DE602007011601D1 - Neue verbindung mit affinität zu amyloid - Google Patents

Neue verbindung mit affinität zu amyloid

Info

Publication number
DE602007011601D1
DE602007011601D1 DE602007011601T DE602007011601T DE602007011601D1 DE 602007011601 D1 DE602007011601 D1 DE 602007011601D1 DE 602007011601 T DE602007011601 T DE 602007011601T DE 602007011601 T DE602007011601 T DE 602007011601T DE 602007011601 D1 DE602007011601 D1 DE 602007011601D1
Authority
DE
Germany
Prior art keywords
compound
amyloid
affinity
carbon
represented
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602007011601T
Other languages
English (en)
Inventor
Shigeyuki Tanifuji
Daisaku Nakamura
Shinya Takasaki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nihon Medi Physics Co Ltd
Original Assignee
Nihon Medi Physics Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nihon Medi Physics Co Ltd filed Critical Nihon Medi Physics Co Ltd
Publication of DE602007011601D1 publication Critical patent/DE602007011601D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/041Heterocyclic compounds
    • A61K51/044Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/041Heterocyclic compounds
    • A61K51/044Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0459Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/22Tin compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F7/00Compounds containing elements of Groups 4 or 14 of the Periodic Table
    • C07F7/22Tin compounds
    • C07F7/2208Compounds having tin linked only to carbon, hydrogen and/or halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Veterinary Medicine (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Carbon And Carbon Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE602007011601T 2006-04-28 2007-04-26 Neue verbindung mit affinität zu amyloid Active DE602007011601D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2006124811 2006-04-28
PCT/JP2007/059048 WO2007125988A1 (ja) 2006-04-28 2007-04-26 新規アミロイド親和性化合物

Publications (1)

Publication Number Publication Date
DE602007011601D1 true DE602007011601D1 (de) 2011-02-10

Family

ID=38655513

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602007011601T Active DE602007011601D1 (de) 2006-04-28 2007-04-26 Neue verbindung mit affinität zu amyloid

Country Status (16)

Country Link
US (2) US8022207B2 (de)
EP (1) EP2022792B1 (de)
JP (1) JP5048655B2 (de)
KR (1) KR20080112343A (de)
CN (1) CN101472923A (de)
AT (1) ATE493410T1 (de)
AU (1) AU2007244313B2 (de)
CA (1) CA2657312A1 (de)
DE (1) DE602007011601D1 (de)
ES (1) ES2355079T3 (de)
IL (1) IL194889A0 (de)
NO (1) NO20084897L (de)
NZ (1) NZ572741A (de)
RU (1) RU2008147002A (de)
TW (1) TW200803903A (de)
WO (1) WO2007125988A1 (de)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2007252658B2 (en) 2006-05-19 2012-03-29 Nihon Medi-Physics Co., Ltd. Novel compound having affinity for amyloid
EP2098523A4 (de) * 2006-11-17 2011-09-21 Nihon Mediphysics Co Ltd Neue, amyloid-affine verbindungen
TW200823211A (en) 2006-11-30 2008-06-01 Nihon Mediphysics Co Ltd Novel compound having affinity for amyloid
CA2703649A1 (en) * 2007-10-24 2009-04-30 Shigeyuki Tanifuji Novel compound having affinity for amyloid
EP2213671A4 (de) * 2007-10-26 2012-02-22 Nihon Mediphysics Co Ltd Neue verbindung mit affinität zu amyloid
CA2704168A1 (en) * 2007-10-30 2009-05-07 Nihon Medi-Physics Co., Ltd. Use of novel compound having affinity for amyloid, and process for production of the same
EP2218464A1 (de) * 2009-02-11 2010-08-18 Technische Universität München Verbindungen zur nichtinvasiven Messung von Aggregaten von Amyloidpeptiden
US9926316B2 (en) * 2016-03-03 2018-03-27 The Cleveland Clinic Foundation Antitumor derivatives for differentiation therapy
CN108822105A (zh) * 2018-08-14 2018-11-16 河南师范大学 一种由乙苯类化合物合成2-芳基咪唑并[1,2-a]吡啶类化合物的方法

