BR0318125A - Derivados de benzeno trìmeros macrociclicamente substituìdos - Google Patents
Derivados de benzeno trìmeros macrociclicamente substituìdosInfo
- Publication number
- BR0318125A BR0318125A BR0318125-1A BR0318125A BR0318125A BR 0318125 A BR0318125 A BR 0318125A BR 0318125 A BR0318125 A BR 0318125A BR 0318125 A BR0318125 A BR 0318125A
- Authority
- BR
- Brazil
- Prior art keywords
- macrocyclically
- benzene derivatives
- substituted
- trimeric benzene
- substituted trimeric
- Prior art date
Links
- 125000001997 phenyl group Chemical class [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 title 1
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 abstract 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 239000002872 contrast media Substances 0.000 abstract 1
- 229910052740 iodine Inorganic materials 0.000 abstract 1
- 239000011630 iodine Substances 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
- A61K49/0438—Organic X-ray contrast-enhancing agent comprising an iodinated group or an iodine atom, e.g. iopamidol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Radiology & Medical Imaging (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Abstract
"DERIVADOS DE BENZENO TRìMEROS MACROCICLICAMENTE SUBSTITUìDOS". A presente invenção refere-se a complexos metálicos de fórmula geral (I), na qual Hal representa bromo ou iodo e A¬ 1¬ e A¬ 2¬ têm diferentes significados, que são apropriados como agentes de contraste.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10307759A DE10307759B3 (de) | 2003-02-19 | 2003-02-19 | Trimere makrocyclisch substituierte Benzolderivate, deren Herstellung und Verwendung als Kontrastmittel sowie diese enthaltende pharmazeutische Mittel |
PCT/EP2003/014149 WO2004074267A1 (de) | 2003-02-19 | 2003-12-12 | Trimere makrocyclisch substituierte benzolderivate |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0318125A true BR0318125A (pt) | 2006-02-07 |
Family
ID=32891780
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0318125-1A BR0318125A (pt) | 2003-02-19 | 2003-12-12 | Derivados de benzeno trìmeros macrociclicamente substituìdos |
Country Status (16)
Country | Link |
---|---|
EP (1) | EP1594851A1 (pt) |
JP (1) | JP2006514664A (pt) |
KR (1) | KR20050105474A (pt) |
CN (1) | CN1753878A (pt) |
AR (1) | AR043205A1 (pt) |
AU (1) | AU2003290032B2 (pt) |
BR (1) | BR0318125A (pt) |
CA (1) | CA2516467A1 (pt) |
CR (1) | CR7937A (pt) |
DE (1) | DE10307759B3 (pt) |
EC (1) | ECSP056026A (pt) |
MX (1) | MXPA05008781A (pt) |
NO (1) | NO20054291L (pt) |
RU (1) | RU2005128834A (pt) |
WO (1) | WO2004074267A1 (pt) |
ZA (1) | ZA200507437B (pt) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2165768B1 (es) | 1999-07-14 | 2003-04-01 | Almirall Prodesfarma Sa | Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen. |
DE102004023093B3 (de) * | 2004-05-05 | 2006-03-02 | Schering Ag | Trimere makrocyclisch substituierte Halogen-Benzolderivate |
DE102004026103A1 (de) * | 2004-05-25 | 2005-12-22 | Schering Ag | Trimere makrocyclisch substituierte Aminoisophthalsäure-Halogen-Benzolderivate |
ES2257152B1 (es) * | 2004-05-31 | 2007-07-01 | Laboratorios Almirall S.A. | Combinaciones que comprenden agentes antimuscarinicos y agonistas beta-adrenergicos. |
DE102007058220A1 (de) | 2007-12-03 | 2009-06-04 | Bayer Schering Pharma Aktiengesellschaft | Dimere macrocyclisch substituierte Benzolderivate |
EP2100599A1 (en) | 2008-03-13 | 2009-09-16 | Laboratorios Almirall, S.A. | Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease |
EP2100598A1 (en) | 2008-03-13 | 2009-09-16 | Laboratorios Almirall, S.A. | Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease |
EP2608785B1 (en) * | 2010-08-26 | 2016-08-17 | Kunyuan Cui | Lipomacrocycles and uses thereof |
EP2510928A1 (en) | 2011-04-15 | 2012-10-17 | Almirall, S.A. | Aclidinium for use in improving the quality of sleep in respiratory patients |
