JP2006514664A - 三量体である大環状で置換されたベンゼン誘導体 - Google Patents

三量体である大環状で置換されたベンゼン誘導体 Download PDF

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Publication number
JP2006514664A
JP2006514664A JP2004568408A JP2004568408A JP2006514664A JP 2006514664 A JP2006514664 A JP 2006514664A JP 2004568408 A JP2004568408 A JP 2004568408A JP 2004568408 A JP2004568408 A JP 2004568408A JP 2006514664 A JP2006514664 A JP 2006514664A
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JP
Japan
Prior art keywords
tris
nhcoch
mmol
group
chz
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JP2004568408A
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English (en)
Japanese (ja)
Inventor
プラツェク ヨハネス
ハンス−ヨアヒム ヴァインマン
シルマー ハイコ
ルイ マルティン ホセ
エル アルト ホァン
リーフケ ビョルン
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Bayer Pharma AG
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Schering AG
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Publication of JP2006514664A publication Critical patent/JP2006514664A/ja
Withdrawn legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/10Organic compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/0002General or multifunctional contrast agents, e.g. chelated agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/04X-ray contrast preparations
    • A61K49/0433X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/04X-ray contrast preparations
    • A61K49/0433X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
    • A61K49/0438Organic X-ray contrast-enhancing agent comprising an iodinated group or an iodine atom, e.g. iopamidol
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00Preparations for testing in vivo
    • A61K49/06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
    • A61K49/08Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
    • A61K49/085Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04Organic compounds
    • A61K51/0497Organic compounds conjugates with a carrier being an organic compounds
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D257/00Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07FACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00Compounds containing elements of Groups 3 or 13 of the Periodic Table

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Radiology & Medical Imaging (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
JP2004568408A 2003-02-19 2003-12-12 三量体である大環状で置換されたベンゼン誘導体 Withdrawn JP2006514664A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10307759A DE10307759B3 (de) 2003-02-19 2003-02-19 Trimere makrocyclisch substituierte Benzolderivate, deren Herstellung und Verwendung als Kontrastmittel sowie diese enthaltende pharmazeutische Mittel
PCT/EP2003/014149 WO2004074267A1 (de) 2003-02-19 2003-12-12 Trimere makrocyclisch substituierte benzolderivate

Publications (1)

Publication Number Publication Date
JP2006514664A true JP2006514664A (ja) 2006-05-11

Family

ID=32891780

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2004568408A Withdrawn JP2006514664A (ja) 2003-02-19 2003-12-12 三量体である大環状で置換されたベンゼン誘導体

Country Status (16)

Country Link
EP (1) EP1594851A1 (pt)
JP (1) JP2006514664A (pt)
KR (1) KR20050105474A (pt)
CN (1) CN1753878A (pt)
AR (1) AR043205A1 (pt)
AU (1) AU2003290032B2 (pt)
BR (1) BR0318125A (pt)
CA (1) CA2516467A1 (pt)
CR (1) CR7937A (pt)
DE (1) DE10307759B3 (pt)
EC (1) ECSP056026A (pt)
MX (1) MXPA05008781A (pt)
NO (1) NO20054291L (pt)
RU (1) RU2005128834A (pt)
WO (1) WO2004074267A1 (pt)
ZA (1) ZA200507437B (pt)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013539469A (ja) * 2010-08-26 2013-10-24 ツイ,クンユァン 巨大環状脂肪族化合物及びその応用

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2165768B1 (es) 1999-07-14 2003-04-01 Almirall Prodesfarma Sa Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen.
DE102004023093B3 (de) * 2004-05-05 2006-03-02 Schering Ag Trimere makrocyclisch substituierte Halogen-Benzolderivate
DE102004026103A1 (de) * 2004-05-25 2005-12-22 Schering Ag Trimere makrocyclisch substituierte Aminoisophthalsäure-Halogen-Benzolderivate
ES2257152B1 (es) * 2004-05-31 2007-07-01 Laboratorios Almirall S.A. Combinaciones que comprenden agentes antimuscarinicos y agonistas beta-adrenergicos.
DE102007058220A1 (de) 2007-12-03 2009-06-04 Bayer Schering Pharma Aktiengesellschaft Dimere macrocyclisch substituierte Benzolderivate
EP2100598A1 (en) 2008-03-13 2009-09-16 Laboratorios Almirall, S.A. Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease
EP2100599A1 (en) 2008-03-13 2009-09-16 Laboratorios Almirall, S.A. Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease
EP2510928A1 (en) 2011-04-15 2012-10-17 Almirall, S.A. Aclidinium for use in improving the quality of sleep in respiratory patients
CN104672259B (zh) * 2015-02-02 2017-04-05 湖北大学 一种含碘稀土铕(ⅲ)配合物及其制备方法和应用
CN104721844B (zh) * 2015-02-02 2017-11-03 湖北大学 一种新型ct,mri,稀土荧光三功能微球及其制备方法和应用
EP3101012A1 (en) 2015-06-04 2016-12-07 Bayer Pharma Aktiengesellschaft New gadolinium chelate compounds for use in magnetic resonance imaging
CN105254529B (zh) * 2015-09-21 2017-05-31 西南石油大学 一种树形席夫碱缓蚀剂的制备方法
WO2018096082A1 (en) 2016-11-28 2018-05-31 Bayer Pharma Aktiengesellschaft High relaxivity gadolinium chelate compounds for use in magnetic resonance imaging
CN107445911B (zh) * 2017-06-19 2019-07-05 南京科技职业学院 一种二核含钆磁共振对比剂及其制备与应用
CA3120665A1 (en) 2018-11-23 2020-05-28 Bayer Aktiengesellschaft Formulation of contrast media and process of preparation thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5324503A (en) * 1992-02-06 1994-06-28 Mallinckrodt Medical, Inc. Iodo-phenylated chelates for x-ray contrast
WO1994027644A1 (en) * 1993-06-02 1994-12-08 Bracco S.P.A. Iodinated paramagnetic chelates, and their use as contrast agents
FR2736051B3 (fr) * 1995-06-29 1997-09-26 Guerbet Sa Complexes metalliques de polyaminoacides, leur procede de preparation et leur utilisation en imagerie diagnostique
FR2793795B1 (fr) * 1999-05-21 2001-08-03 Guerbet Sa Isomeres de tetramides du complexe de gadolinium de l'acide (1,4,7,10-tetrazacyclododecane)1,4,7,10-tetra(2-glutarique) leur procede de preparation et leur application en imagerie medicale
FR2794744B1 (fr) * 1999-06-09 2001-09-21 Guerbet Sa Complexes metalliques de polyaminoacides bicycliques, leur procede de preparation et leur application en imagerie medicale

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013539469A (ja) * 2010-08-26 2013-10-24 ツイ,クンユァン 巨大環状脂肪族化合物及びその応用

Also Published As

Publication number Publication date
ECSP056026A (es) 2006-01-27
CN1753878A (zh) 2006-03-29
WO2004074267A1 (de) 2004-09-02
CA2516467A1 (en) 2004-09-02
CR7937A (es) 2006-02-07
RU2005128834A (ru) 2006-03-20
AU2003290032B2 (en) 2009-04-23
NO20054291L (no) 2005-11-17
AU2003290032A1 (en) 2004-09-09
KR20050105474A (ko) 2005-11-04
NO20054291D0 (no) 2005-09-16
EP1594851A1 (de) 2005-11-16
BR0318125A (pt) 2006-02-07
MXPA05008781A (es) 2006-03-10
AR043205A1 (es) 2005-07-20
ZA200507437B (en) 2007-02-28
DE10307759B3 (de) 2004-11-18

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