BR112012021448A2 - polímero de amina, método para tratar doença, método de remoção de sais biliares de um indivíduo animal, método para melhorar o controle glicêmico em um indivíduo, e, processo para preparar o polímero de amina. - Google Patents

polímero de amina, método para tratar doença, método de remoção de sais biliares de um indivíduo animal, método para melhorar o controle glicêmico em um indivíduo, e, processo para preparar o polímero de amina.

Info

Publication number
BR112012021448A2
BR112012021448A2 BR112012021448A BR112012021448A BR112012021448A2 BR 112012021448 A2 BR112012021448 A2 BR 112012021448A2 BR 112012021448 A BR112012021448 A BR 112012021448A BR 112012021448 A BR112012021448 A BR 112012021448A BR 112012021448 A2 BR112012021448 A2 BR 112012021448A2
Authority
BR
Brazil
Prior art keywords
amine polymer
individual
bile salts
preparing
glycemic control
Prior art date
Application number
BR112012021448A
Other languages
English (en)
Portuguese (pt)
Inventor
Angela Lee
Deidre Madsen
Elizabeth Goka
Eric Connor
Hongmin Zhang
Inez Lees
Jun Shao
Kalpesh Biyani
Michael James Cope
Scott Hecker
Xinnan Zhang
Original Assignee
Relypsa Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Relypsa Inc filed Critical Relypsa Inc
Publication of BR112012021448A2 publication Critical patent/BR112012021448A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08F—MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
    • C08F226/00—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen
    • C08F226/06—Copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by a single or double bond to nitrogen or by a heterocyclic ring containing nitrogen by a heterocyclic ring containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/397—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having four-membered rings, e.g. azetidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/74—Synthetic polymeric materials
    • A61K31/785—Polymers containing nitrogen
    • A61K31/787—Polymers containing nitrogen containing heterocyclic rings having nitrogen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G61/00—Macromolecular compounds obtained by reactions forming a carbon-to-carbon link in the main chain of the macromolecule
    • C08G61/12—Macromolecular compounds containing atoms other than carbon in the main chain of the macromolecule
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/02—Polyamines
    • C08G73/0273—Polyamines containing heterocyclic moieties in the main chain
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/06—Polycondensates having nitrogen-containing heterocyclic rings in the main chain of the macromolecule
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/06—Polycondensates having nitrogen-containing heterocyclic rings in the main chain of the macromolecule
    • C08G73/0605—Polycondensates containing five-membered rings, not condensed with other rings, with nitrogen atoms as the only ring hetero atoms
    • C08G73/0616—Polycondensates containing five-membered rings, not condensed with other rings, with nitrogen atoms as the only ring hetero atoms with only two nitrogen atoms in the ring
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/06—Polycondensates having nitrogen-containing heterocyclic rings in the main chain of the macromolecule
    • C08G73/0622—Polycondensates containing six-membered rings, not condensed with other rings, with nitrogen atoms as the only ring hetero atoms
    • C08G73/0627—Polycondensates containing six-membered rings, not condensed with other rings, with nitrogen atoms as the only ring hetero atoms with only one nitrogen atom in the ring
    • C—CHEMISTRY; METALLURGY
    • C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
    • C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
    • C08G73/06—Polycondensates having nitrogen-containing heterocyclic rings in the main chain of the macromolecule
    • C08G73/18—Polybenzimidazoles

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Polymers & Plastics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Endocrinology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Epoxy Resins (AREA)
BR112012021448A 2010-02-24 2011-02-24 polímero de amina, método para tratar doença, método de remoção de sais biliares de um indivíduo animal, método para melhorar o controle glicêmico em um indivíduo, e, processo para preparar o polímero de amina. BR112012021448A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30781910P 2010-02-24 2010-02-24
US30781610P 2010-02-24 2010-02-24
PCT/US2011/026102 WO2011106545A1 (en) 2010-02-24 2011-02-24 Polyimidazoles for use as bile acid sequestrants

Publications (1)

Publication Number Publication Date
BR112012021448A2 true BR112012021448A2 (pt) 2016-05-31

Family

ID=43975199

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012021448A BR112012021448A2 (pt) 2010-02-24 2011-02-24 polímero de amina, método para tratar doença, método de remoção de sais biliares de um indivíduo animal, método para melhorar o controle glicêmico em um indivíduo, e, processo para preparar o polímero de amina.

