BR112012004246A2 - métodos para tratar inflamação neurogênica crônica usando uma toxina clostridial modificada - Google Patents

métodos para tratar inflamação neurogênica crônica usando uma toxina clostridial modificada

Info

Publication number
BR112012004246A2
BR112012004246A2 BR112012004246A BR112012004246A BR112012004246A2 BR 112012004246 A2 BR112012004246 A2 BR 112012004246A2 BR 112012004246 A BR112012004246 A BR 112012004246A BR 112012004246 A BR112012004246 A BR 112012004246A BR 112012004246 A2 BR112012004246 A2 BR 112012004246A2
Authority
BR
Brazil
Prior art keywords
methods
clostridial toxin
treating chronic
modified clostridial
neurogenic inflammation
Prior art date
Application number
BR112012004246A
Other languages
English (en)
Portuguese (pt)
Inventor
Gilberto P Paz
Gustavo M Gaxiola
Ivan E Aguilar
Original Assignee
Allergan Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Allergan Inc filed Critical Allergan Inc
Publication of BR112012004246A2 publication Critical patent/BR112012004246A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/08—Clostridium, e.g. Clostridium tetani
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/4886—Metalloendopeptidases (3.4.24), e.g. collagenase
    • A61K38/4893—Botulinum neurotoxin (3.4.24.69)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/24—Metalloendopeptidases (3.4.24)
    • C12Y304/24069—Bontoxilysin (3.4.24.69), i.e. botulinum neurotoxin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Endocrinology (AREA)
  • Immunology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Toxicology (AREA)
  • Urology & Nephrology (AREA)
  • Dermatology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
BR112012004246A 2009-08-26 2010-08-10 métodos para tratar inflamação neurogênica crônica usando uma toxina clostridial modificada BR112012004246A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12/548,073 US8147848B2 (en) 2009-08-26 2009-08-26 Method for treating premature ejaculation with a botulinum neurotoxin
PCT/US2010/044959 WO2011028371A1 (en) 2009-08-26 2010-08-10 Methods of treating chronic neurogenic inflammation using a modified clostridial toxin

Publications (1)

Publication Number Publication Date
BR112012004246A2 true BR112012004246A2 (pt) 2016-04-05

Family

ID=43127150

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112012004246A BR112012004246A2 (pt) 2009-08-26 2010-08-10 métodos para tratar inflamação neurogênica crônica usando uma toxina clostridial modificada

Country Status (18)

Country Link
US (8) US8147848B2 (cg-RX-API-DMAC10.html)
EP (2) EP2470202B1 (cg-RX-API-DMAC10.html)
JP (2) JP5766699B2 (cg-RX-API-DMAC10.html)
KR (1) KR101612988B1 (cg-RX-API-DMAC10.html)
CN (2) CN103816530B (cg-RX-API-DMAC10.html)
AU (2) AU2010289969B2 (cg-RX-API-DMAC10.html)
BR (1) BR112012004246A2 (cg-RX-API-DMAC10.html)
CA (1) CA2772372C (cg-RX-API-DMAC10.html)
CY (1) CY1114792T1 (cg-RX-API-DMAC10.html)
DK (2) DK2470202T3 (cg-RX-API-DMAC10.html)
ES (2) ES2564677T3 (cg-RX-API-DMAC10.html)
IN (1) IN2012DN02210A (cg-RX-API-DMAC10.html)
MX (2) MX349947B (cg-RX-API-DMAC10.html)
PL (1) PL2470202T3 (cg-RX-API-DMAC10.html)
PT (1) PT2470202E (cg-RX-API-DMAC10.html)
RU (1) RU2568844C2 (cg-RX-API-DMAC10.html)
SI (1) SI2470202T1 (cg-RX-API-DMAC10.html)
WO (1) WO2011028371A1 (cg-RX-API-DMAC10.html)

