RU2005128834A - Тримерные макроциклически замещенные бензольные производные - Google Patents
Тримерные макроциклически замещенные бензольные производные Download PDFInfo
- Publication number
- RU2005128834A RU2005128834A RU2005128834/04A RU2005128834A RU2005128834A RU 2005128834 A RU2005128834 A RU 2005128834A RU 2005128834/04 A RU2005128834/04 A RU 2005128834/04A RU 2005128834 A RU2005128834 A RU 2005128834A RU 2005128834 A RU2005128834 A RU 2005128834A
- Authority
- RU
- Russia
- Prior art keywords
- nhcoch
- chz
- group
- general formula
- denotes
- Prior art date
Links
- UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical class C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 title 1
- 239000013638 trimer Substances 0.000 title 1
- 229910052751 metal Inorganic materials 0.000 claims 11
- 239000002184 metal Substances 0.000 claims 11
- 125000006239 protecting group Chemical group 0.000 claims 7
- 150000004696 coordination complex Chemical group 0.000 claims 6
- 230000003993 interaction Effects 0.000 claims 6
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 5
- 150000001413 amino acids Chemical class 0.000 claims 4
- 150000001491 aromatic compounds Chemical class 0.000 claims 4
- 150000002678 macrocyclic compounds Chemical class 0.000 claims 4
- 239000000825 pharmaceutical preparation Substances 0.000 claims 4
- 229910052740 iodine Inorganic materials 0.000 claims 3
- 229910021645 metal ion Inorganic materials 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims 2
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 239000000654 additive Substances 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 150000007529 inorganic bases Chemical class 0.000 claims 2
- 229910044991 metal oxide Inorganic materials 0.000 claims 2
- 150000004706 metal oxides Chemical class 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 150000007530 organic bases Chemical class 0.000 claims 2
- 229940127557 pharmaceutical product Drugs 0.000 claims 2
- 239000002504 physiological saline solution Substances 0.000 claims 2
- 238000002360 preparation method Methods 0.000 claims 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims 1
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 1
- 229910052692 Dysprosium Inorganic materials 0.000 claims 1
- 229910052693 Europium Inorganic materials 0.000 claims 1
- VTLYFUHAOXGGBS-UHFFFAOYSA-N Fe3+ Chemical compound [Fe+3] VTLYFUHAOXGGBS-UHFFFAOYSA-N 0.000 claims 1
- 229910052688 Gadolinium Inorganic materials 0.000 claims 1
- 206010019695 Hepatic neoplasm Diseases 0.000 claims 1
- 210000000683 abdominal cavity Anatomy 0.000 claims 1
- 230000002378 acidificating effect Effects 0.000 claims 1
- 150000001408 amides Chemical class 0.000 claims 1
- 210000004204 blood vessel Anatomy 0.000 claims 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 1
- 229910052794 bromium Inorganic materials 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 150000001768 cations Chemical class 0.000 claims 1
- 206010008118 cerebral infarction Diseases 0.000 claims 1
- 208000026106 cerebrovascular disease Diseases 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 claims 1
- KBQHZAAAGSGFKK-UHFFFAOYSA-N dysprosium atom Chemical compound [Dy] KBQHZAAAGSGFKK-UHFFFAOYSA-N 0.000 claims 1
- OGPBJKLSAFTDLK-UHFFFAOYSA-N europium atom Chemical compound [Eu] OGPBJKLSAFTDLK-UHFFFAOYSA-N 0.000 claims 1
- UIWYJDYFSGRHKR-UHFFFAOYSA-N gadolinium atom Chemical compound [Gd] UIWYJDYFSGRHKR-UHFFFAOYSA-N 0.000 claims 1
- 125000001841 imino group Chemical group [H]N=* 0.000 claims 1
- 238000001361 intraarterial administration Methods 0.000 claims 1
- 238000010253 intravenous injection Methods 0.000 claims 1
- 239000011630 iodine Substances 0.000 claims 1
- 229910052742 iron Inorganic materials 0.000 claims 1
- 210000003734 kidney Anatomy 0.000 claims 1
