BR112012004335A8 - Composto, composição farmacêutica, e, uso do composto. - Google Patents
Composto, composição farmacêutica, e, uso do composto.Info
- Publication number
- BR112012004335A8 BR112012004335A8 BR112012004335A BR112012004335A BR112012004335A8 BR 112012004335 A8 BR112012004335 A8 BR 112012004335A8 BR 112012004335 A BR112012004335 A BR 112012004335A BR 112012004335 A BR112012004335 A BR 112012004335A BR 112012004335 A8 BR112012004335 A8 BR 112012004335A8
- Authority
- BR
- Brazil
- Prior art keywords
- compound
- pharmaceutical composition
- peptidase
- dipeptidyl
- enzyme
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title abstract 6
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 3
- 102000016622 Dipeptidyl Peptidase 4 Human genes 0.000 abstract 3
- 101000930822 Giardia intestinalis Dipeptidyl-peptidase 4 Proteins 0.000 abstract 3
- 206010012601 diabetes mellitus Diseases 0.000 abstract 1
- 201000010099 disease Diseases 0.000 abstract 1
- 230000006806 disease prevention Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 208000001072 type 2 diabetes mellitus Diseases 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Emergency Medicine (AREA)
- Endocrinology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US23924209P | 2009-09-02 | 2009-09-02 | |
| US26227809P | 2009-11-18 | 2009-11-18 | |
| PCT/US2010/046270 WO2011028455A1 (en) | 2009-09-02 | 2010-08-23 | Aminotetrahydropyrans as dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR112012004335A2 BR112012004335A2 (pt) | 2015-09-08 |
| BR112012004335A8 true BR112012004335A8 (pt) | 2016-06-21 |
Family
ID=43649576
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BR112012004335A BR112012004335A8 (pt) | 2009-09-02 | 2010-08-23 | Composto, composição farmacêutica, e, uso do composto. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8455533B2 (enExample) |
| EP (1) | EP2473047B1 (enExample) |
| JP (1) | JP5734981B2 (enExample) |
| KR (1) | KR20120092096A (enExample) |
| CN (1) | CN102595897A (enExample) |
| AU (1) | AU2010289871B2 (enExample) |
| BR (1) | BR112012004335A8 (enExample) |
| CA (1) | CA2771352A1 (enExample) |
| IN (1) | IN2012DN00721A (enExample) |
| MX (1) | MX2012002633A (enExample) |
| RU (1) | RU2550508C2 (enExample) |
| WO (1) | WO2011028455A1 (enExample) |
Families Citing this family (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8853212B2 (en) | 2010-02-22 | 2014-10-07 | Merck Sharp & Dohme Corp | Substituted aminotetrahydrothiopyrans and derivatives thereof as dipeptidyl peptidase-IV inhibitors for the treatment of diabetes |
| EP2571876B1 (en) | 2010-05-21 | 2016-09-07 | Merck Sharp & Dohme Corp. | Substituted seven-membered heterocyclic compounds as dipeptidyl peptidase-iv inhibitors for the treatment of diabetes |
| WO2012078448A1 (en) | 2010-12-06 | 2012-06-14 | Schering Corporation | Tricyclic heterocycles useful as dipeptidyl peptidase-iv inhibitors |
| PH12013501686A1 (en) | 2011-02-25 | 2017-10-25 | Merck Sharp & Dohme | Novel cyclic azabenzimidazole derivatives useful as anti-diabetic agents |
| WO2012170702A1 (en) | 2011-06-08 | 2012-12-13 | Arena Pharmaceuticals, Inc. | Modulators of the gpr119 receptor and the treatment of disorders related thereto |
| EA031618B1 (ru) * | 2011-06-09 | 2019-01-31 | Ризен Фармасьютикалз Са | Соединения-модуляторы gpr-119 |
| CN103987388A (zh) | 2011-06-29 | 2014-08-13 | 默沙东公司 | 二肽基肽酶-iv抑制剂的新晶形 |
| EP2729468A4 (en) | 2011-07-05 | 2015-03-18 | Merck Sharp & Dohme | Tricyclic heterocycles useful as dipeptidyl peptidase-iv inhibitors |
| WO2013122920A1 (en) | 2012-02-17 | 2013-08-22 | Merck Sharp & Dohme Corp. | Dipeptidyl peptidase-iv inhibitors for the treatment or prevention of diabetes |
