BR112012018458A2 - métodos e composições para diagnóstico pré-natal não invasivo de aneuploidias fetais - Google Patents
métodos e composições para diagnóstico pré-natal não invasivo de aneuploidias fetaisInfo
- Publication number
- BR112012018458A2 BR112012018458A2 BR112012018458A BR112012018458A BR112012018458A2 BR 112012018458 A2 BR112012018458 A2 BR 112012018458A2 BR 112012018458 A BR112012018458 A BR 112012018458A BR 112012018458 A BR112012018458 A BR 112012018458A BR 112012018458 A2 BR112012018458 A2 BR 112012018458A2
- Authority
- BR
- Brazil
- Prior art keywords
- dna
- fetal
- methods
- compositions
- hypomethylated
- Prior art date
Links
- 230000001605 fetal effect Effects 0.000 title abstract 8
- 208000036878 aneuploidy Diseases 0.000 title abstract 4
- 231100001075 aneuploidy Toxicity 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 title abstract 3
- 238000003793 prenatal diagnosis Methods 0.000 title abstract 2
- 239000008280 blood Substances 0.000 abstract 4
- 210000004369 blood Anatomy 0.000 abstract 4
- 238000003745 diagnosis Methods 0.000 abstract 1
- 238000001114 immunoprecipitation Methods 0.000 abstract 1
- 230000008774 maternal effect Effects 0.000 abstract 1
- 230000035935 pregnancy Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6804—Nucleic acid analysis using immunogens
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/154—Methylation markers
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Pathology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29833910P | 2010-01-26 | 2010-01-26 | |
| US40542110P | 2010-10-21 | 2010-10-21 | |
| PCT/IB2011/000217 WO2011092592A2 (en) | 2010-01-26 | 2011-01-26 | Methods and compositions for noninvasive prenatal diagnosis of fetal aneuploidies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BR112012018458A2 true BR112012018458A2 (pt) | 2018-07-10 |
Family
ID=44278821
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112012018458A BR112012018458A2 (pt) | 2010-01-26 | 2011-01-26 | métodos e composições para diagnóstico pré-natal não invasivo de aneuploidias fetais |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US9249462B2 (https=) |
| EP (1) | EP2529032B1 (https=) |
| JP (1) | JP2013517789A (https=) |
| KR (1) | KR20120107512A (https=) |
| CN (1) | CN102892899A (https=) |
| AU (1) | AU2011210255B2 (https=) |
| BR (1) | BR112012018458A2 (https=) |
| CA (1) | CA2786174A1 (https=) |
| CY (1) | CY1118864T1 (https=) |
| DK (1) | DK2529032T3 (https=) |
| EA (1) | EA023565B1 (https=) |
| ES (1) | ES2623156T3 (https=) |
| NZ (1) | NZ601079A (https=) |
| PL (1) | PL2529032T3 (https=) |
| PT (1) | PT2529032T (https=) |
| SG (1) | SG182322A1 (https=) |
| WO (1) | WO2011092592A2 (https=) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI335354B (en) | 2006-09-27 | 2011-01-01 | Univ Hong Kong Chinese | Methods for the detection of the degree of the methylation of a target dna and kits |
| US8962247B2 (en) | 2008-09-16 | 2015-02-24 | Sequenom, Inc. | Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses |
| US8476013B2 (en) | 2008-09-16 | 2013-07-02 | Sequenom, Inc. | Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses |
| EP3088532B1 (en) | 2009-12-22 | 2019-10-30 | Sequenom, Inc. | Processes and kits for identifying aneuploidy |
| HK1206055A1 (en) | 2012-03-02 | 2015-12-31 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| US9920361B2 (en) | 2012-05-21 | 2018-03-20 | Sequenom, Inc. | Methods and compositions for analyzing nucleic acid |
| US10504613B2 (en) | 2012-12-20 | 2019-12-10 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| US20140093873A1 (en) | 2012-07-13 | 2014-04-03 | Sequenom, Inc. | Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses |
| US9732390B2 (en) | 2012-09-20 | 2017-08-15 | The Chinese University Of Hong Kong | Non-invasive determination of methylome of fetus or tumor from plasma |
| US10706957B2 (en) | 2012-09-20 | 2020-07-07 | The Chinese University Of Hong Kong | Non-invasive determination of methylome of tumor from plasma |
| BR122021021823B1 (pt) * | 2012-09-20 | 2023-04-25 | The Chinese University Of Hong Kong | Método para determinar um primeiro perfil de metilação de uma amostra biológica de um organismo, e, meio de armazenamento de memória |
| EP2900837A4 (en) * | 2012-09-26 | 2016-06-01 | Agency Science Tech & Res | BIOMARKERS FOR THE PRENATAL DIAGNOSIS OF THE DOWN SYNDROME |
| HK1216655A1 (zh) | 2013-03-13 | 2016-11-25 | Sequenom, Inc. | 用於dna甲基化分析的引物 |
| KR20140118682A (ko) | 2013-03-29 | 2014-10-08 | (주)셀트리온 | 2 이상의 인플루엔자 ａ 바이러스 중화 결합 분자를 포함하는 조성물 |
| US11365447B2 (en) | 2014-03-13 | 2022-06-21 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| RU2583830C2 (ru) * | 2014-04-21 | 2016-05-10 | Закрытое акционерное общество "Геноаналитика" | Способ неинвазивной пренатальной диагностики анеуплоидий плода |
| EP2942400A1 (en) | 2014-05-09 | 2015-11-11 | Lifecodexx AG | Multiplex detection of DNA that originates from a specific cell-type |
| WO2015169947A1 (en) | 2014-05-09 | 2015-11-12 | Lifecodexx Ag | Detection of dna that originates from a specific cell-type and related methods |
| EP2942401A1 (en) | 2014-05-09 | 2015-11-11 | Lifecodexx AG | Detection of DNA that originates from a specific cell-type |
| US20180187267A1 (en) * | 2017-01-05 | 2018-07-05 | Michael J. Powell | Method for conducting early detection of colon cancer and/or of colon cancer precursor cells and for monitoring colon cancer recurrence |
| US10174383B2 (en) * | 2014-08-13 | 2019-01-08 | Vanadis Diagnostics | Method of estimating the amount of a methylated locus in a sample |
| WO2016176846A1 (zh) * | 2015-05-06 | 2016-11-10 | 安诺优达基因科技(北京)有限公司 | 检测染色体非整倍性的试剂盒、装置和方法 |
| PL3666902T3 (pl) | 2015-05-22 | 2025-02-03 | Medicover Public Co Ltd | Multipleksowa równoległa analiza docelowych regionów genomowych do nieinwazyjnych badań prenatalnych |
| HUE050491T2 (hu) * | 2015-11-10 | 2020-12-28 | Eurofins Lifecodexx Gmbh | Magzati kromoszomális aneuploidiák kimutatása olyan DNS régiókat alkalmazva, amelyek különbözõképpen vannak metilezve a magzat és a terhes nõstény között |
| WO2017094941A1 (ko) * | 2015-12-04 | 2017-06-08 | 주식회사 녹십자지놈 | 핵산의 혼합물을 포함하는 샘플에서 복제수 변이를 결정하는 방법 |
| KR101817180B1 (ko) * | 2016-01-20 | 2018-01-10 | 이원다이애그노믹스(주) | 염색체 이상 판단 방법 |
| AU2017274038B2 (en) | 2016-05-30 | 2023-03-16 | The Chinese University Of Hong Kong | Detecting hematological disorders using cell-free DNA in blood |
| CN109112209B (zh) * | 2017-06-25 | 2022-06-24 | 国家卫生计生委科学技术研究所 | 用于无创产前检测胎儿非整倍体染色体的参考品 |
| CN111989407B (zh) | 2018-03-13 | 2024-10-29 | 格里尔公司 | 异常的片段检测及分类 |
| KR20200060969A (ko) | 2018-11-23 | 2020-06-02 | (주)셀트리온 | 인플루엔자 바이러스 질환을 치료하기 위한 투여 요법 |
| WO2020132572A1 (en) | 2018-12-21 | 2020-06-25 | Grail, Inc. | Source of origin deconvolution based on methylation fragments in cell-free-dna samples |
| US20230151409A1 (en) * | 2020-03-30 | 2023-05-18 | Vilnius University | Methods and compositions for noninvasive prenatal diagnosis through targeted covalent labeling of genomic sites |
| US12592321B2 (en) | 2020-06-19 | 2026-03-31 | University Health Network | Cancer detection and classification using methylome analysis |
| KR102332540B1 (ko) * | 2020-07-02 | 2021-11-29 | 의료법인 성광의료재단 | 다운증후군 특이적인 후성학적 마커를 이용한 다운증후군 진단 방법 |
| WO2023133572A2 (en) * | 2022-01-10 | 2023-07-13 | Washington State University | Dna methylation biomarkers for preterm birth |
| EP4695417A1 (en) * | 2023-04-14 | 2026-02-18 | Adela, Inc. | Methods and systems for cell-free nucleic acid processing |