- 125000005647 linker group Chemical group 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 238000002595 magnetic resonance imaging Methods 0.000 claims 1
- -1 manganese (II) ions Chemical class 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 210000002346 musculoskeletal system Anatomy 0.000 claims 1
- RRBYUSWBLVXTQN-UHFFFAOYSA-N tricyclene Chemical compound C12CC3CC2C1(C)C3(C)C RRBYUSWBLVXTQN-UHFFFAOYSA-N 0.000 claims 1
- RRBYUSWBLVXTQN-VZCHMASFSA-N tricyclene Natural products C([C@@H]12)C3C[C@H]1C2(C)C3(C)C RRBYUSWBLVXTQN-VZCHMASFSA-N 0.000 claims 1
- 0 *CN1CCN(C*)CCN(**)CCN(C*)CC1 Chemical compound *CN1CCN(C*)CCN(**)CCN(C*)CC1 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/0002—General or multifunctional contrast agents, e.g. chelated agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/04—X-ray contrast preparations
- A61K49/0433—X-ray contrast preparations containing an organic halogenated X-ray contrast-enhancing agent
- A61K49/0438—Organic X-ray contrast-enhancing agent comprising an iodinated group or an iodine atom, e.g. iopamidol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0497—Organic compounds conjugates with a carrier being an organic compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Radiology & Medical Imaging (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Optics & Photonics (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10307759.6 | 2003-02-19 | ||
| DE10307759A DE10307759B3 (de) | 2003-02-19 | 2003-02-19 | Trimere makrocyclisch substituierte Benzolderivate, deren Herstellung und Verwendung als Kontrastmittel sowie diese enthaltende pharmazeutische Mittel |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2005128834A true RU2005128834A (ru) | 2006-03-20 |
Family
ID=32891780
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2005128834/04A RU2005128834A (ru) | 2003-02-19 | 2003-12-12 | Тримерные макроциклически замещенные бензольные производные |
Country Status (16)
| Country | Link |
|---|---|
| EP (1) | EP1594851A1 (pt) |
| JP (1) | JP2006514664A (pt) |
| KR (1) | KR20050105474A (pt) |
| CN (1) | CN1753878A (pt) |
| AR (1) | AR043205A1 (pt) |
| AU (1) | AU2003290032B2 (pt) |
| BR (1) | BR0318125A (pt) |
| CA (1) | CA2516467A1 (pt) |
| CR (1) | CR7937A (pt) |
| DE (1) | DE10307759B3 (pt) |
| EC (1) | ECSP056026A (pt) |
| MX (1) | MXPA05008781A (pt) |
| NO (1) | NO20054291L (pt) |
| RU (1) | RU2005128834A (pt) |
| WO (1) | WO2004074267A1 (pt) |
| ZA (1) | ZA200507437B (pt) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2165768B1 (es) | 1999-07-14 | 2003-04-01 | Almirall Prodesfarma Sa | Nuevos derivados de quinuclidina y composiciones farmaceuticas que los contienen. |
| DE102004023093B3 (de) * | 2004-05-05 | 2006-03-02 | Schering Ag | Trimere makrocyclisch substituierte Halogen-Benzolderivate |
| DE102004026103A1 (de) * | 2004-05-25 | 2005-12-22 | Schering Ag | Trimere makrocyclisch substituierte Aminoisophthalsäure-Halogen-Benzolderivate |
| ES2257152B1 (es) * | 2004-05-31 | 2007-07-01 | Laboratorios Almirall S.A. | Combinaciones que comprenden agentes antimuscarinicos y agonistas beta-adrenergicos. |
| DE102007058220A1 (de) | 2007-12-03 | 2009-06-04 | Bayer Schering Pharma Aktiengesellschaft | Dimere macrocyclisch substituierte Benzolderivate |
| EP2100598A1 (en) | 2008-03-13 | 2009-09-16 | Laboratorios Almirall, S.A. | Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease |
| EP2100599A1 (en) | 2008-03-13 | 2009-09-16 | Laboratorios Almirall, S.A. | Inhalation composition containing aclidinium for treatment of asthma and chronic obstructive pulmonary disease |
| JP6124078B2 (ja) * | 2010-08-26 | 2017-05-10 | ツイ，クンユァン | 巨大環状脂肪族化合物及びその応用 |
| EP2510928A1 (en) | 2011-04-15 | 2012-10-17 | Almirall, S.A. | Aclidinium for use in improving the quality of sleep in respiratory patients |
| CN104672259B (zh) * | 2015-02-02 | 2017-04-05 | 湖北大学 | 一种含碘稀土铕(ⅲ)配合物及其制备方法和应用 |
| CN104721844B (zh) * | 2015-02-02 | 2017-11-03 | 湖北大学 | 一种新型ct，mri，稀土荧光三功能微球及其制备方法和应用 |