| EP2874626A4 (en) * | 2012-07-23 | 2016-03-23 | Merck Sharp & Dohme | TREATMENT OF DIABETES WITH DIPEPTIDYLPEPTIDASE IV INHIBITORS |
| WO2014018350A1 (en) | 2012-07-23 | 2014-01-30 | Merck Sharp & Dohme Corp. | Treating diabetes with dipeptidyl peptidase-iv inhibitors |
| TWI500613B (zh) * | 2012-10-17 | 2015-09-21 | Cadila Healthcare Ltd | 新穎之雜環化合物 |
| CN105085528A (zh) * | 2014-05-15 | 2015-11-25 | 成都贝斯凯瑞生物科技有限公司 | 作为二肽基肽酶-iv抑制剂的氨基四氢吡喃衍生物 |
| JP6535034B2 (ja) | 2014-06-17 | 2019-06-26 | スーチュアン ハイスーク ファーマシューティカル カンパニー リミテッド | アミノピラン環誘導体及びその組成物と用途 |
| US9862725B2 (en) | 2014-07-21 | 2018-01-09 | Merck Sharp & Dohme Corp. | Process for preparing chiral dipeptidyl peptidase-IV inhibitors |
| CN105985357A (zh) * | 2015-02-12 | 2016-10-05 | 北京赛林泰医药技术有限公司 | 取代的氨基六元饱和杂脂环类长效dpp-iv抑制剂 |
| TWI681962B (zh) * | 2015-08-26 | 2020-01-11 | 大陸商四川海思科製藥有限公司 | 胺基六員環類衍生物及其在醫藥上的應用 |
| EP3630775B1 (en) | 2017-05-31 | 2022-12-14 | ChemoCentryx, Inc. | 6-5 FUSED RINGS AS C5a INHIBITORS |
| CN107459501B (zh) * | 2017-08-22 | 2020-06-09 | 钟桂发 | 一种奥格列汀的手性中间体的制备方法 |
| EP3728203B1 (en) | 2017-12-22 | 2024-03-13 | ChemoCentryx, Inc. | DIARYL SUBSTITUTED 6,5-FUSED RING COMPOUNDS AS C5aR INHIBITORS |
| MY208423A (en) | 2018-02-06 | 2025-05-08 | Sichuan Haisco Pharmaceutical Co Ltd | Composition of aminopyran derivative |
| ES2993034T3 (en) | 2018-04-02 | 2024-12-20 | Chemocentryx Inc | Prodrugs of fused-bicyclic c5ar antagonists |
| KR102131359B1 (ko) * | 2018-09-07 | 2020-07-07 | 오토텔릭바이오 주식회사 | 안정성이 향상된 의약 조성물 |
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| US20090292110A1 (en) | 2004-07-23 | 2009-11-26 | Defrees Shawn | Enzymatic modification of glycopeptides |
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| JO2870B1 (en) * | 2008-11-13 | 2015-03-15 | ميرك شارب اند دوهم كورب | Amino Tetra Hydro Pirans as Inhibitors of Peptide Dipeptide IV for the Treatment or Prevention of Diabetes |
| WO2011037793A1 (en) | 2009-09-25 | 2011-03-31 | Merck Sharp & Dohme Corp. | Substituted aminopiperidines as dipeptidyl peptidase-iv inhibitors for the treatment of diabetes |
-
2010
- 2010-08-23 WO PCT/US2010/046270 patent/WO2011028455A1/en not_active Ceased
- 2010-08-23 JP JP2012527901A patent/JP5734981B2/ja not_active Expired - Fee Related
- 2010-08-23 EP EP10814188.8A patent/EP2473047B1/en not_active Not-in-force
- 2010-08-23 CN CN2010800391645A patent/CN102595897A/zh active Pending
- 2010-08-23 AU AU2010289871A patent/AU2010289871B2/en not_active Ceased
- 2010-08-23 RU RU2012112471/04A patent/RU2550508C2/ru not_active IP Right Cessation
- 2010-08-23 CA CA2771352A patent/CA2771352A1/en not_active Abandoned
- 2010-08-23 MX MX2012002633A patent/MX2012002633A/es active IP Right Grant
- 2010-08-23 BR BR112012004335A patent/BR112012004335A8/pt not_active IP Right Cessation
- 2010-08-23 IN IN721DEN2012 patent/IN2012DN00721A/en unknown
- 2010-08-23 US US13/390,538 patent/US8455533B2/en active Active
- 2010-08-23 KR KR1020127005395A patent/KR20120092096A/ko not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| CA2771352A1 (en) | 2011-03-10 |
| KR20120092096A (ko) | 2012-08-20 |
| CN102595897A (zh) | 2012-07-18 |
| US20120149734A1 (en) | 2012-06-14 |
| US8455533B2 (en) | 2013-06-04 |
| RU2012112471A (ru) | 2013-10-10 |
| BR112012004335A2 (pt) | 2015-09-08 |
| JP5734981B2 (ja) | 2015-06-17 |
| RU2550508C2 (ru) | 2015-05-10 |
| AU2010289871A1 (en) | 2012-04-26 |
| WO2011028455A1 (en) | 2011-03-10 |
| AU2010289871B2 (en) | 2014-07-10 |
| EP2473047A4 (en) | 2013-02-13 |
| EP2473047A1 (en) | 2012-07-11 |
| JP2013503864A (ja) | 2013-02-04 |
| EP2473047B1 (en) | 2014-08-13 |
| IN2012DN00721A (enExample) | 2015-06-19 |
| MX2012002633A (es) | 2012-04-20 |
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