BR112012033548A2 - métodos e composições para melhorar a mobilização de células-tronco - Google Patents

métodos e composições para melhorar a mobilização de células-tronco

Info

Publication number
BR112012033548A2
BR112012033548A2 BR112012033548A BR112012033548A BR112012033548A2 BR 112012033548 A2 BR112012033548 A2 BR 112012033548A2 BR 112012033548 A BR112012033548 A BR 112012033548A BR 112012033548 A BR112012033548 A BR 112012033548A BR 112012033548 A2 BR112012033548 A2 BR 112012033548A2
Authority
BR
Brazil
Prior art keywords
stem cell
hscs
circulation
compositions
methods
Prior art date
Application number
BR112012033548A
Other languages
English (en)
Portuguese (pt)
Inventor
Christian Drapeau
Gitte S Jensen
Original Assignee
Stemtech Int Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Stemtech Int Inc filed Critical Stemtech Int Inc
Publication of BR112012033548A2 publication Critical patent/BR112012033548A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/20—Milk; Whey; Colostrum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/28—Bone marrow; Haematopoietic stem cells; Mesenchymal stem cells of any origin, e.g. adipose-derived stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/74—Bacteria
    • A61K35/748—Cyanobacteria, i.e. blue-green bacteria or blue-green algae, e.g. spirulina
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/02—Algae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/02—Algae
    • A61K36/03—Phaeophycota or phaeophyta (brown algae), e.g. Fucus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/062—Ascomycota
    • A61K36/066—Clavicipitaceae
    • A61K36/068—Cordyceps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/074—Ganoderma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815—Lycium (desert-thorn)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Biotechnology (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Zoology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
BR112012033548A 2010-06-28 2011-06-28 métodos e composições para melhorar a mobilização de células-tronco BR112012033548A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US35928810P 2010-06-28 2010-06-28
US201061427023P 2010-12-23 2010-12-23
PCT/US2011/042211 WO2012006100A2 (en) 2010-06-28 2011-06-28 Methods and compositions for enhancing stem cell mobilization

Publications (1)

Publication Number Publication Date
BR112012033548A2 true BR112012033548A2 (pt) 2017-06-20

Family

ID=45441732

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012033548A BR112012033548A2 (pt) 2010-06-28 2011-06-28 métodos e composições para melhorar a mobilização de células-tronco

Country Status (10)

Country Link
US (1) US10159705B2 (https=)
EP (2) EP2588119A4 (https=)
JP (2) JP2013531012A (https=)
KR (1) KR20140011295A (https=)
AU (1) AU2011276479B2 (https=)
BR (1) BR112012033548A2 (https=)
MX (1) MX344304B (https=)
MY (1) MY170013A (https=)
WO (1) WO2012006100A2 (https=)
ZA (1) ZA201300101B (https=)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012006100A2 (en) 2010-06-28 2012-01-12 Stemtech International, Inc. Methods and compositions for enhancing stem cell mobilization
US8679474B2 (en) 2010-08-04 2014-03-25 StemBios Technologies, Inc. Somatic stem cells
WO2013074801A1 (en) 2011-11-18 2013-05-23 Stemtech International, Inc. Use of foti to enhance stem cell mobilization and proliferation
CN104411316B (zh) 2012-05-09 2018-05-01 坎泰克斯制药股份有限公司 骨髓抑制的治疗
JP6050033B2 (ja) * 2012-06-05 2016-12-21 日本メナード化粧品株式会社 幹細胞から外胚葉系細胞への分化誘導剤
RU2015104535A (ru) * 2012-07-11 2016-08-27 Стемтек Интернэшнл, Инк. Композиции и способы для усиления мобилизации и пролиферации бластомероподобных стволовых клеток
TWI687519B (zh) 2012-12-06 2020-03-11 美商幹細胞生物科技股份有限公司 Ｌｇｒ５＋體幹細胞
EP2746769A1 (en) * 2012-12-21 2014-06-25 Stembios Technologies, Inc. Method for evaluating effect of action on subject based on stem celldynamics
KR20160021182A (ko) * 2013-06-19 2016-02-24 스템테크 인터내셔널, 인크. 줄기세포 동원을 증강하기 위한 방법 및 조성물
TW201920951A (zh) * 2013-06-24 2019-06-01 美商幹細胞生物科技公司 獲得幹細胞及其資料的方法
US20150141901A1 (en) * 2013-11-08 2015-05-21 Alan S. Lichtbroun Low-level laser irradiation of stimulated human stem cells
US10052346B2 (en) 2015-02-17 2018-08-21 Cantex Pharmaceuticals, Inc. Treatment of myelodysplastic syndromes with 2-O and,or 3-O desulfated heparinoids
US20160243168A1 (en) * 2015-02-17 2016-08-25 Cantex Pharmaceuticals, Inc. Adoptive cell transfer methods
US12264333B2 (en) 2018-09-20 2025-04-01 Mystem Biotechnologies Inc. Colostrum derived stem cells, neural differentiation, compositions and supplements for enhancing mammalian health
CN109432028A (zh) * 2018-11-30 2019-03-08 广东乾禾药用植物发展有限公司 一种猴头菌胃漂浮片的制备方法
JP7205880B2 (ja) * 2018-12-13 2023-01-17 日本メナード化粧品株式会社 メラノサイト分化誘導促進剤及びその使用方法
CN112806569A (zh) * 2021-01-20 2021-05-18 中科优术(黑龙江)科技产业有限公司 一种具有保护胃黏膜和抗幽门螺杆菌功能的组合物的制备方法与应用

