BR112013003506A2 - método para detectar a presença de uma isoforma de bard1, polipeptídeo isolado e/ou puriicado, peptídeo, kit para detectar a presença de isoformas da bard1, método para discriminar câncer, anticorpo ou fragmento do mesmo, molécula de sirna recombinante, modulador da atividade biológica das isoformas da bard1 - Google Patents

método para detectar a presença de uma isoforma de bard1, polipeptídeo isolado e/ou puriicado, peptídeo, kit para detectar a presença de isoformas da bard1, método para discriminar câncer, anticorpo ou fragmento do mesmo, molécula de sirna recombinante, modulador da atividade biológica das isoformas da bard1

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Publication number
BR112013003506A2
BR112013003506A2 BR112013003506A BR112013003506A BR112013003506A2 BR 112013003506 A2 BR112013003506 A2 BR 112013003506A2 BR 112013003506 A BR112013003506 A BR 112013003506A BR 112013003506 A BR112013003506 A BR 112013003506A BR 112013003506 A2 BR112013003506 A2 BR 112013003506A2
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BR
Brazil
Prior art keywords
bard1
detecting
isoforms
bard1 isoforms
modulator
Prior art date
Application number
BR112013003506A
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English (en)
Other versions
BR112013003506B1 (pt
Inventor
Irminger-Finger Irmgard
Zhang Yong-Qiang
Original Assignee
Hopitaux Univ De Geneve
Univ Geneve
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Publication date
Application filed by Hopitaux Univ De Geneve, Univ Geneve filed Critical Hopitaux Univ De Geneve
Publication of BR112013003506A2 publication Critical patent/BR112013003506A2/pt
Publication of BR112013003506B1 publication Critical patent/BR112013003506B1/pt

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    • G—PHYSICS
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57407—Specifically defined cancers
    • G01N33/57423—Specifically defined cancers of lung
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6854—Immunoglobulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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    • C12N9/93—Ligases (6)
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    • C12Y603/00—Ligases forming carbon-nitrogen bonds (6.3)
    • C12Y603/02—Acid—amino-acid ligases (peptide synthases)(6.3.2)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
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    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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    • C12N2310/00—Structure or type of the nucleic acid
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    • G01N2333/91—Transferases (2.)
    • G01N2333/91045—Acyltransferases (2.3)
    • G01N2333/91074—Aminoacyltransferases (general) (2.3.2)
    • G01N2333/9108—Aminoacyltransferases (general) (2.3.2) with definite EC number (2.3.2.-)

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Abstract

método para detectar a presença de uma isoforma de bard1, polipeptídeo isolado e/ou puriicado, peptídeo, kit para detectar a presença de isoformas da bard1, método para discriminar câncer, anticorpo ou fragmento do mesmo, molécula de sirna recombinante, modulador da atividade biológica das isoformas da bard1. a presente invenção refere-se às novas isoformas bard1 específicas para o câncer de pulmão e o cãncer colorretal, um método para a detecção dos mesmos e um método para tratar e /ou prevenir cãncer de pulmão e câncer colorretal.
BR112013003506-4A 2010-08-17 2011-08-17 Método para detectar a presença de uma isoforma de bard1 e método para discriminar câncer BR112013003506B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US37437010P 2010-08-17 2010-08-17
US61/374,370 2010-08-17
CH00621/11 2011-04-06
CH6212011 2011-04-06
PCT/IB2011/053635 WO2012023112A2 (en) 2010-08-17 2011-08-17 Bard1 isoforms in lung and colorectal cancer and use thereof

Publications (2)

Publication Number Publication Date
BR112013003506A2 true BR112013003506A2 (pt) 2017-03-28
BR112013003506B1 BR112013003506B1 (pt) 2022-02-08

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BR112013003506-4A BR112013003506B1 (pt) 2010-08-17 2011-08-17 Método para detectar a presença de uma isoforma de bard1 e método para discriminar câncer

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US (2) US9599624B2 (pt)
EP (1) EP2606358B1 (pt)
JP (2) JP5938406B2 (pt)
CN (2) CN103238069B (pt)
AU (1) AU2011292809B2 (pt)
BR (1) BR112013003506B1 (pt)
CA (1) CA2807104C (pt)
ES (1) ES2716241T3 (pt)
IL (1) IL224766A (pt)
RU (1) RU2013104137A (pt)
SG (2) SG10201506437PA (pt)
WO (1) WO2012023112A2 (pt)

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JP6934861B2 (ja) 2015-11-24 2021-09-15 シンク サージカル， インコーポレイテッド 膝関節全置換術における、能動的なロボットピン配置
CN111253483B (zh) * 2020-03-02 2021-07-30 江苏莱森生物科技研究院有限公司 一种抗brca1单克隆抗体及其用途
CN114685641B (zh) * 2022-02-25 2024-03-08 西安交通大学医学院第一附属医院 一种抑制brca1/bard1复合体结合的多肽及其应用和防治癌症的药物

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JP2013535696A (ja) 2013-09-12
ES2716241T3 (es) 2019-06-11
US20170205415A1 (en) 2017-07-20
CN106153944B (zh) 2018-09-28
CA2807104C (en) 2020-03-10
CN103238069B (zh) 2016-06-29
SG187674A1 (en) 2013-03-28
JP6271636B2 (ja) 2018-01-31
JP2017006117A (ja) 2017-01-12
CN106153944A (zh) 2016-11-23
CN103238069A (zh) 2013-08-07
EP2606358A2 (en) 2013-06-26
AU2011292809B2 (en) 2017-04-13
CA2807104A1 (en) 2012-02-23
EP2606358B1 (en) 2018-12-26
WO2012023112A3 (en) 2012-05-18
WO2012023112A2 (en) 2012-02-23
RU2013104137A (ru) 2014-09-27
BR112013003506B1 (pt) 2022-02-08
SG10201506437PA (en) 2015-10-29
AU2011292809A1 (en) 2013-03-28
US20130149711A1 (en) 2013-06-13
JP5938406B2 (ja) 2016-06-22
US11022612B2 (en) 2021-06-01
US9599624B2 (en) 2017-03-21
IL224766A (en) 2017-11-30

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