CN102892899A - 无创产前诊断胎儿非整倍体性的方法和组合物 - Google Patents

无创产前诊断胎儿非整倍体性的方法和组合物 Download PDF

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CN102892899A
CN102892899A CN2011800097571A CN201180009757A CN102892899A CN 102892899 A CN102892899 A CN 102892899A CN 2011800097571 A CN2011800097571 A CN 2011800097571A CN 201180009757 A CN201180009757 A CN 201180009757A CN 102892899 A CN102892899 A CN 102892899A
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dna
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dmrs
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P·C·帕特萨里斯
E·A·帕帕乔治乌
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6804—Nucleic acid analysis using immunogens
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    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6809—Methods for determination or identification of nucleic acids involving differential detection
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers

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CN2011800097571A 2010-01-26 2011-01-26 无创产前诊断胎儿非整倍体性的方法和组合物 Pending CN102892899A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US29833910P 2010-01-26 2010-01-26
US61/298,339 2010-01-26
US40542110P 2010-10-21 2010-10-21
US61/405,421 2010-10-21
PCT/IB2011/000217 WO2011092592A2 (en) 2010-01-26 2011-01-26 Methods and compositions for noninvasive prenatal diagnosis of fetal aneuploidies

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CN102892899A true CN102892899A (zh) 2013-01-23

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US (1) US9249462B2 (https=)
EP (1) EP2529032B1 (https=)
JP (1) JP2013517789A (https=)
KR (1) KR20120107512A (https=)
CN (1) CN102892899A (https=)
AU (1) AU2011210255B2 (https=)
BR (1) BR112012018458A2 (https=)
CA (1) CA2786174A1 (https=)
CY (1) CY1118864T1 (https=)
DK (1) DK2529032T3 (https=)
EA (1) EA023565B1 (https=)
ES (1) ES2623156T3 (https=)
NZ (1) NZ601079A (https=)
PL (1) PL2529032T3 (https=)
PT (1) PT2529032T (https=)
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WO2016176846A1 (zh) * 2015-05-06 2016-11-10 安诺优达基因科技(北京)有限公司 检测染色体非整倍性的试剂盒、装置和方法
CN107109468A (zh) * 2014-08-13 2017-08-29 苏州新波生物技术有限公司 评估样品中甲基化基因座的量的方法
CN107223159A (zh) * 2014-05-09 2017-09-29 科戴克斯生命股份公司 源自特定细胞类型的dna的检测及相关方法
CN108475301A (zh) * 2015-12-04 2018-08-31 绿十字基因组公司 用于确定包含核酸的混合物的样品中的拷贝数变异的方法
CN108604258A (zh) * 2016-01-20 2018-09-28 伊万基因诊断中心有限公司 染色体异常判断方法
CN109996891A (zh) * 2017-01-05 2019-07-09 南京帝基生物科技有限公司 用于进行结肠癌和/或结肠癌前体细胞的早期检测和用于监测结肠癌复发的方法

