BR112012021581A2 - processo de preparação de alfa-aciloxil beta-formamido amidas - Google Patents

processo de preparação de alfa-aciloxil beta-formamido amidas

Info

Publication number
BR112012021581A2
BR112012021581A2 BR112012021581A BR112012021581A BR112012021581A2 BR 112012021581 A2 BR112012021581 A2 BR 112012021581A2 BR 112012021581 A BR112012021581 A BR 112012021581A BR 112012021581 A BR112012021581 A BR 112012021581A BR 112012021581 A2 BR112012021581 A2 BR 112012021581A2
Authority
BR
Brazil
Prior art keywords
compound
formula
acyloxyl
beta
alpha
Prior art date
Application number
BR112012021581A
Other languages
English (en)
Inventor
Znabet Anass
Ruijter Eelco
Polak Marloes
Turner Nicholas
Orru Romano
Original Assignee
Ver Voor Christelijk Hoger Onderwijs Wetenschappelijk Onderzoek En Patiëntenzorg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ver Voor Christelijk Hoger Onderwijs Wetenschappelijk Onderzoek En Patiëntenzorg filed Critical Ver Voor Christelijk Hoger Onderwijs Wetenschappelijk Onderzoek En Patiëntenzorg
Publication of BR112012021581A2 publication Critical patent/BR112012021581A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C291/00—Compounds containing carbon and nitrogen and having functional groups not covered by groups C07C201/00 - C07C281/00
    • C07C291/10—Isocyanides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/06—Preparation of carboxylic acid amides from nitriles by transformation of cyano groups into carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C237/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups
    • C07C237/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C237/14—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups having the carbon atoms of the carboxamide groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being saturated and containing rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/80—[b, c]- or [b, d]-condensed
    • C07D209/94—[b, c]- or [b, d]-condensed containing carbocyclic rings other than six-membered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D241/24—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/04—Systems containing only non-condensed rings with a four-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Toxicology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Communicable Diseases (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

processo de preparação de alfa-aciloxil beta-formamido amidas. a presente invenção refere-se a um processo para a apresentação de um composto de fórmula geral (i), compreendendo: a) reagir um composto de fórmula geral (ii) com um composto de fórmula iii r² cooh e um composto de fórmula geral iv r³nc em condições tais que o composto i é formado, em que r¹ representa uma estrutura substituída ou não substituída de alquila, alquelina. alquilina, aromática ou não aromática, mono-, di-ou tricícla ou heterocíclica, e r³ representa uma estrutura substituída ou não substituída de alquila, alquenila, alquilina. no aspecto mais aprofundado, o objeto da invenção diz respeito ao uso dos produtos obtidos como intermédios para diversos peptidomiméticos e, de preferência, como um bloco de construção de uma síntese convergente de estruturas dipeptídeo prolila.
BR112012021581A 2010-02-25 2010-09-16 processo de preparação de alfa-aciloxil beta-formamido amidas BR112012021581A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US30787310P 2010-02-25 2010-02-25
PCT/EP2010/063657 WO2011103933A1 (en) 2010-02-25 2010-09-16 PROCESS FOR THE PREPARATION OF α-ACYLOXY β-FORMAMIDO AMIDES

Publications (1)

Publication Number Publication Date
BR112012021581A2 true BR112012021581A2 (pt) 2017-03-21

Family

ID=43088069

Family Applications (2)

Application Number Title Priority Date Filing Date
BR112012021581A BR112012021581A2 (pt) 2010-02-25 2010-09-16 processo de preparação de alfa-aciloxil beta-formamido amidas
BR112012021556A BR112012021556A2 (pt) 2010-02-25 2010-09-16 processo para a preparação de peptídeos prolila substituídos e peptidomiméticos similares

Family Applications After (1)

Application Number Title Priority Date Filing Date
BR112012021556A BR112012021556A2 (pt) 2010-02-25 2010-09-16 processo para a preparação de peptídeos prolila substituídos e peptidomiméticos similares

Country Status (7)

Country Link
US (3) US20120329704A1 (pt)
EP (2) EP2539334A1 (pt)
CN (2) CN102844314B (pt)
BR (2) BR112012021581A2 (pt)
CA (2) CA2791045A1 (pt)
MX (2) MX2012009926A (pt)
WO (2) WO2011103933A1 (pt)

