BR112012021995A8 - Composição,célula hospedeira bacteriana não patogênica, método para a produção de um sulfato de condroitina,condroitina, composição e anticorpo ou fragmento de anticorpo - Google Patents

Composição,célula hospedeira bacteriana não patogênica, método para a produção de um sulfato de condroitina,condroitina, composição e anticorpo ou fragmento de anticorpo

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Publication number
BR112012021995A8
BR112012021995A8 BR112012021995A BR112012021995A BR112012021995A8 BR 112012021995 A8 BR112012021995 A8 BR 112012021995A8 BR 112012021995 A BR112012021995 A BR 112012021995A BR 112012021995 A BR112012021995 A BR 112012021995A BR 112012021995 A8 BR112012021995 A8 BR 112012021995A8
Authority
BR
Brazil
Prior art keywords
composition
chondroitin
antibody
production
host cell
Prior art date
Application number
BR112012021995A
Other languages
English (en)
Other versions
BR112012021995A2 (pt
Inventor
A Weaver Craig
Miyamoto Kentaro
Minamisawa Toshikazu
H Doherty Daniel
Original Assignee
Dsm Ip Assets Bv
Seikagaku Kogyo Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Ip Assets Bv, Seikagaku Kogyo Co Ltd filed Critical Dsm Ip Assets Bv
Publication of BR112012021995A2 publication Critical patent/BR112012021995A2/pt
Publication of BR112012021995A8 publication Critical patent/BR112012021995A8/pt

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K14/245—Escherichia (G)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
    • C07K16/1228—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
    • C07K16/1232—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia from Escherichia (G)
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0069—Chondroitin-4-sulfate, i.e. chondroitin sulfate A; Dermatan sulfate, i.e. chondroitin sulfate B or beta-heparin; Chondroitin-6-sulfate, i.e. chondroitin sulfate C; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
    • C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
    • C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/52—Genes encoding for enzymes or proenzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P19/00—Preparation of compounds containing saccharide radicals
    • C12P19/26—Preparation of nitrogen-containing carbohydrates

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Dermatology (AREA)
  • Materials Engineering (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Peptides Or Proteins (AREA)

Abstract

CONSTRUÇÃO, CÉLULA HOSPEDEIRA BACTERIANA NÃO PATOGÊNICA, MÉTODO PARA A PRODUÇÃO DE UM SULFATO DE CONDROITINA, COMPOSIÇÃO E ANTICORPO OU FRAGMENTO DE ANTICORPO. A invenção está relacionada ao campo da tecnologia de DNA recombinante para a produção de condroitina, incluindo a produção de sulfato de condroitina por meio de uma combinação de fermentação bacteriana recombinante e sulfatação pós-fermentação.
BR112012021995A 2010-03-01 2011-03-01 Composição,célula hospedeira bacteriana não patogênica, método para a produção de um sulfato de condroitina,condroitina, composição e anticorpo ou fragmento de anticorpo BR112012021995A8 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30940710P 2010-03-01 2010-03-01
PCT/US2011/026748 WO2011109438A1 (en) 2010-03-01 2011-03-01 Compositions and methods for bacterial production of chondroitin

Publications (2)

Publication Number Publication Date
BR112012021995A2 BR112012021995A2 (pt) 2015-10-06
BR112012021995A8 true BR112012021995A8 (pt) 2018-01-02

Family

ID=44542545

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012021995A BR112012021995A8 (pt) 2010-03-01 2011-03-01 Composição,célula hospedeira bacteriana não patogênica, método para a produção de um sulfato de condroitina,condroitina, composição e anticorpo ou fragmento de anticorpo

Country Status (8)

Country Link
US (2) US8697398B2 (pt)
EP (1) EP2542686B1 (pt)
JP (1) JP5875531B2 (pt)
KR (1) KR101848102B1 (pt)
CN (1) CN102869782B (pt)
BR (1) BR112012021995A8 (pt)
ES (1) ES2661593T3 (pt)
WO (1) WO2011109438A1 (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5875531B2 (ja) 2010-03-01 2016-03-02 生化学工業株式会社 コンドロイチンの細菌生産のための組成物および方法
SI2591127T1 (sl) 2010-07-09 2017-12-29 Gnosis S.P.A. Biotehnološka proizvodnja hondroitina
WO2013172154A1 (ja) * 2012-05-17 2013-11-21 東洋紡株式会社 担子菌酵母変異体
ITMI20120896A1 (it) 2012-05-23 2013-11-24 Bongulielmi Reto Condroitina per uso in medicina
ITMI20121316A1 (it) * 2012-07-27 2014-01-28 Altergon Sa Complessi di condroitina ad assorbimento transcutaneo
US9902756B2 (en) 2012-11-16 2018-02-27 The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. Gonorrheal MtrE peptides and vaccines
US20150247174A1 (en) * 2012-12-28 2015-09-03 Anhui Huaheng Bioengineering Co., Ltd, Engineering bacteria for producing dl-alanine and method for producing dl-alanine by using engineering bacteria
EP3053599A4 (en) * 2013-09-30 2017-06-14 Seikagaku Corporation Method for improving blood persistence of protein
FR3016637B1 (fr) * 2014-01-23 2020-11-27 Centre Nat Rech Scient Procede de production in vivo de glycosaminoglycane
US9616114B1 (en) 2014-09-18 2017-04-11 David Gordon Bermudes Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity
EP3050973A1 (en) * 2015-01-30 2016-08-03 Jennewein Biotechnologie GmbH Fermentation process for producing monosaccharides in free form from nucleotide-activated sugars
US10259889B2 (en) 2015-03-31 2019-04-16 Seikagaku Corporation Method for sulfating glycosaminoglycan
US11129906B1 (en) 2016-12-07 2021-09-28 David Gordon Bermudes Chimeric protein toxins for expression by therapeutic bacteria
US11180535B1 (en) 2016-12-07 2021-11-23 David Gordon Bermudes Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria
IT202000013633A1 (it) * 2020-06-08 2021-12-08 Vivatis Pharma Gmbh Processo di estrazione di una condroitina solfato da un fungo, una condroitina solfato di origine vegetale e suo uso
EP4067487A1 (en) 2021-04-01 2022-10-05 Givaudan SA Chondroitin-producing recombinant cell