Country Status (10)

Country Link
US (2) US20130189215A1 (enExample)
EP (2) EP2538947B1 (enExample)
JP (3) JP5964247B2 (enExample)
CN (2) CN106478948B (enExample)
AU (2) AU2011220745B2 (enExample)
BR (1) BR112012021448A2 (enExample)
CA (1) CA2790899C (enExample)
ES (1) ES2598500T3 (enExample)
GB (1) GB2490853B (enExample)
WO (1) WO2011106545A1 (enExample)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112012021444A2 (pt) 2010-02-24 2016-05-31 Relypsa Inc polímero de amina reticulado, composição farmacêutica, método de redução do colesterol ldl sérico em um indivíduo, métodos para tratar doença, de remoção de sais biliares de um indivíduo, e para melhorar o controle glicêmico em um indivíduo, e, processo para preparar o polímero de aminas.
CA2790901C (en) 2010-02-24 2018-05-01 Relypsa, Inc. Amine polymers for use as bile acid sequestrants
US20130244234A1 (en) * 2012-01-23 2013-09-19 Glc Biotechnology, Inc. Stool collection methods for analysis of dna in stool
JP6227535B2 (ja) * 2012-08-30 2017-11-08 株式会社三和化学研究所 脂質異常症の予防又は治療薬
ES2834485T3 (es) 2013-06-05 2021-06-17 Tricida Inc Polímeros de unión a protones para administración oral
ES2895625T3 (es) 2014-04-16 2022-02-22 Uab Res Found Nanoporos de MSP y usos de los mismos
AU2015274377B2 (en) 2014-06-13 2020-07-23 United Therapeutics Corporation Treprostinil formulations
MA41150B1 (fr) 2014-12-10 2020-06-30 Tricida Inc Polymères de liaison aux protons pour administration orale
MA41202A (fr) 2014-12-18 2017-10-24 Genzyme Corp Copolymères polydiallymine réticulé pour le traitement du diabète de type 2
EP3331499A4 (en) * 2015-08-06 2019-04-10 The Johns Hopkins University COMPOSITION AND METHOD FOR THE TREATMENT OF METABOLISM DISEASES
CN106967217A (zh) * 2016-01-14 2017-07-21 华南理工大学 聚咪唑类化合物及其原位制备方法和应用
MA44875A (fr) 2016-05-06 2019-03-13 Tricida Inc Compositions pour le traitement de troubles acido-basiques
BR112019013364A2 (pt) 2016-12-28 2020-04-14 Fujifilm Corp emulsão de polímero contendo átomo de nitrogênio ou sal do mesmo, método de produção para o mesmo e método de produção para partículas
TW201922267A (zh) 2017-10-16 2019-06-16 日商富士軟片股份有限公司 高磷血症治療劑
IL273960B2 (en) 2017-11-03 2025-08-01 Tricida Inc Nonabsorable compositions for use in treating or preventing metabolic acidosis
CN109932349B (zh) * 2019-04-04 2021-04-20 济南大学 一种检测次氯酸的有机硅小分子荧光探针
WO2021040440A1 (ko) * 2019-08-30 2021-03-04 (주)셀트리온 비알콜성 지방간염(nash, nonalcoholic steatohepatitis) 치료 또는 예방을 위한 약학 조성물
WO2021055759A1 (en) 2019-09-20 2021-03-25 Glyscend, Inc. Substituted phenyl boronic acid containing polymers and methods of use

