BR112012030552A2 - composição imunogênica - Google Patents
composição imunogênicaInfo
- Publication number
- BR112012030552A2 BR112012030552A2 BR112012030552A BR112012030552A BR112012030552A2 BR 112012030552 A2 BR112012030552 A2 BR 112012030552A2 BR 112012030552 A BR112012030552 A BR 112012030552A BR 112012030552 A BR112012030552 A BR 112012030552A BR 112012030552 A2 BR112012030552 A2 BR 112012030552A2
- Authority
- BR
- Brazil
- Prior art keywords
- immunogenic composition
- composition
- sublingually
- tlr
- agonist
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/542—Mucosal route oral/gastrointestinal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
- A61K2039/55516—Proteins; Peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55588—Adjuvants of undefined constitution
- A61K2039/55594—Adjuvants of undefined constitution from bacteria
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Inorganic Chemistry (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Abstract
composição imunogênica. a presente invenção fornece uma composição imunogênica que compreende um ou mais antígenos e um agonista do receptor tipo toll (tlr) em uma composição oralmente (por exemplo, sublingualmente) administrada.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1009273.2A GB201009273D0 (en) | 2010-06-03 | 2010-06-03 | Novel vaccine |
PCT/EP2011/059167 WO2011151431A1 (en) | 2010-06-03 | 2011-06-02 | Oral vaccine comprising an antigen and a toll-like receptor agonist |
Publications (1)
Publication Number | Publication Date |
---|---|
BR112012030552A2 true BR112012030552A2 (pt) | 2016-08-16 |
Family
ID=42471081
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112012030552A BR112012030552A2 (pt) | 2010-06-03 | 2011-06-02 | composição imunogênica |
Country Status (15)
Country | Link |
---|---|
US (1) | US20130089570A1 (pt) |
EP (1) | EP2575871A1 (pt) |
JP (1) | JP2013527218A (pt) |
KR (1) | KR20130082139A (pt) |
CN (1) | CN102905726A (pt) |
AU (1) | AU2011260215B2 (pt) |
BR (1) | BR112012030552A2 (pt) |
CA (1) | CA2801266A1 (pt) |
EA (1) | EA201291105A1 (pt) |
GB (1) | GB201009273D0 (pt) |
IL (1) | IL223151A0 (pt) |
MX (1) | MX2012014083A (pt) |
SG (1) | SG185729A1 (pt) |
WO (1) | WO2011151431A1 (pt) |
ZA (1) | ZA201208915B (pt) |
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WO2009002401A2 (en) | 2007-06-21 | 2008-12-31 | President And Fellows Of Harvard College | Scaffolds for cell collection or elimination |
EP2254602B1 (en) | 2008-02-13 | 2018-11-21 | President and Fellows of Harvard College | Continuous cell programming devices |
US9370558B2 (en) | 2008-02-13 | 2016-06-21 | President And Fellows Of Harvard College | Controlled delivery of TLR agonists in structural polymeric devices |
WO2009146456A1 (en) | 2008-05-30 | 2009-12-03 | President And Fellows Of Harvard College | Controlled release of growth factors and signaling molecules for promoting angiogenesis |
US9297005B2 (en) | 2009-04-13 | 2016-03-29 | President And Fellows Of Harvard College | Harnessing cell dynamics to engineer materials |
US8728456B2 (en) | 2009-07-31 | 2014-05-20 | President And Fellows Of Harvard College | Programming of cells for tolerogenic therapies |
WO2011109834A2 (en) | 2010-03-05 | 2011-09-09 | President And Fellows Of Harvard College | Enhancement of skeletal muscle stem cell engrafment by dual delivery of vegf and igf-1 |
WO2011163669A2 (en) | 2010-06-25 | 2011-12-29 | President And Fellows Of Harvard College | Co-delivery of stimulatory and inhibitory factors to create temporally stable and spatially restricted zones |
US11202759B2 (en) | 2010-10-06 | 2021-12-21 | President And Fellows Of Harvard College | Injectable, pore-forming hydrogels for materials-based cell therapies |
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US9603894B2 (en) | 2010-11-08 | 2017-03-28 | President And Fellows Of Harvard College | Materials presenting notch signaling molecules to control cell behavior |
EP2701753B1 (en) | 2011-04-27 | 2018-12-26 | President and Fellows of Harvard College | Cell-friendly inverse opal hydrogels for cell encapsulation, drug and protein delivery, and functional nanoparticle encapsulation |
