BR112012021995A2 - ''composições e métodos para a produção bacteriana de condroitina'' - Google Patents
''composições e métodos para a produção bacteriana de condroitina''Info
- Publication number
- BR112012021995A2 BR112012021995A2 BR112012021995A BR112012021995A BR112012021995A2 BR 112012021995 A2 BR112012021995 A2 BR 112012021995A2 BR 112012021995 A BR112012021995 A BR 112012021995A BR 112012021995 A BR112012021995 A BR 112012021995A BR 112012021995 A2 BR112012021995 A2 BR 112012021995A2
- Authority
- BR
- Brazil
- Prior art keywords
- compositions
- methods
- chondroitin production
- bacterial
- bacterial chondroitin
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/245—Escherichia (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
- C07K16/1228—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K16/1232—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia from Escherichia (G)
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0069—Chondroitin-4-sulfate, i.e. chondroitin sulfate A; Dermatan sulfate, i.e. chondroitin sulfate B or beta-heparin; Chondroitin-6-sulfate, i.e. chondroitin sulfate C; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
- C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dermatology (AREA)
- Materials Engineering (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30940710P | 2010-03-01 | 2010-03-01 | |
PCT/US2011/026748 WO2011109438A1 (en) | 2010-03-01 | 2011-03-01 | Compositions and methods for bacterial production of chondroitin |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112012021995A2 true BR112012021995A2 (pt) | 2015-10-06 |
BR112012021995A8 BR112012021995A8 (pt) | 2018-01-02 |
Family
ID=44542545
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112012021995A BR112012021995A8 (pt) | 2010-03-01 | 2011-03-01 | Composição,célula hospedeira bacteriana não patogênica, método para a produção de um sulfato de condroitina,condroitina, composição e anticorpo ou fragmento de anticorpo |
Country Status (8)
Country | Link |
---|---|
US (2) | US8697398B2 (pt) |
EP (1) | EP2542686B1 (pt) |
JP (1) | JP5875531B2 (pt) |
KR (1) | KR101848102B1 (pt) |
CN (1) | CN102869782B (pt) |
BR (1) | BR112012021995A8 (pt) |
ES (1) | ES2661593T3 (pt) |
WO (1) | WO2011109438A1 (pt) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2661593T3 (es) | 2010-03-01 | 2018-04-02 | Seikagaku Corporation | Composiciones y métodos para producción bacteriana de condroitina |
KR101855062B1 (ko) * | 2010-07-09 | 2018-05-09 | 그노시스 에스.피.에이. | 콘드로이틴의 생물공학적 생산 |
WO2013172154A1 (ja) * | 2012-05-17 | 2013-11-21 | 東洋紡株式会社 | 担子菌酵母変異体 |
ITMI20120896A1 (it) | 2012-05-23 | 2013-11-24 | Bongulielmi Reto | Condroitina per uso in medicina |
ITMI20121316A1 (it) | 2012-07-27 | 2014-01-28 | Altergon Sa | Complessi di condroitina ad assorbimento transcutaneo |
CA2891552A1 (en) * | 2012-11-16 | 2014-05-22 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Gonorrheal mtre peptides and vaccines |
WO2014100920A1 (zh) * | 2012-12-28 | 2014-07-03 | 安徽华恒生物工程有限公司 | 生产dl-丙氨酸的工程菌及利用该工程菌生产dl-丙氨酸的方法 |
JP6478115B2 (ja) * | 2013-09-30 | 2019-03-06 | 生化学工業株式会社 | タンパク質の血中滞留性の増強方法 |
FR3016637B1 (fr) * | 2014-01-23 | 2020-11-27 | Centre Nat Rech Scient | Procede de production in vivo de glycosaminoglycane |
US9616114B1 (en) | 2014-09-18 | 2017-04-11 | David Gordon Bermudes | Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity |
EP3050973A1 (en) * | 2015-01-30 | 2016-08-03 | Jennewein Biotechnologie GmbH | Fermentation process for producing monosaccharides in free form from nucleotide-activated sugars |
EP3279220A4 (en) | 2015-03-31 | 2018-12-19 | Seikagaku Corporation | Method for sulfating glycosaminoglycan |
US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
IT202000013633A1 (it) * | 2020-06-08 | 2021-12-08 | Vivatis Pharma Gmbh | Processo di estrazione di una condroitina solfato da un fungo, una condroitina solfato di origine vegetale e suo uso |
EP4067487A1 (en) | 2021-04-01 | 2022-10-05 | Givaudan SA | Chondroitin-producing recombinant cell |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6444447B1 (en) | 1998-11-11 | 2002-09-03 | The Board Of Regents Of The University Of Oklahoma | Polymer grafting by polysaccharide synthases |