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60209523A (ja) * 1984-04-03 1985-10-22 Mitsubishi Petrochem Co Ltd コレステロ−ル低下剤
US4600578A (en) * 1984-05-11 1986-07-15 Bristol-Myers Company Method of inhibiting diarrhea
US4649048A (en) * 1984-05-11 1987-03-10 Bristol-Myers Company Novel bile sequestrant resin
EP0563731B1 (de) * 1992-03-28 1995-11-15 Hoechst Aktiengesellschaft Arzneimittel aus Polyhydroxymethylenderivaten, Verfahren zu deren Herstellung und Verwendung
JPH066667A (ja) 1992-06-22 1994-01-14 Canon Inc ぶれ検出装置及びぶれ補正装置
US5631365A (en) 1993-09-21 1997-05-20 Schering Corporation Hydroxy-substituted azetidinone compounds useful as hypocholesterolemic agents
US5414068A (en) 1994-01-24 1995-05-09 Rohm And Haas Company Crosslinked anion exchange particles and method for producing the particles
CN1189168A (zh) * 1995-06-06 1998-07-29 吉尔特药品公司 用于清除胆固醇的含疏水杂原子的螯合剂
JP4156684B2 (ja) * 1996-03-05 2008-09-24 三菱化学株式会社 高リン血症予防および／または治療剤
ATE281508T1 (de) * 1997-09-15 2004-11-15 Procter & Gamble Waschmittelzusammensetzungen mit cyclische aminpolymeren um die aussehen- und integritätseigenschaften der damit gewaschenen wäsche zu
US6147183A (en) * 1997-09-15 2000-11-14 Basf Aktiengesellschaft Amphoteric amine based polymers having a net cationic charge and process for their production
US5900233A (en) * 1997-10-16 1999-05-04 Day; Charles E. Epichlorohydrin and 1-(3-aminopropyl) imidazole copolymer and its use in treating irritable bowel syndrome
DE69923855T2 (de) * 1998-10-13 2005-12-29 The Procter & Gamble Company, Cincinnati Waschmittelzusammensetzungen enthaltend eine kombination von auf cyklischem amin basierenden copolymeren und hydrophob modifizierten cellulosen
US6472364B1 (en) * 1998-10-13 2002-10-29 The Procter & Gamble Company Detergent compositions or components
AU1906500A (en) * 1999-10-29 2001-05-14 Procter & Gamble Company, The Laundry detergent compositions with fabric care
JP2002068985A (ja) * 2000-08-30 2002-03-08 Mitsubishi-Tokyo Pharmaceuticals Inc 薬剤性肝障害治療薬
JPWO2002043761A1 (ja) * 2000-11-28 2004-04-02 三菱ウェルファーマ株式会社 抗肥満剤及び健康食品
CA2454732C (en) * 2001-07-30 2010-07-20 Mitsubishi Pharma Corporation Drugs for ameliorating postcibal hyperglycemia
JP2003113091A (ja) * 2001-10-02 2003-04-18 Sekisui Chem Co Ltd 胆汁酸特異的認識ポリマー及びコレステロール低下剤
US7459502B2 (en) * 2003-11-03 2008-12-02 Ilypsa, Inc. Pharmaceutical compositions comprising crosslinked polyamine polymers
US7608674B2 (en) * 2003-11-03 2009-10-27 Ilypsa, Inc. Pharmaceutical compositions comprising cross-linked small molecule amine polymers
ATE433984T1 (de) * 2004-03-26 2009-07-15 Lilly Co Eli Verbindungen und verfahren zur behandlung von dyslipidämie
JP4896480B2 (ja) * 2004-10-01 2012-03-14 第一三共ヘルスケア株式会社 陰イオン交換樹脂の粒子状組成物
JP6218355B2 (ja) * 2011-02-10 2017-10-25 ソニー株式会社 濾材
CN105900233A (zh) * 2013-12-13 2016-08-24 Wow研究中心有限公司 半导体装置及其制造方法
CN106147183A (zh) * 2015-04-01 2016-11-23 合肥杰事杰新材料股份有限公司 一种pc/abs合金材料及其制备方法

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JP6431499B2 (ja) 2018-11-28
CN106478948A (zh) 2017-03-08
AU2017201276A1 (en) 2017-03-16
AU2011220745B2 (en) 2016-12-01
CN102858347A (zh) 2013-01-02
CA2790899C (en) 2018-12-18
GB2490853A (en) 2012-11-14
JP2017101258A (ja) 2017-06-08
CA2790899A1 (en) 2011-09-01
GB2490853B (en) 2018-08-08
EP2538947A1 (en) 2013-01-02
EP2538947B1 (en) 2016-08-17
JP2013520562A (ja) 2013-06-06
EP3130343B1 (en) 2018-05-09
JP5964247B2 (ja) 2016-08-03
CN106478948B (zh) 2019-05-07
CN102858347B (zh) 2016-11-02
WO2011106545A1 (en) 2011-09-01
ES2598500T3 (es) 2017-01-27
US20130189215A1 (en) 2013-07-25
AU2017201276B2 (en) 2018-09-27
AU2011220745A1 (en) 2012-09-13
US20190169342A1 (en) 2019-06-06
EP3130343A1 (en) 2017-02-15
GB201216799D0 (en) 2012-11-07
JP2016169388A (ja) 2016-09-23

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