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2878597B2 (ja) 1994-04-15 1999-04-05 惇 額田 養毛剤
US6814961B1 (en) 2001-05-14 2004-11-09 Gitte S. Jensen Method for enhancing stem cell trafficking
CN1827766B (zh) 2001-06-28 2010-08-25 徐荣祥 体外细胞的培养方法
JP2003135028A (ja) 2001-07-27 2003-05-13 Social Excellent Community Kk 健康機能食品
JP3721432B2 (ja) 2002-03-12 2005-11-30 株式会社コムス 海藻を原料とする飲料用食品の製造方法
US20050042314A1 (en) 2003-08-22 2005-02-24 National Yang-Ming University Extracts of Polygonum multiflorum Thunb., and preparation process and uses of the same
US20060068022A1 (en) 2004-09-29 2006-03-30 Playford Raymond J Bioactive agent compositions for repair of cell injuries
JP2008520588A (ja) 2004-11-18 2008-06-19 ビオファーマコペ デジン アンテルナショナル インク． 植物抽出物およびその皮膚科使用法
US20070020358A1 (en) * 2005-03-18 2007-01-25 Mower Thomas E Sports drink concentrate
ATE471665T1 (de) * 2005-04-21 2010-07-15 Nutricia Nv Nahrungsergänzungsmittel für hiv-patienten
US20080085330A1 (en) * 2005-05-02 2008-04-10 Cyndy Davis Sanberg Compounds for stimulating stem cell proliferation including spirulina
US20070003669A1 (en) * 2005-06-02 2007-01-04 Troy Kearl Fucoidan delivery system
JP4839021B2 (ja) * 2005-06-10 2011-12-14 国立大学法人 岡山大学 白血球及び／又は造血幹・前駆細胞動員剤
RU2417093C2 (ru) * 2005-06-24 2011-04-27 Дезерт Лейк Текнолоджиз Очищенный компонент цианобактерий и способ применения
CA2640087A1 (en) * 2006-01-25 2007-08-02 Mount Sinai School Of Medicine Methods and compositions for modulating the mobilization of stem cells
MX2008015299A (es) * 2006-06-01 2009-02-06 Sakura Properties Llc Composiciones de fucoidano y métodos.
KR20080007698A (ko) 2006-07-18 2008-01-23 전홍일 푸코이단을 포함하는 산후 조리용 식품 조성물
EP2099465A4 (en) 2006-09-21 2011-09-14 Academia Sinica IMPROVEMENT BY REISHI OF HUMAN TISSUE PROGENITOR CELLULAR ADHESION AND DIFFERENTIATION
JP5679663B2 (ja) * 2007-02-23 2015-03-04 バクスター・インターナショナル・インコーポレイテッドＢａｘｔｅｒ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｉｎｃｏｒｐ０Ｒａｔｅｄ 海藻抽出物からのフコイダン精製のためのプロセスの方法
HUP0700594A2 (en) * 2007-09-13 2009-04-28 Laszlo Szabo Composition and process for the protection and increasing the number of stem cells in the blood circulation and for enhancing p53 gene expression
CN101433313B (zh) * 2007-11-13 2012-05-30 蒋爱芳 一种具有抗辐射功能的保健食品
JP5186253B2 (ja) 2008-03-14 2013-04-17 第一薬品工業株式会社 抗ウイルス活性強化組成物
KR20090099374A (ko) * 2008-03-17 2009-09-22 김명숙 후코이단을 보강한 미역추출물 및 그 제조방법
US8871492B2 (en) * 2008-05-02 2014-10-28 Masaki Shirota Anti-dementia substance from Hericium erinaceum and method of extraction
CN102300578A (zh) 2008-12-01 2011-12-28 延寿有限责任公司 用于改变健康、安康和寿命的方法和组合物
TW201041586A (en) * 2009-05-22 2010-12-01 Du Peng Medicine and its preparation method for treating Parkinson's disease
US20110287061A1 (en) 2010-05-20 2011-11-24 Cathy Beggan Dietary composition and method for promoting healthy hair growth and melanogenesis
WO2012006100A2 (en) 2010-06-28 2012-01-12 Stemtech International, Inc. Methods and compositions for enhancing stem cell mobilization
WO2012135337A2 (en) 2011-03-28 2012-10-04 Mary Kay Inc. Topical skin care formulations comprising plant extracts
CA2841133A1 (en) 2011-08-05 2013-02-14 Stemtech International, Inc. Skin care compositions containing combinations of natural ingredients
WO2013074801A1 (en) 2011-11-18 2013-05-23 Stemtech International, Inc. Use of foti to enhance stem cell mobilization and proliferation
EP2797595A4 (en) 2011-12-29 2015-11-25 Entia Biosciences Inc NUTRITIONAL APPROACH FOR THE USE OF ERGOTHIONEIN AND VITAMIN D2 FOR HAIR, NAIL AND SKIN GROWTH
RU2015104535A (ru) 2012-07-11 2016-08-27 Стемтек Интернэшнл, Инк. Композиции и способы для усиления мобилизации и пролиферации бластомероподобных стволовых клеток
KR20160021182A (ko) 2013-06-19 2016-02-24 스템테크 인터내셔널, 인크. 줄기세포 동원을 증강하기 위한 방법 및 조성물