| EP3101012A1 (en) | 2015-06-04 | 2016-12-07 | Bayer Pharma Aktiengesellschaft | New gadolinium chelate compounds for use in magnetic resonance imaging |
| CN105254529B (zh) * | 2015-09-21 | 2017-05-31 | 西南石油大学 | 一种树形席夫碱缓蚀剂的制备方法 |
| WO2018096082A1 (en) | 2016-11-28 | 2018-05-31 | Bayer Pharma Aktiengesellschaft | High relaxivity gadolinium chelate compounds for use in magnetic resonance imaging |
| CN107445911B (zh) * | 2017-06-19 | 2019-07-05 | 南京科技职业学院 | 一种二核含钆磁共振对比剂及其制备与应用 |
| CA3120665A1 (en) | 2018-11-23 | 2020-05-28 | Bayer Aktiengesellschaft | Formulation of contrast media and process of preparation thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5324503A (en) * | 1992-02-06 | 1994-06-28 | Mallinckrodt Medical, Inc. | Iodo-phenylated chelates for x-ray contrast |
| WO1994027644A1 (en) * | 1993-06-02 | 1994-12-08 | Bracco S.P.A. | Iodinated paramagnetic chelates, and their use as contrast agents |
| FR2736051B3 (fr) * | 1995-06-29 | 1997-09-26 | Guerbet Sa | Complexes metalliques de polyaminoacides, leur procede de preparation et leur utilisation en imagerie diagnostique |
| FR2793795B1 (fr) * | 1999-05-21 | 2001-08-03 | Guerbet Sa | Isomeres de tetramides du complexe de gadolinium de l'acide (1,4,7,10-tetrazacyclododecane)1,4,7,10-tetra(2-glutarique) leur procede de preparation et leur application en imagerie medicale |
| FR2794744B1 (fr) * | 1999-06-09 | 2001-09-21 | Guerbet Sa | Complexes metalliques de polyaminoacides bicycliques, leur procede de preparation et leur application en imagerie medicale |
-
2003
- 2003-02-19 DE DE10307759A patent/DE10307759B3/de not_active Expired - Fee Related
- 2003-12-12 MX MXPA05008781A patent/MXPA05008781A/es active IP Right Grant
- 2003-12-12 WO PCT/EP2003/014149 patent/WO2004074267A1/de active Application Filing
- 2003-12-12 KR KR1020057015199A patent/KR20050105474A/ko not_active Application Discontinuation
- 2003-12-12 JP JP2004568408A patent/JP2006514664A/ja not_active Withdrawn
- 2003-12-12 CA CA002516467A patent/CA2516467A1/en not_active Abandoned
- 2003-12-12 AU AU2003290032A patent/AU2003290032B2/en not_active Expired - Fee Related
- 2003-12-12 BR BR0318125-1A patent/BR0318125A/pt not_active IP Right Cessation
- 2003-12-12 EP EP03782386A patent/EP1594851A1/de not_active Withdrawn
- 2003-12-12 RU RU2005128834/04A patent/RU2005128834A/ru not_active Application Discontinuation
- 2003-12-12 CN CNA2003801098702A patent/CN1753878A/zh active Pending
-
2004
- 2004-02-18 AR ARP040100490A patent/AR043205A1/es unknown
-
2005
- 2005-08-09 CR CR7937A patent/CR7937A/es not_active Application Discontinuation
- 2005-09-15 ZA ZA200507437A patent/ZA200507437B/en unknown
- 2005-09-16 NO NO20054291A patent/NO20054291L/no not_active Application Discontinuation
- 2005-09-19 EC EC2005006026A patent/ECSP056026A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ECSP056026A (es) | 2006-01-27 |
| CN1753878A (zh) | 2006-03-29 |
| WO2004074267A1 (de) | 2004-09-02 |
| JP2006514664A (ja) | 2006-05-11 |
| CA2516467A1 (en) | 2004-09-02 |
| CR7937A (es) | 2006-02-07 |
| AU2003290032B2 (en) | 2009-04-23 |
| NO20054291L (no) | 2005-11-17 |
| AU2003290032A1 (en) | 2004-09-09 |
| KR20050105474A (ko) | 2005-11-04 |
| NO20054291D0 (no) | 2005-09-16 |
| EP1594851A1 (de) | 2005-11-16 |
| BR0318125A (pt) | 2006-02-07 |
| MXPA05008781A (es) | 2006-03-10 |
| AR043205A1 (es) | 2005-07-20 |
| ZA200507437B (en) | 2007-02-28 |
| DE10307759B3 (de) | 2004-11-18 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20081014 |
|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20081014 |
|
| FZ9A | Application not withdrawn (correction of the notice of withdrawal) |
Effective date: 20081216 |
|
| FZ9A | Application not withdrawn (correction of the notice of withdrawal) |
Effective date: 20081216 |
|
| FA94 | Acknowledgement of application withdrawn (non-payment of fees) |
Effective date: 20101013 |