BR112012011591A2 - reator para a produção de partículas de medicamentos em um processo de precipitação - Google Patents

reator para a produção de partículas de medicamentos em um processo de precipitação

Info

Publication number
BR112012011591A2
BR112012011591A2 BR112012011591A BR112012011591A BR112012011591A2 BR 112012011591 A2 BR112012011591 A2 BR 112012011591A2 BR 112012011591 A BR112012011591 A BR 112012011591A BR 112012011591 A BR112012011591 A BR 112012011591A BR 112012011591 A2 BR112012011591 A2 BR 112012011591A2
Authority
BR
Brazil
Prior art keywords
reactor
reaction chamber
production
precipitation process
particles
Prior art date
Application number
BR112012011591A
Other languages
English (en)
Other versions
BR112012011591B1 (pt
Inventor
Jachowicz Jadwiga
Moraleda Karen
Zupon Michael
Gandhi Sanket
Original Assignee
Mannkind Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mannkind Corp filed Critical Mannkind Corp
Publication of BR112012011591A2 publication Critical patent/BR112012011591A2/pt
Publication of BR112012011591B1 publication Critical patent/BR112012011591B1/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0053—Details of the reactor
    • B01J19/0066—Stirrers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D43/00—Separating particles from liquids, or liquids from solids, otherwise than by sedimentation or filtration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F27/00—Mixers with rotary stirring devices in fixed receptacles; Kneaders
    • B01F27/27—Mixers with stator-rotor systems, e.g. with intermeshing teeth or cylinders or having orifices
    • B01F27/271—Mixers with stator-rotor systems, e.g. with intermeshing teeth or cylinders or having orifices with means for moving the materials to be mixed radially between the surfaces of the rotor and the stator
    • B01F27/2711—Mixers with stator-rotor systems, e.g. with intermeshing teeth or cylinders or having orifices with means for moving the materials to be mixed radially between the surfaces of the rotor and the stator provided with intermeshing elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/18—Stationary reactors having moving elements inside

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Mixers Of The Rotary Stirring Type (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Accessories For Mixers (AREA)

Abstract

reator para a produção de partículas de medicamentos em um processo de precipitação. tem-se provisão de reatores, sistemas e métodos de reatores voltados para a produção de partículas em um processo de precipitação. o reator inclui um compartimento definindo uma câmara de reação, um conjunto de estator incluindo dois ou mais estatores, um conjunto de rotor incluindo dois ou mais rotores, o conjunto de rotor configurado por rotacionar em torno de um eixo de rotação em relação ao conjunto de estator, com a primeira entrada fornecendo um primeiro material reagente até a câmara de reação junto á primeira localização radial, sendo que o primeiro e segundo materiais reagentes reagem para produzirem a precipitação das partículas na câmara de reação, e uma saída para fornecimento das partículas formadas na câmara de reação.
BR112012011591-0A 2009-11-02 2010-11-02 Reator, sistema e método voltado para a produção de partículas em um processo de precipitação BR112012011591B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US25731109P 2009-11-02 2009-11-02
US61/257,311 2009-11-02
US38466210P 2010-09-20 2010-09-20
US61/384,662 2010-09-20
PCT/US2010/055090 WO2011053963A1 (en) 2009-11-02 2010-11-02 Reactor for producing pharmaceutical particles in a precipitation process

Publications (2)

Publication Number Publication Date
BR112012011591A2 true BR112012011591A2 (pt) 2018-09-11
BR112012011591B1 BR112012011591B1 (pt) 2020-02-27

Family

ID=43922631

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012011591-0A BR112012011591B1 (pt) 2009-11-02 2010-11-02 Reator, sistema e método voltado para a produção de partículas em um processo de precipitação

Country Status (14)

Country Link
US (4) US8491848B2 (pt)
EP (1) EP2496339B1 (pt)
JP (2) JP5981343B2 (pt)
KR (1) KR101907699B1 (pt)
CN (2) CN102596379B (pt)
AU (1) AU2010313177B2 (pt)
BR (1) BR112012011591B1 (pt)
CA (2) CA2779614C (pt)
HK (2) HK1173695A1 (pt)
IL (1) IL219305B (pt)
MX (1) MX2012005091A (pt)
RU (2) RU2553881C2 (pt)
SG (1) SG10201406836SA (pt)
WO (1) WO2011053963A1 (pt)

