BR112012021995A2 - ''composições e métodos para a produção bacteriana de condroitina'' - Google Patents
''composições e métodos para a produção bacteriana de condroitina''Info
- Publication number
- BR112012021995A2 BR112012021995A2 BR112012021995A BR112012021995A BR112012021995A2 BR 112012021995 A2 BR112012021995 A2 BR 112012021995A2 BR 112012021995 A BR112012021995 A BR 112012021995A BR 112012021995 A BR112012021995 A BR 112012021995A BR 112012021995 A2 BR112012021995 A2 BR 112012021995A2
- Authority
- BR
- Brazil
- Prior art keywords
- compositions
- methods
- chondroitin production
- bacterial
- bacterial chondroitin
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
- C07K14/24—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K14/245—Escherichia (G)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
- C07K16/1228—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
- C07K16/1232—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia from Escherichia (G)
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0069—Chondroitin-4-sulfate, i.e. chondroitin sulfate A; Dermatan sulfate, i.e. chondroitin sulfate B or beta-heparin; Chondroitin-6-sulfate, i.e. chondroitin sulfate C; Derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
- C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/70—Vectors or expression systems specially adapted for E. coli
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/74—Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/04—Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P19/00—Preparation of compounds containing saccharide radicals
- C12P19/26—Preparation of nitrogen-containing carbohydrates
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Polymers & Plastics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dermatology (AREA)
- Materials Engineering (AREA)
- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US30940710P | 2010-03-01 | 2010-03-01 | |
PCT/US2011/026748 WO2011109438A1 (en) | 2010-03-01 | 2011-03-01 | Compositions and methods for bacterial production of chondroitin |
Publications (2)
Publication Number | Publication Date |
---|---|
BR112012021995A2 true BR112012021995A2 (pt) | 2015-10-06 |
BR112012021995A8 BR112012021995A8 (pt) | 2018-01-02 |
Family
ID=44542545
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112012021995A BR112012021995A8 (pt) | 2010-03-01 | 2011-03-01 | Composição,célula hospedeira bacteriana não patogênica, método para a produção de um sulfato de condroitina,condroitina, composição e anticorpo ou fragmento de anticorpo |
Country Status (8)
Country | Link |
---|---|
US (2) | US8697398B2 (pt) |
EP (1) | EP2542686B1 (pt) |
JP (1) | JP5875531B2 (pt) |
KR (1) | KR101848102B1 (pt) |
CN (1) | CN102869782B (pt) |
BR (1) | BR112012021995A8 (pt) |
ES (1) | ES2661593T3 (pt) |
WO (1) | WO2011109438A1 (pt) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2661593T3 (es) | 2010-03-01 | 2018-04-02 | Seikagaku Corporation | Composiciones y métodos para producción bacteriana de condroitina |
CN103228781B (zh) * | 2010-07-09 | 2015-04-29 | 灵知股份公司 | 软骨素的生物技术制备 |
JP5588578B2 (ja) * | 2012-05-17 | 2014-09-10 | 東洋紡株式会社 | 担子菌酵母変異体 |
ITMI20120896A1 (it) | 2012-05-23 | 2013-11-24 | Bongulielmi Reto | Condroitina per uso in medicina |
ITMI20121316A1 (it) * | 2012-07-27 | 2014-01-28 | Altergon Sa | Complessi di condroitina ad assorbimento transcutaneo |
AU2013344571A1 (en) | 2012-11-16 | 2015-06-04 | The Henry M. Jackson Foundation For The Advancement Of Military Medicine, Inc. | Gonorrheal MtrE peptides and vaccines |
WO2014100920A1 (zh) * | 2012-12-28 | 2014-07-03 | 安徽华恒生物工程有限公司 | 生产dl-丙氨酸的工程菌及利用该工程菌生产dl-丙氨酸的方法 |
JP6478115B2 (ja) * | 2013-09-30 | 2019-03-06 | 生化学工業株式会社 | タンパク質の血中滞留性の増強方法 |
FR3016637B1 (fr) * | 2014-01-23 | 2020-11-27 | Centre Nat Rech Scient | Procede de production in vivo de glycosaminoglycane |
US9616114B1 (en) | 2014-09-18 | 2017-04-11 | David Gordon Bermudes | Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity |
EP3050973A1 (en) * | 2015-01-30 | 2016-08-03 | Jennewein Biotechnologie GmbH | Fermentation process for producing monosaccharides in free form from nucleotide-activated sugars |
JP6063103B1 (ja) | 2015-03-31 | 2017-01-18 | 生化学工業株式会社 | グリコサミノグリカンの硫酸化方法 |
US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
IT202000013633A1 (it) * | 2020-06-08 | 2021-12-08 | Vivatis Pharma Gmbh | Processo di estrazione di una condroitina solfato da un fungo, una condroitina solfato di origine vegetale e suo uso |