EP2701745B1 (en) | 2011-04-28 | 2018-07-11 | President and Fellows of Harvard College | Injectable preformed macroscopic 3-dimensional scaffolds for minimally invasive administration |
US9675561B2 (en) | 2011-04-28 | 2017-06-13 | President And Fellows Of Harvard College | Injectable cryogel vaccine devices and methods of use thereof |
JP6062426B2 (ja) | 2011-06-03 | 2017-01-18 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | インサイチュー抗原生成癌ワクチン |
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CA2861107A1 (en) * | 2012-01-13 | 2013-07-18 | President And Fellows Of Harvard College | Controlled delivery of tlr agonists in structural polymeric devices |
US20140086849A1 (en) | 2012-09-21 | 2014-03-27 | Elizabeth McKenna | Naturally-Occurring CpG Oligonucleotide Compositions and Therapeutic Applications Thereof |
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JP5650780B2 (ja) * | 2012-04-04 | 2015-01-07 | 日東電工株式会社 | ワクチン組成物 |
ES2773895T3 (es) | 2012-04-16 | 2020-07-15 | Harvard College | Composiciones de sílice mesoporosa para modular las respuestas inmunitarias |
CA2840959A1 (en) * | 2013-02-05 | 2014-08-05 | Nitto Denko Corporation | Vaccine composition |
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KR102045029B1 (ko) * | 2013-02-05 | 2019-11-14 | 닛토덴코 가부시키가이샤 | 점막 투여용 wt1 펩티드 암 백신 조성물 |
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BR112016006245A2 (pt) * | 2013-10-03 | 2017-08-01 | Nitto Denko Corp | composição de vacina de mucosa |
JP7348708B2 (ja) | 2014-04-30 | 2023-09-21 | プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ | 組み合わせワクチン装置および癌細胞を殺滅する方法 |
EP2950095B1 (en) * | 2014-05-28 | 2018-08-29 | Technische Universität Dresden | Cell-based assay and screening methods for modulators of p75NTR signaling |
KR101586468B1 (ko) * | 2014-12-30 | 2016-01-18 | 성균관대학교산학협력단 | 아주번트 조성물, 이의 제조 방법, 및 이를 포함하는 백신 조성물 |
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US11786457B2 (en) | 2015-01-30 | 2023-10-17 | President And Fellows Of Harvard College | Peritumoral and intratumoral materials for cancer therapy |
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US10286068B2 (en) | 2015-04-15 | 2019-05-14 | Ohio State Innovation Foundation | Methods to improve induction of IgA antibodies by vaccines |
KR101595949B1 (ko) * | 2015-05-27 | 2016-02-19 | 성균관대학교산학협력단 | 아주번트 조성물 및 백신 조성물의 제조 방법 |
CN115531609A (zh) | 2016-02-06 | 2022-12-30 | 哈佛学院校长同事会 | 重塑造血巢以重建免疫 |
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-
2010
- 2010-06-03 GB GBGB1009273.2A patent/GB201009273D0/en not_active Ceased
-
2011
- 2011-02-06 US US13/701,237 patent/US20130089570A1/en not_active Abandoned
- 2011-06-02 CN CN2011800273836A patent/CN102905726A/zh active Pending
- 2011-06-02 MX MX2012014083A patent/MX2012014083A/es not_active Application Discontinuation
- 2011-06-02 EP EP11724181.0A patent/EP2575871A1/en not_active Withdrawn
- 2011-06-02 WO PCT/EP2011/059167 patent/WO2011151431A1/en active Application Filing
- 2011-06-02 EA EA201291105A patent/EA201291105A1/ru unknown
- 2011-06-02 JP JP2013512932A patent/JP2013527218A/ja active Pending
- 2011-06-02 BR BR112012030552A patent/BR112012030552A2/pt not_active IP Right Cessation
- 2011-06-02 SG SG2012086294A patent/SG185729A1/en unknown
- 2011-06-02 AU AU2011260215A patent/AU2011260215B2/en not_active Ceased
- 2011-06-02 KR KR1020137000048A patent/KR20130082139A/ko not_active Application Discontinuation
- 2011-06-02 CA CA2801266A patent/CA2801266A1/en not_active Abandoned
-
2012
- 2012-11-20 IL IL223151A patent/IL223151A0/en unknown
- 2012-11-26 ZA ZA2012/08915A patent/ZA201208915B/en unknown
Also Published As
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ZA201208915B (en) | 2014-04-30 |
KR20130082139A (ko) | 2013-07-18 |
EP2575871A1 (en) | 2013-04-10 |
GB201009273D0 (en) | 2010-07-21 |
EA201291105A1 (ru) | 2013-05-30 |
AU2011260215A1 (en) | 2013-01-17 |
WO2011151431A1 (en) | 2011-12-08 |
AU2011260215B2 (en) | 2014-06-12 |
CA2801266A1 (en) | 2011-12-08 |
JP2013527218A (ja) | 2013-06-27 |
CN102905726A (zh) | 2013-01-30 |
IL223151A0 (en) | 2013-02-03 |
SG185729A1 (en) | 2012-12-28 |
US20130089570A1 (en) | 2013-04-11 |
MX2012014083A (es) | 2013-01-29 |
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