BR112012027316A2 - métodos para obter um traçador de tomografia por emissão de pósitron e para a preparação do composto, e, cassete - Google Patents

métodos para obter um traçador de tomografia por emissão de pósitron e para a preparação do composto, e, cassete

Info

Publication number
BR112012027316A2
BR112012027316A2 BR112012027316A BR112012027316A BR112012027316A2 BR 112012027316 A2 BR112012027316 A2 BR 112012027316A2 BR 112012027316 A BR112012027316 A BR 112012027316A BR 112012027316 A BR112012027316 A BR 112012027316A BR 112012027316 A2 BR112012027316 A2 BR 112012027316A2
Authority
BR
Brazil
Prior art keywords
preparing
positron emission
emission tomography
methods
cassette
Prior art date
Application number
BR112012027316A
Other languages
English (en)
Other versions
BR112012027316B1 (pt
Inventor
Bräthe Anders
Olsson Andreas
Thaning Mikkel
Bugge Steffen
Original Assignee
Ge Healthcare Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ge Healthcare Ltd filed Critical Ge Healthcare Ltd
Publication of BR112012027316A2 publication Critical patent/BR112012027316A2/pt
Publication of BR112012027316B1 publication Critical patent/BR112012027316B1/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/001—Acyclic or carbocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/14—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides
    • C07C319/20—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of sulfides by reactions not involving the formation of sulfide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C319/00—Preparation of thiols, sulfides, hydropolysulfides or polysulfides
    • C07C319/22—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of hydropolysulfides or polysulfides
    • C07C319/24—Preparation of thiols, sulfides, hydropolysulfides or polysulfides of hydropolysulfides or polysulfides by reactions involving the formation of sulfur-to-sulfur bonds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/31—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
    • C07C323/33—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to a carbon atom of the same non-condensed six-membered aromatic ring
    • C07C323/35—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to a carbon atom of the same non-condensed six-membered aromatic ring the thio group being a sulfide group
    • C07C323/37—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to a carbon atom of the same non-condensed six-membered aromatic ring the thio group being a sulfide group the sulfur atom of the sulfide group being further bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/43—Y being a hetero atom
    • C07C323/44—X or Y being nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

métodos para obter um traçador de tomografia por emissão de pósitron e para a preparação do composto, e, cassete. a presente invenção fornece um método para a preparação de um derivado de guanidina radiorrotulado, em particular, em que o derivado de guanidina radiorrotulado é um traçador de tomografia por emissão de pósitron (pet). certos intermediários úteis no dito método também são fornecidos, bem como meios para a realização do dito método em uma maneira automática. o método da invenção fornece vantagens nos métodos conhecidos para a preparação dos derivados de guanidina radiorrotulados.
BR112012027316-7A 2010-05-14 2011-05-13 métodos para obter um traçador de tomografia por emissão de pósitron e para a preparação do composto, e, cassete BR112012027316B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US33459910P 2010-05-14 2010-05-14
GBGB1008047.1A GB201008047D0 (en) 2010-05-14 2010-05-14 Method of synthesis
US61/334599 2010-05-14
GB1008047.1 2010-05-14
PCT/EP2011/057757 WO2011141568A1 (en) 2010-05-14 2011-05-13 Method of synthesis

Publications (2)

Publication Number Publication Date
BR112012027316A2 true BR112012027316A2 (pt) 2017-06-06
BR112012027316B1 BR112012027316B1 (pt) 2018-11-13

Family

ID=42334757

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012027316-7A BR112012027316B1 (pt) 2010-05-14 2011-05-13 métodos para obter um traçador de tomografia por emissão de pósitron e para a preparação do composto, e, cassete

Country Status (17)

Country Link
US (1) US8633337B2 (pt)
EP (1) EP2569279B1 (pt)
JP (1) JP5865351B2 (pt)
KR (1) KR101859782B1 (pt)
CN (1) CN102884043B (pt)
AU (1) AU2011251902B2 (pt)
BR (1) BR112012027316B1 (pt)
CA (1) CA2795558C (pt)
DK (1) DK2569279T3 (pt)
ES (1) ES2493140T3 (pt)
GB (1) GB201008047D0 (pt)
IL (1) IL222474A (pt)
NZ (1) NZ602950A (pt)
PL (1) PL2569279T3 (pt)
RU (1) RU2572554C2 (pt)
SG (1) SG184937A1 (pt)
WO (1) WO2011141568A1 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI623520B (zh) * 2012-12-12 2018-05-11 德商拜耳作物科學股份有限公司 製備雙（３－胺基苯基）二硫化物及３－胺基硫醇之方法
RU2021100620A (ru) * 2015-07-06 2021-01-29 Сейдж Терапьютикс, Инк. Оксистеролы и способы их применения
MY197698A (en) * 2015-07-06 2023-07-06 Sage Therapeutics Inc Oxysterols and methods of use thereof
LT3436022T (lt) 2016-04-01 2022-06-27 Sage Therapeutics, Inc. Oksisteroliai ir jų panaudojimo būdai
GB201607572D0 (en) * 2016-04-29 2016-06-15 Ge Healthcare Ltd Ip And Kings College London Alyklation method
CN111153840A (zh) * 2020-01-09 2020-05-15 复旦大学附属华山医院 [18f]-ge-179的合成方法

