BR112012008035A2 - módulo de hplc, e, alojamento de detector de radiação - Google Patents

módulo de hplc, e, alojamento de detector de radiação

Info

Publication number
BR112012008035A2
BR112012008035A2 BR112012008035A BR112012008035A BR112012008035A2 BR 112012008035 A2 BR112012008035 A2 BR 112012008035A2 BR 112012008035 A BR112012008035 A BR 112012008035A BR 112012008035 A BR112012008035 A BR 112012008035A BR 112012008035 A2 BR112012008035 A2 BR 112012008035A2
Authority
BR
Brazil
Prior art keywords
hplc
module
radiation detector
detector housing
flow cell
Prior art date
Application number
BR112012008035A
Other languages
English (en)
Inventor
Steel Colin
Shah Farah
Luthura Sajinder
Original Assignee
Ge Healthcare Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ge Healthcare Ltd filed Critical Ge Healthcare Ltd
Publication of BR112012008035A2 publication Critical patent/BR112012008035A2/pt

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/74—Optical detectors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N21/05—Flow-through cuvettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/84—Systems specially adapted for particular applications
    • G01N21/85—Investigating moving fluids or granular solids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/26—Conditioning of the fluid carrier; Flow patterns
    • G01N30/38—Flow patterns
    • G01N30/46—Flow patterns using more than one column
    • G01N30/466—Flow patterns using more than one column with separation columns in parallel
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G—PHYSICS
    • G21—NUCLEAR PHYSICS; NUCLEAR ENGINEERING
    • G21H—OBTAINING ENERGY FROM RADIOACTIVE SOURCES; APPLICATIONS OF RADIATION FROM RADIOACTIVE SOURCES, NOT OTHERWISE PROVIDED FOR; UTILISING COSMIC RADIATION
    • G21H5/00—Applications of radiation from radioactive sources or arrangements therefor, not otherwise provided for 
    • G21H5/02—Applications of radiation from radioactive sources or arrangements therefor, not otherwise provided for  as tracers
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N2021/0321—One time use cells, e.g. integrally moulded
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N2021/0346—Capillary cells; Microcells
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01—Arrangements or apparatus for facilitating the optical investigation
    • G01N21/03—Cuvette constructions
    • G01N2021/0357—Sets of cuvettes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/74—Optical detectors
    • G01N2030/746—Optical detectors detecting along the line of flow, e.g. axial
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8868—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample elemental analysis, e.g. isotope dilution analysis
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8881—Modular construction, specially adapted therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
    • G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
    • G01N21/33—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using ultraviolet light

Landscapes

  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Engineering & Computer Science (AREA)
  • High Energy & Nuclear Physics (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • General Engineering & Computer Science (AREA)
  • Optical Measuring Cells (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Investigating Or Analysing Materials By Optical Means (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

módulo de hplc, e, alojamento de detector de radiação é descrito um módulo de hplc que utiliza uma combinação de hardware de composto dedicado que provê liberação de linha entre diferentes radiossínteses e inclui múltiplas válvulas de injeção de hplc de composto dedicado, cada válvula de injeção direcionando um fluido para uma coluna hplc conectada serialmente e célula de fluxo uv de maneira a impedir contaminação cruzada entre diferentes sínteses radiofarmacêuticas. o módulo provê um caminho de fluido descartável de cada célula de fluxo uv que permite deyecção radioativa, coleta de fração, formulação e dispensação de produto final. desta maneira, o nível de conformidade de gmp é alcançadp, que é adeuado para atender as exigências de uma licança local aprovada pelo mhra.
BR112012008035A 2009-10-08 2010-10-08 módulo de hplc, e, alojamento de detector de radiação BR112012008035A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24970709P 2009-10-08 2009-10-08
PCT/US2010/051944 WO2011044440A2 (en) 2009-10-08 2010-10-08 Multi-stream high-pressure liquid chromatography module

Publications (1)

Publication Number Publication Date
BR112012008035A2 true BR112012008035A2 (pt) 2017-07-04

Family

ID=43242257

Family Applications (3)

Application Number Title Priority Date Filing Date
BR112012008035A BR112012008035A2 (pt) 2009-10-08 2010-10-08 módulo de hplc, e, alojamento de detector de radiação
BR112012008026A BR112012008026A2 (pt) 2009-10-08 2010-10-08 célula de fluxo óptico de interrogação, e, sistema de purificação.
BR112012008036A BR112012008036A2 (pt) 2009-10-08 2010-10-08 purificação cromatográfica, célula de fluxo uv ótico, tampa de extremidade para uma coluna de cromatografia, coluna de cromatografia, método para operar uma coluna de cromatografia, dispositivo de cassete, método para operar um dispositivo de cassete, sistema de purificação, e, método para formar uma célula de fluxo uv ótico

Family Applications After (2)

Application Number Title Priority Date Filing Date
BR112012008026A BR112012008026A2 (pt) 2009-10-08 2010-10-08 célula de fluxo óptico de interrogação, e, sistema de purificação.
BR112012008036A BR112012008036A2 (pt) 2009-10-08 2010-10-08 purificação cromatográfica, célula de fluxo uv ótico, tampa de extremidade para uma coluna de cromatografia, coluna de cromatografia, método para operar uma coluna de cromatografia, dispositivo de cassete, método para operar um dispositivo de cassete, sistema de purificação, e, método para formar uma célula de fluxo uv ótico

Country Status (6)

Country Link
US (3) US9063158B2 (pt)
EP (3) EP2486399A2 (pt)
JP (3) JP5867868B2 (pt)
CN (4) CN102648409B (pt)
BR (3) BR112012008035A2 (pt)
WO (3) WO2011044440A2 (pt)

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Also Published As

Publication number Publication date
WO2011044453A3 (en) 2011-08-04
US20120184722A1 (en) 2012-07-19
BR112012008026A2 (pt) 2017-07-04
EP2486399A2 (en) 2012-08-15
WO2011044474A1 (en) 2011-04-14
CN102648409B (zh) 2016-05-18
WO2011044440A2 (en) 2011-04-14
CN102648409A (zh) 2012-08-22
US20120193555A1 (en) 2012-08-02
JP2013507615A (ja) 2013-03-04
CN102639988A (zh) 2012-08-15
EP2486390A2 (en) 2012-08-15
JP2013507614A (ja) 2013-03-04
CN104597179A (zh) 2015-05-06
WO2011044440A3 (en) 2011-06-03
BR112012008036A2 (pt) 2016-03-01
WO2011044453A2 (en) 2011-04-14
US8664617B2 (en) 2014-03-04
JP5867868B2 (ja) 2016-02-24
JP2013507616A (ja) 2013-03-04
JP5735519B2 (ja) 2015-06-17
CN102648498A (zh) 2012-08-22
EP2486571A1 (en) 2012-08-15
US9063158B2 (en) 2015-06-23
US20120207650A1 (en) 2012-08-16

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