US20030104601A1 (en) | 1999-04-01 | 2003-06-05 | Deangelis Paul L. | Chondroitin synthase gene and methods of making and using same |
US20060105431A1 (en) | 1998-11-11 | 2006-05-18 | Deangelis Paul L | Polymer grafting by polysaccharide synthases using artificial sugar acceptors |
US6235510B1 (en) | 1999-08-18 | 2001-05-22 | Smithkline Beecham Corporation | ppGaNTase-T6 |
CA2392463C (en) | 1999-11-25 | 2009-10-20 | Yamasa Corporation | Novel use of uridine diphosphate glucose 4-epimerase |
DE10019881A1 (de) * | 2000-04-20 | 2001-11-15 | Gerhard Miksch | Verfahren zur Überexpression und extrazellulären Produktion bakterieller Phytasen in Escherichia coli |
EP1470235A4 (en) | 2001-07-13 | 2008-05-21 | Univ Oklahoma | GLYCOSAMINOGLYCAN POLYMERS AND METHODS OF PREPARING AND USING THE SAME |
JP4702819B2 (ja) | 2001-08-01 | 2011-06-15 | 生化学工業株式会社 | コンドロイチン合成酵素 |
JP4101548B2 (ja) | 2001-08-10 | 2008-06-18 | 生化学工業株式会社 | コンドロイチン合成酵素及びそれをコードするdna |
DE60324797D1 (de) | 2002-05-31 | 2009-01-02 | Seikagaku Kogyo Co Ltd | Chondroitinsynthetase und das enzym codierende dna |
WO2003102193A1 (fr) | 2002-05-31 | 2003-12-11 | Seikagaku Corporation | Chondroitine synthetase et acide nucleique codant pour cette enzyme |
AU2005287397A1 (en) | 2004-06-30 | 2006-03-30 | Paul L. Deangelis | Methods of selectively treating diseases with specific glycosaminoglycan polymers |
ES2299284B1 (es) * | 2004-11-04 | 2009-04-16 | Universidad Pablo De Olavide | Control de la expresion genica mediante el uso de un atenuador de la transcripcion. |
JP2008523804A (ja) * | 2004-12-16 | 2008-07-10 | ステイヒテイング・トツプ・インステイテユト・フード・アンド・ニユトリシヨン | 非病原性の非侵襲性グラム陽性細菌中での複合多糖の異種発現および分泌による、病原性グラム陽性細菌の莢膜多糖の新規効率的製造方法 |
KR101304921B1 (ko) * | 2005-06-06 | 2013-09-13 | 피페넥스 인크. | 세균 숙주 세포에서의 만니톨 유도 프로모터 시스템 |
EP1964924B1 (en) | 2005-12-15 | 2015-09-30 | Seikagaku Corporation | Long-chain chondroitin sugar chain and method for producing the same and method for promoting synthesis of chondroitin |
EP2690178B1 (en) | 2006-10-03 | 2021-12-22 | The Board Of Regents Of The University Of Oklahoma | Targeted glycosaminoglycan polymers by polymer grafting and methods of making and using same |
KR101548139B1 (ko) * | 2007-04-24 | 2015-08-28 | 세이가가쿠 고교 가부시키가이샤 | 콘드로이틴 생산 세균 및 콘드로이틴 생산 방법 |
ES2661593T3 (es) | 2010-03-01 | 2018-04-02 | Seikagaku Corporation | Composiciones y métodos para producción bacteriana de condroitina |
KR101855062B1 (ko) | 2010-07-09 | 2018-05-09 | 그노시스 에스.피.에이. | 콘드로이틴의 생물공학적 생산 |
-
2011
- 2011-03-01 ES ES11751231.9T patent/ES2661593T3/es active Active
- 2011-03-01 CN CN201180022154.5A patent/CN102869782B/zh active Active
- 2011-03-01 JP JP2012556184A patent/JP5875531B2/ja active Active
- 2011-03-01 WO PCT/US2011/026748 patent/WO2011109438A1/en active Application Filing
- 2011-03-01 BR BR112012021995A patent/BR112012021995A8/pt not_active Application Discontinuation
- 2011-03-01 EP EP11751231.9A patent/EP2542686B1/en active Active
- 2011-03-01 US US13/038,326 patent/US8697398B2/en active Active
- 2011-03-01 KR KR1020127025916A patent/KR101848102B1/ko active IP Right Grant
-
2014
- 2014-02-20 US US14/185,639 patent/US9175293B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
US9175293B2 (en) | 2015-11-03 |
CN102869782B (zh) | 2015-11-25 |
EP2542686B1 (en) | 2018-01-03 |
JP2013520995A (ja) | 2013-06-10 |
US20110244520A1 (en) | 2011-10-06 |
ES2661593T3 (es) | 2018-04-02 |
EP2542686A4 (en) | 2014-03-26 |
US20140296505A1 (en) | 2014-10-02 |
JP5875531B2 (ja) | 2016-03-02 |
EP2542686A1 (en) | 2013-01-09 |
US8697398B2 (en) | 2014-04-15 |
KR101848102B1 (ko) | 2018-04-11 |
BR112012021995A8 (pt) | 2018-01-02 |
WO2011109438A1 (en) | 2011-09-09 |
CN102869782A (zh) | 2013-01-09 |
KR20130055571A (ko) | 2013-05-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B25A | Requested transfer of rights approved |
Owner name: SEIKAGAKU CORPORATION (JP) |
|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] |
Free format text: MANTIDO O INDEFERIMENTO UMA VEZ QUE NAO FOI APRESENTADO RECURSO DENTRO DO PRAZO LEGAL |