| WO2025179073A1 (en) * | 2024-02-21 | 2025-08-28 | Adela, Inc. | Methods and systems for tissue informed differentially methylated region analysis |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6582908B2 (en) * | 1990-12-06 | 2003-06-24 | Affymetrix, Inc. | Oligonucleotides |
| CN1882700A (zh) * | 2003-09-22 | 2006-12-20 | 特莱索根生物科技有限合伙公司 | 用于检测基因座拷贝数改变的方法和试剂盒 |
| US20050282213A1 (en) * | 2003-09-22 | 2005-12-22 | Trisogen Biotechnology Limited Partnership | Methods and kits useful for detecting an alteration in a locus copy number |
| GB0413688D0 (en) * | 2004-06-18 | 2004-07-21 | Novartis Forschungsstiftung | Analysis of methylated nucleic acid |
| EP1817430B1 (en) * | 2004-11-29 | 2009-09-16 | Klinikum der Universität Regensburg | Means and methods for detecting methylated dna |
| WO2007044780A2 (en) * | 2005-10-07 | 2007-04-19 | Emory University | Methods and systems for screening for and diagnosing dna methylation associated abnormalities and sex chromosome aneuploidies |
| US7901884B2 (en) * | 2006-05-03 | 2011-03-08 | The Chinese University Of Hong Kong | Markers for prenatal diagnosis and monitoring |
| LT2557517T (lt) * | 2007-07-23 | 2023-01-10 | The Chinese University Of Hong Kong | Nukleino rūgščių sekos disbalanso nustatymas |
| JP5322471B2 (ja) * | 2008-03-27 | 2013-10-23 | シスメックス株式会社 | メチル化ｄｎａの解析方法及びプライマーセット |
| US8476013B2 (en) | 2008-09-16 | 2013-07-02 | Sequenom, Inc. | Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses |
-
2011
- 2011-01-26 DK DK11709465.6T patent/DK2529032T3/en active
- 2011-01-26 CN CN2011800097571A patent/CN102892899A/zh active Pending
- 2011-01-26 AU AU2011210255A patent/AU2011210255B2/en active Active
- 2011-01-26 JP JP2012550529A patent/JP2013517789A/ja active Pending
- 2011-01-26 SG SG2012049003A patent/SG182322A1/en unknown
- 2011-01-26 BR BR112012018458A patent/BR112012018458A2/pt not_active IP Right Cessation
- 2011-01-26 CA CA2786174A patent/CA2786174A1/en not_active Abandoned
- 2011-01-26 EP EP11709465.6A patent/EP2529032B1/en active Active
- 2011-01-26 ES ES11709465.6T patent/ES2623156T3/es active Active
- 2011-01-26 EA EA201290716A patent/EA023565B1/ru not_active IP Right Cessation
- 2011-01-26 KR KR1020127020832A patent/KR20120107512A/ko not_active Withdrawn
- 2011-01-26 WO PCT/IB2011/000217 patent/WO2011092592A2/en not_active Ceased
- 2011-01-26 PL PL11709465T patent/PL2529032T3/pl unknown
- 2011-01-26 PT PT117094656T patent/PT2529032T/pt unknown
- 2011-01-26 NZ NZ601079A patent/NZ601079A/en unknown
- 2011-01-26 US US13/520,708 patent/US9249462B2/en active Active
-
2017
- 2017-04-21 CY CY20171100452T patent/CY1118864T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2011210255B2 (en) | 2014-11-20 |
| CY1118864T1 (el) | 2018-01-10 |
| EA201290716A1 (ru) | 2013-06-28 |
| CN102892899A (zh) | 2013-01-23 |
| EA023565B1 (ru) | 2016-06-30 |
| PL2529032T3 (pl) | 2017-07-31 |
| DK2529032T3 (en) | 2017-05-01 |
| CA2786174A1 (en) | 2011-08-04 |
| PT2529032T (pt) | 2017-05-04 |
| EP2529032A2 (en) | 2012-12-05 |
| SG182322A1 (en) | 2012-08-30 |
| KR20120107512A (ko) | 2012-10-02 |
| EP2529032B1 (en) | 2017-01-25 |
| AU2011210255A1 (en) | 2012-07-26 |
| WO2011092592A3 (en) | 2011-11-03 |
| NZ601079A (en) | 2014-08-29 |
| ES2623156T3 (es) | 2017-07-10 |
| US9249462B2 (en) | 2016-02-02 |
| JP2013517789A (ja) | 2013-05-20 |
| WO2011092592A2 (en) | 2011-08-04 |
| US20120282613A1 (en) | 2012-11-08 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B08F | Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette] | ||
| B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2480 DE 17-07-2018 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013. |