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KR101721904B1 (ko) * 2008-08-29 2017-04-11 오럴 헬스 오스트레일리아 피티와이 엘티디 Ｐ．진지발리스 감염의 예방, 치료 및 진단
MX2012009926A (es) * 2010-02-25 2012-10-05 Vereniging Voor Christelijk Hoger Onderwijs Wetenschappelijk Onderzoek En Patientenzorg Un proceso para la preparacion de peptidos prolil sustituidos y peptidomimeticos similares.
US8820164B2 (en) * 2012-01-31 2014-09-02 Sikorsky Aircraft Corporation Retroreflector for ultrasonic inspection
ITMI20120359A1 (it) * 2012-03-07 2013-09-08 Dipharma Francis Srl Procedimento per la preparazione di intermedi utili nella preparazione di un inibitore delle proteasi virali
WO2013178682A2 (en) 2012-05-30 2013-12-05 Chemo Ibérica, S.A. Multicomponent process for the preparation of bicyclic compounds
CN103570605B (zh) * 2012-08-01 2015-08-05 上海迪赛诺药业有限公司 特拉匹韦及其中间体的制备方法
WO2014096374A1 (en) * 2012-12-21 2014-06-26 Sandoz Ag Process for the synthesis of pyrrolidines and pyrroles
WO2014102816A1 (en) * 2012-12-26 2014-07-03 Glenmark Pharmaceuticals Limited; Glenmark Generics Limited Process for preparation of telaprevir and intermediates
US11351149B2 (en) 2020-09-03 2022-06-07 Pfizer Inc. Nitrile-containing antiviral compounds
CN115253696B (zh) * 2021-04-29 2023-09-22 天津膜天膜科技股份有限公司 手性分离膜及其制备方法
IL309732A (en) * 2021-07-09 2024-02-01 Aligos Therapeutics Inc Antiviral compounds
CN114736882B (zh) * 2022-05-20 2023-09-22 苏州百福安酶技术有限公司 一种单胺氧化酶及其应用

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US7244721B2 (en) 2000-07-21 2007-07-17 Schering Corporation Peptides as NS3-serine protease inhibitors of hepatitis C virus
RU2355700C9 (ru) * 2000-07-21 2010-03-20 Шеринг Корпорейшн Новые пептиды как ингибиторы ns3-серинпротеазы вируса гепатита с
GB0206415D0 (en) 2002-03-19 2002-05-01 Glaxo Group Ltd Deracemisation of amines
EP1742913A1 (en) * 2003-12-11 2007-01-17 Schering Corporation Inhibitors of hepatitis c virus ns3/ns4a serine protease
TWI389688B (zh) * 2004-06-08 2013-03-21 Vertex Pharma Vx-950之形態與調配物及其製備方法與用途
EP2374464A3 (en) * 2004-10-01 2011-10-26 Vertex Pharmaceuticals Incorporated HCV N3S-NS4A protease inhibition
GB0426661D0 (en) * 2004-12-06 2005-01-05 Isis Innovation Pyrrolidine compounds
WO2006130686A2 (en) * 2005-06-02 2006-12-07 Schering Corporation Hcv protease inhibitors in combination with food
WO2007022450A1 (en) 2005-08-18 2007-02-22 Clean Filtration Technologies, Inc. Hydroclone based fluid filtration system
ES2344156T3 (es) * 2005-08-19 2010-08-19 Vertex Pharmaceuticals Incorporated Procedimientos e intermedios.
CN102816106A (zh) 2008-06-24 2012-12-12 默沙东公司 用于制备基本上立体异构纯的稠合二环脯氨酸化合物的生物催化方法
MX2012009926A (es) * 2010-02-25 2012-10-05 Vereniging Voor Christelijk Hoger Onderwijs Wetenschappelijk Onderzoek En Patientenzorg Un proceso para la preparacion de peptidos prolil sustituidos y peptidomimeticos similares.

Also Published As

Publication number Publication date
CN102822147A (zh) 2012-12-12
BR112012021556A2 (pt) 2017-03-21
EP2539320A1 (en) 2013-01-02
MX2012009927A (es) 2012-10-05
CN102844314B (zh) 2015-05-20
EP2539334A1 (en) 2013-01-02
US20120329704A1 (en) 2012-12-27
CN102844314A (zh) 2012-12-26
WO2011103932A1 (en) 2011-09-01
US8686145B2 (en) 2014-04-01
MX2012009926A (es) 2012-10-05
WO2011103933A1 (en) 2011-09-01
US20120330015A1 (en) 2012-12-27
US20140213788A1 (en) 2014-07-31
CA2791045A1 (en) 2011-09-01
CA2790930A1 (en) 2011-09-01

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]
B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]