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5832861A (ja) * 1981-08-21 1983-02-25 Toubishi Yakuhin Kogyo Kk ２−置換アミノ−４−クロロ−チオフエノ−ル誘導体及びその製造方法
KR20030097618A (ko) * 1993-05-27 2003-12-31 캠브리지 뉴로사이언스, 인코포레이티드 치료용 치환 구아니딘류
US6242198B1 (en) 1996-07-25 2001-06-05 Cambridge Neuroscience, Inc. Methods of treatment of eye trauma and disorders
AU8278498A (en) 1997-07-07 1999-02-08 Cambridge Neuroscience, Inc. Combination drug therapies comprising aminoglycoside antibiotics and n,n'-disubstituted guanidines
US6774263B1 (en) 1997-10-10 2004-08-10 Cambridge Neuroscience, Inc. Pharmaceutically active compound and methods of use
WO1999018962A1 (en) 1997-10-10 1999-04-22 Cambridge Neuroscience, Inc. Pharmaceutically active compound and methods of use
DE19746540A1 (de) * 1997-10-22 1999-04-29 Bayer Ag S-(4-Biphenyl)-thioschwefelsäuren und ihre Salze, Verfahren zu deren Herstellung und die Herstellung von 4-Mercaptobiphenylen
AR035311A1 (es) * 1999-01-27 2004-05-12 Wyeth Corp Derivados de acido hidroxamico que contienen alquinilo, como inhibidores de las metalloproteinasas de matriz y de la tace, composicion farmaceutica y el uso de los mismos para la manufactura de un medicamento
GB0216621D0 (en) 2002-07-17 2002-08-28 Imaging Res Solutions Ltd Imaging compounds
GB0512770D0 (en) 2005-06-23 2005-07-27 Hammersmith Imanet Ltd Imaging compounds
EP1935867A1 (en) * 2006-12-20 2008-06-25 F. Hoffmann-La Roche Ag Process for preparing 1-(2-ethyl-butyl)-cyclohexanecarboxylic acid
US8137560B2 (en) * 2007-03-09 2012-03-20 Ge Healthcare Limited Separation process
WO2009029633A1 (en) * 2007-08-27 2009-03-05 Ge Healthcare Limited Synthesis of [18f]-labelled alkyl mesylates using fluorous spe separation

Also Published As

Publication number Publication date
IL222474A (en) 2015-10-29
US8633337B2 (en) 2014-01-21
CA2795558A1 (en) 2011-11-17
IL222474A0 (en) 2012-12-31
CN102884043A (zh) 2013-01-16
PL2569279T3 (pl) 2015-02-27
EP2569279B1 (en) 2014-07-09
KR101859782B1 (ko) 2018-05-18
RU2012143885A (ru) 2014-06-20
BR112012027316B1 (pt) 2018-11-13
ES2493140T3 (es) 2014-09-11
NZ602950A (en) 2014-08-29
CA2795558C (en) 2018-06-26
EP2569279A1 (en) 2013-03-20
CN102884043B (zh) 2016-01-20
US20130060064A1 (en) 2013-03-07
GB201008047D0 (en) 2010-06-30
SG184937A1 (en) 2012-12-28
JP5865351B2 (ja) 2016-02-17
RU2572554C2 (ru) 2016-01-20
KR20130091645A (ko) 2013-08-19
DK2569279T3 (da) 2014-08-11
AU2011251902A1 (en) 2012-12-20
WO2011141568A1 (en) 2011-11-17
JP2013528159A (ja) 2013-07-08
AU2011251902B2 (en) 2014-09-04

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Legal Events

Date Code Title Description
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 13/05/2011, OBSERVADAS AS CONDICOES LEGAIS.

B21F Lapse acc. art. 78, item iv - on non-payment of the annual fees in time

Free format text: REFERENTE A 10A ANUIDADE.

B24J Lapse because of non-payment of annual fees (definitively: art 78 iv lpi, resolution 113/2013 art. 12)

Free format text: EM VIRTUDE DA EXTINCAO PUBLICADA NA RPI 2622 DE 06-04-2021 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDA A EXTINCAO DA PATENTE E SEUS CERTIFICADOS, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.