo[3.1.0]hexanes
WO2007135527A2 (en) 2006-05-23 2007-11-29 Pfizer Products Inc. Benzimidazolyl compounds
WO2007135529A2 (en) 2006-05-23 2007-11-29 Pfizer Products Inc. Azabenzimidazolyl compounds as mglur2 potentiators
WO2007138431A2 (en) 2006-05-30 2007-12-06 Pfizer Products Inc. Azabicyclic ether histamine-3 antagonists
US20080058535A1 (en) 2006-07-25 2008-03-06 Zhengming Chen Methods and compositions for production, formulation and use of 1 aryl-3-azabicyclo[3.1.0]hexanes
EP2059505A2 (en) 2006-09-04 2009-05-20 Ranbaxy Laboratories Limited Muscarinic receptor antagonists
WO2008053131A1 (en) 2006-10-30 2008-05-08 Chroma Therapeutics Ltd. Hydroxamates as inhibitors of histone deacetylase
WO2008075162A2 (en) 2006-12-15 2008-06-26 Pfizer Limited Selective mu opioid receptor antagonists for the treatment of female sexual dysfunction
GB0625198D0 (en) 2006-12-18 2007-01-24 Glaxo Group Ltd Chemical compounds
US20080287479A1 (en) 2006-12-20 2008-11-20 Pfizer Inc Inhibitors of serine palmitoyltransferase
US20080176860A1 (en) 2007-01-19 2008-07-24 Lutz Weber Pyridin-2-one compounds
WO2008117229A1 (en) 2007-03-23 2008-10-02 Ranbaxy Laboratories Limited Muscarinic receptor antagonists
EP1980150A1 (en) 2007-04-13 2008-10-15 Basf Se Fungicidal mixtures based on triazolopyrimidine compounds
EP2167083B1 (en) 2007-06-06 2015-10-28 Euthymics Bioscience, Inc. 1- heteroaryl-3-azabicyclo[3.1.0]hexanes, methods for their preparation and their use as medicaments
JP2009040709A (ja) 2007-08-08 2009-02-26 Kyorin Pharmaceut Co Ltd １２位置換ムチリン誘導体
GB0716632D0 (en) 2007-08-24 2007-10-03 Glaxo Group Ltd Compounds
CA2705719C (en) 2007-09-14 2016-10-11 Janssen Pharmaceutica N.V. Thieno-and furo-pyrimidine modulators of the histamine h4 receptor
WO2009090548A2 (en) 2008-01-17 2009-07-23 Glenmark Pharmaceuticals, S.A. 3-azabicyclo [3.1.0] hexane derivatives as vanilloid receptor ligands
US8278311B2 (en) 2008-04-28 2012-10-02 Abbott Laboratories Substituted pyrimidine derivatives
GB0809479D0 (en) 2008-05-23 2008-07-02 Glaxo Group Ltd Novel compounds
US20120108565A1 (en) 2008-07-30 2012-05-03 Lalima Sharma Pyrrole carboxylic acid derivatives as antibacterial agents
EP2344470B1 (en) 2008-09-02 2013-11-06 Janssen Pharmaceuticals, Inc. 3-azabicyclo[3.1.0]hexyl derivatives as modulators of metabotropic glutamate receptors
KR20120106697A (ko) 2009-06-26 2012-09-26 파나세아 바이오테크 리미티드 신규 아자비시클로헥산

Also Published As

Publication number Publication date
US9133116B2 (en) 2015-09-15
WO2012042539A2 (en) 2012-04-05
US20130253029A1 (en) 2013-09-26
EP2621902B1 (en) 2017-04-12
EP2621902A2 (en) 2013-08-07
WO2012042539A3 (en) 2012-05-31
JP2013542929A (ja) 2013-11-28
AR083202A1 (es) 2013-02-06

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