EP4067487A1 (en) | 2021-04-01 | 2022-10-05 | Givaudan SA | Chondroitin-producing recombinant cell |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6444447B1 (en) | 1998-11-11 | 2002-09-03 | The Board Of Regents Of The University Of Oklahoma | Polymer grafting by polysaccharide synthases |
US20030104601A1 (en) | 1999-04-01 | 2003-06-05 | Deangelis Paul L. | Chondroitin synthase gene and methods of making and using same |
US20060105431A1 (en) | 1998-11-11 | 2006-05-18 | Deangelis Paul L | Polymer grafting by polysaccharide synthases using artificial sugar acceptors |
US6235510B1 (en) | 1999-08-18 | 2001-05-22 | Smithkline Beecham Corporation | ppGaNTase-T6 |
WO2001038555A1 (fr) | 1999-11-25 | 2001-05-31 | Yamasa Corporation | Nouvelle utilisation de l'uridine-diphosphate-glucose 4-epimerase |
DE10019881A1 (de) * | 2000-04-20 | 2001-11-15 | Gerhard Miksch | Verfahren zur Überexpression und extrazellulären Produktion bakterieller Phytasen in Escherichia coli |
AU2002361549A1 (en) | 2001-07-13 | 2003-04-14 | Paul L. Deangelis | Glycosaminoglycan polymers and methods of making and using same |
JP4702819B2 (ja) | 2001-08-01 | 2011-06-15 | 生化学工業株式会社 | コンドロイチン合成酵素 |
JP4101548B2 (ja) | 2001-08-10 | 2008-06-18 | 生化学工業株式会社 | コンドロイチン合成酵素及びそれをコードするdna |
ATE388233T1 (de) | 2002-05-31 | 2008-03-15 | Seikagaku Kogyo Co Ltd | Chondroitinsynthetase und das enzym codierende nukleinsäure |
WO2003102194A1 (fr) | 2002-05-31 | 2003-12-11 | Seikagaku Corporation | Chondroitine synthetase et codage de l'adn pour l'enzyme |
AU2005287397A1 (en) | 2004-06-30 | 2006-03-30 | Paul L. Deangelis | Methods of selectively treating diseases with specific glycosaminoglycan polymers |
ES2299284B1 (es) * | 2004-11-04 | 2009-04-16 | Universidad Pablo De Olavide | Control de la expresion genica mediante el uso de un atenuador de la transcripcion. |
US20080219960A1 (en) | 2004-12-16 | 2008-09-11 | Masja Nathalie Nierop Groot | Novel Efficient Production Process for Capsular Polysaccharides of Pathogenic Grampositive Bacteria by Heterologous Expression and Secretion of Complex Polysaccharides in Non-Pathogenic, Non-Invasive Gram-Positive Bacteria |
BRPI0611112A2 (pt) * | 2005-06-06 | 2010-08-10 | Dow Global Technologies Inc | sistemas promotores induzidos por manitol em células hospedeiras bacterianas |
US8067204B2 (en) | 2005-12-15 | 2011-11-29 | Seikagaku Corporation | Long-chain chondroitin sugar chain and method for producing the same and method for promoting synthesis of chondroitin |
CA2701601C (en) | 2006-10-03 | 2020-06-30 | The Board Of Regents Of The University Of Oklahoma | Targeted glycosaminoglycan polymers by polymer grafting and methods of making and using same |
US8283145B2 (en) | 2007-04-24 | 2012-10-09 | Seikagaku Corporation | Chondroitin-producing bacterium and method of producing chondroitin |
ES2661593T3 (es) | 2010-03-01 | 2018-04-02 | Seikagaku Corporation | Composiciones y métodos para producción bacteriana de condroitina |
CN103228781B (zh) | 2010-07-09 | 2015-04-29 | 灵知股份公司 | 软骨素的生物技术制备 |
-
2011
- 2011-03-01 ES ES11751231.9T patent/ES2661593T3/es active Active
- 2011-03-01 KR KR1020127025916A patent/KR101848102B1/ko active IP Right Grant
- 2011-03-01 EP EP11751231.9A patent/EP2542686B1/en active Active
- 2011-03-01 WO PCT/US2011/026748 patent/WO2011109438A1/en active Application Filing
- 2011-03-01 CN CN201180022154.5A patent/CN102869782B/zh active Active
- 2011-03-01 US US13/038,326 patent/US8697398B2/en active Active
- 2011-03-01 BR BR112012021995A patent/BR112012021995A8/pt not_active Application Discontinuation
- 2011-03-01 JP JP2012556184A patent/JP5875531B2/ja active Active
-
2014
- 2014-02-20 US US14/185,639 patent/US9175293B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
US9175293B2 (en) | 2015-11-03 |
EP2542686A1 (en) | 2013-01-09 |
EP2542686B1 (en) | 2018-01-03 |
CN102869782B (zh) | 2015-11-25 |
US20110244520A1 (en) | 2011-10-06 |
EP2542686A4 (en) | 2014-03-26 |
JP2013520995A (ja) | 2013-06-10 |
BR112012021995A8 (pt) | 2018-01-02 |
CN102869782A (zh) | 2013-01-09 |
WO2011109438A1 (en) | 2011-09-09 |
US20140296505A1 (en) | 2014-10-02 |
ES2661593T3 (es) | 2018-04-02 |
JP5875531B2 (ja) | 2016-03-02 |
US8697398B2 (en) | 2014-04-15 |
KR20130055571A (ko) | 2013-05-28 |
KR101848102B1 (ko) | 2018-04-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B25A | Requested transfer of rights approved |
Owner name: SEIKAGAKU CORPORATION (JP) |
|
B06F | Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette] | ||
B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] | ||
B09B | Patent application refused [chapter 9.2 patent gazette] |
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