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CN102596379B (zh) 2009-11-02 2015-04-01 曼康公司 以沉淀过程产生药物颗粒的反应器
EP2529829B1 (de) * 2011-06-01 2013-10-16 Vakumix Rühr- und Homogenisiertechnik Aktiengesellschaft Dispergierrotor zum Homogenisieren fließfähiger Medien
WO2012174472A1 (en) 2011-06-17 2012-12-20 Mannkind Corporation High capacity diketopiperazine microparticles
US9630901B2 (en) * 2012-04-11 2017-04-25 The Procter & Gamble Company Poly(acrylic acid) from bio-based acrylic acid and its derivatives
EP2868369B1 (en) 2013-11-01 2016-05-25 Umicore AG & Co. KG In-line rotor-stator disperser and method
DE102016102728A1 (de) * 2015-08-13 2017-02-16 Netzsch-Feinmahltechnik Gmbh Vorrichtung und Verfahren zum Dispergieren mindestens einer Substanz in einem Fluid
US20170216538A1 (en) * 2016-01-29 2017-08-03 Mannkind Corporation Dry Powder Inhaler
JP7049798B2 (ja) * 2017-09-29 2022-04-07 株式会社明治 微粒化装置
JP7065580B2 (ja) * 2017-09-29 2022-05-12 株式会社明治 微粒化装置
CN107661705A (zh) * 2017-10-16 2018-02-06 江浩 一种管线式流体物料处理机
FR3077011B1 (fr) * 2018-01-24 2020-02-14 Capsum Dispositif de production d'une dispersion, ensemble et procede associes
KR102054426B1 (ko) * 2019-02-26 2019-12-10 캐비트론 주식회사 가스입구를 구비한 균질기
KR102181672B1 (ko) * 2019-03-14 2020-11-23 캐비트론 주식회사 균질기를 이용한 폴리머 분산 시스템
KR102226886B1 (ko) * 2019-03-14 2021-03-11 캐비트론 주식회사 균질기를 이용한 파우더 분산 시스템
RU2765953C1 (ru) * 2020-12-28 2022-02-07 Общество с ограниченной ответственностью "АГРО ЛЭНД" Растворный узел для приготовления жидких комплексных удобрений
CN114887569B (zh) * 2022-05-23 2023-10-03 南通富莱克流体装备有限公司 气液固超重力强化反应器

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CN102596379B (zh) 2009-11-02 2015-04-01 曼康公司 以沉淀过程产生药物颗粒的反应器

Also Published As

Publication number Publication date
US11103847B2 (en) 2021-08-31
WO2011053963A1 (en) 2011-05-05
RU2015113474A3 (pt) 2018-09-28
CA2979182C (en) 2021-03-02
CN104801215B (zh) 2017-11-17
CN104801215A (zh) 2015-07-29
IL219305A0 (en) 2012-06-28
EP2496339A1 (en) 2012-09-12
US20180193813A1 (en) 2018-07-12
EP2496339B1 (en) 2019-06-26
JP5981343B2 (ja) 2016-08-31
RU2012120395A (ru) 2013-12-10
AU2010313177A1 (en) 2012-05-10
SG10201406836SA (en) 2014-12-30
HK1212943A1 (zh) 2016-06-24
EP2496339A4 (en) 2015-12-16
US20210362122A1 (en) 2021-11-25
MX2012005091A (es) 2012-06-19
KR101907699B1 (ko) 2018-10-12
CA2979182A1 (en) 2011-05-05
JP2013509299A (ja) 2013-03-14
KR20120091277A (ko) 2012-08-17
BR112012011591B1 (pt) 2020-02-27
US20110105719A1 (en) 2011-05-05
US8491848B2 (en) 2013-07-23
JP6097858B2 (ja) 2017-03-15
CN102596379A (zh) 2012-07-18
CA2779614C (en) 2017-10-31
HK1173695A1 (en) 2013-05-24
RU2015113474A (ru) 2015-11-10
CN102596379B (zh) 2015-04-01
JP2016166199A (ja) 2016-09-15
IL219305B (en) 2018-04-30
RU2673525C2 (ru) 2018-11-27
US20130296566A1 (en) 2013-11-07
RU2553881C2 (ru) 2015-06-20
CA2779614A1 (en) 2011-05-05
AU2010313177B2 (en) 2015-04-30

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Legal Events

Date Code Title Description
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06T Formal requirements before examination [chapter 6.20 patent gazette]

Free format text: O DEPOSITANTE DEVE RESPONDER A EXIGENCIA FORMULADA NESTE PARECER POR MEIO DO SERVICO DE CODIGO 206 EM ATE 60 (SESSENTA) DIAS, A PARTIR DA DATA DE PUBLICACAO NA RPI, SOB PENA DO ARQUIVAMENTO DO PEDIDO, DE ACORDO COM O ART. 34 DA LPI.PUBLIQUE-SE A EXIGENCIA (6.20).

B25G Requested change of headquarter approved

Owner name: MANNKIND CORPORATION (US)

B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09A Decision: intention to grant [chapter 9.1 patent gazette]
B16A Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]

Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 02/11/2010, OBSERVADAS AS CONDICOES LEGAIS.