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US8962247B2 (en) 2008-09-16 2015-02-24 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses
US8476013B2 (en) 2008-09-16 2013-07-02 Sequenom, Inc. Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
EP3088532B1 (en) 2009-12-22 2019-10-30 Sequenom, Inc. Processes and kits for identifying aneuploidy
HK1206055A1 (en) 2012-03-02 2015-12-31 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US9920361B2 (en) 2012-05-21 2018-03-20 Sequenom, Inc. Methods and compositions for analyzing nucleic acid
US10504613B2 (en) 2012-12-20 2019-12-10 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US20140093873A1 (en) 2012-07-13 2014-04-03 Sequenom, Inc. Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
US9732390B2 (en) 2012-09-20 2017-08-15 The Chinese University Of Hong Kong Non-invasive determination of methylome of fetus or tumor from plasma
US10706957B2 (en) 2012-09-20 2020-07-07 The Chinese University Of Hong Kong Non-invasive determination of methylome of tumor from plasma
BR122021021823B1 (pt) * 2012-09-20 2023-04-25 The Chinese University Of Hong Kong Método para determinar um primeiro perfil de metilação de uma amostra biológica de um organismo, e, meio de armazenamento de memória
EP2900837A4 (en) * 2012-09-26 2016-06-01 Agency Science Tech & Res BIOMARKERS FOR THE PRENATAL DIAGNOSIS OF THE DOWN SYNDROME
HK1216655A1 (zh) 2013-03-13 2016-11-25 Sequenom, Inc. 用於dna甲基化分析的引物
KR20140118682A (ko) 2013-03-29 2014-10-08 (주)셀트리온 2 이상의 인플루엔자 ａ 바이러스 중화 결합 분자를 포함하는 조성물
US11365447B2 (en) 2014-03-13 2022-06-21 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
RU2583830C2 (ru) * 2014-04-21 2016-05-10 Закрытое акционерное общество "Геноаналитика" Способ неинвазивной пренатальной диагностики анеуплоидий плода
EP2942400A1 (en) 2014-05-09 2015-11-11 Lifecodexx AG Multiplex detection of DNA that originates from a specific cell-type
EP2942401A1 (en) 2014-05-09 2015-11-11 Lifecodexx AG Detection of DNA that originates from a specific cell-type
PL3666902T3 (pl) 2015-05-22 2025-02-03 Medicover Public Co Ltd Multipleksowa równoległa analiza docelowych regionów genomowych do nieinwazyjnych badań prenatalnych
HUE050491T2 (hu) * 2015-11-10 2020-12-28 Eurofins Lifecodexx Gmbh Magzati kromoszomális aneuploidiák kimutatása olyan DNS régiókat alkalmazva, amelyek különbözõképpen vannak metilezve a magzat és a terhes nõstény között
AU2017274038B2 (en) 2016-05-30 2023-03-16 The Chinese University Of Hong Kong Detecting hematological disorders using cell-free DNA in blood
CN109112209B (zh) * 2017-06-25 2022-06-24 国家卫生计生委科学技术研究所 用于无创产前检测胎儿非整倍体染色体的参考品
CN111989407B (zh) 2018-03-13 2024-10-29 格里尔公司 异常的片段检测及分类
KR20200060969A (ko) 2018-11-23 2020-06-02 (주)셀트리온 인플루엔자 바이러스 질환을 치료하기 위한 투여 요법
WO2020132572A1 (en) 2018-12-21 2020-06-25 Grail, Inc. Source of origin deconvolution based on methylation fragments in cell-free-dna samples
US20230151409A1 (en) * 2020-03-30 2023-05-18 Vilnius University Methods and compositions for noninvasive prenatal diagnosis through targeted covalent labeling of genomic sites
US12592321B2 (en) 2020-06-19 2026-03-31 University Health Network Cancer detection and classification using methylome analysis
KR102332540B1 (ko) * 2020-07-02 2021-11-29 의료법인 성광의료재단 다운증후군 특이적인 후성학적 마커를 이용한 다운증후군 진단 방법
WO2023133572A2 (en) * 2022-01-10 2023-07-13 Washington State University Dna methylation biomarkers for preterm birth
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WO2025179073A1 (en) * 2024-02-21 2025-08-28 Adela, Inc. Methods and systems for tissue informed differentially methylated region analysis

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Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107223159A (zh) * 2014-05-09 2017-09-29 科戴克斯生命股份公司 源自特定细胞类型的dna的检测及相关方法
CN107109468A (zh) * 2014-08-13 2017-08-29 苏州新波生物技术有限公司 评估样品中甲基化基因座的量的方法
CN107109468B (zh) * 2014-08-13 2020-09-08 苏州新波生物技术有限公司 评估样品中甲基化基因座的量的方法
WO2016176846A1 (zh) * 2015-05-06 2016-11-10 安诺优达基因科技(北京)有限公司 检测染色体非整倍性的试剂盒、装置和方法
CN108475301A (zh) * 2015-12-04 2018-08-31 绿十字基因组公司 用于确定包含核酸的混合物的样品中的拷贝数变异的方法
CN108604258A (zh) * 2016-01-20 2018-09-28 伊万基因诊断中心有限公司 染色体异常判断方法
CN108604258B (zh) * 2016-01-20 2022-05-13 伊万基因诊断中心有限公司 染色体异常判断方法
CN109996891A (zh) * 2017-01-05 2019-07-09 南京帝基生物科技有限公司 用于进行结肠癌和/或结肠癌前体细胞的早期检测和用于监测结肠癌复发的方法

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AU2011210255B2 (en) 2014-11-20
CY1118864T1 (el) 2018-01-10
EA201290716A1 (ru) 2013-06-28
EA023565B1 (ru) 2016-06-30
PL2529032T3 (pl) 2017-07-31
BR112012018458A2 (pt) 2018-07-10
DK2529032T3 (en) 2017-05-01
CA2786174A1 (en) 2011-08-04
PT2529032T (pt) 2017-05-04
EP2529032A2 (en) 2012-12-05
SG182322A1 (en) 2012-08-30
KR20120107512A (ko) 2012-10-02
EP2529032B1 (en) 2017-01-25
AU2011210255A1 (en) 2012-07-26
WO2011092592A3 (en) 2011-11-03
NZ601079A (en) 2014-08-29
ES2623156T3 (es) 2017-07-10
US9249462B2 (en) 2016-02-02
JP2013517789A (ja) 2013-05-20
WO2011092592A2 (en) 2011-08-04
US20120282613A1 (en) 2012-11-08

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