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4833149A (en) * 1986-09-22 1989-05-23 Ortho Pharmaceutical Corporation 2- or 3-aryl substituted imidazo[1,2-a]pyridines
US4791117A (en) * 1986-09-22 1988-12-13 Ortho Pharmaceutical Corporation 2- or 3-aryl substituted imidazo[1,2-a]pyridines and their use as calcium channel blockers
US4871745A (en) * 1986-09-22 1989-10-03 Ortho Pharmaceutical Corporation 2- or 3-aryl substituted imidazo(1,2-A)pyridines and their use as antisecretory agents
US4727145A (en) * 1986-09-22 1988-02-23 Ortho Pharmaceutical Corporation 2- Or 3- aryl substituted imidazo [1,2-a]pyridines
BR9611047A (pt) * 1995-10-17 2000-03-08 Searle & Co Processo de deteção de ciclo oxigenase-2
US6812327B1 (en) * 1996-10-25 2004-11-02 Human Genome Sciences, Inc. Neutrokine-alpha polypeptides
EP1105163A4 (de) 1998-08-20 2003-05-02 Univ California Verfahren zur markierung amyloider plaques und neurofibrillisches gewirrs
US20010051632A1 (en) * 2000-03-31 2001-12-13 Wenying Chai Phenyl-substituted indolizines and tetrahydroindolizines
US6514969B2 (en) * 2000-08-16 2003-02-04 Boehringer Ingelheim Pharma Kg β-amyloid inhibitors, processes for preparing them, and their use in pharmaceutical compositions
DE10040016A1 (de) 2000-08-16 2002-02-28 Boehringer Ingelheim Pharma Neue beta-Amyloid Inhibitoren, Verfahren zu deren Herstellung und deren Verwendung als Arzneimittel
ES2536449T3 (es) 2000-08-24 2015-05-25 University Of Pittsburgh Of The Commonwealth System Of Higher Education Derivados de tioflavina para uso en diagnosis de la enfermedad de Alzheimer
JP2004529884A (ja) * 2001-02-26 2004-09-30 ブリストル−マイヤーズ・スクイブ・ファーマ・カンパニー 金属放射性医薬のためのアスコルビン酸類似体
US6596731B2 (en) * 2001-03-27 2003-07-22 Hoffmann-La Roche Inc. Substituted imidazo[1,2-A] pyridine derivatives
DE60217090T2 (de) * 2001-04-23 2007-07-12 The Trustees Of The University Of Pennsylvania Amyloid plaque aggregationshemmer und diagnostische bilderzeugungsmittel
DK1432453T3 (da) 2001-08-27 2013-11-18 Univ Pennsylvania Stilbenderivater og anvendelse heraf til binding og billeddannelse af amyloid-plaques
GB0205281D0 (en) * 2002-03-06 2002-04-17 Novartis Ag Organic compounds
EP1356827A1 (de) * 2002-04-24 2003-10-29 Mallinckrodt Inc. Verfahren zur Herstellung von einer 2-18F-Fluor-2-Deoxy-D-Glucose (18F-FDG)-Lösung
WO2003106439A1 (ja) 2002-06-12 2003-12-24 株式会社ビーエフ研究所 アミロイド蓄積性疾患の画像診断プローブ化合物、老人斑/びまん性老人斑染色用化合物、ならびにアミロイド蓄積性疾患の治療薬
WO2004035522A1 (ja) * 2002-08-30 2004-04-29 Bf Research Institute, Inc. プリオン蛋白蓄積性疾患の診断プローブおよび治療薬ならびにプリオン蛋白の染色剤
GB0229695D0 (en) * 2002-12-20 2003-01-29 Amersham Plc Solid-phase preparation of 18F-labelled amino acids
NZ548098A (en) * 2003-12-31 2010-05-28 Schering Plough Ltd Control of parasites in animals by the use of imidazo[1,2-b]pyridazine derivatives
AU2007252658B2 (en) 2006-05-19 2012-03-29 Nihon Medi-Physics Co., Ltd. Novel compound having affinity for amyloid
AU2007261985B2 (en) 2006-06-21 2012-04-19 Nihon Medi-Physics Co., Ltd. Novel compound having affinity for amyloid
EP2098523A4 (de) 2006-11-17 2011-09-21 Nihon Mediphysics Co Ltd Neue, amyloid-affine verbindungen
TW200823211A (en) 2006-11-30 2008-06-01 Nihon Mediphysics Co Ltd Novel compound having affinity for amyloid
CA2703649A1 (en) * 2007-10-24 2009-04-30 Shigeyuki Tanifuji Novel compound having affinity for amyloid
EP2213671A4 (de) * 2007-10-26 2012-02-22 Nihon Mediphysics Co Ltd Neue verbindung mit affinität zu amyloid
CA2704139A1 (en) * 2007-10-30 2009-05-07 Nihon Medi-Physics Co., Ltd. Utilization of novel compounds with amyloid affinity and method of producing the same

Also Published As

Publication number Publication date
CA2657312A1 (en) 2007-11-08
RU2008147002A (ru) 2010-06-10
AU2007244313A1 (en) 2007-11-08
US20110201808A1 (en) 2011-08-18
JP5048655B2 (ja) 2012-10-17
TW200803903A (en) 2008-01-16
KR20080112343A (ko) 2008-12-24
NO20084897L (no) 2009-01-15
EP2022792A4 (de) 2009-11-11
NZ572741A (en) 2010-07-30
ES2355079T3 (es) 2011-03-22
WO2007125988A1 (ja) 2007-11-08
JPWO2007125988A1 (ja) 2009-09-10
US8022207B2 (en) 2011-09-20
EP2022792B1 (de) 2010-12-29
EP2022792A8 (de) 2009-04-29
IL194889A0 (en) 2011-08-01
EP2022792A1 (de) 2009-02-11
AU2007244313B2 (en) 2011-09-08
ATE493410T1 (de) 2011-01-15
CN101472923A (zh) 2009-07-01
US20100249407A1 (en) 2010-09-30

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