Also Published As

Publication number Publication date
AU2011276479A1 (en) 2013-01-17
EP2588119A2 (en) 2013-05-08
US10159705B2 (en) 2018-12-25
EP3153173A1 (en) 2017-04-12
AU2011276479B2 (en) 2015-06-25
MX2012015063A (es) 2013-04-03
JP2013531012A (ja) 2013-08-01
WO2012006100A3 (en) 2012-03-15
WO2012006100A2 (en) 2012-01-12
US20130108587A1 (en) 2013-05-02
KR20140011295A (ko) 2014-01-28
MY170013A (en) 2019-06-20
EP2588119A4 (en) 2014-01-08
JP2016153430A (ja) 2016-08-25
MX344304B (es) 2016-12-13
ZA201300101B (en) 2014-03-26

Similar Documents

Publication Publication Date Title
BR112012033548A2 (pt) métodos e composições para melhorar a mobilização de células-tronco
ES2544967T3 (es) Formulación y método para la prevención y el tratamiento de las metástasis óseas o de otras enfermedades óseas
ECSP12011685A (es) Inmunoconjugados dirigidos
BR112012029389A2 (pt) injeção bacteriana na cana de açúcar
BR112013028907A2 (pt) conjugados de proteína-agente ativo e método para preparar os mesmos
BR112013018352A2 (pt) composição de minociclina tópica e método
BRPI0911176B8 (pt) método de tratar uma composição de célula vermelha sanguínea, composição de célula vermelha sanguínea, e método de reduzir a desidratação em uma composição de célula vermelha sanguínea
NI201100082A (es) Compuestos de isoindolina para uso en el tratamiento de cáncer.
PH12015502827A1 (en) Methods and compositions for enhancing stem cell mobilization
MX346206B (es) Moleculas de enlace humanas capaces de neutralizar los virus de la influenza a del grupo filogenetico 1 y grupo filogenetico 2 y virus de la influenza b.
BR112015011244A2 (pt) Análogos de compstatina de ação prolongada, método de fabricação e uso dos mesmos, bem como composição de qualidade farmacêutica
BR112015011933A2 (pt) composições bacterianas sinérgicas e métodos de produção e uso das mesmas
WO2009089110A3 (en) Methods for repair and regeneration of bone marrow
MX339068B (es) Metodos y composiciones para el tratamiento de defectos oseos con poblaciones de celulas placentarias.
BR112014006244A2 (pt) microrganismos e métodos para produzir alcenos
NZ609201A (en) Means and methods for treating dlbcl
WO2013006474A3 (en) Requlatora t cells and methods of identifying and isolating them using cd6 -expression or the combination of cd4, cd25 and cd127
GT201400043A (es) Imidazopiridazinas sustituidas con amino
BR112012006283A2 (pt) formulação de adamts13 estabilizada, método para fabricar uma formulação de adamts13 estabilizada, kit, e métodos para tratar ou prevenir uma doença e para tratar ou previnir um enfarte
BR112012028711A2 (pt) métodos para a fabricação de uma emulsão de óleo em água, para a preparação de um kit de vacina e para redestilação de uma composição compreendendo 99% de esqualeno ou mais, assim como emulsão de óleo em água e kit
BR112013004700A2 (pt) método para prevenir ou tratar doenças ou distúrbios cardiovasculares
MX2016005824A (es) Metodo de cultivo celular.
CO6761392A2 (es) Administración de proteínas a partir de microportadores de células madre
ECSP15001113A (es) Composiciones y métodos para mejorar la movilización y proliferación de células madre similares a blastómeros
BR112015009229A2 (pt) composição tendo como alvo a expressão de genes para plaquetas, célula tronco hematopoiética, uso da referida célula tronco e método in vitro ou ex vivo para gerar uma célula tronco modificada

Legal Events

Date Code Title Description
B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8A ANUIDADE.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO ARQUIVAMENTO PUBLICADO NA RPI 2520 DE 25/04/2019.