CN104672259B (zh) * | 2015-02-02 | 2017-04-05 | 湖北大学 | 一种含碘稀土铕(ⅲ)配合物及其制备方法和应用 |
CN104721844B (zh) * | 2015-02-02 | 2017-11-03 | 湖北大学 | 一种新型ct,mri,稀土荧光三功能微球及其制备方法和应用 |
EP3101012A1 (en) | 2015-06-04 | 2016-12-07 | Bayer Pharma Aktiengesellschaft | New gadolinium chelate compounds for use in magnetic resonance imaging |
CN105254529B (zh) * | 2015-09-21 | 2017-05-31 | 西南石油大学 | 一种树形席夫碱缓蚀剂的制备方法 |
US10975060B2 (en) | 2016-11-28 | 2021-04-13 | Bayer Pharma Aktiengesellschaft | High relaxivity gadolinium chelate compounds for use in magnetic resonance imaging |
CN107445911B (zh) * | 2017-06-19 | 2019-07-05 | 南京科技职业学院 | 一种二核含钆磁共振对比剂及其制备与应用 |
CN113164628A (zh) | 2018-11-23 | 2021-07-23 | 拜耳股份有限公司 | 造影介质制剂及其制备方法 |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5324503A (en) * | 1992-02-06 | 1994-06-28 | Mallinckrodt Medical, Inc. | Iodo-phenylated chelates for x-ray contrast |
US5660814A (en) * | 1993-06-02 | 1997-08-26 | Dibra S.P.A. | Iodinated paramagnetic chelates, and their use as contrast agents |
FR2736051B3 (fr) * | 1995-06-29 | 1997-09-26 | Guerbet Sa | Complexes metalliques de polyaminoacides, leur procede de preparation et leur utilisation en imagerie diagnostique |
FR2793795B1 (fr) * | 1999-05-21 | 2001-08-03 | Guerbet Sa | Isomeres de tetramides du complexe de gadolinium de l'acide (1,4,7,10-tetrazacyclododecane)1,4,7,10-tetra(2-glutarique) leur procede de preparation et leur application en imagerie medicale |
FR2794744B1 (fr) * | 1999-06-09 | 2001-09-21 | Guerbet Sa | Complexes metalliques de polyaminoacides bicycliques, leur procede de preparation et leur application en imagerie medicale |
-
2003
- 2003-02-19 DE DE10307759A patent/DE10307759B3/de not_active Expired - Fee Related
- 2003-12-12 CN CNA2003801098702A patent/CN1753878A/zh active Pending
- 2003-12-12 CA CA002516467A patent/CA2516467A1/en not_active Abandoned
- 2003-12-12 EP EP03782386A patent/EP1594851A1/de not_active Withdrawn
- 2003-12-12 MX MXPA05008781A patent/MXPA05008781A/es active IP Right Grant
- 2003-12-12 JP JP2004568408A patent/JP2006514664A/ja not_active Withdrawn
- 2003-12-12 RU RU2005128834/04A patent/RU2005128834A/ru not_active Application Discontinuation
- 2003-12-12 AU AU2003290032A patent/AU2003290032B2/en not_active Expired - Fee Related
- 2003-12-12 BR BR0318125-1A patent/BR0318125A/pt not_active IP Right Cessation
- 2003-12-12 KR KR1020057015199A patent/KR20050105474A/ko not_active Application Discontinuation
- 2003-12-12 WO PCT/EP2003/014149 patent/WO2004074267A1/de active Application Filing
-
2004
- 2004-02-18 AR ARP040100490A patent/AR043205A1/es unknown
-
2005
- 2005-08-09 CR CR7937A patent/CR7937A/es not_active Application Discontinuation
- 2005-09-15 ZA ZA200507437A patent/ZA200507437B/en unknown
- 2005-09-16 NO NO20054291A patent/NO20054291L/no not_active Application Discontinuation
- 2005-09-19 EC EC2005006026A patent/ECSP056026A/es unknown
Also Published As
Publication number | Publication date |
---|---|
EP1594851A1 (de) | 2005-11-16 |
CA2516467A1 (en) | 2004-09-02 |
AU2003290032A1 (en) | 2004-09-09 |
CN1753878A (zh) | 2006-03-29 |
NO20054291L (no) | 2005-11-17 |
RU2005128834A (ru) | 2006-03-20 |
AU2003290032B2 (en) | 2009-04-23 |
JP2006514664A (ja) | 2006-05-11 |
ECSP056026A (es) | 2006-01-27 |
ZA200507437B (en) | 2007-02-28 |
WO2004074267A1 (de) | 2004-09-02 |
NO20054291D0 (no) | 2005-09-16 |
KR20050105474A (ko) | 2005-11-04 |
CR7937A (es) | 2006-02-07 |
DE10307759B3 (de) | 2004-11-18 |
AR043205A1 (es) | 2005-07-20 |
MXPA05008781A (es) | 2006-03-10 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B08F | Application fees: application dismissed [chapter 8.6 patent gazette] |
Free format text: REFERENTE A 7A E 8A ANUIDADE(S). |
|
B08K | Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette] |
Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 2144 DE 07/02/2012. |