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US8147848B2 (en) 2009-08-26 2012-04-03 Allergan, Inc. Method for treating premature ejaculation with a botulinum neurotoxin
US20120251518A1 (en) * 2011-03-29 2012-10-04 Allergan, Inc. Endopeptidase Treatment of Sexual Dysfunction Disorders
US20130066148A1 (en) * 2011-09-12 2013-03-14 Kang Seon Cho Method of augmenting glans
EP2649985A1 (en) 2012-04-13 2013-10-16 Lipotec, S.A. Compounds which inhibit neuronal exocytosis (III)
EP2649983A1 (en) 2012-04-13 2013-10-16 Lipotec, S.A. Compounds which inhibit neuronal exocytosis (II)
EP2649984A1 (en) 2012-04-13 2013-10-16 Lipotec, S.A. Compounds which inhibit neuronal exocytosis
ES2660901T3 (es) 2012-04-13 2018-03-26 Lubrizol Advanced Materials, Inc. Compuestos que inhiben la exocitosis neuronal (II)
US9764010B2 (en) * 2012-08-24 2017-09-19 Allergan, Inc. Method for treating premature ejaculation with a neurotoxin
DK3188706T3 (da) * 2014-09-02 2020-01-20 American Silver Llc Botulinumtoksin og kolloide sølvpartikler
RU2565104C1 (ru) * 2014-10-24 2015-10-20 Государственное бюджетное образовательное учреждение высшего профессионального образования Первый Московский государственный медицинский университет им. И.М. Сеченова Министерства здравоохранения Российской Федерации (ГБОУ ВПО Первый МГМУ им. И.М. Сеченова Минздрава России) Способ лечения преждевременной эякуляции
AU2018270092C1 (en) * 2017-05-18 2026-01-08 Revance Therapeutics, Inc. Methods of treatment for cervical dystonia
WO2018220232A1 (en) * 2017-06-02 2018-12-06 Universite De Versailles-St Quentin En Yvelines Pharmaceutical combination product comprising botulinum toxin for the treatment of erectile dysfunction
US12102556B2 (en) 2022-05-31 2024-10-01 Max Azevedo System and method for fallopian birth control
US12337014B1 (en) 2024-06-17 2025-06-24 Enrico Guarino Intracavernosal gel infusion system with neurotoxin modulation for erectile function
WO2026118698A1 (en) * 2024-12-03 2026-06-11 Obigen Pharma, Inc. Novel use of clostridium botulinum toxin type a for treatment of glabellar lines

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US5427291A (en) 1993-09-21 1995-06-27 Smith; David S. Ski carrier and method employing same
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US5766605A (en) 1994-04-15 1998-06-16 Mount Sinai School Of Medicine Of The City University Of New York Treatment of autonomic nerve dysfunction with botulinum toxin
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ATE320815T1 (de) 1997-07-15 2006-04-15 Univ Colorado Verwendung einer neurotoxintherapie zur behandlung von prostata erkrankungen
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Also Published As

Publication number Publication date
CN102802663B (zh) 2014-03-19
RU2012110324A (ru) 2013-10-10
KR101612988B1 (ko) 2016-04-15
SI2470202T1 (sl) 2014-02-28
CN103816530A (zh) 2014-05-28
US20180185460A1 (en) 2018-07-05
US9186395B2 (en) 2015-11-17
ES2564677T3 (es) 2016-03-28
KR20120103760A (ko) 2012-09-19
CY1114792T1 (el) 2016-12-14
DK2470202T3 (da) 2014-01-27
US20110052636A1 (en) 2011-03-03
US20160067319A1 (en) 2016-03-10
EP2708239A1 (en) 2014-03-19
AU2010289969A1 (en) 2012-03-22
US8147848B2 (en) 2012-04-03
US20140140981A1 (en) 2014-05-22
JP2015163654A (ja) 2015-09-10
EP2470202B1 (en) 2013-12-18
ES2446969T3 (es) 2014-03-11
CN103816530B (zh) 2016-12-07
JP6078108B2 (ja) 2017-02-08
JP2013503165A (ja) 2013-01-31
EP2708239B1 (en) 2015-12-09
DK2708239T3 (en) 2016-03-14
AU2010289969B2 (en) 2015-05-14
HK1171658A1 (en) 2013-04-05
JP5766699B2 (ja) 2015-08-19
US20130059789A1 (en) 2013-03-07
AU2015213381B2 (en) 2017-05-25
US8617570B2 (en) 2013-12-31
WO2011028371A1 (en) 2011-03-10
US10420823B2 (en) 2019-09-24
AU2015213381A1 (en) 2015-09-03
US9907841B2 (en) 2018-03-06
PT2470202E (pt) 2014-02-24
US20120148563A1 (en) 2012-06-14
CN102802663A (zh) 2012-11-28
CA2772372C (en) 2016-07-12
US8329193B2 (en) 2012-12-11
HK1194292A1 (en) 2014-10-17
RU2568844C2 (ru) 2015-11-20
MX2012002378A (es) 2012-06-28
US20170020997A1 (en) 2017-01-26
PL2470202T3 (pl) 2014-05-30
IN2012DN02210A (cg-RX-API-DMAC10.html) 2015-08-21
US9457069B2 (en) 2016-10-04
CA2772372A1 (en) 2011-03-10
US8916177B2 (en) 2014-12-23
US20150064167A1 (en) 2015-03-05
MX349947B (es) 2017-08-22
EP2470202A1 (en) 2012-07-04

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B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B07E Notice of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

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B06T Formal requirements before examination [chapter 6.20 patent gazette]
B07A Technical examination (opinion): publication of technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]

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