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US20030104601A1 (en) 1999-04-01 2003-06-05 Deangelis Paul L. Chondroitin synthase gene and methods of making and using same
WO2000027437A2 (en) 1998-11-11 2000-05-18 The Board Of Regents Of The University Of Oklahoma Polymer grafting by polysaccharide synthases
US20060105431A1 (en) 1998-11-11 2006-05-18 Deangelis Paul L Polymer grafting by polysaccharide synthases using artificial sugar acceptors
US6235510B1 (en) 1999-08-18 2001-05-22 Smithkline Beecham Corporation ppGaNTase-T6
EP1233072B1 (en) 1999-11-25 2006-08-02 Yamasa Corporation Novel use of uridine diphosphate glucose 4-epimerase
DE10019881A1 (de) * 2000-04-20 2001-11-15 Gerhard Miksch Verfahren zur Überexpression und extrazellulären Produktion bakterieller Phytasen in Escherichia coli
EP1470235A4 (en) 2001-07-13 2008-05-21 Univ Oklahoma GLYCOSAMINOGLYCAN POLYMERS AND METHODS OF PREPARING AND USING THE SAME
JP4702819B2 (ja) 2001-08-01 2011-06-15 生化学工業株式会社 コンドロイチン合成酵素
JP4101548B2 (ja) 2001-08-10 2008-06-18 生化学工業株式会社 コンドロイチン合成酵素及びそれをコードするｄｎａ
JP4338038B2 (ja) 2002-05-31 2009-09-30 生化学工業株式会社 コンドロイチン合成酵素および該酵素をコードする核酸
JP4333880B2 (ja) 2002-05-31 2009-09-16 生化学工業株式会社 コンドロイチン合成酵素および該酵素をコードするｄｎａ
AU2005287397A1 (en) 2004-06-30 2006-03-30 Paul L. Deangelis Methods of selectively treating diseases with specific glycosaminoglycan polymers
ES2299284B1 (es) * 2004-11-04 2009-04-16 Universidad Pablo De Olavide Control de la expresion genica mediante el uso de un atenuador de la transcripcion.
US20080219960A1 (en) * 2004-12-16 2008-09-11 Masja Nathalie Nierop Groot Novel Efficient Production Process for Capsular Polysaccharides of Pathogenic Grampositive Bacteria by Heterologous Expression and Secretion of Complex Polysaccharides in Non-Pathogenic, Non-Invasive Gram-Positive Bacteria
JP5176114B2 (ja) * 2005-06-06 2013-04-03 フェネックス インコーポレイテッド 細菌宿主細胞におけるマンニトール誘導のプロモーター系
EP1964924B1 (en) 2005-12-15 2015-09-30 Seikagaku Corporation Long-chain chondroitin sugar chain and method for producing the same and method for promoting synthesis of chondroitin
EP2690178B1 (en) 2006-10-03 2021-12-22 The Board Of Regents Of The University Of Oklahoma Targeted glycosaminoglycan polymers by polymer grafting and methods of making and using same
WO2008133350A1 (en) * 2007-04-24 2008-11-06 Seikagaku Corporation Chondroitin-producing bacterium and method of producing chondroitin
JP5875531B2 (ja) 2010-03-01 2016-03-02 生化学工業株式会社 コンドロイチンの細菌生産のための組成物および方法
SI2591127T1 (sl) 2010-07-09 2017-12-29 Gnosis S.P.A. Biotehnološka proizvodnja hondroitina

Also Published As

Publication number Publication date
CN102869782A (zh) 2013-01-09
KR101848102B1 (ko) 2018-04-11
JP2013520995A (ja) 2013-06-10
EP2542686B1 (en) 2018-01-03
CN102869782B (zh) 2015-11-25
EP2542686A4 (en) 2014-03-26
BR112012021995A2 (pt) 2015-10-06
WO2011109438A1 (en) 2011-09-09
US20110244520A1 (en) 2011-10-06
ES2661593T3 (es) 2018-04-02
US9175293B2 (en) 2015-11-03
US8697398B2 (en) 2014-04-15
JP5875531B2 (ja) 2016-03-02
EP2542686A1 (en) 2013-01-09
KR20130055571A (ko) 2013-05-28
US20140296505A1 (en) 2014-10-02

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Owner name: SEIKAGAKU CORPORATION (JP)

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